GREMLIN Database
PDRP - Putative pyruvate, phosphate dikinase regulatory protein
UniProt: P54470 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 270 (250)
Sequences: 1470 (922)
Seq/√Len: 58.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
161_S171_V5.5851.00
147_I169_L4.6351.00
99_E106_A3.9811.00
50_N75_Y3.9341.00
205_N229_I3.2461.00
46_I71_E3.2431.00
147_I266_K2.8401.00
40_I52_V2.7131.00
237_E241_D2.6481.00
65_F87_Y2.6121.00
142_I174_V2.5911.00
179_E228_R2.4851.00
60_G101_A2.4611.00
73_R92_G2.4541.00
133_Y141_G2.4051.00
57_K83_A2.3971.00
145_A172_A2.3941.00
8_V21_V2.3801.00
169_L263_H2.3531.00
184_E188_N2.3391.00
236_F240_V2.3211.00
199_I204_L2.1671.00
44_E48_T2.1551.00
246_Q265_L2.1551.00
199_I251_S2.1321.00
130_A133_Y2.0971.00
49_I72_I1.9731.00
53_I85_V1.9701.00
198_K237_E1.9111.00
124_V255_V1.8881.00
176_I236_F1.8821.00
99_E105_T1.8581.00
98_M102_Y1.8080.99
210_E213_K1.7850.99
187_F242_R1.7190.99
5_I38_R1.6910.99
21_V64_C1.6890.99
46_I75_Y1.6870.99
64_C94_L1.6540.99
230_K234_E1.6530.99
67_L72_I1.6480.99
9_V76_L1.6210.99
56_A61_G1.6200.99
161_S169_L1.6190.99
148_V189_V1.6040.99
196_G240_V1.5980.99
127_I255_V1.5950.99
150_I174_V1.5890.99
7_Y40_I1.5760.98
178_P228_R1.5700.98
166_H255_V1.5440.98
22_K37_V1.5420.98
16_T111_G1.5000.98
201_P233_L1.4690.98
149_L162_Q1.4620.98
138_D141_G1.4540.97
24_A98_M1.4520.97
230_K241_D1.4450.97
86_L100_T1.4430.97
62_I98_M1.4390.97
11_D16_T1.4370.97
155_T250_V1.4060.97
9_V52_V1.3930.97
125_E128_E1.3860.97
240_V247_V1.3840.97
261_I264_H1.3660.96
57_K84_N1.3620.96
133_Y138_D1.3620.96
97_K101_A1.3570.96
8_V22_K1.3560.96
29_N107_K1.3540.96
152_V204_L1.3470.96
46_I72_I1.3440.96
89_D92_G1.3170.95
152_V236_F1.3030.95
53_I75_Y1.2970.95
129_F132_K1.2930.95
144_K170_K1.2840.95
8_V37_V1.2800.95
62_I101_A1.2610.94
227_N231_E1.2550.94
66_T114_R1.2290.93
206_H252_N1.2230.93
54_S58_A1.2220.93
179_E243_I1.2140.93
49_I76_L1.2040.93
30_G104_L1.1990.92
27_Q68_V1.1970.92
8_V17_A1.1950.92
201_P226_I1.1910.92
68_V111_G1.1790.92
143_L188_N1.1760.92
127_I166_H1.1740.92
151_G155_T1.1690.91
49_I75_Y1.1620.91
150_I194_C1.1510.91
25_L98_M1.1400.90
133_Y163_Y1.1390.90
69_V123_K1.1360.90
65_F76_L1.1360.90
226_I230_K1.1140.89
52_V234_E1.1040.89
200_S251_S1.0990.89
221_A224_A1.0910.88
199_I207_I1.0900.88
195_I265_L1.0900.88
133_Y137_R1.0740.88
230_K237_E1.0580.87
65_F224_A1.0510.86
70_P108_Y1.0500.86
130_A142_I1.0500.86
186_L194_C1.0460.86
28_F95_I1.0360.86
146_D170_K1.0330.85
9_V43_V1.0320.85
10_S16_T1.0250.85
81_E87_Y1.0230.85
16_T68_V1.0170.85
190_D193_K1.0160.85
150_I186_L1.0110.84
38_R114_R1.0110.84
25_L123_K1.0070.84
120_Y124_V0.9990.84
14_G27_Q0.9940.83
176_I240_V0.9920.83
38_R55_L0.9840.83
