GREMLIN Database
YQFU - UPF0750 membrane protein YqfU
UniProt: P54478 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 293 (273)
Sequences: 3731 (2717)
Seq/√Len: 164.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
23_L95_I5.7101.00
217_Q220_E4.9861.00
237_K246_E3.9331.00
238_G249_V3.7841.00
216_E247_K3.4971.00
223_D227_H3.4771.00
215_S221_I3.1271.00
27_A103_I2.9401.00
211_V262_L2.7321.00
123_F185_M2.7251.00
47_I73_L2.6201.00
239_K244_D2.5391.00
224_A265_I2.3991.00
236_L249_V2.3061.00
215_S218_Y2.3051.00
219_D223_D2.2891.00
239_K248_D2.2801.00
224_A228_R2.2691.00
54_L58_F2.2281.00
209_K279_N2.1401.00
237_K248_D2.0881.00
233_T241_G2.0741.00
19_V95_I2.0651.00
18_R92_S1.9871.00
23_L99_G1.9621.00
34_E107_L1.9611.00
25_G131_G1.9181.00
176_V184_A1.9151.00
30_A103_I1.9131.00
32_S128_L1.9121.00
98_V102_V1.9111.00
29_A100_L1.8711.00
31_V35_L1.8531.00
231_R258_E1.8491.00
21_M138_N1.8411.00
196_K200_A1.8231.00
67_A105_S1.7841.00
222_S241_G1.7671.00
135_V142_M1.7521.00
176_V181_P1.7141.00
161_G199_D1.7061.00
266_V273_A1.7001.00
54_L69_F1.7001.00
235_K250_I1.6741.00
225_I262_L1.6451.00
40_N120_A1.6421.00
218_Y248_D1.6401.00
180_G183_Q1.6241.00
233_T250_I1.6171.00
216_E245_E1.6021.00
116_Q186_Y1.5921.00
266_V275_I1.5741.00
239_K246_E1.5601.00
222_S244_D1.5291.00
18_R138_N1.5271.00
229_L262_L1.5101.00
216_E272_N1.5061.00
58_F63_F1.5041.00
219_D244_D1.4971.00
224_A269_V1.4911.00
133_G201_V1.4911.00
79_I83_K1.4601.00
251_Y276_T1.4351.00
210_A278_M1.4311.00
118_I189_M1.4061.00
89_F141_S1.4001.00
22_I96_G1.3901.00
212_I251_Y1.3831.00
170_F174_W1.3751.00
25_G135_V1.3731.00
222_S235_K1.3651.00
31_V107_L1.3631.00
166_F170_F1.3571.00
47_I77_F1.3481.00
34_E108_H1.3261.00
70_V104_E1.3171.00
254_V262_L1.3071.00
65_N105_S1.2971.00
272_N286_G1.2921.00
238_G247_K1.2881.00
172_F191_Y1.2871.00
50_V54_L1.2831.00
41_D183_Q1.2811.00
75_I79_I1.2731.00
27_A107_L1.2691.00
37_L124_G1.2671.00
129_G133_G1.2671.00
225_I252_A1.2601.00
220_E269_V1.2431.00
85_I89_F1.2341.00
165_M195_M1.2211.00
67_A101_A1.2171.00
81_G90_L1.1991.00
82_Y87_K1.1911.00
91_V95_I1.1821.00
192_Y196_K1.1761.00
26_A99_G1.1751.00
149_G164_V1.1741.00
32_S131_G1.1741.00
212_I278_M1.1651.00
22_I140_G1.1631.00
210_A276_T1.1601.00
32_S127_L1.1591.00
19_V92_S1.1491.00
259_V277_I1.1441.00
226_L241_G1.1441.00
210_A280_T1.1361.00
16_I20_F1.1331.00
263_K282_E1.1291.00
38_I66_F1.1271.00
235_K248_D1.1251.00
78_M97_I1.1241.00
71_V101_A1.1211.00
152_L156_L1.1151.00
224_A268_E1.1071.00
67_A71_V1.1021.00
126_L197_T1.1001.00
169_V173_I1.0951.00
117_P183_Q1.0891.00
213_I266_V1.0871.00
64_L69_F1.0851.00
99_G103_I1.0851.00
211_V259_V1.0841.00
270_D273_A1.0760.99
222_S233_T1.0700.99
119_L123_F1.0670.99
17_F21_M1.0650.99
234_T238_G1.0570.99
265_I268_E1.0460.99
121_T125_G1.0450.99
82_Y90_L1.0430.99
20_F24_V1.0370.99
84_Y155_K1.0290.99
95_I99_G1.0210.99
85_I150_I1.0200.99
240_G243_T1.0170.99
235_K241_G1.0140.99
96_G140_G1.0120.99
