GREMLIN Database
YQEZ - Uncharacterized protein YqeZ
UniProt: P54465 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 437 (410)
Sequences: 960 (804)
Seq/√Len: 39.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
64_H94_T7.0351.00
400_V409_V6.2601.00
95_A112_A5.1481.00
423_K435_R5.1471.00
82_M108_I5.0061.00
420_K436_E3.9571.00
390_T416_T3.9361.00
50_L82_M3.8151.00
38_V42_V3.8001.00
239_P319_S3.7651.00
149_E163_L3.6891.00
69_I95_A3.6701.00
125_A171_D3.5691.00
402_I424_V3.5331.00
388_G402_I3.5301.00
36_I53_S3.4071.00
192_E195_Y3.3481.00
54_L65_I3.2381.00
178_P183_L3.1681.00
71_T105_G3.0191.00
386_K403_D2.7551.00
33_V215_A2.6941.00
390_T393_P2.4361.00
51_S85_L2.4321.00
203_L206_L2.4121.00
388_G422_V2.3931.00
196_S199_T2.3851.00
52_R226_E2.3611.00
56_D60_A2.2501.00
390_T422_V2.2321.00
66_I190_A2.2261.00
272_F276_H2.2060.99
388_G424_V2.2020.99
391_F406_R2.1470.99
76_V79_A2.1440.99
407_L432_I2.1400.99
129_V136_A2.1300.99
224_F228_T2.1190.99
188_D192_E2.1150.99
389_I419_D2.1080.99
47_A81_D2.0470.99
387_V423_K2.0460.99
76_V144_W2.0430.99
116_Y198_G2.0080.99
110_L162_A1.9810.99
68_D98_N1.9610.99
251_V254_F1.9570.99
390_T419_D1.9570.99
252_E262_G1.9050.98
109_A123_M1.8990.98
393_P418_K1.8760.98
127_A169_D1.8610.98
102_L143_L1.8280.98
106_A165_M1.8160.98
393_P417_E1.7780.97
387_V421_K1.7600.97
417_E420_K1.7560.97
293_G309_G1.7410.97
161_Y165_M1.7160.97
34_Y62_A1.7000.97
390_T394_L1.6910.97
122_K171_D1.6560.96
303_L308_I1.6200.96
292_A296_L1.6160.96
388_G400_V1.6090.95
426_K433_V1.6060.95
223_S226_E1.5990.95
127_A135_A1.5890.95
293_G297_I1.5860.95
94_T196_S1.5750.95
250_T254_F1.5740.95
135_A138_Q1.5710.95
316_I341_S1.5700.95
67_L93_V1.5540.95
164_A168_P1.5460.94
248_G261_P1.5330.94
127_A182_L1.5240.94
410_V433_V1.5190.94
304_P309_G1.5140.94
399_T406_R1.5130.94
109_A115_I1.5110.94
401_I404_D1.5090.94
70_N84_D1.5060.94
42_V46_L1.4980.93
36_I49_F1.4950.93
37_P68_D1.4910.93
295_I299_L1.4740.93
265_G269_L1.4710.93
34_Y60_A1.4410.92
70_N99_K1.4340.92
413_G436_E1.4310.92
399_T408_D1.4290.92
238_V245_A1.4280.92
164_A183_L1.4240.91
35_V66_I1.4110.91
83_A111_Q1.4050.91
380_R427_V1.3910.90
389_I421_K1.3830.90
67_L86_I1.3830.90
33_V64_H1.3760.90
83_A151_A1.3720.90
145_L163_L1.3650.90
75_L78_S1.3630.90
310_L314_G1.3530.89
69_I109_A1.3460.89
416_T422_V1.3420.89
103_S139_K1.3390.89
394_L416_T1.3300.88
54_L85_L1.3270.88
410_V428_E1.3190.88
412_E435_R1.3190.88
53_S220_A1.3170.88
32_T216_Q1.3030.87
79_A83_A1.2960.87
68_D219_Y1.2920.87
39_E70_N1.2860.87
37_P49_F1.2820.86
239_P243_T1.2650.86
38_V50_L1.2580.85
149_E153_V1.2530.85
