GTPC1 - BACSU - GREMLIN Contacts

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GTPC1 - Putative GTP cyclohydrolase 1 type 2

UniProt:	P54472	Sequences: MAKSVNGQQIIQLFEQFSPKAYAVEGDKIGLQIGTLNKPIKNVMVTLDVLESVIDEAIEKEVDLIIAHHPPIFRSLKHISTDQPAGRLIEKCLKHDIAVYAAHTNLDVADGGVNDLLAEALELSETEVLAPTYTDPLKKLAVYVPKEYEEQVRAALGNAGAGHIGEYSHCAFSSEGIGSFKPLDGAKPFIGEVGELELVHEVRLETVFPKSVEKAVINAMIKSHPYEEVAYDIYPVEQTPAEKGLGRVGTLKNEMTLKEFALFVKDKLDVNGVRMVGDADSMVKKVAVLGGDGNKYIHHAKRKGADVYVTGDLYFHVAHDAMMLGLNVVDPGHYAEKIMKEGVTRKLTSMCNDKKFGVNIFVSETDTNPFTFL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	373 (361)
Sequences:	989 (768)
Seq/√Len:	40.4

BACSU - GTPC1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
168_S	181_K	4.280	1.00
55_D	91_K	3.409	1.00
142_V	220_M	3.348	1.00
149_E	204_L	3.185	1.00
141_A	203_R	3.106	1.00
190_I	199_V	3.102	1.00
60_K	364_E	3.003	1.00
117_L	268_L	2.996	1.00
192_E	195_E	2.897	1.00
15_E	100_Y	2.834	1.00
148_Y	189_F	2.797	1.00
152_V	223_S	2.730	1.00
138_K	213_E	2.651	1.00
139_K	232_D	2.614	1.00
331_P	336_E	2.606	1.00
41_K	63_D	2.570	1.00
217_I	221_I	2.562	1.00
46_T	67_A	2.554	1.00
173_S	179_S	2.529	1.00
250_T	284_K	2.523	1.00
254_E	284_K	2.516	1.00
56_E	363_S	2.510	1.00
312_D	330_D	2.508	1.00
23_A	29_I	2.468	1.00
255_M	263_F	2.440	1.00
92_C	99_V	2.375	1.00
171_A	179_S	2.360	1.00
124_S	252_K	2.315	1.00
42_N	63_D	2.275	1.00
209_P	212_V	2.272	1.00
42_N	359_N	2.270	1.00
283_V	307_V	2.259	1.00
51_E	87_R	2.246	1.00
185_G	193_V	2.232	1.00
153_R	173_S	2.216	1.00
208_F	213_E	2.213	1.00
313_L	328_V	2.203	0.99
186_A	193_V	2.182	0.99
181_K	196_L	2.067	0.99
250_T	285_K	2.059	0.99
146_K	175_E	2.059	0.99
154_A	158_N	1.978	0.99
183_L	186_A	1.976	0.99
49_V	67_A	1.975	0.99
275_M	279_A	1.943	0.99
10_I	64_L	1.906	0.99
182_P	186_A	1.901	0.98
149_E	153_R	1.883	0.98
208_F	216_V	1.871	0.98
115_D	247_R	1.869	0.98
138_K	208_F	1.866	0.98
149_E	173_S	1.849	0.98
125_E	250_T	1.846	0.98
310_T	313_L	1.815	0.98
258_K	280_D	1.785	0.98
221_I	231_Y	1.784	0.98
263_F	267_K	1.782	0.98
256_T	259_E	1.771	0.98
177_I	198_L	1.770	0.98
190_I	197_E	1.751	0.97
152_V	155_A	1.751	0.97
220_M	229_V	1.738	0.97
146_K	200_H	1.700	0.97
113_V	290_G	1.692	0.97
289_L	296_Y	1.686	0.97
149_E	202_V	1.680	0.97
150_E	154_A	1.664	0.96
307_V	327_N	1.645	0.96