225_I231_R1.0120.99
19_V23_L1.0090.99
43_I175_A1.0030.99
262_L266_V0.9950.99
52_L55_D0.9950.99
116_Q182_E0.9860.99
36_F123_F0.9790.99
50_V174_W0.9730.99
212_I236_L0.9700.99
68_F105_S0.9640.99
48_I104_E0.9590.99
21_M134_L0.9530.99
15_F18_R0.9330.99
69_F73_L0.9290.99
210_A251_Y0.9270.98
210_A253_V0.9260.98
226_L233_T0.9260.98
209_K282_E0.9210.98
260_T264_S0.9200.98
117_P121_T0.9180.98
276_T280_T0.9180.98
76_P79_I0.9160.98
121_T189_M0.9160.98
26_A96_G0.9140.98
161_G195_M0.9090.98
43_I168_N0.9080.98
161_G198_I0.9060.98
41_D56_H0.9000.98
37_L190_T0.8980.98
199_D256_R0.8800.98
212_I276_T0.8760.98
105_S108_H0.8750.98
221_I265_I0.8750.98
15_F92_S0.8720.98
126_L192_Y0.8690.98
84_Y151_L0.8670.98
88_T92_S0.8630.98
194_A198_I0.8610.98
211_V254_V0.8530.97
255_T258_E0.8500.97
253_V276_T0.8480.97
80_F84_Y0.8470.97
85_I141_S0.8450.97
215_S270_D0.8450.97
26_A135_V0.8430.97
125_G129_G0.8380.97
132_V136_I0.8380.97
236_L251_Y0.8360.97
235_K239_K0.8300.97
68_F72_I0.8220.97
130_F201_V0.8220.97
132_V198_I0.8210.97
164_V168_N0.8160.97
224_A227_H0.8120.97
136_I150_I0.7990.96
141_S150_I0.7980.96
158_F163_F0.7970.96
29_A131_G0.7960.96
78_M94_F0.7940.96
226_L232_G0.7930.96
50_V53_I0.7880.96
27_A99_G0.7870.96
119_L185_M0.7870.96
17_F138_N0.7860.96
42_F121_T0.7850.96
43_I187_S0.7840.96
152_L163_F0.7840.96
78_M93_T0.7800.96
53_I57_L0.7770.96
211_V266_V0.7760.95
151_L155_K0.7740.95
265_I269_V0.7730.95
72_I76_P0.7720.95
133_G137_R0.7710.95
53_I179_F0.7700.95
223_D244_D0.7650.95
28_S130_F0.7620.95
222_S226_L0.7560.95
32_S36_F0.7560.95
148_L152_L0.7550.95
263_K284_R0.7550.95
77_F148_L0.7510.95
166_F169_V0.7470.94
159_S162_E0.7460.94
196_K199_D0.7450.94
71_V75_I0.7430.94
33_I100_L0.7410.94
71_V98_V0.7410.94
264_S268_E0.7400.94
114_T182_E0.7390.94
53_I174_W0.7390.94
165_M192_Y0.7350.94
208_T252_A0.7340.94
76_P80_F0.7290.94
145_T167_I0.7250.94
55_D66_F0.7190.93
142_M146_E0.7170.93
77_F93_T0.7150.93
16_I19_V0.7120.93
228_R265_I0.7110.93
120_A182_E0.7100.93
116_Q121_T0.7090.93
29_A128_L0.7090.93
233_T252_A0.7060.93
58_F69_F0.7050.93
191_Y195_M0.7020.92
26_A100_L0.7010.92
159_S199_D0.7000.92
115_T182_E0.6960.92
50_V73_L0.6950.92
54_L73_L0.6930.92
78_M81_G0.6920.92
49_G186_Y0.6920.92
91_V94_F0.6900.92
228_R261_K0.6900.92
217_Q269_V0.6870.92
174_W177_F0.6870.92
150_I160_V0.6870.92
218_Y221_I0.6870.92
231_R255_T0.6870.92
103_I106_S0.6860.92
135_V140_G0.6840.91
209_K277_I0.6830.91
221_I269_V0.6790.91
55_D63_F0.6790.91
79_I82_Y0.6770.91
35_L111_E0.6770.91
117_P120_A0.6770.91
121_T193_I0.6760.91
33_I38_I0.6760.91
240_G247_K0.6760.91
21_M24_V0.6700.91
122_V193_I0.6700.91
267_F284_R0.6650.90
232_G242_Y0.6650.90
234_T240_G0.6640.90
145_T168_N0.6630.90
132_V142_M0.6620.90
92_S139_G0.6620.90
81_G89_F0.6610.90
217_Q270_D0.6590.90
211_V277_I0.6590.90
128_L194_A0.6590.90
170_F173_I0.6590.90
134_L138_N0.6580.90
89_F150_I0.6570.90
65_N68_F0.6560.90
122_V189_M0.6550.90
214_V251_Y0.6540.90
162_E199_D0.6530.89
