GREMLIN Database
GTPC1 - Putative GTP cyclohydrolase 1 type 2
UniProt: P54472 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 373 (361)
Sequences: 989 (768)
Seq/√Len: 40.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
168_S181_K4.2801.00
55_D91_K3.4091.00
142_V220_M3.3481.00
149_E204_L3.1851.00
141_A203_R3.1061.00
190_I199_V3.1021.00
60_K364_E3.0031.00
117_L268_L2.9961.00
192_E195_E2.8971.00
15_E100_Y2.8341.00
148_Y189_F2.7971.00
152_V223_S2.7301.00
138_K213_E2.6511.00
139_K232_D2.6141.00
331_P336_E2.6061.00
41_K63_D2.5701.00
217_I221_I2.5621.00
46_T67_A2.5541.00
173_S179_S2.5291.00
250_T284_K2.5231.00
254_E284_K2.5161.00
56_E363_S2.5101.00
312_D330_D2.5081.00
23_A29_I2.4681.00
255_M263_F2.4401.00
92_C99_V2.3751.00
171_A179_S2.3601.00
124_S252_K2.3151.00
42_N63_D2.2751.00
209_P212_V2.2721.00
42_N359_N2.2701.00
283_V307_V2.2591.00
51_E87_R2.2461.00
185_G193_V2.2321.00
153_R173_S2.2161.00
208_F213_E2.2131.00
313_L328_V2.2030.99
186_A193_V2.1820.99
181_K196_L2.0670.99
250_T285_K2.0590.99
146_K175_E2.0590.99
154_A158_N1.9780.99
183_L186_A1.9760.99
49_V67_A1.9750.99
275_M279_A1.9430.99
10_I64_L1.9060.99
182_P186_A1.9010.98
149_E153_R1.8830.98
208_F216_V1.8710.98
115_D247_R1.8690.98
138_K208_F1.8660.98
149_E173_S1.8490.98
125_E250_T1.8460.98
310_T313_L1.8150.98
258_K280_D1.7850.98
221_I231_Y1.7840.98
263_F267_K1.7820.98
256_T259_E1.7710.98
177_I198_L1.7700.98
190_I197_E1.7510.97
152_V155_A1.7510.97
220_M229_V1.7380.97
146_K200_H1.7000.97
113_V290_G1.6920.97
289_L296_Y1.6860.97
149_E202_V1.6800.97
150_E154_A1.6640.96
307_V327_N1.6450.96
141_A234_Y1.6190.96
45_V344_T1.6140.96
169_H181_K1.6110.96
254_E282_M1.6030.96
148_Y151_Q1.6010.96
17_F346_K1.5980.96
317_V320_D1.5920.95
67_A101_A1.5670.95
292_D314_Y1.5560.95
7_G40_I1.5360.94
127_E303_K1.5170.94
6_N39_P1.5050.94
212_V215_A1.4920.93
166_E183_L1.4890.93
168_S183_L1.4890.93
55_D59_E1.4740.93
213_E233_I1.4640.93
58_I95_H1.4620.93
49_V65_I1.4380.92
300_A305_A1.4270.92
140_L156_L1.4210.92
314_Y317_V1.4190.92
44_M62_V1.4190.92
130_A299_H1.4170.92
136_P210_K1.4140.92
274_R312_D1.3830.91
58_I91_K1.3800.90
54_I92_C1.3660.90
285_K304_G1.3640.90
152_V156_L1.3600.90
44_M63_D1.3600.90
28_K77_K1.3570.90
182_P193_V1.3490.89
44_M65_I1.3480.89
8_Q37_N1.3470.89
287_A305_A1.3350.89
54_I65_I1.3300.89
52_S365_T1.3250.89
186_A206_T1.3140.88
299_H302_R1.3090.88
113_V116_L1.2990.88
76_L89_I1.2980.88
144_V152_V1.2970.88
315_F319_H1.2900.87
123_L126_T1.2870.87
14_F66_I1.2740.87
18_S106_L1.2720.86
163_H183_L1.2650.86
50_L319_H1.2620.86
260_F329_V1.2580.86
182_P197_E1.2540.86
118_A309_V1.2410.85
150_E198_L1.2370.85
116_L342_G1.2360.85
108_V245_L1.2210.84
161_A216_V1.2110.84
140_L208_F1.2070.83
51_E91_K1.2050.83
163_H168_S1.2050.83
106_L113_V1.2020.83
35_T38_K1.1990.83
129_L300_A1.1960.83
10_I40_I1.1870.82
182_P199_V1.1800.82
45_V360_I1.1730.82
