GREMLIN Database
YQFD - Uncharacterized protein YqfD
UniProt: P54469 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 398 (381)
Sequences: 603 (551)
Seq/√Len: 28.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
198_A246_G9.9531.00
225_V242_A6.5851.00
196_K384_E5.5971.00
15_L48_L4.5361.00
197_K220_K4.1451.00
38_H49_Y3.8831.00
266_T324_E3.6191.00
246_G386_I3.5131.00
271_T319_K3.3471.00
192_I387_V3.3051.00
192_I225_V3.1871.00
14_Q49_Y3.1811.00
116_A121_E3.0831.00
333_T336_E3.0751.00
197_K219_E2.9091.00
196_K250_Y2.8781.00
267_G324_E2.8161.00
112_D170_T2.7411.00
190_R239_A2.7331.00
113_V124_M2.6150.99
247_E381_Q2.5720.99
294_L324_E2.5720.99
139_Q166_L2.5240.99
346_K362_E2.5220.99
159_I175_V2.5140.99
115_G177_E2.4610.99
191_N223_L2.4390.99
133_V171_I2.4130.99
99_I103_L2.4030.99
15_L50_I2.3940.99
273_H317_Y2.3440.99
265_Y323_R2.3260.99
74_R79_F2.2910.99
129_N134_K2.2470.98
191_N390_T2.1220.98
11_G78_P2.1170.97
51_Q54_D2.0710.97
251_R377_I2.0610.97
153_T159_I2.0250.97
192_I244_I1.9930.96
201_T383_I1.9690.96
17_L48_L1.9630.96
206_Q241_K1.9340.96
259_E329_L1.9330.96
144_S147_K1.9120.95
23_E37_F1.9100.95
255_T375_K1.8780.95
253_E377_I1.8760.95
263_N298_K1.8700.95
269_V323_R1.8580.95
68_K79_F1.7930.93
128_L173_M1.7570.93
36_V39_V1.7410.92
359_V364_V1.7220.92
343_K347_Q1.7150.92
116_A177_E1.7030.92
305_S316_S1.6970.91
261_L327_E1.6920.91
263_N325_S1.6880.91
97_F102_F1.6860.91
205_V225_V1.6640.91
265_Y298_K1.6610.91
268_K324_E1.6550.90
245_Y383_I1.6500.90
50_I54_D1.6290.90
212_A224_L1.5820.88
225_V387_V1.5690.88
191_N392_I1.5600.87
143_M215_H1.5570.87
37_F49_Y1.5440.87
247_E383_I1.5350.87
211_M223_L1.5260.86
14_Q73_N1.5200.86
114_T200_I1.5150.86
200_I246_G1.5050.85
203_M225_V1.4990.85
16_E47_S1.4970.85
29_C34_I1.4920.85
248_T382_V1.4800.85
127_H156_I1.4660.84
258_L337_A1.4610.84
299_T320_E1.4590.84
63_S79_F1.4550.83
156_I159_I1.4400.83
337_A341_G1.4340.83
142_M215_H1.4280.82
163_G176_V1.4250.82
128_L225_V1.4220.82
297_P322_T1.4200.82
202_R245_Y1.4200.82
152_L159_I1.4000.81
276_S316_S1.3980.81
37_F78_P1.3770.80
50_I58_F1.3610.79
262_F330_R1.3530.79
200_I203_M1.3490.78
192_I200_I1.3360.78
212_A222_Q1.3340.78
193_V223_L1.3330.78
16_E45_A1.3300.77
165_D172_H1.3170.77
121_E125_R1.3060.76
55_V71_F1.3050.76
12_K37_F1.2910.75
324_E345_G1.2840.75
276_S303_K1.2810.75
217_H247_E1.2810.75
116_A124_M1.2780.75
145_P164_V1.2530.73
200_I244_I1.2460.73