7_Y56_A0.9830.83
129_F138_D0.9770.82
99_E103_G0.9720.82
45_D48_T0.9680.82
254_A257_E0.9640.81
49_I67_L0.9630.81
152_V240_V0.9580.81
162_Q236_F0.9460.80
132_K138_D0.9430.80
182_P186_L0.9260.79
85_V229_I0.9250.78
127_I179_E0.9220.78
28_F99_E0.9180.78
12_S16_T0.9150.78
14_G111_G0.9140.78
144_K262_I0.9120.78
31_S35_T0.9100.77
250_V258_T0.9070.77
56_A85_V0.9040.77
96_D100_T0.9000.77
70_P74_E0.8860.75
25_L148_V0.8830.75
7_Y59_D0.8760.75
64_C88_Y0.8730.74
150_I170_K0.8720.74
85_V92_G0.8720.74
20_V90_I0.8720.74
43_V104_L0.8690.74
69_V72_I0.8670.74
162_Q165_A0.8660.74
130_A171_V0.8650.74
95_I99_E0.8640.74
55_L97_K0.8590.73
235_Y239_I0.8560.73
147_I171_V0.8550.73
129_F133_Y0.8520.73
194_C243_I0.8510.72
129_F249_D0.8490.72
181_D184_E0.8480.72
86_L101_A0.8430.72
46_I262_I0.8380.71
9_V53_I0.8360.71
138_D142_I0.8360.71
171_V251_S0.8350.71
135_D175_P0.8330.71
130_A137_R0.8320.71
221_A225_N0.8310.71
109_E112_R0.8310.71
253_K258_T0.8270.70
64_C90_I0.8170.69
129_F168_R0.8160.69
122_K234_E0.8090.69
60_G105_T0.8090.69
150_I240_V0.8070.68
61_G85_V0.8020.68
29_N161_S0.8010.68
225_N237_E0.7970.67
201_P230_K0.7960.67
40_I43_V0.7960.67
136_G175_P0.7920.67
90_I94_L0.7870.66
9_V85_V0.7870.66
150_I245_C0.7840.66
176_I209_K0.7760.65
7_Y61_G0.7750.65
12_S161_S0.7700.65
27_Q259_A0.7680.65
51_E74_E0.7670.64
253_K261_I0.7670.64
142_I182_P0.7660.64
12_S15_E0.7620.64
18_E210_E0.7600.64
152_V199_I0.7590.64
65_F90_I0.7570.63
224_A240_V0.7560.63
140_R144_K0.7510.63
123_K246_Q0.7490.63
88_Y97_K0.7490.63
53_I63_I0.7450.62
71_E75_Y0.7360.61
97_K100_T0.7340.61
67_L151_G0.7330.61
203_K251_S0.7310.61
74_E104_L0.7270.60
81_E227_N0.7270.60
204_L255_V0.7250.60
127_I233_L0.7190.59
254_A258_T0.7190.59
115_Q149_L0.7160.59
84_N122_K0.7160.59
212_L221_A0.7140.59
150_I176_I0.7090.58
168_R203_K0.7060.58
5_I36_H0.7050.58
155_T259_A0.7040.58
54_S84_N0.7030.58
212_L224_A0.7020.58
43_V60_G0.7020.58
129_F139_P0.6990.57
6_I255_V0.6950.57
161_S177_V0.6930.57
53_I83_A0.6920.57
23_A91_I0.6920.57
111_G255_V0.6890.56
40_I98_M0.6870.56
155_T207_I0.6860.56
225_N228_R0.6840.56
193_K239_I0.6830.56
131_V160_L0.6820.55
6_I249_D0.6820.55
143_L190_D0.6800.55
45_D255_V0.6790.55
26_S113_V0.6770.55
210_E240_V0.6750.55
150_I187_F0.6730.54
7_Y38_R0.6620.53
88_Y163_Y0.6620.53
99_E102_Y0.6610.53
187_F239_I0.6600.53
90_I96_D0.6540.52
110_P204_L0.6530.52
50_N54_S0.6510.52
26_S112_R0.6500.52
20_V23_A0.6500.52
39_R160_L0.6490.52
137_R156_S0.6470.52
203_K206_H0.6470.52
162_Q258_T0.6460.51
20_V92_G0.6420.51
162_Q240_V0.6390.51
86_L97_K0.6360.50
22_K150_I0.6350.50
140_R169_L0.6340.50
45_D124_V0.6310.50
46_I49_I0.6270.49
200_S233_L0.6260.49
128_E141_G0.6250.49
29_N112_R0.6240.49
128_E233_L0.6200.49