141_A	234_Y	1.619	0.96
45_V	344_T	1.614	0.96
169_H	181_K	1.611	0.96
254_E	282_M	1.603	0.96
148_Y	151_Q	1.601	0.96
17_F	346_K	1.598	0.96
317_V	320_D	1.592	0.95
67_A	101_A	1.567	0.95
292_D	314_Y	1.556	0.95
7_G	40_I	1.536	0.94
127_E	303_K	1.517	0.94
6_N	39_P	1.505	0.94
212_V	215_A	1.492	0.93
166_E	183_L	1.489	0.93
168_S	183_L	1.489	0.93
55_D	59_E	1.474	0.93
213_E	233_I	1.464	0.93
58_I	95_H	1.462	0.93
49_V	65_I	1.438	0.92
300_A	305_A	1.427	0.92
140_L	156_L	1.421	0.92
314_Y	317_V	1.419	0.92
44_M	62_V	1.419	0.92
130_A	299_H	1.417	0.92
136_P	210_K	1.414	0.92
274_R	312_D	1.383	0.91
58_I	91_K	1.380	0.90
54_I	92_C	1.366	0.90
285_K	304_G	1.364	0.90
152_V	156_L	1.360	0.90
44_M	63_D	1.360	0.90
28_K	77_K	1.357	0.90
182_P	193_V	1.349	0.89
44_M	65_I	1.348	0.89
8_Q	37_N	1.347	0.89
287_A	305_A	1.335	0.89
54_I	65_I	1.330	0.89
52_S	365_T	1.325	0.89
186_A	206_T	1.314	0.88
299_H	302_R	1.309	0.88
113_V	116_L	1.299	0.88
76_L	89_I	1.298	0.88
144_V	152_V	1.297	0.88
315_F	319_H	1.290	0.87
123_L	126_T	1.287	0.87
14_F	66_I	1.274	0.87
18_S	106_L	1.272	0.86
163_H	183_L	1.265	0.86
50_L	319_H	1.262	0.86
260_F	329_V	1.258	0.86
182_P	197_E	1.254	0.86
118_A	309_V	1.241	0.85
150_E	198_L	1.237	0.85
116_L	342_G	1.236	0.85
108_V	245_L	1.221	0.84
161_A	216_V	1.211	0.84
140_L	208_F	1.207	0.83
51_E	91_K	1.205	0.83
163_H	168_S	1.205	0.83
106_L	113_V	1.202	0.83
35_T	38_K	1.199	0.83
129_L	300_A	1.196	0.83
10_I	40_I	1.187	0.82
182_P	199_V	1.180	0.82
45_V	360_I	1.173	0.82
127_E	285_K	1.163	0.81
70_P	101_A	1.157	0.81
264_V	309_V	1.156	0.81
113_V	338_I	1.154	0.81
157_G	169_H	1.149	0.80
292_D	317_V	1.149	0.80
60_K	361_F	1.149	0.80
257_L	327_N	1.147	0.80
173_S	204_L	1.146	0.80
274_R	330_D	1.145	0.80
26_G	29_I	1.145	0.80
68_H	105_N	1.139	0.80
294_N	314_Y	1.130	0.79
334_Y	340_K	1.127	0.79
45_V	66_I	1.126	0.79
17_F	343_V	1.124	0.79
315_F	334_Y	1.121	0.79
138_K	237_E	1.120	0.78
294_N	317_V	1.119	0.78
116_L	339_M	1.117	0.78
157_G	179_S	1.117	0.78
219_A	223_S	1.116	0.78
122_E	263_F	1.110	0.78
260_F	309_V	1.109	0.78
169_H	196_L	1.107	0.78
279_A	282_M	1.105	0.78
340_K	363_S	1.101	0.77
222_K	285_K	1.096	0.77
288_V	309_V	1.091	0.77
120_A	341_E	1.079	0.76
118_A	247_R	1.079	0.76
24_V	296_Y	1.073	0.75
182_P	190_I	1.071	0.75
130_A	308_Y	1.066	0.75