411_S416_T1.2340.84
107_Y127_A1.2260.84
48_S225_A1.2240.84
184_T199_T1.2120.83
236_V333_S1.2080.83
58_K89_S1.2030.83
16_L61_H1.2010.83
263_T296_L1.1950.82
161_Y170_I1.1950.82
38_V82_M1.1950.82
393_P398_G1.1930.82
107_Y148_M1.1830.82
114_H196_S1.1770.81
382_D404_D1.1740.81
106_A123_M1.1720.81
256_P261_P1.1710.81
305_G308_I1.1630.80
249_L253_L1.1550.80
113_D203_L1.1490.80
410_V431_R1.1460.79
50_L67_L1.1410.79
400_V422_V1.1360.79
144_W148_M1.1360.79
394_L398_G1.1330.79
390_T418_K1.1320.79
390_T411_S1.1270.78
58_K90_E1.1260.78
79_A144_W1.1210.78
53_S65_I1.1200.78
243_T247_L1.1160.78
87_T155_N1.1070.77
242_L276_H1.1040.77
80_I100_R1.1040.77
169_D179_K1.1020.77
87_T111_Q1.0990.77
300_E309_G1.0930.76
197_E213_E1.0830.75
392_T399_T1.0790.75
71_T104_A1.0660.74
244_I250_T1.0650.74
44_Q75_L1.0610.74
142_S184_T1.0600.74
228_T232_L1.0540.73
190_A290_F1.0530.73
127_A141_Q1.0480.73
51_S54_L1.0450.73
66_I191_I1.0420.73
163_L167_D1.0370.72
200_A207_V1.0350.72
113_D155_N1.0330.72
24_L28_A1.0310.72
13_G18_S1.0300.72
171_D177_A1.0290.72
52_R400_V1.0250.71
317_I346_I1.0210.71
54_L90_E1.0170.71
76_V147_E1.0140.70
297_I309_G1.0090.70
413_G435_R1.0080.70
244_I264_A1.0060.70
38_V46_L1.0020.70
153_V159_P1.0000.69
141_Q145_L0.9950.69
106_A126_A0.9940.69
248_G256_P0.9910.69
402_I409_V0.9890.69
251_V296_L0.9890.69
71_T103_S0.9870.68
111_Q151_A0.9860.68
52_R223_S0.9860.68
334_L338_S0.9840.68
129_V140_A0.9830.68
86_I93_V0.9790.68
68_D203_L0.9780.68
35_V219_Y0.9750.67
47_A85_L0.9730.67
97_V129_V0.9680.67
355_R359_F0.9660.67
102_L182_L0.9620.66
158_D161_Y0.9600.66
91_I346_I0.9520.66
19_L23_Q0.9500.65
148_M162_A0.9450.65
289_L315_A0.9430.65
32_T218_S0.9430.65
95_A109_A0.9380.64
258_V262_G0.9340.64
31_Q215_A0.9270.63
177_A405_E0.9260.63
48_S52_R0.9260.63
249_L269_L0.9260.63
237_I241_L0.9160.63
77_K81_D0.9130.62
135_A244_I0.9110.62
350_R354_K0.9100.62
388_G416_T0.9090.62
264_A268_A0.9090.62
161_Y172_A0.9060.62
247_L250_T0.9050.62
425_I435_R0.9040.62
149_E245_A0.9040.62
197_E212_F0.9000.61
145_L167_D0.8950.61
128_I141_Q0.8950.61
69_I108_I0.8880.60
143_L146_A0.8800.59
54_L93_V0.8790.59
185_L195_Y0.8790.59
111_Q155_N0.8770.59
40_K70_N0.8690.58
222_E230_R0.8690.58
106_A148_M0.8680.58
100_R147_E0.8670.58
110_L148_M0.8650.58
32_T60_A0.8630.58
332_V340_V0.8590.58
120_G171_D0.8580.57
116_Y193_V0.8580.57
106_A172_A0.8570.57
382_D403_D0.8570.57
162_A166_A0.8570.57
125_A139_K0.8570.57
294_V298_L0.8530.57
193_V196_S0.8480.57
97_V318_A0.8470.56
325_G330_M0.8460.56
428_E433_V0.8450.56
366_D381_T0.8440.56
19_L22_V0.8440.56
67_L95_A0.8410.56
