GREMLIN Database
YQFA - UPF0365 protein YqfA
UniProt: P54466 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 331 (316)
Sequences: 376 (134)
Seq/√Len: 7.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
289_E293_E4.6670.99
144_D191_K4.4910.98
33_S36_A4.0120.97
184_I229_K3.9960.97
282_E285_L3.9150.96
268_R271_E3.6820.95
138_I173_V3.4400.92
33_S37_A3.0430.87
100_R147_E2.8840.83
250_K253_E2.7430.80
244_K248_Q2.6160.76
32_I36_A2.5400.74
33_S126_M2.5040.73
39_V63_L2.4970.73
118_R163_L2.4840.72
135_T168_G2.4730.72
272_M278_E2.4290.71
225_V282_E2.4140.70
109_R161_E2.4130.70
119_D122_E2.3290.67
237_T241_E2.3170.67
65_K93_N2.2880.66
23_F28_V2.2790.66
138_I183_T2.1600.61
137_F149_K2.1470.61
281_A292_R2.0990.59
33_S89_D2.0860.58
144_D190_H2.0770.58
269_V277_V2.0490.57
27_P135_T2.0090.55
65_K97_A2.0090.55
36_A126_M2.0000.55
305_K308_D1.9810.54
139_A147_E1.9750.54
229_K234_I1.9310.52
134_E168_G1.9220.52
138_I211_S1.9180.52
291_L296_I1.9070.51
24_T97_A1.9050.51
211_S273_R1.9040.51
126_M134_E1.8990.51
62_P89_D1.8760.50
151_K225_V1.8630.50
85_G190_H1.8500.49
190_H253_E1.8310.48
291_L295_N1.8280.48
147_E184_I1.8190.48
54_V80_S1.7740.46
87_N277_V1.7550.45
139_A150_A1.7140.44
54_V76_N1.6980.43
287_M291_L1.6910.43
30_L56_P1.6640.42
102_N187_S1.6410.41
41_I305_K1.5820.39
287_M296_I1.5780.38
119_D163_L1.5680.38
39_V67_H1.5650.38
65_K147_E1.5440.37
129_N158_A1.5370.37
140_G224_D1.5300.37
225_V272_M1.5060.36
183_T203_T1.4850.35
283_V287_M1.4750.35
89_D153_R1.4720.35
245_N305_K1.4650.34
122_E131_K1.4630.34
65_K100_R1.4570.34
315_D319_K1.4470.34
16_I320_L1.4390.33
134_E139_A1.4350.33
99_Q144_D1.4180.33
109_R269_V1.4160.33
66_A92_V1.4120.32
162_R268_R1.4110.32
163_L238_D1.3970.32
33_S63_L1.3460.30
202_Q318_G1.3450.30
144_D189_N1.3420.30
29_M229_K1.3410.30
278_E282_E1.3230.29
68_K218_L1.3180.29
273_R280_E1.3120.29
126_M135_T1.3110.29
80_S119_D1.3050.29
265_M291_L1.2960.28
93_N184_I1.2920.28
88_V211_S1.2840.28
53_R291_L1.2840.28
27_P63_L1.2760.28
27_P39_V1.2750.28
150_A184_I1.2750.28
144_D150_A1.2620.27
162_R183_T1.2430.27
92_V246_I1.2370.27
126_M158_A1.2260.26
150_A229_K1.2240.26
303_N307_I1.2220.26
100_R111_A1.2150.26
168_G237_T1.2140.26
74_G108_E1.2120.26
119_D238_D1.2110.26
41_I120_V1.2060.26
275_K278_E1.1920.25
37_A51_L1.1920.25
21_V48_G1.1880.25
37_A68_K1.1790.25
19_L189_N1.1740.25
97_A100_R1.1710.25
168_G212_G1.1690.25
134_E151_K1.1600.24
63_L68_K1.1590.24
47_V295_N1.1570.24
212_G218_L1.1420.24
138_I162_R1.1410.24
265_M276_V1.1370.24
140_G285_L1.1250.23