13_L	351_C	1.061	0.75
135_D	211_S	1.061	0.75
47_L	106_L	1.060	0.75
283_V	286_V	1.059	0.74
183_L	193_V	1.059	0.74
118_A	123_L	1.057	0.74
45_V	347_L	1.055	0.74
78_H	82_D	1.055	0.74
165_G	228_E	1.049	0.74
344_T	348_T	1.042	0.73
16_Q	350_M	1.040	0.73
315_F	332_G	1.036	0.73
315_F	337_K	1.032	0.73
81_T	90_E	1.032	0.73
309_V	329_V	1.027	0.72
114_N	308_Y	1.026	0.72
9_Q	12_Q	1.024	0.72
260_F	264_V	1.012	0.71
150_E	153_R	1.000	0.70
7_G	64_L	0.995	0.70
175_E	200_H	0.989	0.69
148_Y	225_P	0.988	0.69
257_L	278_D	0.980	0.69
295_K	314_Y	0.979	0.68
148_Y	169_H	0.978	0.68
122_E	252_K	0.977	0.68
7_G	98_A	0.967	0.67
159_A	219_A	0.966	0.67
128_V	244_G	0.965	0.67
248_V	305_A	0.963	0.67
315_F	336_E	0.957	0.67
56_E	60_K	0.951	0.66
113_V	339_M	0.951	0.66
6_N	9_Q	0.944	0.66
8_Q	36_L	0.942	0.65
127_E	250_T	0.930	0.64
316_H	330_D	0.922	0.64
307_V	329_V	0.917	0.63
257_L	280_D	0.915	0.63
179_S	198_L	0.914	0.63
258_K	262_L	0.913	0.63
123_L	252_K	0.911	0.63
15_E	20_K	0.906	0.62
309_V	327_N	0.899	0.62
42_N	61_E	0.899	0.62
38_K	96_D	0.897	0.62
106_L	339_M	0.897	0.62
173_S	202_V	0.892	0.61
347_L	360_I	0.891	0.61
260_F	306_D	0.888	0.61
39_P	248_V	0.886	0.61
139_K	205_E	0.880	0.60
108_V	132_T	0.879	0.60
110_D	241_A	0.878	0.60
301_K	324_L	0.875	0.60
58_I	283_V	0.875	0.60
92_C	97_I	0.866	0.59
177_I	200_H	0.864	0.59
331_P	335_A	0.863	0.59
260_F	307_V	0.861	0.58
46_T	49_V	0.858	0.58
14_F	18_S	0.858	0.58
174_S	203_R	0.858	0.58
205_E	232_D	0.857	0.58
339_M	342_G	0.856	0.58
116_L	120_A	0.856	0.58
256_T	261_A	0.848	0.57
46_T	65_I	0.841	0.57
301_K	325_G	0.841	0.57
311_G	332_G	0.839	0.56
260_F	286_V	0.838	0.56
129_L	303_K	0.833	0.56
128_V	131_P	0.829	0.56
44_M	56_E	0.825	0.55
312_D	316_H	0.824	0.55
45_V	340_K	0.824	0.55
119_E	126_T	0.823	0.55
351_C	360_I	0.822	0.55
172_F	202_V	0.821	0.55
75_S	93_L	0.819	0.55
257_L	307_V	0.818	0.55
51_E	55_D	0.817	0.54
116_L	345_R	0.817	0.54
208_F	233_I	0.815	0.54
102_A	343_V	0.814	0.54
115_D	119_E	0.813	0.54
140_L	220_M	0.812	0.54
116_L	119_E	0.812	0.54
208_F	235_P	0.808	0.54
189_F	221_I	0.806	0.53
14_F	100_Y	0.806	0.53
153_R	179_S	0.803	0.53
334_Y	367_T	0.802	0.53
206_T	220_M	0.798	0.53
163_H	186_A	0.796	0.53
51_E	88_L	0.795	0.52
79_I	93_L	0.793	0.52
33_I	92_C	0.790	0.52
79_I	86_G	0.790	0.52
102_A	105_N	0.789	0.52