39_R247_V0.6180.48
142_I172_A0.6180.48
89_D131_V0.6180.48
73_R207_I0.6160.48
48_T144_K0.6150.48
95_I193_K0.6130.48
111_G114_R0.6130.48
156_S229_I0.6110.48
42_Y260_N0.6070.47
20_V204_L0.6060.47
102_Y176_I0.6050.47
40_I55_L0.6040.47
47_G50_N0.6040.47
69_V74_E0.6030.47
138_D177_V0.6020.47
45_D57_K0.6010.46
42_Y106_A0.5960.46
15_E229_I0.5930.46
37_V147_I0.5930.46
162_Q260_N0.5930.46
180_V221_A0.5910.45
107_K114_R0.5890.45
139_P189_V0.5890.45
66_T170_K0.5880.45
88_Y91_I0.5870.45
209_K220_K0.5870.45
188_N192_K0.5860.45
131_V148_V0.5860.45
237_E249_D0.5850.45
119_D170_K0.5830.45
16_T66_T0.5820.44
13_V133_Y0.5800.44
118_E201_P0.5790.44
168_R198_K0.5790.44
27_Q111_G0.5780.44
59_D104_L0.5780.44
109_E115_Q0.5760.44
136_G257_E0.5740.44
42_Y179_E0.5740.44
148_V172_A0.5740.44
83_A237_E0.5740.44
11_D23_A0.5730.43
27_Q117_D0.5730.43
130_A191_P0.5720.43
6_I35_T0.5690.43
56_A180_V0.5680.43
129_F143_L0.5660.43
16_T114_R0.5650.43
62_I75_Y0.5630.42
17_A66_T0.5630.42
153_S223_Y0.5620.42
183_P259_A0.5620.42
54_S74_E0.5600.42
51_E188_N0.5580.42
90_I108_Y0.5510.41
209_K227_N0.5500.41
54_S57_K0.5500.41
54_S231_E0.5490.41
65_F73_R0.5460.41
117_D156_S0.5450.40
107_K263_H0.5440.40
186_L266_K0.5440.40
199_I250_V0.5430.40
162_Q228_R0.5420.40
197_L262_I0.5420.40
116_L194_C0.5400.40
31_S88_Y0.5390.40
152_V155_T0.5370.40
81_E192_K0.5360.39
20_V93_P0.5360.39
15_E167_K0.5340.39
240_V245_C0.5340.39
210_E245_C0.5330.39
130_A184_E0.5320.39
16_T120_Y0.5320.39
73_R76_L0.5320.39
13_V102_Y0.5310.39
200_S249_D0.5310.39
63_I83_A0.5300.39
185_E188_N0.5290.39
76_L171_V0.5270.38
189_V194_C0.5210.38
143_L189_V0.5200.38
15_E26_S0.5190.38
150_I255_V0.5180.38
48_T198_K0.5170.37
145_A226_I0.5170.37
17_A123_K0.5160.37
114_R230_K0.5150.37
52_V61_G0.5140.37
91_I131_V0.5140.37
64_C251_S0.5130.37
118_E122_K0.5130.37
240_V243_I0.5130.37
200_S203_K0.5130.37
125_E170_K0.5130.37
142_I261_I0.5120.37
107_K266_K0.5110.37
58_A184_E0.5100.37
227_N230_K0.5090.37
26_S261_I0.5080.37
52_V57_K0.5070.36
53_I57_K0.5060.36
222_I228_R0.5060.36
119_D249_D0.5050.36
22_K259_A0.5040.36
129_F142_I0.5040.36
105_T263_H0.5040.36
231_E235_Y0.5030.36
105_T122_K0.5000.36
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ckeA 1 0.4444 97.3 0.928 Contact Map
1khtA 5 0.463 96.9 0.932 Contact Map
4cvnA 1 0.4481 96.9 0.932 Contact Map
2h92A 1 0.4444 96.8 0.933 Contact Map
4e22A 1 0.4407 96.8 0.933 Contact Map
1viaA 2 0.4556 96.7 0.934 Contact Map
3t61A 2 0.4481 96.6 0.934 Contact Map
2iyvA 1 0.4593 96.6 0.934 Contact Map
1e6cA 1 0.4593 96.5 0.935 Contact Map
1akyA 1 0.4593 96.5 0.935 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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