272_M277_V1.1220.23
21_V250_K1.1170.23
37_A89_D1.1110.23
186_S224_D1.1090.23
148_V170_E1.1080.23
108_E147_E1.1070.23
32_I66_A1.1030.23
73_V148_V1.0990.23
140_G182_S1.0980.23
76_N246_I1.0980.23
15_A225_V1.0930.22
287_M305_K1.0840.22
154_I245_N1.0800.22
51_L277_V1.0770.22
126_M168_G1.0760.22
236_Q239_Q1.0750.22
172_I201_S1.0720.22
246_I305_K1.0700.22
34_A208_G1.0690.22
269_V272_M1.0620.22
135_T139_A1.0570.21
62_P184_I1.0570.21
170_E269_V1.0550.21
140_G186_S1.0550.21
24_T135_T1.0490.21
304_I308_D1.0480.21
261_Q268_R1.0480.21
218_L234_I1.0430.21
187_S199_M1.0340.21
172_I203_T1.0290.21
53_R65_K1.0260.21
162_R272_M1.0230.21
298_V303_N1.0220.20
59_V150_A1.0210.20
211_S281_A1.0160.20
22_F42_S1.0160.20
17_I22_F1.0140.20
143_M188_D1.0120.20
225_V285_L1.0110.20
73_V89_D1.0100.20
281_A315_D1.0070.20
88_V148_V1.0050.20
140_G227_I1.0010.20
13_A17_I0.9950.20
71_L268_R0.9870.20
164_V218_L0.9870.20
147_E229_K0.9860.20
87_N192_K0.9830.20
72_N76_N0.9830.20
36_A67_H0.9800.19
24_T147_E0.9780.19
77_Q100_R0.9650.19
178_E207_K0.9580.19
36_A89_D0.9500.19
188_D192_K0.9470.19
55_I272_M0.9440.19
92_V244_K0.9430.19
164_V299_M0.9410.18
37_A140_G0.9400.18
57_N61_N0.9370.18
77_Q108_E0.9350.18
24_T27_P0.9340.18
296_I318_G0.9290.18
144_D309_A0.9280.18
259_V305_K0.9260.18
89_D147_E0.9230.18
134_E237_T0.9220.18
21_V305_K0.9140.18
33_S39_V0.9110.18
199_M303_N0.9100.18
102_N182_S0.9090.18
35_L271_E0.9080.18
91_V148_V0.9070.18
55_I100_R0.9050.18
27_P168_G0.8930.17
73_V189_N0.8910.17
138_I227_I0.8890.17
162_R172_I0.8850.17
107_F139_A0.8800.17
97_A269_V0.8750.17
202_Q322_K0.8750.17
97_A147_E0.8740.17
256_A259_V0.8740.17
93_N168_G0.8730.17
139_A184_I0.8730.17
21_V287_M0.8730.17
99_Q139_A0.8650.17
158_A163_L0.8620.17
265_M271_E0.8620.17
41_I316_S0.8610.17
52_R79_E0.8610.17
107_F140_G0.8580.17
267_A270_E0.8560.17
73_V322_K0.8560.17
26_V135_T0.8550.17
65_K99_Q0.8530.16
138_I218_L0.8520.16
126_M229_K0.8510.16
140_G196_N0.8500.16
26_V63_L0.8500.16
291_L320_L0.8500.16
99_Q246_I0.8430.16
100_R184_I0.8430.16
198_D236_Q0.8410.16
54_V242_A0.8400.16
164_V244_K0.8390.16
139_A149_K0.8380.16
39_V135_T0.8320.16
146_I275_K0.8320.16
46_L236_Q0.8260.16
48_G51_L0.8240.16
143_M279_A0.8220.16
234_I238_D0.8200.16
33_S65_K0.8160.16
202_Q317_F0.8140.16
63_L135_T0.8130.16
152_A236_Q0.8060.15
160_I207_K0.8060.15
125_Q282_E0.8030.15
58_R65_K0.8020.15
297_G306_N0.7990.15
75_T82_Y0.7970.15
291_L304_I0.7960.15
27_P33_S0.7940.15
10_A138_I0.7920.15
151_K158_A0.7900.15
60_V143_M0.7890.15
