GREMLIN Database
END4 - Probable endonuclease 4
UniProt: P54476 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 297 (268)
Sequences: 2182 (1386)
Seq/√Len: 84.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
219_K230_E4.3061.00
127_I167_G4.1501.00
193_D196_G3.4991.00
221_V236_E3.0571.00
56_A60_E2.8481.00
114_H118_G2.8411.00
86_E90_D2.8331.00
162_A166_E2.8191.00
146_T183_T2.6811.00
178_F183_T2.6781.00
141_Q211_K2.6191.00
23_A28_A2.6101.00
199_N203_K2.5721.00
159_E204_I2.5011.00
217_D233_G2.4791.00
194_F248_H2.4171.00
123_I163_Q2.2121.00
119_A160_E2.1961.00
100_A139_N2.1681.00
85_F129_G2.1321.00
80_T83_S2.1291.00
120_E163_Q2.1111.00
156_R160_E2.0971.00
67_I257_I2.0271.00
213_L256_K1.9961.00
158_F197_V1.9891.00
184_H236_E1.9861.00
24_V61_N1.9801.00
20_S57_H1.9791.00
163_Q167_G1.9551.00
80_T84_T1.9521.00
237_I241_A1.9321.00
201_F210_I1.9251.00
220_N226_K1.8911.00
17_L50_N1.8411.00
131_N169_T1.8381.00
242_L245_V1.8161.00
119_A156_R1.8061.00
124_K167_G1.7831.00
85_F125_K1.7391.00
23_A31_F1.7391.00
230_E234_F1.7291.00
76_I129_G1.7271.00
176_V201_F1.7231.00
200_E204_I1.7191.00
99_T104_A1.6811.00
200_E203_K1.6551.00
77_G122_G1.6461.00
89_V132_E1.6451.00
55_R103_G1.6331.00
240_D243_Q1.6291.00
50_N53_A1.5681.00
165_I174_L1.5591.00
113_A152_S1.5421.00
32_M257_I1.5391.00
159_E200_E1.5141.00
198_L251_L1.5020.99
67_I212_V1.4930.99
194_F198_L1.4890.99
18_A22_E1.4710.99
118_G121_A1.4670.99
195_D199_N1.4620.99
93_R136_P1.4580.99
78_N84_T1.4570.99
106_Q211_K1.4390.99
52_E56_A1.4370.99
85_F89_V1.4260.99
189_N192_E1.4080.99
185_D220_N1.4030.99
144_L161_L1.3970.99
184_H222_K1.3930.99
157_S160_E1.3870.99
21_Q57_H1.3660.99
168_V174_L1.3560.99
3_R65_E1.3540.99
171_N209_R1.3440.99
165_I209_R1.3100.99
113_A153_E1.3060.99
194_F244_Y1.2960.98
90_D94_S1.2910.98
114_H122_G1.2850.98
249_E252_K1.2770.98
48_D52_E1.2710.98
83_S87_L1.2560.98
55_R59_Q1.2420.98
131_N171_N1.2380.98
161_L176_V1.2330.98
22_E25_S1.2290.98
123_I154_C1.2170.98
157_S200_E1.2170.98
20_S24_V1.2150.98
37_A40_N1.2100.98
174_L209_R1.2040.97
46_I51_I1.2000.97
99_T107_I1.1910.97
131_N168_V1.1830.97
124_K163_Q1.1730.97
68_V99_T1.1690.97
48_D101_A1.1670.97
125_K128_E1.1610.97
85_F128_E1.1600.97
20_S31_F1.1550.97
165_I176_V1.1530.97
92_L109_L1.1410.97
54_G58_M1.1400.96
163_Q166_E1.1380.96
10_M33_I1.1330.96
224_A236_E1.1240.96
137_N173_Q1.1240.96
114_H119_A1.1190.96
218_S236_E1.1080.96
24_V57_H1.1040.96
158_F201_F1.1010.96
17_L53_A1.0920.96
3_R29_N1.0890.95
17_L57_H1.0790.95
196_G200_E1.0740.95
35_T68_V1.0640.95
57_H60_E1.0580.95
170_H173_Q1.0570.95
251_L256_K1.0570.95
67_I108_V1.0560.95
183_T190_I1.0560.95
92_L133_V1.0540.95
108_V177_C1.0540.95
121_A124_K1.0420.94
264_G267_K1.0370.94
82_P86_E1.0300.94
171_N174_L1.0170.93
68_V104_A1.0090.93
57_H61_N1.0070.93
36_G43_R1.0060.93
130_L142_I1.0010.93
176_V205_I0.9980.93
106_Q143_A0.9970.93
