GREMLIN Database
YQFW - Putative nucleotidase YqfW
UniProt: P54480 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 193 (171)
Sequences: 727 (608)
Seq/√Len: 46.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
3_R84_K5.2671.00
78_L178_V5.2541.00
156_N161_Q5.0761.00
64_K105_R3.4451.00
5_G130_I3.3911.00
156_N172_N2.7871.00
6_I76_L2.7841.00
23_N29_S2.6981.00
160_N170_R2.6821.00
75_S178_V2.6341.00
64_K101_E2.5541.00
47_T50_E2.4241.00
71_H175_L2.3051.00
156_N170_R2.2641.00
96_T100_Y2.2531.00
73_K77_D2.1831.00
20_P24_R2.1741.00
53_D57_Q2.1391.00
5_G88_I2.1181.00
89_T115_L2.1101.00
71_H75_S2.0290.99
79_L181_M1.8480.99
12_I76_L1.8290.99
76_L85_L1.7860.99
78_L81_E1.7300.98
97_D101_E1.7160.98
5_G128_H1.6890.98
153_I180_W1.6830.98
6_I134_F1.5020.96
141_A152_V1.4980.96
15_Q66_A1.4170.94
134_F153_I1.4080.94
153_I177_A1.4030.94
80_K111_D1.3780.93
27_N129_N1.3780.93
75_S78_L1.3740.93
74_Q175_L1.3570.93
16_D67_L1.3480.92
172_N176_E1.3440.92
88_I130_I1.3340.92
8_I99_T1.3340.92
138_H141_A1.3260.92
141_A168_I1.3010.91
63_Y95_L1.3000.91
17_T65_E1.2820.90
132_L181_M1.2640.90
62_I159_Y1.2630.90
18_F22_L1.2630.90
10_G15_Q1.2610.90
141_A154_L1.2600.90
37_D42_K1.2550.89
91_R99_T1.2550.89
10_G135_E1.2370.89
145_A167_N1.2320.89
93_T96_T1.2060.88
61_I98_I1.2040.87
22_L51_F1.2010.87
49_E53_D1.1960.87
105_R166_S1.1940.87
87_Y109_H1.1820.86
135_E144_I1.1770.86
12_I87_Y1.1690.86
23_N28_L1.1680.86
132_L151_P1.1490.85
11_T69_A1.1480.85
120_H143_M1.1420.84
173_N176_E1.1360.84
18_F158_P1.1220.83
14_A69_A1.1020.82
175_L179_Q1.0950.82
4_L79_L1.0890.82
83_H132_L1.0800.81
134_F177_A1.0740.81
78_L82_E1.0730.81
151_P169_I1.0690.80
10_G140_N1.0680.80
155_F177_A1.0570.80
4_L7_D1.0530.79
8_I87_Y1.0390.78
77_D81_E1.0390.78
42_K153_I1.0370.78
79_L168_I1.0330.78
138_H163_P1.0160.77
63_Y99_T1.0110.76
78_L105_R0.9860.75
144_I150_I0.9860.75
88_I128_H0.9650.73
117_G170_R0.9610.73
23_N31_S0.9520.72
169_I180_W0.9420.71
11_T14_A0.9310.70
176_E179_Q0.9310.70
13_T157_S0.9240.70
101_E104_D0.9190.69
71_H80_K0.9160.69
38_Y141_A0.9020.68
153_I171_V0.9020.68
154_L163_P0.8960.67
49_E106_Q0.8960.67
132_L152_V0.8920.67
3_R130_I0.8890.67
18_F88_I0.8830.66
115_L119_H0.8750.65
107_N172_N0.8710.65
25_S57_Q0.8690.65
154_L170_R0.8560.64
40_L109_H0.8500.63
72_A174_W0.8450.63
12_I38_Y0.8360.62
27_N101_E0.8360.62
49_E153_I0.8360.62
24_R28_L0.8350.62
70_Q78_L0.8340.62
10_G159_Y0.8310.61
68_L106_Q0.8250.61
85_L145_A0.8250.61
8_I91_R0.8140.60
63_Y174_W0.8060.59
12_I143_M0.8050.59
71_H173_N0.7990.58
10_G133_F0.7910.58
91_R127_N0.7890.57
19_V35_M0.7860.57
87_Y102_W0.7850.57
89_T132_L0.7810.57
36_T43_L0.7660.55
80_K85_L0.7610.55
68_L73_K0.7600.55
11_T133_F0.7590.54
8_I150_I0.7550.54
135_E152_V0.7520.54
41_T48_Q0.7520.54
102_W158_P0.7500.54
5_G133_F0.7500.54
101_E147_E0.7420.53
100_Y104_D0.7400.53