127_E285_K1.1630.81
70_P101_A1.1570.81
264_V309_V1.1560.81
113_V338_I1.1540.81
157_G169_H1.1490.80
292_D317_V1.1490.80
60_K361_F1.1490.80
257_L327_N1.1470.80
173_S204_L1.1460.80
274_R330_D1.1450.80
26_G29_I1.1450.80
68_H105_N1.1390.80
294_N314_Y1.1300.79
334_Y340_K1.1270.79
45_V66_I1.1260.79
17_F343_V1.1240.79
315_F334_Y1.1210.79
138_K237_E1.1200.78
294_N317_V1.1190.78
116_L339_M1.1170.78
157_G179_S1.1170.78
219_A223_S1.1160.78
122_E263_F1.1100.78
260_F309_V1.1090.78
169_H196_L1.1070.78
279_A282_M1.1050.78
340_K363_S1.1010.77
222_K285_K1.0960.77
288_V309_V1.0910.77
120_A341_E1.0790.76
118_A247_R1.0790.76
24_V296_Y1.0730.75
182_P190_I1.0710.75
130_A308_Y1.0660.75
13_L351_C1.0610.75
135_D211_S1.0610.75
47_L106_L1.0600.75
283_V286_V1.0590.74
183_L193_V1.0590.74
118_A123_L1.0570.74
45_V347_L1.0550.74
78_H82_D1.0550.74
165_G228_E1.0490.74
344_T348_T1.0420.73
16_Q350_M1.0400.73
315_F332_G1.0360.73
315_F337_K1.0320.73
81_T90_E1.0320.73
309_V329_V1.0270.72
114_N308_Y1.0260.72
9_Q12_Q1.0240.72
260_F264_V1.0120.71
150_E153_R1.0000.70
7_G64_L0.9950.70
175_E200_H0.9890.69
148_Y225_P0.9880.69
257_L278_D0.9800.69
295_K314_Y0.9790.68
148_Y169_H0.9780.68
122_E252_K0.9770.68
7_G98_A0.9670.67
159_A219_A0.9660.67
128_V244_G0.9650.67
248_V305_A0.9630.67
315_F336_E0.9570.67
56_E60_K0.9510.66
113_V339_M0.9510.66
6_N9_Q0.9440.66
8_Q36_L0.9420.65
127_E250_T0.9300.64
316_H330_D0.9220.64
307_V329_V0.9170.63
257_L280_D0.9150.63
179_S198_L0.9140.63
258_K262_L0.9130.63
123_L252_K0.9110.63
15_E20_K0.9060.62
309_V327_N0.8990.62
42_N61_E0.8990.62
38_K96_D0.8970.62
106_L339_M0.8970.62
173_S202_V0.8920.61
347_L360_I0.8910.61
260_F306_D0.8880.61
39_P248_V0.8860.61
139_K205_E0.8800.60
108_V132_T0.8790.60
110_D241_A0.8780.60
301_K324_L0.8750.60
58_I283_V0.8750.60
92_C97_I0.8660.59
177_I200_H0.8640.59
331_P335_A0.8630.59
260_F307_V0.8610.58
46_T49_V0.8580.58
14_F18_S0.8580.58
174_S203_R0.8580.58
205_E232_D0.8570.58
339_M342_G0.8560.58
116_L120_A0.8560.58
256_T261_A0.8480.57
46_T65_I0.8410.57
301_K325_G0.8410.57
311_G332_G0.8390.56
260_F286_V0.8380.56
129_L303_K0.8330.56
128_V131_P0.8290.56
44_M56_E0.8250.55
312_D316_H0.8240.55
45_V340_K0.8240.55
119_E126_T0.8230.55
351_C360_I0.8220.55
172_F202_V0.8210.55
75_S93_L0.8190.55
257_L307_V0.8180.55
51_E55_D0.8170.54
116_L345_R0.8170.54
208_F233_I0.8150.54
102_A343_V0.8140.54
115_D119_E0.8130.54
140_L220_M0.8120.54
116_L119_E0.8120.54
208_F235_P0.8080.54
189_F221_I0.8060.53
14_F100_Y0.8060.53
153_R179_S0.8030.53
334_Y367_T0.8020.53
206_T220_M0.7980.53
163_H186_A0.7960.53
51_E88_L0.7950.52
79_I93_L0.7930.52
33_I92_C0.7900.52
79_I86_G0.7900.52
102_A105_N0.7890.52
86_G277_G0.7880.52
44_M50_L0.7840.51
321_A328_V0.7830.51
149_E156_L0.7820.51
180_F199_V0.7810.51
271_N368_N0.7770.51
22_Y243_K0.7740.50
29_I292_D0.7730.50
268_L331_P0.7710.50
207_V230_A0.7690.50
118_A126_T0.7690.50