184_H191_V0.9960.93
96_I107_I0.9930.93
217_D238_G0.9920.93
198_L248_H0.9850.92
70_A109_L0.9840.92
58_M66_I0.9830.92
16_L102_I0.9810.92
210_I251_L0.9810.92
126_I164_I0.9760.92
184_H237_I0.9740.92
34_Y72_Y0.9730.92
123_I167_G0.9730.92
124_K128_E0.9720.92
38_P71_P0.9690.92
89_V129_G0.9610.91
118_G122_G0.9590.91
143_A175_S0.9460.91
41_T87_L0.9460.91
123_I164_I0.9410.90
191_V222_K0.9400.90
4_I246_V0.9390.90
36_G71_P0.9350.90
41_T73_I0.9330.90
53_A56_A0.9320.90
175_S211_K0.9280.90
193_D197_V0.9220.90
84_T87_L0.9160.89
232_I246_V0.9150.89
44_K47_E0.9130.89
53_A57_H0.9080.89
138_Q173_Q0.9080.89
22_E26_Y0.9070.89
130_L174_L0.9000.88
52_E59_Q0.8900.88
267_K270_K0.8870.88
12_G22_E0.8850.88
262_Y267_K0.8850.88
36_G91_F0.8810.87
134_I142_I0.8780.87
56_A59_Q0.8770.87
114_H152_S0.8690.87
121_A125_K0.8660.86
215_I245_V0.8660.86
267_K271_K0.8650.86
74_I91_F0.8650.86
231_N262_Y0.8540.86
184_H224_A0.8510.85
217_D235_G0.8470.85
148_A185_D0.8450.85
3_R62_G0.8430.85
106_Q175_S0.8370.84
106_Q141_Q0.8350.84
3_R64_D0.8320.84
94_S97_E0.8310.84
30_T257_I0.8280.84
79_T115_V0.8270.84
221_V224_A0.8260.84
156_R225_R0.8190.83
70_A92_L0.8180.83
231_N234_F0.8170.83
33_I102_I0.8160.83
143_A212_V0.8150.83
35_T98_R0.8150.83
93_R137_N0.8060.82
96_I140_V0.8010.82
3_R63_I0.7990.82
239_F243_Q0.7920.81
96_I142_I0.7920.81
17_L21_Q0.7880.81
202_D205_I0.7860.81
122_G154_C0.7850.80
158_F204_I0.7840.80
199_N250_Q0.7820.80
93_R97_E0.7810.80
51_I101_A0.7800.80
77_G125_K0.7770.80
245_V251_L0.7770.80
135_D169_T0.7750.80
76_I92_L0.7750.80
194_F241_A0.7730.79
31_F58_M0.7700.79
268_K271_K0.7640.79
51_I55_R0.7640.79
201_F205_I0.7600.78
49_L53_A0.7560.78
158_F188_Y0.7500.77
233_G238_G0.7490.77
232_I242_L0.7480.77
70_A107_I0.7480.77
162_A204_I0.7470.77
213_L245_V0.7450.77
151_G225_R0.7430.77
188_Y200_E0.7420.77
82_P125_K0.7410.77
10_M19_A0.7400.76
95_E107_I0.7370.76
76_I88_G0.7360.76
212_V257_I0.7340.76
132_E135_D0.7330.76
243_Q247_H0.7320.76
21_Q25_S0.7320.76
159_E162_A0.7290.75
8_V19_A0.7280.75
266_D270_K0.7270.75
122_G125_K0.7240.75
100_A138_Q0.7230.75
135_D170_H0.7210.75
190_I194_F0.7210.75
134_I170_H0.7180.74
40_N71_P0.7150.74
80_T117_A0.7140.74
30_T65_E0.7100.73
213_L250_Q0.7050.73
191_V236_E0.7040.73
79_T117_A0.7040.73
178_F251_L0.7040.73
147_M153_E0.7030.73
70_A74_I0.6980.72
47_E50_N0.6940.72
201_F206_G0.6940.72
97_E100_A0.6920.72
20_S66_I0.6900.71
150_K153_E0.6900.71
269_N272_P0.6890.71
231_N261_P0.6870.71
16_L19_A0.6860.71
195_D248_H0.6810.70
266_D269_N0.6780.70
160_E205_I0.6770.70
77_G126_I0.6700.69
125_K129_G0.6700.69
194_F251_L0.6690.69
6_S26_Y0.6690.69
215_I246_V0.6680.69
130_L134_I0.6660.69
93_R133_V0.6640.68
151_G226_K0.6630.68
100_A140_V0.6600.68
241_A245_V0.6600.68
178_F197_V0.6580.68
123_I160_E0.6530.67
210_I213_L0.6520.67
71_P91_F0.6510.67
78_N125_K0.6500.67
142_I174_L0.6500.67
128_E132_E0.6490.67
119_A157_S0.6480.67