390_T398_G0.8390.56
239_P272_F0.8380.56
91_I191_I0.8380.56
43_E230_R0.8370.56
102_L127_A0.8310.55
355_R358_F0.8300.55
345_F349_T0.8300.55
94_T114_H0.8300.55
394_L420_K0.8290.55
413_G429_G0.8280.55
263_T292_A0.8240.54
292_A315_A0.8230.54
395_R408_D0.8230.54
237_I264_A0.8220.54
13_G22_V0.8220.54
238_V265_G0.8210.54
336_I341_S0.8170.54
55_Q85_L0.8150.54
41_N234_N0.8140.53
323_A337_A0.8110.53
305_G310_L0.8110.53
92_P114_H0.8060.53
173_K176_G0.8060.53
95_A302_F0.8030.52
13_G16_L0.7990.52
248_G268_A0.7980.52
71_T139_K0.7970.52
129_V139_K0.7960.52
37_P69_I0.7960.52
313_L418_K0.7960.52
106_A109_A0.7950.52
19_L24_L0.7940.52
258_V261_P0.7930.52
120_G245_A0.7920.51
118_A121_G0.7880.51
112_A184_T0.7870.51
276_H432_I0.7860.51
161_Y182_L0.7850.51
267_I311_L0.7840.51
80_I143_L0.7820.51
275_G279_A0.7810.50
90_E418_K0.7800.50
246_F250_T0.7800.50
107_Y110_L0.7710.50
177_A193_V0.7680.49
223_S314_G0.7660.49
318_A324_A0.7660.49
182_L251_V0.7650.49
22_V432_I0.7650.49
240_I246_F0.7630.49
391_F401_I0.7610.49
100_R122_K0.7590.48
249_L270_L0.7590.48
79_A107_Y0.7580.48
172_A293_G0.7560.48
49_F240_I0.7550.48
150_D244_I0.7550.48
334_L350_R0.7530.48
31_Q63_D0.7500.48
197_E211_G0.7500.48
238_V276_H0.7500.48
259_G308_I0.7500.48
338_S341_S0.7490.48
262_G279_A0.7480.47
83_A107_Y0.7470.47
98_N407_L0.7440.47
172_A180_G0.7440.47
86_I267_I0.7400.47
104_A139_K0.7380.47
15_F24_L0.7350.46
260_L264_A0.7340.46
159_P383_L0.7340.46
79_A147_E0.7320.46
394_L409_V0.7310.46
102_L147_E0.7290.46
100_R143_L0.7290.46
209_K227_K0.7280.46
36_I273_F0.7250.45
181_D188_D0.7220.45
178_P181_D0.7190.45
116_Y210_L0.7190.45
351_V354_K0.7180.45
102_L286_T0.7180.45
286_T322_L0.7170.45
216_Q317_I0.7160.45
224_F286_T0.7150.44
241_L268_A0.7140.44
26_A348_L0.7130.44
103_S129_V0.7130.44
198_G209_K0.7130.44
240_I244_I0.7120.44
249_L313_L0.7110.44
152_A166_A0.7110.44
130_D134_N0.7090.44
23_Q314_G0.7090.44
398_G409_V0.7080.44
97_V115_I0.7080.44
277_L281_L0.7060.44
22_V27_K0.7040.43
132_Q267_I0.7040.43
63_D216_Q0.7030.43
122_K173_K0.6990.43
55_Q59_D0.6980.43
202_N207_V0.6980.43
297_I344_A0.6980.43
229_A279_A0.6920.42
259_G296_L0.6920.42
43_E123_M0.6910.42
219_Y303_L0.6900.42
223_S361_K0.6890.42
130_D133_G0.6880.42
13_G23_Q0.6870.42
54_L67_L0.6850.42
54_L91_I0.6820.42
395_R413_G0.6810.41
44_Q78_S0.6800.41
310_L411_S0.6800.41
79_A102_L0.6790.41
82_M422_V0.6780.41
299_L302_F0.6760.41
107_Y144_W0.6740.41
33_V66_I0.6730.41
35_V217_I0.6720.41
342_I410_V0.6710.41
242_L265_G0.6700.40
346_I350_R0.6690.40
71_T74_G0.6690.40
91_I422_V0.6680.40
245_A262_G0.6670.40
220_A402_I0.6660.40