86_G	277_G	0.788	0.52
44_M	50_L	0.784	0.51
321_A	328_V	0.783	0.51
149_E	156_L	0.782	0.51
180_F	199_V	0.781	0.51
271_N	368_N	0.777	0.51
22_Y	243_K	0.774	0.50
29_I	292_D	0.773	0.50
268_L	331_P	0.771	0.50
207_V	230_A	0.769	0.50
118_A	126_T	0.769	0.50
26_G	295_K	0.768	0.50
281_S	327_N	0.768	0.50
24_V	28_K	0.767	0.50
252_K	284_K	0.766	0.50
350_M	359_N	0.766	0.50
206_T	234_Y	0.764	0.50
157_G	171_A	0.762	0.49
53_V	363_S	0.762	0.49
10_I	43_V	0.761	0.49
255_M	307_V	0.757	0.49
117_L	288_V	0.756	0.49
90_E	93_L	0.755	0.49
116_L	290_G	0.755	0.49
7_G	38_K	0.754	0.49
259_E	329_V	0.753	0.49
130_A	289_L	0.753	0.49
122_E	267_K	0.752	0.48
261_A	273_V	0.748	0.48
23_A	289_L	0.744	0.48
138_K	235_P	0.743	0.48
26_G	292_D	0.742	0.48
146_K	202_V	0.742	0.48
53_V	56_E	0.742	0.48
188_P	227_E	0.742	0.48
298_H	301_K	0.738	0.47
156_L	161_A	0.737	0.47
199_V	207_V	0.734	0.47
178_G	201_E	0.732	0.47
318_A	370_F	0.731	0.47
245_L	296_Y	0.729	0.46
143_Y	234_Y	0.728	0.46
154_A	169_H	0.725	0.46
318_A	328_V	0.721	0.46
138_K	233_I	0.721	0.46
97_I	292_D	0.721	0.46
164_I	170_C	0.717	0.45
262_L	266_D	0.716	0.45
253_N	259_E	0.715	0.45
65_I	97_I	0.715	0.45
42_N	60_K	0.714	0.45
257_L	261_A	0.707	0.44
297_I	313_L	0.704	0.44
11_I	100_Y	0.704	0.44
7_G	11_I	0.703	0.44
31_L	34_G	0.702	0.44
215_A	222_K	0.698	0.44
216_V	254_E	0.698	0.44
165_G	236_V	0.697	0.43
101_A	113_V	0.697	0.43
26_G	319_H	0.696	0.43
256_T	282_M	0.695	0.43
218_N	222_K	0.692	0.43
187_K	283_V	0.691	0.43
346_K	350_M	0.690	0.43
180_F	190_I	0.687	0.43
98_A	229_V	0.686	0.42
163_H	206_T	0.686	0.42
39_P	345_R	0.686	0.42
278_D	281_S	0.684	0.42
177_I	347_L	0.681	0.42
294_N	313_L	0.681	0.42
313_L	316_H	0.680	0.42
68_H	118_A	0.674	0.41
145_P	225_P	0.673	0.41
297_I	326_L	0.673	0.41
137_L	343_V	0.672	0.41
26_G	314_Y	0.670	0.41
23_A	26_G	0.669	0.41
294_N	297_I	0.668	0.41
114_N	247_R	0.668	0.41
23_A	245_L	0.668	0.41
106_L	343_V	0.667	0.41
248_V	303_K	0.666	0.41
250_T	254_E	0.665	0.41
54_I	164_I	0.661	0.40
28_K	78_H	0.661	0.40
189_F	206_T	0.660	0.40
259_E	262_L	0.658	0.40
248_V	292_D	0.657	0.40
180_F	197_E	0.656	0.40
49_V	54_I	0.655	0.40
71_P	89_I	0.653	0.39
46_T	315_F	0.651	0.39
32_Q	101_A	0.648	0.39
153_R	204_L	0.647	0.39
71_P	98_A	0.645	0.39
121_L	264_V	0.644	0.39
144_V	225_P	0.642	0.39