30_A100_L0.6520.89
150_I154_K0.6520.89
24_V28_S0.6490.89
28_S127_L0.6460.89
51_S70_V0.6450.89
175_A184_A0.6450.89
38_I55_D0.6430.89
205_L208_T0.6430.89
69_F72_I0.6410.89
97_I101_A0.6380.88
114_T117_P0.6370.88
132_V194_A0.6370.88
35_L107_L0.6370.88
123_F188_F0.6350.88
261_K264_S0.6320.88
164_V198_I0.6310.88
143_D146_E0.6310.88
93_T147_I0.6290.88
33_I51_S0.6290.88
203_Q281_H0.6290.88
231_R287_K0.6280.88
172_F175_A0.6270.88
206_D289_K0.6230.87
147_I161_G0.6220.87
213_I262_L0.6220.87
136_I146_E0.6200.87
231_R288_F0.6190.87
38_I52_L0.6170.87
213_I252_A0.6150.86
44_D146_E0.6110.86
219_D248_D0.6100.86
168_N187_S0.6100.86
277_I282_E0.6100.86
264_S267_F0.6080.86
48_I100_L0.6060.86
187_S254_V0.6010.85
145_T179_F0.5970.85
121_T190_T0.5970.85
218_Y222_S0.5950.85
253_V280_T0.5940.85
114_T120_A0.5940.85
162_E165_M0.5910.84
274_F283_T0.5900.84
117_P186_Y0.5890.84
56_H179_F0.5880.84
168_N287_K0.5870.84
254_V259_V0.5810.83
54_L64_L0.5770.83
80_F83_K0.5750.83
55_D69_F0.5740.83
263_K267_F0.5710.82
93_T97_I0.5700.82
35_L39_P0.5700.82
228_R268_E0.5700.82
96_G142_M0.5690.82
80_F151_L0.5660.82
129_G198_I0.5620.81
184_A190_T0.5620.81
66_F70_V0.5610.81
102_V106_S0.5610.81
209_K247_K0.5610.81
29_A132_V0.5600.81
57_L76_P0.5600.81
43_I52_L0.5580.81
17_F137_R0.5570.81
212_I249_V0.5570.81
222_S248_D0.5560.81
125_G193_I0.5550.80
147_I198_I0.5530.80
235_K244_D0.5510.80
17_F268_E0.5480.80
173_I177_F0.5460.79
51_S66_F0.5460.79
51_S251_Y0.5440.79
52_L66_F0.5420.79
119_L192_Y0.5420.79
179_F183_Q0.5410.79
52_L56_H0.5400.79
136_I160_V0.5400.79
94_F97_I0.5390.78
136_I202_I0.5370.78
234_T274_F0.5370.78
160_V199_D0.5360.78
83_K101_A0.5350.78
130_F197_T0.5340.78
166_F174_W0.5330.78
212_I280_T0.5310.77
87_K90_L0.5280.77
92_S187_S0.5270.77
42_F114_T0.5270.77
27_A110_V0.5240.76
51_S73_L0.5240.76
215_S248_D0.5230.76
158_F162_E0.5230.76
52_L251_Y0.5150.75
122_V247_K0.5150.75
212_I250_I0.5150.75
220_E223_D0.5140.75
37_L175_A0.5120.75
167_I171_I0.5120.75
136_I148_L0.5110.75
58_F64_L0.5090.74
33_I48_I0.5080.74
70_V136_I0.5080.74
229_L258_E0.5070.74
86_G208_T0.5070.74
250_I275_I0.5060.74
118_I128_L0.5060.74
23_L103_I0.5050.74
32_S37_L0.5040.74
78_M148_L0.5040.74
99_G106_S0.5030.74
117_P182_E0.5030.74
128_L136_I0.5030.74
33_I70_V0.5030.74
125_G194_A0.5020.73
78_M147_I0.5020.73
243_T272_N0.5020.73
221_I266_V0.5010.73
140_G153_T0.5010.73
142_M286_G0.5010.73
13_T17_F0.5000.73
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3hluA 2 0.2491 99.9 0.699 Contact Map
4rwwA 3 0.2867 77.1 0.946 Contact Map
4affA 3 0.3003 70.8 0.949 Contact Map
2gw8A 3 0.2969 70.4 0.949 Contact Map
3ncqA 4 0.3003 70.3 0.949 Contact Map
3t9zA 3 0.2867 70.2 0.949 Contact Map
2eg2A 5 0.2867 69.2 0.949 Contact Map
4co3A 3 0.2935 68.9 0.95 Contact Map
2o66A 5 0.3208 68.6 0.95 Contact Map
2j9cA 3 0.3038 67.1 0.95 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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