GREMLIN Database
CSHB - DEAD-box ATP-dependent RNA helicase CshB
UniProt: P54475 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 438 (356)
Sequences: 45128 (25936)
Seq/√Len: 1374.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
59_L92_A3.8181.00
62_L75_V3.7581.00
273_G296_F3.2001.00
38_V184_L3.0781.00
290_Q295_E3.0481.00
89_Y93_L2.6931.00
289_K293_D2.6701.00
286_K290_Q2.5811.00
79_A88_I2.5791.00
271_K297_T2.5731.00
262_A266_T2.5361.00
273_G290_Q2.5241.00
255_K278_G2.4711.00
105_R127_H2.3751.00
262_A272_I2.3721.00
262_A274_L2.3451.00
107_K126_P2.2941.00
252_A258_A2.2601.00
131_G136_I2.1851.00
167_L170_V2.1681.00
259_D274_L2.1451.00
285_K289_K2.0641.00
237_F268_K2.0611.00
30_I46_G2.0481.00
248_G316_H2.0381.00
343_G347_T2.0071.00
273_G287_V1.9381.00
89_Y106_S1.9251.00
139_L144_A1.9241.00
252_A261_I1.9211.00
89_Y108_C1.9201.00
222_H333_V1.8951.00
221_E344_Q1.8831.00
39_L64_N1.8621.00
246_Y315_S1.8601.00
252_A300_I1.8341.00
280_T283_E1.8261.00
42_E206_K1.7991.00
247_L313_G1.7971.00
158_A185_V1.7601.00
74_Q151_E1.7571.00
169_D172_Y1.7551.00
58_Y186_F1.7381.00
233_D264_Y1.7291.00
91_E94_K1.7281.00
168_A171_D1.7271.00
333_V345_A1.7261.00
65_K152_S1.7051.00
75_V152_S1.7001.00
235_L238_D1.6961.00
170_V173_I1.6711.00
258_A274_L1.6561.00
166_F170_V1.6491.00
167_L171_D1.6481.00
357_L361_E1.6091.00
316_H346_M1.6061.00
86_N285_K1.6051.00
258_A276_H1.6041.00
264_Y268_K1.6011.00
319_N333_V1.5811.00
223_I344_Q1.5731.00
107_K121_K1.5551.00
174_G177_M1.5491.00
257_T321_E1.5481.00
114_D117_K1.5461.00
301_A305_A1.5411.00
32_K36_P1.5391.00
36_P40_K1.5241.00
261_I320_Y1.5071.00
86_N90_Q1.5071.00
270_M298_Y1.4961.00
305_A309_I1.4961.00
34_L57_A1.4841.00
317_V336_T1.4831.00
205_P210_V1.4821.00
38_V44_V1.4811.00
237_F241_S1.4801.00
353_D356_A1.4581.00
254_T257_T1.4521.00
265_L300_I1.4451.00
21_R101_G1.4391.00
91_E310_D1.4371.00
46_G186_F1.4341.00
24_F56_H1.4261.00
116_Q120_D1.4251.00
92_A128_L1.4081.00
66_I75_V1.4031.00
313_G341_S1.4031.00
38_V61_P1.3971.00
58_Y154_V1.3761.00
72_V149_K1.3751.00
62_L154_V1.3721.00
257_T260_H1.3661.00
222_H329_Y1.3631.00
73_V151_E1.3561.00
322_L347_T1.3481.00
195_K199_K1.3461.00
248_G318_I1.3431.00
217_A220_I1.3421.00
195_K207_Y1.3401.00
74_Q127_H1.3321.00
279_L287_V1.3281.00
287_V296_F1.3271.00
239_I242_H1.3171.00
92_A106_S1.3151.00
290_Q296_F1.3121.00
266_T272_I1.3111.00
283_E286_K1.3031.00
159_D307_R1.3001.00
357_L360_L1.2981.00
37_A44_V1.2971.00
62_L152_S1.2951.00
236_L318_I1.2921.00
137_A172_Y1.2891.00
79_A85_A1.2881.00
343_G346_M1.2771.00
354_E357_L1.2611.00
90_Q94_K1.2601.00
126_P129_V1.2571.00
168_A172_Y1.2551.00
84_L308_G1.2481.00
35_I39_L1.2461.00
319_N347_T1.2451.00
76_V150_A1.2411.00
283_E287_V1.2391.00
49_Q52_T1.2381.00
160_L163_D1.2331.00
241_S268_K1.2281.00
356_A359_R1.2221.00
115_K119_I1.2201.00
205_P208_A1.2151.00