332_G	370_F	0.642	0.39
129_L	248_V	0.641	0.38
300_A	303_K	0.639	0.38
29_I	105_N	0.637	0.38
52_S	59_E	0.636	0.38
85_A	319_H	0.636	0.38
124_S	266_D	0.636	0.38
28_K	32_Q	0.629	0.37
200_H	264_V	0.628	0.37
45_V	343_V	0.627	0.37
11_I	15_E	0.626	0.37
16_Q	122_E	0.623	0.37
340_K	362_V	0.622	0.37
201_E	227_E	0.622	0.37
152_V	229_V	0.622	0.37
172_F	229_V	0.621	0.37
20_K	100_Y	0.621	0.37
109_A	115_D	0.618	0.36
64_L	98_A	0.618	0.36
245_L	289_L	0.618	0.36
121_L	263_F	0.617	0.36
83_Q	86_G	0.615	0.36
210_K	213_E	0.615	0.36
216_V	365_T	0.614	0.36
31_L	98_A	0.614	0.36
68_H	296_Y	0.610	0.36
14_F	343_V	0.609	0.36
192_E	197_E	0.608	0.36
156_L	206_T	0.608	0.36
26_G	68_H	0.608	0.36
143_Y	309_V	0.606	0.35
152_V	292_D	0.605	0.35
172_F	212_V	0.605	0.35
153_R	171_A	0.603	0.35
17_F	229_V	0.603	0.35
111_G	115_D	0.602	0.35
306_D	367_T	0.602	0.35
49_V	311_G	0.602	0.35
43_V	264_V	0.601	0.35
217_I	233_I	0.601	0.35
167_Y	188_P	0.600	0.35
43_V	198_L	0.599	0.35
129_L	289_L	0.599	0.35
178_G	227_E	0.599	0.35
43_V	363_S	0.599	0.35
184_D	193_V	0.596	0.35
79_I	88_L	0.594	0.34
257_L	275_M	0.593	0.34
238_Q	315_F	0.593	0.34
32_Q	54_I	0.592	0.34
118_A	288_V	0.589	0.34
314_Y	334_Y	0.588	0.34
27_D	30_G	0.588	0.34
167_Y	227_E	0.586	0.34
161_A	206_T	0.586	0.34
29_I	32_Q	0.585	0.34
344_T	362_V	0.584	0.34
179_S	196_L	0.583	0.34
120_A	123_L	0.583	0.34
270_V	273_V	0.582	0.33
171_A	206_T	0.582	0.33
72_I	98_A	0.582	0.33
11_I	64_L	0.581	0.33
272_G	372_F	0.580	0.33
151_Q	223_S	0.579	0.33
44_M	363_S	0.577	0.33
345_R	349_S	0.577	0.33
141_A	179_S	0.576	0.33
315_F	335_A	0.575	0.33
38_K	63_D	0.574	0.33
26_G	276_V	0.574	0.33
140_L	368_N	0.571	0.33
113_V	131_P	0.570	0.32
298_H	320_D	0.570	0.32
54_I	290_G	0.568	0.32
203_R	232_D	0.567	0.32
192_E	218_N	0.564	0.32
17_F	111_G	0.560	0.32
180_F	191_G	0.558	0.31
251_L	260_F	0.556	0.31
192_E	266_D	0.556	0.31
105_N	137_L	0.556	0.31
205_E	234_Y	0.555	0.31
175_E	202_V	0.553	0.31
80_S	98_A	0.553	0.31
114_N	117_L	0.553	0.31
281_S	329_V	0.553	0.31
102_A	117_L	0.548	0.31
28_K	314_Y	0.548	0.31
130_A	296_Y	0.548	0.31
14_F	102_A	0.548	0.31
114_N	265_K	0.548	0.31
50_L	55_D	0.548	0.31
300_A	304_G	0.547	0.31
169_H	204_L	0.547	0.31
142_V	156_L	0.546	0.31
168_S	206_T	0.546	0.31
220_M	230_A	0.546	0.31
294_N	334_Y	0.546	0.31