26_G295_K0.7680.50
281_S327_N0.7680.50
24_V28_K0.7670.50
252_K284_K0.7660.50
350_M359_N0.7660.50
206_T234_Y0.7640.50
157_G171_A0.7620.49
53_V363_S0.7620.49
10_I43_V0.7610.49
255_M307_V0.7570.49
117_L288_V0.7560.49
90_E93_L0.7550.49
116_L290_G0.7550.49
7_G38_K0.7540.49
259_E329_V0.7530.49
130_A289_L0.7530.49
122_E267_K0.7520.48
261_A273_V0.7480.48
23_A289_L0.7440.48
138_K235_P0.7430.48
26_G292_D0.7420.48
146_K202_V0.7420.48
53_V56_E0.7420.48
188_P227_E0.7420.48
298_H301_K0.7380.47
156_L161_A0.7370.47
199_V207_V0.7340.47
178_G201_E0.7320.47
318_A370_F0.7310.47
245_L296_Y0.7290.46
143_Y234_Y0.7280.46
154_A169_H0.7250.46
318_A328_V0.7210.46
138_K233_I0.7210.46
97_I292_D0.7210.46
164_I170_C0.7170.45
262_L266_D0.7160.45
253_N259_E0.7150.45
65_I97_I0.7150.45
42_N60_K0.7140.45
257_L261_A0.7070.44
297_I313_L0.7040.44
11_I100_Y0.7040.44
7_G11_I0.7030.44
31_L34_G0.7020.44
215_A222_K0.6980.44
216_V254_E0.6980.44
165_G236_V0.6970.43
101_A113_V0.6970.43
26_G319_H0.6960.43
256_T282_M0.6950.43
218_N222_K0.6920.43
187_K283_V0.6910.43
346_K350_M0.6900.43
180_F190_I0.6870.43
98_A229_V0.6860.42
163_H206_T0.6860.42
39_P345_R0.6860.42
278_D281_S0.6840.42
177_I347_L0.6810.42
294_N313_L0.6810.42
313_L316_H0.6800.42
68_H118_A0.6740.41
145_P225_P0.6730.41
297_I326_L0.6730.41
137_L343_V0.6720.41
26_G314_Y0.6700.41
23_A26_G0.6690.41
294_N297_I0.6680.41
114_N247_R0.6680.41
23_A245_L0.6680.41
106_L343_V0.6670.41
248_V303_K0.6660.41
250_T254_E0.6650.41
54_I164_I0.6610.40
28_K78_H0.6610.40
189_F206_T0.6600.40
259_E262_L0.6580.40
248_V292_D0.6570.40
180_F197_E0.6560.40
49_V54_I0.6550.40
71_P89_I0.6530.39
46_T315_F0.6510.39
32_Q101_A0.6480.39
153_R204_L0.6470.39
71_P98_A0.6450.39
121_L264_V0.6440.39
144_V225_P0.6420.39
332_G370_F0.6420.39
129_L248_V0.6410.38
300_A303_K0.6390.38
29_I105_N0.6370.38
52_S59_E0.6360.38
85_A319_H0.6360.38
124_S266_D0.6360.38
28_K32_Q0.6290.37
200_H264_V0.6280.37
45_V343_V0.6270.37
11_I15_E0.6260.37
16_Q122_E0.6230.37
340_K362_V0.6220.37
201_E227_E0.6220.37
152_V229_V0.6220.37
172_F229_V0.6210.37
20_K100_Y0.6210.37
109_A115_D0.6180.36
64_L98_A0.6180.36
245_L289_L0.6180.36
121_L263_F0.6170.36
83_Q86_G0.6150.36
210_K213_E0.6150.36
216_V365_T0.6140.36
31_L98_A0.6140.36
68_H296_Y0.6100.36
14_F343_V0.6090.36
192_E197_E0.6080.36
156_L206_T0.6080.36
26_G68_H0.6080.36
143_Y309_V0.6060.35
152_V292_D0.6050.35
172_F212_V0.6050.35
153_R171_A0.6030.35
17_F229_V0.6030.35
111_G115_D0.6020.35
306_D367_T0.6020.35
49_V311_G0.6020.35
43_V264_V0.6010.35
217_I233_I0.6010.35
167_Y188_P0.6000.35
43_V198_L0.5990.35
129_L289_L0.5990.35
178_G227_E0.5990.35
43_V363_S0.5990.35
184_D193_V0.5960.35
79_I88_L0.5940.34
257_L275_M0.5930.34
238_Q315_F0.5930.34
32_Q54_I0.5920.34
118_A288_V0.5890.34
314_Y334_Y0.5880.34
27_D30_G0.5880.34
167_Y227_E0.5860.34
161_A206_T0.5860.34
29_I32_Q0.5850.34
344_T362_V0.5840.34