71_T125_A0.6660.40
252_E257_G0.6640.40
65_I222_E0.6620.40
122_K255_S0.6610.40
294_V348_L0.6590.39
365_N382_D0.6580.39
120_G127_A0.6570.39
106_A162_A0.6560.39
354_K357_K0.6560.39
427_V431_R0.6540.39
40_K97_V0.6540.39
97_V285_E0.6530.39
71_T129_V0.6530.39
319_S323_A0.6530.39
121_G186_N0.6490.39
125_A184_T0.6490.39
141_Q150_D0.6470.38
393_P416_T0.6470.38
381_T384_M0.6460.38
294_V332_V0.6460.38
13_G237_I0.6460.38
96_Y343_T0.6450.38
237_I260_L0.6440.38
313_L383_L0.6440.38
17_L24_L0.6420.38
27_K216_Q0.6420.38
278_A303_L0.6400.38
303_L310_L0.6390.38
72_P80_I0.6380.38
102_L151_A0.6370.38
111_Q122_K0.6370.38
105_G129_V0.6360.37
217_I227_K0.6350.37
389_I392_T0.6350.37
318_A323_A0.6340.37
120_G154_K0.6330.37
54_L58_K0.6330.37
46_L230_R0.6320.37
407_L430_S0.6300.37
65_I90_E0.6290.37
110_L309_G0.6290.37
87_T154_K0.6260.37
388_G396_P0.6250.37
26_A294_V0.6250.37
239_P262_G0.6240.36
97_V250_T0.6240.36
25_N28_A0.6230.36
396_P416_T0.6210.36
86_I298_L0.6200.36
68_D302_F0.6200.36
70_N429_G0.6170.36
40_K234_N0.6140.36
165_M252_E0.6140.36
347_L351_V0.6130.36
105_G108_I0.6130.36
12_L28_A0.6110.35
25_N389_I0.6110.35
66_I96_Y0.6090.35
192_E237_I0.6090.35
247_L344_A0.6080.35
12_L25_N0.6070.35
16_L27_K0.6060.35
416_T436_E0.6060.35
240_I310_L0.6060.35
386_K402_I0.6030.35
128_I166_A0.6030.35
80_I281_L0.6020.35
83_A166_A0.6010.35
122_K143_L0.6000.34
83_A147_E0.6000.34
60_A66_I0.5980.34
38_V108_I0.5980.34
121_G174_E0.5970.34
391_F418_K0.5960.34
26_A301_I0.5960.34
61_H298_L0.5960.34
31_Q361_K0.5950.34
129_V166_A0.5950.34
12_L22_V0.5930.34
72_P100_R0.5930.34
22_V28_A0.5910.34
43_E233_T0.5910.34
293_G302_F0.5910.34
218_S292_A0.5900.34
397_S410_V0.5900.34
22_V217_I0.5890.34
392_T396_P0.5890.34
263_T267_I0.5890.34
404_D423_K0.5880.33
96_Y288_L0.5880.33
412_E433_V0.5870.33
175_V179_K0.5860.33
21_G26_A0.5860.33
253_L333_S0.5860.33
222_E227_K0.5860.33
84_D147_E0.5830.33
163_L176_G0.5820.33
78_S247_L0.5820.33
286_T323_A0.5810.33
115_I157_R0.5800.33
165_M262_G0.5800.33
45_G230_R0.5790.33
77_K120_G0.5790.33
38_V53_S0.5770.33
397_S408_D0.5770.33
117_M121_G0.5750.32
164_A180_G0.5750.32
45_G265_G0.5730.32
222_E300_E0.5720.32
291_I313_L0.5720.32
80_I147_E0.5720.32
273_F323_A0.5710.32
228_T386_K0.5710.32
64_H215_A0.5710.32
32_T62_A0.5700.32
32_T66_I0.5700.32
301_I304_P0.5700.32
335_L339_A0.5690.32
266_L296_L0.5690.32
71_T75_L0.5690.32
76_V100_R0.5680.32
109_A112_A0.5680.32
98_N121_G0.5680.32
61_H214_K0.5680.32
14_I27_K0.5670.32
259_G403_D0.5660.32
12_L55_Q0.5660.32
364_L408_D0.5650.32
116_Y196_S0.5650.32
297_I316_I0.5650.32
311_L315_A0.5640.32
39_E230_R0.5630.31