250_Y384_E1.2430.72
52_L79_F1.2300.72
250_Y382_V1.2300.72
8_F12_K1.2290.72
275_L284_I1.2190.71
113_V125_R1.2050.70
201_T247_E1.2010.70
50_I211_M1.1980.70
260_T332_Y1.1950.69
203_M214_I1.1920.69
356_N359_V1.1850.69
191_N228_L1.1820.69
147_K151_S1.1780.68
132_G337_A1.1750.68
265_Y325_S1.1740.68
131_I155_G1.1740.68
348_D352_K1.1580.67
76_G79_F1.1580.67
252_S345_G1.1530.67
63_S132_G1.1370.65
225_V244_I1.1350.65
16_E70_R1.1300.65
17_L203_M1.1280.65
342_I346_K1.1240.65
156_I163_G1.1210.64
102_F106_N1.1140.64
152_L277_F1.1040.63
106_N110_K1.1010.63
349_V382_V1.0970.63
363_K366_H1.0930.62
258_L374_V1.0900.62
363_K373_K1.0790.61
254_V257_P1.0700.61
119_E371_N1.0680.61
357_G364_V1.0650.60
165_D174_K1.0610.60
309_L316_S1.0590.60
93_G97_F1.0520.59
12_K49_Y1.0470.59
147_K200_I1.0430.59
23_E109_W1.0390.58
259_E331_K1.0370.58
56_H71_F1.0360.58
149_Q366_H1.0330.58
23_E27_N1.0330.58
273_H319_K1.0290.58
113_V359_V1.0260.57
249_W384_E1.0240.57
131_I152_L1.0240.57
52_L74_R1.0230.57
219_E222_Q1.0160.57
95_A277_F1.0130.56
192_I389_T1.0070.56
193_V331_K1.0050.56
113_V333_T1.0020.56
8_F80_L1.0020.56
92_I100_L1.0010.55
330_R336_E0.9970.55
346_K367_Q0.9960.55
190_R389_T0.9920.55
334_K338_V0.9910.55
116_A125_R0.9900.55
357_G362_E0.9880.54
113_V175_V0.9820.54
356_N364_V0.9800.54
354_G357_G0.9780.54
10_S101_L0.9740.53
268_K294_L0.9710.53
225_V385_D0.9700.53
71_F74_R0.9680.53
353_I357_G0.9660.53
114_T174_K0.9590.52
255_T373_K0.9550.52
24_R27_N0.9550.52
108_V343_K0.9510.52
113_V121_E0.9500.52
36_V274_K0.9500.52
82_L85_K0.9470.51
195_K385_D0.9380.51
93_G189_P0.9340.50
353_I359_V0.9330.50
61_V295_K0.9310.50
206_Q243_E0.9250.50
146_E277_F0.9240.50
128_L133_V0.9220.49
277_F343_K0.9200.49
44_E303_K0.9150.49
84_S90_F0.9130.49
264_V328_A0.9120.49
81_L170_T0.9120.49
73_N276_S0.9110.49
126_Q295_K0.9110.49
303_K316_S0.9090.48
91_T191_N0.9090.48
138_L142_M0.9080.48
55_V69_A0.9070.48
192_I242_A0.9000.48
253_E375_K0.8980.48
159_I368_T0.8910.47
23_E78_P0.8860.47
198_A247_E0.8810.46
128_L248_T0.8790.46
113_V128_L0.8780.46
95_A339_Q0.8770.46
349_V380_Y0.8750.46
81_L182_E0.8740.46
218_V386_I0.8730.46
28_E65_F0.8690.45
29_C387_V0.8680.45
201_T245_Y0.8660.45
160_T225_V0.8650.45
203_M244_I0.8560.44
52_L78_P0.8550.44
112_D193_V0.8540.44
353_I362_E0.8530.44
71_F119_E0.8460.44
102_F306_L0.8460.44
143_M149_Q0.8450.44
114_T222_Q0.8450.44
74_R93_G0.8450.44
86_L331_K0.8380.43
228_L392_I0.8360.43