179_S196_L0.5830.34
120_A123_L0.5830.34
270_V273_V0.5820.33
171_A206_T0.5820.33
72_I98_A0.5820.33
11_I64_L0.5810.33
272_G372_F0.5800.33
151_Q223_S0.5790.33
44_M363_S0.5770.33
345_R349_S0.5770.33
141_A179_S0.5760.33
315_F335_A0.5750.33
38_K63_D0.5740.33
26_G276_V0.5740.33
140_L368_N0.5710.33
113_V131_P0.5700.32
298_H320_D0.5700.32
54_I290_G0.5680.32
203_R232_D0.5670.32
192_E218_N0.5640.32
17_F111_G0.5600.32
180_F191_G0.5580.31
251_L260_F0.5560.31
192_E266_D0.5560.31
105_N137_L0.5560.31
205_E234_Y0.5550.31
175_E202_V0.5530.31
80_S98_A0.5530.31
114_N117_L0.5530.31
281_S329_V0.5530.31
102_A117_L0.5480.31
28_K314_Y0.5480.31
130_A296_Y0.5480.31
14_F102_A0.5480.31
114_N265_K0.5480.31
50_L55_D0.5480.31
300_A304_G0.5470.31
169_H204_L0.5470.31
142_V156_L0.5460.31
168_S206_T0.5460.31
220_M230_A0.5460.31
294_N334_Y0.5460.31
213_E217_I0.5450.30
181_K194_G0.5440.30
20_K29_I0.5440.30
201_E226_Y0.5430.30
228_E231_Y0.5430.30
319_H323_M0.5420.30
156_L204_L0.5420.30
335_A368_N0.5410.30
13_L16_Q0.5400.30
61_E284_K0.5400.30
70_P238_Q0.5390.30
292_D302_R0.5370.30
182_P185_G0.5370.30
278_D327_N0.5370.30
254_E280_D0.5360.30
301_K326_L0.5350.30
99_V331_P0.5350.30
121_L143_Y0.5350.30
258_K349_S0.5340.30
92_C368_N0.5340.30
290_G367_T0.5340.30
281_S341_E0.5330.30
43_V351_C0.5330.30
276_V321_A0.5330.30
70_P149_E0.5330.30
295_K331_P0.5320.29
81_T86_G0.5300.29
71_P88_L0.5300.29
138_K210_K0.5300.29
141_A205_E0.5300.29
248_V327_N0.5290.29
337_K368_N0.5290.29
84_P324_L0.5270.29
101_A336_E0.5260.29
68_H320_D0.5260.29
56_E129_L0.5230.29
79_I89_I0.5220.29
41_K345_R0.5210.29
234_Y253_N0.5210.29
11_I20_K0.5210.29
260_F284_K0.5210.29
331_P363_S0.5200.29
105_N289_L0.5180.28
23_A68_H0.5180.28
46_T365_T0.5170.28
122_E202_V0.5160.28
195_E282_M0.5160.28
206_T302_R0.5150.28
358_V371_T0.5150.28
48_D67_A0.5150.28
55_D58_I0.5150.28
64_L94_K0.5130.28
245_L295_K0.5120.28
29_I70_P0.5110.28
14_F345_R0.5110.28
29_I92_C0.5100.28
65_I332_G0.5100.28
260_F268_L0.5090.28
152_V204_L0.5090.28
313_L330_D0.5080.28
142_V197_E0.5080.28
123_L249_G0.5070.28
72_I79_I0.5060.28
18_S47_L0.5060.28
115_D126_T0.5050.27
25_E28_K0.5050.27
177_I258_K0.5040.27
13_L350_M0.5030.27
157_G173_S0.5030.27
71_P79_I0.5030.27
87_R91_K0.5030.27
227_E230_A0.5030.27
28_K101_A0.5010.27
332_G336_E0.5010.27
192_E253_N0.5010.27
276_V328_V0.5010.27
26_G317_V0.5000.27
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2gx8A 5 0.9759 100 0.142 Contact Map
2nydA 5 0.9303 100 0.156 Contact Map
2fywA 3 0.7024 100 0.479 Contact Map
1nmoA 4 0.6568 100 0.527 Contact Map
3wsfA 3 0.6488 100 0.536 Contact Map
2yybA 3 0.6408 100 0.543 Contact Map
3rxyA 4 0.689 100 0.582 Contact Map
2eg2A 5 0.2466 99.8 0.877 Contact Map
4co3A 3 0.2788 99.7 0.887 Contact Map
2ns1B 3 0.2949 99.7 0.887 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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