103_S125_A0.5620.31
27_K221_K0.5610.31
156_N179_K0.5600.31
49_F65_I0.5590.31
29_E296_L0.5580.31
95_A384_M0.5580.31
148_M165_M0.5580.31
79_A148_M0.5580.31
43_E46_L0.5580.31
56_D291_I0.5580.31
86_I95_A0.5550.31
182_L351_V0.5540.31
189_K193_V0.5540.31
102_L144_W0.5530.31
20_L213_E0.5520.31
72_P103_S0.5510.31
388_G394_L0.5510.31
66_I206_L0.5510.31
413_G433_V0.5500.30
263_T411_S0.5490.30
138_Q179_K0.5490.30
40_K113_D0.5480.30
92_P177_A0.5480.30
409_V432_I0.5470.30
37_P287_V0.5460.30
22_V29_E0.5450.30
283_G363_I0.5440.30
398_G416_T0.5430.30
233_T242_L0.5420.30
228_T278_A0.5420.30
217_I424_V0.5410.30
240_I264_A0.5400.30
394_L422_V0.5400.30
125_A146_A0.5400.30
200_A295_I0.5400.30
167_D424_V0.5390.30
263_T311_L0.5390.30
277_L284_Y0.5380.30
243_T396_P0.5350.29
295_I307_I0.5350.29
254_F296_L0.5340.29
42_V139_K0.5340.29
18_S24_L0.5340.29
253_L259_G0.5330.29
258_V271_L0.5320.29
245_A275_G0.5320.29
251_V261_P0.5320.29
253_L271_L0.5310.29
228_T271_L0.5310.29
25_N56_D0.5310.29
302_F309_G0.5300.29
107_Y162_A0.5290.29
229_A274_Y0.5290.29
111_Q166_A0.5290.29
100_R252_E0.5280.29
202_N217_I0.5260.29
246_F294_V0.5260.29
115_I201_D0.5260.29
55_Q65_I0.5260.29
44_Q319_S0.5250.29
14_I26_A0.5250.29
264_A278_A0.5230.28
106_A154_K0.5220.28
212_F215_A0.5200.28
126_A129_V0.5200.28
296_L300_E0.5200.28
49_F319_S0.5200.28
274_Y315_A0.5200.28
87_T149_E0.5190.28
164_A170_I0.5190.28
79_A151_A0.5190.28
153_V293_G0.5190.28
146_A150_D0.5190.28
333_S336_I0.5180.28
290_F296_L0.5170.28
144_W166_A0.5170.28
49_F53_S0.5170.28
161_Y167_D0.5170.28
59_D221_K0.5170.28
63_D208_K0.5160.28
246_F249_L0.5160.28
186_N190_A0.5160.28
252_E256_P0.5140.28
145_L184_T0.5140.28
126_A248_G0.5130.28
106_A161_Y0.5120.28
180_G195_Y0.5120.28
157_R197_E0.5120.28
248_G269_L0.5110.28
127_A138_Q0.5110.28
43_E107_Y0.5100.27
254_F274_Y0.5080.27
173_K243_T0.5080.27
296_L328_T0.5070.27
45_G226_E0.5060.27
297_I307_I0.5060.27
179_K219_Y0.5060.27
53_S62_A0.5050.27
66_I231_W0.5040.27
14_I19_L0.5040.27
41_N245_A0.5010.27
121_G151_A0.5010.27
234_N354_K0.5000.27
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3vivA 2 0.476 100 0.755 Contact Map
4gm2A 3 0.3707 99.9 0.817 Contact Map
2f6iA 5 0.4027 99.9 0.829 Contact Map
3p2lA 4 0.3959 99.9 0.829 Contact Map
4jcqA 5 0.3799 99.8 0.832 Contact Map
1yg6A 4 0.405 99.8 0.832 Contact Map
4u0gA 4 0.4096 99.8 0.833 Contact Map
3qwdA 5 0.405 99.8 0.835 Contact Map
3bf0A 3 0.4645 99.8 0.835 Contact Map
2cbyA 3 0.3593 99.8 0.835 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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