287_V299_I1.1991.00
22_L94_K1.1971.00
262_A300_I1.1961.00
37_A206_K1.1951.00
248_G298_Y1.1931.00
353_D357_L1.1921.00
316_H344_Q1.1871.00
204_N207_Y1.1861.00
171_D200_K1.1761.00
325_D328_F1.1751.00
354_E358_V1.1741.00
243_L246_Y1.1701.00
90_Q93_L1.1681.00
63_L96_T1.1621.00
153_L183_M1.1461.00
97_Q101_G1.1431.00
353_D360_L1.1401.00
85_A108_C1.1391.00
319_N332_R1.1391.00
65_K151_E1.1371.00
349_Y352_T1.1201.00
279_L283_E1.1201.00
206_K210_V1.1191.00
19_V24_F1.1161.00
37_A40_K1.1051.00
204_N208_A1.1021.00
323_P329_Y1.1001.00
247_L294_L1.0981.00
259_D276_H1.0961.00
243_L344_Q1.0951.00
291_I299_I1.0911.00
358_V361_E1.0821.00
197_F200_K1.0821.00
245_P248_G1.0811.00
172_Y175_S1.0791.00
207_Y210_V1.0711.00
20_H25_Y1.0701.00
48_S52_T1.0701.00
120_D123_K1.0691.00
236_L320_Y1.0651.00
78_T136_I1.0631.00
239_I243_L1.0601.00
294_L297_T1.0561.00
174_G178_P1.0551.00
29_D33_R1.0551.00
55_T88_I1.0541.00
367_F371_E1.0481.00
234_K237_F1.0471.00
87_Q310_D1.0411.00
29_D32_K1.0341.00
34_L46_G1.0331.00
107_K129_V1.0331.00
275_L305_A1.0321.00
235_L239_I1.0311.00
275_L304_L1.0311.00
258_A300_I1.0261.00
89_Y130_V1.0261.00
78_T131_G1.0131.00
172_Y176_R1.0071.00
353_D358_V1.0041.00
21_R97_Q1.0021.00
239_I318_I1.0011.00
35_I60_L0.9981.00
141_K172_Y0.9931.00
276_H279_L0.9901.00
233_D320_Y0.9881.00
65_K182_Q0.9881.00
241_S270_M0.9881.00
44_V184_L0.9831.00
170_V177_M0.9801.00
359_R362_K0.9771.00
243_L316_H0.9721.00
238_D242_H0.9701.00
92_A130_V0.9701.00
353_D361_E0.9691.00
250_V298_Y0.9671.00
67_D70_K0.9641.00
47_Q209_H0.9631.00
119_I123_K0.9631.00
270_M297_T0.9621.00
198_L201_Y0.9561.00
166_F169_D0.9541.00
261_I300_I0.9541.00
289_K292_N0.9521.00
41_K182_Q0.9521.00
368_E371_E0.9511.00
375_G378_K0.9511.00
211_E214_Q0.9481.00
239_I346_M0.9481.00
137_A169_D0.9481.00
56_H91_E0.9441.00
263_Q266_T0.9431.00
286_K289_K0.9431.00
263_Q267_G0.9411.00
240_M248_G0.9381.00
169_D173_I0.9361.00
191_P194_L0.9341.00
33_R37_A0.9341.00
232_K235_L0.9341.00
85_A130_V0.9341.00
199_K202_M0.9331.00
140_I176_R0.9281.00
197_F202_M0.9271.00
153_L174_G0.9261.00
207_Y211_E0.9251.00
206_K209_H0.9231.00
116_Q119_I0.9221.00
370_L374_K0.9211.00
256_N260_H0.9211.00
204_N210_V0.9161.00
220_I337_A0.9141.00
26_E32_K0.9111.00
173_I177_M0.9061.00
364_G367_F0.9061.00
264_Y267_G0.9051.00
287_V290_Q0.9021.00
237_F264_Y0.8981.00
208_A211_E0.8971.00
292_N313_G0.8961.00
231_D234_K0.8951.00
258_A262_A0.8931.00
233_D237_F0.8891.00
66_I127_H0.8891.00
117_K121_K0.8891.00
245_P297_T0.8871.00
41_K44_V0.8861.00
210_V214_Q0.8851.00
353_D359_R0.8791.00
168_A173_I0.8781.00
66_I104_I0.8761.00
192_E196_P0.8761.00
73_V149_K0.8701.00
221_E342_S0.8651.00
281_P285_K0.8611.00
37_A42_E0.8561.00
306_A328_F0.8561.00
209_H212_P0.8541.00
282_R286_K0.8471.00
57_A61_P0.8471.00
356_A360_L0.8461.00
374_K378_K0.8421.00
250_V318_I0.8421.00