216_D279_S0.8350.43
114_T170_T0.8320.43
171_I185_K0.8320.43
7_S15_L0.8310.42
25_L58_F0.8260.42
280_L283_P0.8180.41
71_F139_Q0.8160.41
44_E214_I0.8140.41
108_V142_M0.8120.41
264_V326_E0.8110.41
191_N234_H0.8110.41
63_S68_K0.8090.41
56_H74_R0.8080.41
274_K383_I0.8070.41
198_A230_G0.8060.41
116_A175_V0.8060.41
118_P170_T0.8030.40
212_A350_E0.8020.40
164_V171_I0.8020.40
74_R220_K0.7990.40
223_L229_I0.7970.40
107_M139_Q0.7970.40
100_L104_L0.7960.40
246_G385_D0.7950.40
55_V68_K0.7930.40
111_I302_E0.7910.39
188_S391_P0.7870.39
26_L46_V0.7860.39
100_L128_L0.7830.39
173_M218_V0.7820.39
222_Q334_K0.7780.39
86_L111_I0.7780.39
153_T332_Y0.7770.38
148_I319_K0.7750.38
184_E360_K0.7740.38
259_E372_G0.7720.38
366_H372_G0.7720.38
89_G93_G0.7700.38
178_K243_E0.7700.38
151_S213_A0.7700.38
198_A217_H0.7690.38
254_V378_I0.7690.38
176_V374_V0.7680.38
22_I32_Q0.7670.38
215_H379_L0.7660.38
273_H280_L0.7660.38
313_L329_L0.7650.38
22_I90_F0.7630.37
137_R171_I0.7620.37
97_F267_G0.7590.37
174_K380_Y0.7570.37
74_R78_P0.7500.37
55_V262_F0.7490.36
265_Y317_Y0.7480.36
175_V229_I0.7440.36
54_D133_V0.7430.36
333_T341_G0.7420.36
11_G79_F0.7420.36
274_K281_A0.7410.36
11_G37_F0.7400.36
252_S378_I0.7390.36
182_E268_K0.7390.36
191_N199_T0.7390.36
169_T382_V0.7380.36
249_W345_G0.7370.36
68_K75_K0.7370.36
366_H371_N0.7370.36
256_V341_G0.7350.35
279_S338_V0.7330.35
34_I258_L0.7310.35
226_S314_P0.7290.35
248_T384_E0.7290.35
265_Y296_H0.7280.35
258_L341_G0.7240.35
160_T171_I0.7240.35
356_N362_E0.7230.35
353_I358_E0.7220.35
249_W381_Q0.7210.34
124_M159_I0.7210.34
163_G204_F0.7210.34
36_V48_L0.7200.34
132_G198_A0.7190.34
9_F86_L0.7190.34
279_S282_I0.7190.34
109_W212_A0.7180.34
243_E385_D0.7170.34
199_T249_W0.7170.34
9_F92_I0.7160.34
136_G166_L0.7160.34
46_V349_V0.7150.34
119_E171_I0.7110.34
124_M305_S0.7090.34
258_L373_K0.7090.34
169_T314_P0.7080.34
359_V380_Y0.7060.33
118_P148_I0.7050.33
19_G67_C0.7050.33
31_R222_Q0.7040.33
133_V306_L0.7030.33
89_G380_Y0.7010.33
89_G181_P0.6990.33
142_M244_I0.6990.33
189_P238_V0.6980.33
82_L86_L0.6980.33
76_G384_E0.6980.33
23_E79_F0.6980.33
12_K277_F0.6970.33
23_E76_G0.6930.33
107_M138_L0.6930.33
213_A216_D0.6930.33
297_P300_E0.6920.32
133_V183_K0.6900.32
160_T389_T0.6870.32
358_E364_V0.6860.32
239_A389_T0.6860.32
160_T206_Q0.6850.32
109_W136_G0.6830.32
179_N222_Q0.6820.32
63_S120_T0.6780.32
131_I275_L0.6770.31
205_V242_A0.6750.31
200_I386_I0.6730.31