18_A21_Q0.6470.66
178_F213_L0.6470.66
77_G231_N0.6420.66
207_I210_I0.6410.66
265_E268_K0.6390.65
8_V23_A0.6380.65
23_A26_Y0.6370.65
132_E136_P0.6350.65
189_N193_D0.6340.65
265_E269_N0.6320.65
168_V171_N0.6300.64
120_E124_K0.6290.64
65_E253_D0.6240.64
85_F132_E0.6230.63
119_A163_Q0.6220.63
230_E261_P0.6200.63
108_V212_V0.6180.63
150_K226_K0.6170.63
41_T88_G0.6170.63
183_T186_A0.6160.63
202_D207_I0.6160.63
8_V26_Y0.6150.62
76_I161_L0.6150.62
111_P147_M0.6150.62
36_G40_N0.6080.62
242_L256_K0.6040.61
263_V266_D0.6040.61
185_D222_K0.6030.61
36_G94_S0.6020.61
198_L213_L0.6010.61
11_S18_A0.5990.60
232_I241_A0.5970.60
241_A244_Y0.5960.60
73_I88_G0.5930.60
191_V244_Y0.5920.60
6_S28_A0.5900.59
155_G161_L0.5900.59
111_P151_G0.5890.59
262_Y268_K0.5880.59
2_L252_K0.5870.59
89_V136_P0.5860.59
135_D138_Q0.5850.59
8_V31_F0.5850.59
157_S186_A0.5850.59
94_S98_R0.5820.58
234_F265_E0.5810.58
24_V63_I0.5810.58
131_N172_E0.5800.58
232_I258_L0.5790.58
69_H110_H0.5790.58
117_A125_K0.5790.58
8_V22_E0.5780.58
126_I147_M0.5780.58
127_I163_Q0.5780.58
33_I104_A0.5740.57
156_R186_A0.5730.57
56_A208_D0.5720.57
184_H242_L0.5720.57
71_P150_K0.5710.57
67_I106_Q0.5680.56
28_A231_N0.5650.56
69_H145_E0.5650.56
32_M67_I0.5650.56
110_H145_E0.5640.56
100_A141_Q0.5620.56
158_F205_I0.5610.56
84_T92_L0.5610.56
69_H182_H0.5580.55
76_I89_V0.5570.55
237_I242_L0.5570.55
146_T205_I0.5550.55
89_V128_E0.5550.55
110_H182_H0.5550.55
164_I168_V0.5550.55
96_I134_I0.5510.54
145_E182_H0.5510.54
20_S54_G0.5480.54
20_S58_M0.5480.54
44_K50_N0.5480.54
41_T91_F0.5460.54
54_G57_H0.5450.53
193_D222_K0.5440.53
90_D97_E0.5440.53
221_V226_K0.5440.53
155_G160_E0.5410.53
191_V194_F0.5390.53
24_V29_N0.5390.53
147_M164_I0.5380.52
141_Q175_S0.5370.52
32_M143_A0.5370.52
60_E203_K0.5360.52
73_I87_L0.5360.52
184_H241_A0.5340.52
248_H251_L0.5340.52
10_M16_L0.5330.52
195_D244_Y0.5330.52
85_F117_A0.5310.52
183_T210_I0.5310.52
58_M61_N0.5280.51
84_T125_K0.5270.51
67_I143_A0.5240.51
115_V118_G0.5240.51
54_G184_H0.5200.50
40_N153_E0.5190.50
16_L33_I0.5170.50
89_V133_V0.5150.49
109_L142_I0.5120.49
35_T226_K0.5090.49
42_R90_D0.5080.48
220_N236_E0.5080.48
191_V221_V0.5080.48
88_G154_C0.5060.48
4_I29_N0.5050.48
245_V256_K0.5050.48
48_D51_I0.5040.48
194_F250_Q0.5030.48
262_Y266_D0.5030.48
107_I140_V0.5020.48
202_D206_G0.5010.48
55_R58_M0.5000.47
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3aalA 1 0.9933 100 0.564 Contact Map
4hnoA 1 0.9461 100 0.584 Contact Map
1qtwA 1 0.9428 100 0.585 Contact Map
3tc3A 1 0.8485 100 0.587 Contact Map
3aamA 1 0.9024 100 0.6 Contact Map
3wqoA 2 0.8923 100 0.678 Contact Map
2j6vA 1 0.8081 100 0.695 Contact Map
3ayvA 2 0.798 100 0.697 Contact Map
2zvrA 2 0.8519 100 0.698 Contact Map
3p14A 2 0.899 100 0.708 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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