68_K100_R0.7890.15
192_K238_D0.7870.15
9_L307_I0.7860.15
42_S309_A0.7840.15
45_T75_T0.7780.15
300_D317_F0.7740.15
100_R298_V0.7730.15
267_A272_M0.7680.15
310_D313_M0.7680.15
143_M153_R0.7680.15
135_T253_E0.7630.15
209_L302_M0.7630.15
304_I318_G0.7620.15
231_I295_N0.7590.15
187_S210_D0.7590.15
42_S266_R0.7590.15
34_A37_A0.7580.14
125_Q160_I0.7570.14
305_K321_T0.7560.14
36_A90_R0.7540.14
202_Q206_G0.7530.14
158_A168_G0.7510.14
248_Q272_M0.7500.14
297_G300_D0.7470.14
121_L153_R0.7450.14
140_G236_Q0.7420.14
15_A227_I0.7420.14
126_M173_V0.7410.14
67_H126_M0.7410.14
312_E315_D0.7400.14
91_V119_D0.7380.14
148_V225_V0.7360.14
168_G183_T0.7320.14
135_T190_H0.7310.14
33_S67_H0.7300.14
104_E283_V0.7280.14
68_K212_G0.7280.14
100_R244_K0.7260.14
64_I144_D0.7200.14
253_E276_V0.7200.14
118_R190_H0.7140.14
172_I268_R0.7040.13
295_N303_N0.7040.13
58_R62_P0.7030.13
312_E321_T0.7010.13
109_R138_I0.7000.13
8_I18_V0.6990.13
35_L73_V0.6990.13
37_A63_L0.6960.13
308_D315_D0.6960.13
24_T33_S0.6940.13
22_F206_G0.6920.13
163_L257_M0.6910.13
179_G201_S0.6880.13
50_R168_G0.6870.13
33_S135_T0.6850.13
20_A82_Y0.6840.13
159_N300_D0.6800.13
37_A43_I0.6790.13
229_K246_I0.6780.13
97_A148_V0.6770.13
16_I19_L0.6750.13
33_S168_G0.6740.13
306_N310_D0.6730.13
306_N313_M0.6730.13
265_M270_E0.6710.13
42_S316_S0.6700.13
80_S234_I0.6690.13
92_V199_M0.6660.13
16_I322_K0.6660.13
17_I25_F0.6650.13
54_V226_D0.6650.13
50_R212_G0.6640.13
14_V73_V0.6630.13
9_L73_V0.6630.13
50_R55_I0.6620.13
253_E257_M0.6620.13
149_K295_N0.6600.13
99_Q106_T0.6590.13
128_V209_L0.6550.13
14_V211_S0.6540.13
26_V168_G0.6510.13
11_I322_K0.6510.13
184_I268_R0.6480.12
11_I122_E0.6480.12
318_G321_T0.6480.12
56_P91_V0.6470.12
20_A283_V0.6460.12
42_S54_V0.6460.12
267_A271_E0.6450.12
44_F126_M0.6450.12
44_F48_G0.6430.12
13_A19_L0.6430.12
208_G212_G0.6420.12
23_F26_V0.6410.12
65_K89_D0.6390.12
152_A239_Q0.6390.12
128_V166_G0.6390.12
25_F119_D0.6380.12
65_K96_I0.6380.12
82_Y312_E0.6370.12
183_T269_V0.6370.12
138_I212_G0.6370.12
14_V188_D0.6310.12
24_T134_E0.6310.12
297_G310_D0.6310.12
297_G313_M0.6310.12
182_S229_K0.6310.12
22_F67_H0.6240.12
76_N87_N0.6230.12
140_G164_V0.6220.12
11_I238_D0.6220.12
158_A238_D0.6210.12
126_M172_I0.6210.12
24_T39_V0.6200.12
12_V293_E0.6200.12
37_A160_I0.6170.12
183_T212_G0.6090.12
186_S226_D0.6080.12
306_N311_T0.6070.12
199_M270_E0.6060.12
234_I241_E0.6060.12
30_L160_I0.6050.12
299_M304_I0.6040.12
178_E258_A0.6030.12
109_R121_L0.6020.12
283_V317_F0.6020.12
29_M62_P0.6010.12
160_I163_L0.6010.12