162_V362_E0.6720.31
69_A194_A0.6720.31
189_P386_I0.6680.31
246_G384_E0.6670.31
59_R79_F0.6670.31
158_N319_K0.6630.31
75_K360_K0.6620.30
68_K244_I0.6610.30
332_Y337_A0.6590.30
160_T332_Y0.6590.30
315_V356_N0.6580.30
217_H246_G0.6570.30
116_A153_T0.6560.30
187_V350_E0.6540.30
248_T254_V0.6530.30
135_K386_I0.6520.30
222_Q377_I0.6510.30
203_M245_Y0.6500.30
10_S219_E0.6500.30
160_T242_A0.6480.30
58_F61_V0.6480.30
192_I209_Q0.6480.30
149_Q153_T0.6480.30
217_H244_I0.6470.30
38_H193_V0.6450.29
58_F330_R0.6430.29
94_F108_V0.6420.29
83_K222_Q0.6400.29
130_E155_G0.6390.29
266_T294_L0.6390.29
22_I28_E0.6390.29
127_H130_E0.6370.29
278_G284_I0.6370.29
21_G154_N0.6350.29
256_V374_V0.6350.29
71_F205_V0.6340.29
215_H254_V0.6320.29
111_I164_V0.6320.29
97_F104_L0.6310.28
261_L264_V0.6300.28
96_I129_N0.6290.28
233_D295_K0.6290.28
272_K299_T0.6290.28
131_I148_I0.6290.28
106_N138_L0.6290.28
193_V334_K0.6290.28
187_V190_R0.6290.28
102_F105_S0.6280.28
27_N181_P0.6260.28
111_I135_K0.6250.28
136_G149_Q0.6250.28
50_I243_E0.6240.28
59_R132_G0.6240.28
355_E359_V0.6230.28
26_L43_K0.6230.28
143_M379_L0.6220.28
87_N160_T0.6220.28
339_Q343_K0.6210.28
124_M175_V0.6210.28
65_F102_F0.6210.28
56_H60_R0.6180.28
99_I325_S0.6180.28
47_S72_I0.6170.28
55_V74_R0.6160.28
95_A259_E0.6150.27
299_T322_T0.6150.27
342_I366_H0.6140.27
91_T175_V0.6130.27
222_Q382_V0.6130.27
152_L162_V0.6130.27
52_L63_S0.6120.27
55_V79_F0.6090.27
22_I99_I0.6090.27
163_G345_G0.6080.27
17_L369_V0.6080.27
160_T163_G0.6080.27
212_A242_A0.6070.27
13_V59_R0.6060.27
39_V364_V0.6050.27
62_R175_V0.6020.27
85_K187_V0.6020.27
116_A119_E0.6020.27
225_V245_Y0.6000.27
151_S155_G0.6000.27
251_R379_L0.5980.26
38_H271_T0.5980.26
200_I263_N0.5910.26
226_S229_I0.5910.26
275_L380_Y0.5910.26
328_A334_K0.5900.26
107_M254_V0.5890.26
137_R247_E0.5870.26
258_L372_G0.5860.26
84_S282_I0.5860.26
33_G317_Y0.5860.26
12_K38_H0.5860.26
349_V355_E0.5860.26
160_T164_V0.5860.26
84_S242_A0.5850.26
113_V361_S0.5840.26
86_L270_R0.5830.26
96_I103_L0.5830.26
47_S152_L0.5820.26
338_V342_I0.5810.25
11_G76_G0.5810.25
260_T392_I0.5800.25
166_L172_H0.5790.25
156_I378_I0.5790.25
223_L244_I0.5750.25
200_I224_L0.5750.25
202_R284_I0.5740.25
13_V71_F0.5710.25
212_A244_I0.5710.25
307_H312_K0.5700.25
37_F115_G0.5700.25
296_H325_S0.5690.25
78_P104_L0.5690.25
256_V384_E0.5680.25
302_E352_K0.5670.25
200_I334_K0.5670.25
190_R226_S0.5670.25
41_K45_A0.5660.25
78_P224_L0.5660.25