213_E	217_I	0.545	0.30
181_K	194_G	0.544	0.30
20_K	29_I	0.544	0.30
201_E	226_Y	0.543	0.30
228_E	231_Y	0.543	0.30
319_H	323_M	0.542	0.30
156_L	204_L	0.542	0.30
335_A	368_N	0.541	0.30
13_L	16_Q	0.540	0.30
61_E	284_K	0.540	0.30
70_P	238_Q	0.539	0.30
292_D	302_R	0.537	0.30
182_P	185_G	0.537	0.30
278_D	327_N	0.537	0.30
254_E	280_D	0.536	0.30
301_K	326_L	0.535	0.30
99_V	331_P	0.535	0.30
121_L	143_Y	0.535	0.30
258_K	349_S	0.534	0.30
92_C	368_N	0.534	0.30
290_G	367_T	0.534	0.30
281_S	341_E	0.533	0.30
43_V	351_C	0.533	0.30
276_V	321_A	0.533	0.30
70_P	149_E	0.533	0.30
295_K	331_P	0.532	0.29
81_T	86_G	0.530	0.29
71_P	88_L	0.530	0.29
138_K	210_K	0.530	0.29
141_A	205_E	0.530	0.29
248_V	327_N	0.529	0.29
337_K	368_N	0.529	0.29
84_P	324_L	0.527	0.29
101_A	336_E	0.526	0.29
68_H	320_D	0.526	0.29
56_E	129_L	0.523	0.29
79_I	89_I	0.522	0.29
41_K	345_R	0.521	0.29
234_Y	253_N	0.521	0.29
11_I	20_K	0.521	0.29
260_F	284_K	0.521	0.29
331_P	363_S	0.520	0.29
105_N	289_L	0.518	0.28
23_A	68_H	0.518	0.28
46_T	365_T	0.517	0.28
122_E	202_V	0.516	0.28
195_E	282_M	0.516	0.28
206_T	302_R	0.515	0.28
358_V	371_T	0.515	0.28
48_D	67_A	0.515	0.28
55_D	58_I	0.515	0.28
64_L	94_K	0.513	0.28
245_L	295_K	0.512	0.28
29_I	70_P	0.511	0.28
14_F	345_R	0.511	0.28
29_I	92_C	0.510	0.28
65_I	332_G	0.510	0.28
260_F	268_L	0.509	0.28
152_V	204_L	0.509	0.28
313_L	330_D	0.508	0.28
142_V	197_E	0.508	0.28
123_L	249_G	0.507	0.28
72_I	79_I	0.506	0.28
18_S	47_L	0.506	0.28
115_D	126_T	0.505	0.27
25_E	28_K	0.505	0.27
177_I	258_K	0.504	0.27
13_L	350_M	0.503	0.27
157_G	173_S	0.503	0.27
71_P	79_I	0.503	0.27
87_R	91_K	0.503	0.27
227_E	230_A	0.503	0.27
28_K	101_A	0.501	0.27
332_G	336_E	0.501	0.27
192_E	253_N	0.501	0.27
276_V	328_V	0.501	0.27
26_G	317_V	0.500	0.27

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2gx8A	5	0.9759	100	0.142	Contact Map
2nydA	5	0.9303	100	0.156	Contact Map
2fywA	3	0.7024	100	0.479	Contact Map
1nmoA	4	0.6568	100	0.527	Contact Map
3wsfA	3	0.6488	100	0.536	Contact Map
2yybA	3	0.6408	100	0.543	Contact Map
3rxyA	4	0.689	100	0.582	Contact Map
2eg2A	5	0.2466	99.8	0.877	Contact Map
4co3A	3	0.2788	99.7	0.887	Contact Map
2ns1B	3	0.2949	99.7	0.887	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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