373_E376_E0.8391.00
62_L128_L0.8371.00
223_I226_P0.8371.00
194_L197_F0.8351.00
348_I351_L0.8341.00
58_Y88_I0.8331.00
118_S121_K0.8331.00
232_K239_I0.8321.00
355_D360_L0.8311.00
152_S184_L0.8281.00
46_G184_L0.8281.00
271_K296_F0.8261.00
371_E375_G0.8251.00
152_S182_Q0.8231.00
206_K211_E0.8221.00
119_I144_A0.8221.00
77_I92_A0.8211.00
117_K120_D0.8201.00
166_F171_D0.8201.00
291_I314_V0.8191.00
171_D175_S0.8181.00
138_D142_E0.8151.00
229_H257_T0.8141.00
113_T118_S0.8141.00
147_V150_A0.8091.00
239_I316_H0.8091.00
233_D268_K0.8041.00
355_D358_V0.7991.00
110_I113_T0.7961.00
104_I127_H0.7921.00
115_K142_E0.7911.00
187_S190_I0.7891.00
189_T331_H0.7881.00
257_T320_Y0.7881.00
170_V174_G0.7871.00
205_P209_H0.7861.00
228_K231_D0.7851.00
253_N321_E0.7821.00
30_I211_E0.7811.00
62_L92_A0.7771.00
166_F173_I0.7771.00
260_H264_Y0.7751.00
84_L87_Q0.7741.00
219_K342_S0.7741.00
113_T117_K0.7741.00
223_I346_M0.7731.00
41_K65_K0.7691.00
366_E371_E0.7671.00
75_V128_L0.7671.00
294_L313_G0.7661.00
137_A141_K0.7631.00
363_M367_F0.7621.00
86_N108_C0.7621.00
232_K321_E0.7601.00
113_T121_K0.7581.00
363_M366_E0.7571.00
154_V184_L0.7551.00
233_D260_H0.7541.00
251_F305_A0.7541.00
253_N324_D0.7531.00
63_L67_D0.7511.00
358_V362_K0.7511.00
36_P39_L0.7501.00
344_Q347_T0.7501.00
225_I235_L0.7471.00
303_D328_F0.7441.00
30_I33_R0.7391.00
75_V154_V0.7381.00
251_F332_R0.7381.00
91_E95_I0.7351.00
259_D263_Q0.7341.00
236_L250_V0.7341.00
61_P152_S0.7331.00
319_N323_P0.7331.00
118_S122_L0.7331.00
355_D359_R0.7321.00
161_M166_F0.7301.00
249_I301_A0.7281.00
159_D331_H0.7261.00
365_I368_E0.7261.00
106_S109_F0.7251.00
121_K126_P0.7241.00
366_E370_L0.7221.00
234_K238_D0.7221.00
222_H226_P0.7191.00
76_V153_L0.7191.00
371_E374_K0.7181.00
212_P215_V0.7161.00
367_F370_L0.7161.00
202_M205_P0.7151.00
303_D332_R0.7101.00
288_M311_I0.7031.00
238_D241_S0.7011.00
192_E195_K0.6961.00
205_P211_E0.6951.00
235_L348_I0.6951.00
250_V320_Y0.6941.00
199_K204_N0.6891.00
188_A334_G0.6871.00
109_F118_S0.6841.00
314_V336_T0.6801.00
200_K204_N0.6791.00
246_Y316_H0.6781.00
160_L307_R0.6771.00
133_P155_I0.6761.00
33_R36_P0.6731.00
227_S235_L0.6721.00
288_M292_N0.6681.00
131_G145_L0.6661.00
348_I352_T0.6661.00
19_V60_L0.6651.00
62_L77_I0.6651.00
232_K236_L0.6601.00
193_K196_P0.6591.00
151_E181_L0.6551.00
45_I190_I0.6541.00
262_A265_L0.6521.00
374_K377_W0.6521.00
135_R138_D0.6511.00
105_R125_Q0.6511.00
246_Y341_S0.6501.00
222_H227_S0.6491.00
247_L297_T0.6481.00
50_T334_G0.6481.00
275_L279_L0.6471.00
56_H60_L0.6461.00
361_E366_E0.6421.00
86_N110_I0.6411.00
368_E372_L0.6391.00
197_F201_Y0.6371.00
108_C111_G0.6331.00
373_E378_K0.6271.00
81_T307_R0.6261.00
82_R132_T0.6251.00
240_M243_L0.6231.00
208_A212_P0.6191.00
247_L315_S0.6181.00
46_G57_A0.6161.00
96_T106_S0.6151.00
59_L96_T0.6141.00
60_L63_L0.6121.00
282_R285_K0.6111.00