103_F108_I0.7240.51
102_W115_L0.7190.51
55_M89_T0.7180.50
14_A148_A0.7150.50
138_H154_L0.7110.50
100_Y181_M0.7110.50
85_L138_H0.7100.50
88_I140_N0.7060.49
11_T66_A0.7020.49
43_L46_I0.6980.48
16_D52_W0.6970.48
97_D163_P0.6920.48
5_G159_Y0.6900.48
18_F21_Y0.6880.47
86_I128_H0.6870.47
141_A145_A0.6860.47
19_V55_M0.6860.47
30_I35_M0.6810.47
35_M92_R0.6750.46
88_I133_F0.6750.46
67_L176_E0.6740.46
16_D53_D0.6700.46
108_I113_I0.6690.46
10_G157_S0.6690.46
4_L106_Q0.6680.45
29_S68_L0.6640.45
171_V175_L0.6630.45
6_I109_H0.6570.44
89_T139_G0.6560.44
60_A127_N0.6500.44
87_Y135_E0.6480.44
66_A102_W0.6470.43
20_P172_N0.6440.43
3_R86_I0.6370.42
10_G69_A0.6370.42
119_H170_R0.6360.42
147_E155_F0.6330.42
38_Y137_H0.6320.42
13_T63_Y0.6320.42
12_I138_H0.6310.42
42_K143_M0.6300.42
171_V180_W0.6290.42
135_E157_S0.6240.41
50_E53_D0.6160.40
11_T63_Y0.6100.40
129_N179_Q0.6100.40
67_L74_Q0.6100.40
52_W70_Q0.6080.40
44_L96_T0.6070.40
24_R162_L0.6060.40
8_I13_T0.6060.40
27_N111_D0.6040.39
8_I130_I0.5990.39
27_N179_Q0.5960.39
139_G142_M0.5930.38
27_N86_I0.5930.38
35_M132_L0.5900.38
166_S169_I0.5860.38
87_Y133_F0.5840.37
145_A168_I0.5840.37
21_Y54_W0.5820.37
83_H112_H0.5810.37
16_D106_Q0.5780.37
56_N82_E0.5780.37
11_T87_Y0.5730.36
81_E105_R0.5720.36
48_Q105_R0.5710.36
89_T122_V0.5700.36
96_T103_F0.5690.36
39_D156_N0.5660.36
55_M71_H0.5640.36
48_Q58_N0.5630.36
133_F144_I0.5630.36
31_S34_D0.5610.35
89_T116_V0.5610.35
9_D136_D0.5600.35
114_E144_I0.5540.35
62_I170_R0.5540.35
28_L128_H0.5530.35
84_K106_Q0.5490.34
113_I116_V0.5480.34
53_D145_A0.5470.34
60_A85_L0.5470.34
53_D67_L0.5460.34
57_Q129_N0.5440.34
4_L12_I0.5430.34
49_E56_N0.5380.33
89_T110_Y0.5370.33
87_Y134_F0.5370.33
94_H113_I0.5330.33
79_L115_L0.5320.33
159_Y170_R0.5310.33
106_Q173_N0.5300.33
68_L102_W0.5280.32
53_D81_E0.5270.32
6_I138_H0.5260.32
5_G91_R0.5250.32
76_L97_D0.5250.32
173_N179_Q0.5250.32
127_N179_Q0.5240.32
135_E141_A0.5240.32
76_L80_K0.5190.32
110_Y137_H0.5190.32
73_K163_P0.5170.31
103_F119_H0.5170.31
68_L171_V0.5160.31
5_G121_K0.5150.31
28_L45_N0.5130.31
24_R36_T0.5130.31
91_R130_I0.5130.31
99_T174_W0.5120.31
35_M158_P0.5100.31
74_Q147_E0.5070.31
142_M168_I0.5050.30
89_T103_F0.5040.30
13_T102_W0.5040.30
13_T144_I0.5030.30
89_T96_T0.5010.30
79_L89_T0.5010.30
50_E113_I0.5000.30
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3bwvA 2 0.8394 99.8 0.633 Contact Map
4mumA 2 0.9016 99.7 0.67 Contact Map
4l57A 2 0.9119 99.7 0.677 Contact Map
2b82A 4 0.8601 99.6 0.698 Contact Map
2zg6A 2 0.8756 99.5 0.727 Contact Map
2obbA 2 0.6114 99.5 0.73 Contact Map
2om6A 2 0.9482 99.4 0.731 Contact Map
3sd7A 1 0.9171 99.4 0.735 Contact Map
2go7A 2 0.9016 99.4 0.74 Contact Map
3kzxA 1 0.886 99.4 0.744 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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