241_K378_I0.5660.25
173_M306_L0.5640.24
94_F98_F0.5620.24
254_V341_G0.5620.24
25_L65_F0.5610.24
48_L90_F0.5590.24
45_A328_A0.5590.24
33_G312_K0.5580.24
169_T384_E0.5560.24
149_Q247_E0.5560.24
332_Y340_E0.5560.24
119_E175_V0.5550.24
176_V278_G0.5550.24
175_V212_A0.5520.24
70_R328_A0.5520.24
256_V332_Y0.5510.24
117_K120_T0.5510.24
313_L347_Q0.5500.24
79_F93_G0.5490.24
8_F334_K0.5490.24
151_S293_E0.5490.24
163_G378_I0.5480.24
167_K172_H0.5480.24
192_I230_G0.5480.24
35_P51_Q0.5480.24
76_G337_A0.5480.24
146_E166_L0.5470.24
186_Y190_R0.5460.23
113_V350_E0.5460.23
23_E136_G0.5450.23
124_M270_R0.5450.23
24_R28_E0.5450.23
14_Q105_S0.5440.23
291_K295_K0.5430.23
37_F109_W0.5430.23
237_E380_Y0.5420.23
251_R341_G0.5420.23
15_L353_I0.5410.23
33_G351_D0.5400.23
33_G133_V0.5400.23
173_M186_Y0.5400.23
185_K351_D0.5400.23
142_M379_L0.5400.23
232_E235_Q0.5390.23
335_E357_G0.5390.23
244_I388_Q0.5370.23
89_G376_L0.5360.23
267_G294_L0.5340.23
202_R279_S0.5340.23
111_I354_G0.5340.23
90_F313_L0.5320.23
226_S376_L0.5310.23
112_D184_E0.5300.23
96_I318_V0.5300.23
62_R97_F0.5290.23
178_K250_Y0.5290.23
134_K300_E0.5280.22
332_Y336_E0.5280.22
59_R346_K0.5270.22
120_T332_Y0.5250.22
99_I271_T0.5240.22
38_H77_F0.5220.22
294_L334_K0.5210.22
92_I338_V0.5210.22
26_L366_H0.5200.22
205_V210_P0.5190.22
128_L156_I0.5180.22
26_L304_H0.5180.22
345_G378_I0.5180.22
97_F109_W0.5160.22
168_G208_G0.5160.22
58_F240_S0.5150.22
222_Q363_K0.5140.22
138_L309_L0.5140.22
124_M385_D0.5140.22
186_Y269_V0.5140.22
212_A218_V0.5130.22
54_D98_F0.5120.22
315_V321_Q0.5100.22
105_S169_T0.5090.21
76_G314_P0.5080.21
244_I275_L0.5070.21
91_T213_A0.5070.21
55_V338_V0.5050.21
159_I237_E0.5050.21
11_G23_E0.5050.21
79_F88_I0.5050.21
248_T353_I0.5040.21
215_H322_T0.5040.21
103_L133_V0.5040.21
83_K387_V0.5020.21
133_V339_Q0.5020.21
34_I187_V0.5020.21
15_L148_I0.5000.21
53_Q101_L0.5000.21
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4k3bA 1 0.6332 92.1 0.949 Contact Map
2kccA 1 0.2111 90.6 0.951 Contact Map
2d5dA 1 0.1709 88 0.953 Contact Map
1bdoA 2 0.196 87.9 0.954 Contact Map
2dn8A 1 0.2462 87.6 0.954 Contact Map
1dczA 1 0.1935 86.4 0.955 Contact Map
3bg3A 4 0.5327 84.4 0.956 Contact Map
3hblA 4 0.5678 83.6 0.956 Contact Map
2vh2A 1 0.495 82.9 0.957 Contact Map
1z6hA 1 0.1759 82.8 0.957 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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