158_A190_I0.6101.00
93_L97_Q0.6091.00
275_L301_A0.6031.00
173_I176_R0.6031.00
274_L279_L0.6021.00
163_D168_A0.6001.00
236_L240_M0.6001.00
43_S185_V0.5991.00
323_P332_R0.5991.00
353_D362_K0.5981.00
350_E353_D0.5951.00
204_N211_E0.5911.00
205_P214_Q0.5901.00
315_S341_S0.5901.00
86_N89_Y0.5891.00
167_L173_I0.5891.00
252_A320_Y0.5891.00
56_H95_I0.5891.00
171_D174_G0.5881.00
66_I128_L0.5881.00
90_Q289_K0.5871.00
194_L198_L0.5861.00
72_V127_H0.5851.00
85_A110_I0.5841.00
77_I88_I0.5831.00
178_P181_L0.5811.00
364_G368_E0.5801.00
94_K97_Q0.5791.00
47_Q190_I0.5781.00
220_I345_A0.5761.00
249_I299_I0.5741.00
196_P199_K0.5741.00
168_A175_S0.5731.00
356_A361_E0.5731.00
82_R112_G0.5731.00
373_E377_W0.5721.00
134_G137_A0.5701.00
170_V175_S0.5691.00
90_Q292_N0.5681.00
96_T102_S0.5681.00
365_I369_Y0.5671.00
240_M270_M0.5661.00
219_K222_H0.5661.00
140_I147_V0.5661.00
234_K264_Y0.5651.00
88_I130_V0.5631.00
93_L106_S0.5631.00
236_L261_I0.5621.00
363_M368_E0.5621.00
250_V261_I0.5611.00
255_K259_D0.5581.00
250_V300_I0.5581.00
171_D177_M0.5571.00
76_V131_G0.5571.00
34_L38_V0.5571.00
292_N312_K0.5561.00
217_A222_H0.5561.00
216_T219_K0.5521.00
208_A214_Q0.5521.00
376_E379_K0.5511.00
34_L37_A0.5511.00
335_R338_R0.5511.00
43_S205_P0.5501.00
103_Q106_S0.5491.00
86_N289_K0.5471.00
200_K203_E0.5451.00
249_I314_V0.5441.00
131_G135_R0.5441.00
37_A208_A0.5431.00
30_I48_S0.5391.00
363_M370_L0.5351.00
28_T339_A0.5351.00
50_T188_A0.5321.00
197_F204_N0.5321.00
307_R331_H0.5321.00
274_L287_V0.5301.00
43_S182_Q0.5291.00
253_N257_T0.5271.00
108_C113_T0.5271.00
215_V218_A0.5271.00
19_V56_H0.5261.00
255_K276_H0.5251.00
197_F203_E0.5251.00
74_Q149_K0.5251.00
206_K212_P0.5251.00
220_I225_I0.5251.00
180_D183_M0.5241.00
204_N212_P0.5241.00
79_A130_V0.5231.00
177_M180_D0.5201.00
43_S183_M0.5201.00
233_D261_I0.5191.00
284_R288_M0.5191.00
196_P200_K0.5191.00
118_S139_L0.5151.00
218_A222_H0.5151.00
355_D361_E0.5151.00
354_E361_E0.5131.00
27_P56_H0.5111.00
211_E215_V0.5111.00
77_I130_V0.5101.00
82_R281_P0.5091.00
370_L377_W0.5091.00
365_I373_E0.5081.00
247_L314_V0.5081.00
318_I348_I0.5081.00
306_A332_R0.5081.00
349_Y357_L0.5071.00
365_I370_L0.5051.00
167_L174_G0.5031.00
329_Y333_V0.5031.00
90_Q285_K0.5021.00
109_F129_V0.5021.00
205_P212_P0.5021.00
271_K290_Q0.5011.00
364_G371_E0.5011.00
153_L181_L0.5011.00
369_Y373_E0.5001.00
169_D174_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4pxaA 1 0.8607 100 0.254 Contact Map
4nhoA 1 0.8493 100 0.255 Contact Map
4c9bA 1 0.8516 100 0.257 Contact Map
4ljyA 1 0.8904 100 0.259 Contact Map
4d25A 1 0.8516 100 0.263 Contact Map
3eiqA 1 0.8082 100 0.267 Contact Map
1s2mA 1 0.8584 100 0.267 Contact Map
2db3A 1 0.8493 100 0.267 Contact Map
4ct4B 1 0.8584 100 0.274 Contact Map
4kbfA 2 0.8242 100 0.279 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0122 seconds.