125_Q158_A0.6000.12
282_E305_K0.6000.12
128_V190_H0.5980.12
92_V256_A0.5980.12
162_R298_V0.5970.12
95_L158_A0.5970.12
54_V224_D0.5950.12
195_E301_Y0.5930.12
225_V299_M0.5930.12
142_A277_V0.5920.12
158_A215_F0.5890.11
178_E190_H0.5880.11
231_I250_K0.5880.11
261_Q287_M0.5870.11
161_E187_S0.5860.11
137_F227_I0.5850.11
147_E150_A0.5840.11
118_R238_D0.5830.11
184_I238_D0.5810.11
58_R99_Q0.5810.11
125_Q257_M0.5800.11
57_N164_V0.5790.11
13_A188_D0.5780.11
54_V196_N0.5770.11
103_I160_I0.5750.11
73_V320_L0.5740.11
69_A125_Q0.5720.11
135_T237_T0.5720.11
287_M295_N0.5720.11
119_D125_Q0.5720.11
44_F55_I0.5710.11
199_M202_Q0.5710.11
162_R173_V0.5690.11
77_Q143_M0.5680.11
25_F85_G0.5680.11
108_E303_N0.5670.11
98_A170_E0.5670.11
104_E109_R0.5670.11
44_F47_V0.5660.11
59_V154_I0.5660.11
53_R318_G0.5650.11
289_E292_R0.5650.11
50_R135_T0.5640.11
90_R119_D0.5630.11
118_R253_E0.5620.11
53_R93_N0.5590.11
119_D140_G0.5550.11
97_A149_K0.5530.11
111_A161_E0.5530.11
55_I184_I0.5520.11
98_A240_A0.5510.11
257_M304_I0.5480.11
209_L228_G0.5480.11
76_N248_Q0.5480.11
41_I246_I0.5470.11
48_G231_I0.5470.11
106_T321_T0.5470.11
13_A16_I0.5450.11
10_A283_V0.5440.11
33_S90_R0.5440.11
119_D128_V0.5430.11
62_P65_K0.5400.11
121_L256_A0.5400.11
169_E299_M0.5400.11
39_V65_K0.5390.11
297_G311_T0.5380.11
43_I277_V0.5370.11
121_L295_N0.5360.11
119_D291_L0.5360.11
58_R111_A0.5360.11
138_I168_G0.5350.11
53_R182_S0.5350.11
20_A245_N0.5330.11
129_N299_M0.5330.11
168_G229_K0.5330.11
35_L51_L0.5320.11
85_G246_I0.5320.11
46_L223_A0.5310.11
26_V50_R0.5310.11
93_N147_E0.5270.10
13_A273_R0.5270.10
118_R160_I0.5260.10
190_H228_G0.5250.10
231_I253_E0.5240.10
55_I62_P0.5220.10
107_F120_V0.5220.10
100_R257_M0.5200.10
135_T229_K0.5160.10
55_I99_Q0.5150.10
102_N159_N0.5140.10
192_K323_D0.5120.10
39_V257_M0.5100.10
60_V261_Q0.5070.10
87_N319_K0.5070.10
91_V309_A0.5060.10
295_N312_E0.5050.10
203_T248_Q0.5050.10
32_I62_P0.5030.10
36_A161_E0.5020.10
47_V282_E0.5000.10
236_Q265_M0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3bk6A 3 0.4773 91.2 0.968 Contact Map
2rpbA 1 0.3263 59.9 0.976 Contact Map
4fvgA 2 0.3142 58.1 0.976 Contact Map
1winA 1 0.3867 53.9 0.977 Contact Map
1sesA 2 0.3716 34.8 0.98 Contact Map
3qneA 2 0.3958 33.1 0.98 Contact Map
2dq0A 2 0.3897 31.9 0.98 Contact Map
2dq3A 2 0.3837 30.3 0.98 Contact Map
4fm3A 3 0.2598 24.3 0.981 Contact Map
1ijdA 3 0.1118 23.9 0.981 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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