GREMLIN Database
YQEY - Uncharacterized protein YqeY
UniProt: P54464 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 148 (144)
Sequences: 2705 (1838)
Seq/√Len: 153.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
22_K89_V3.2941.00
10_D90_Y3.1461.00
105_N146_Q3.1351.00
74_L78_D2.9531.00
69_S81_Q2.9241.00
66_Q70_N2.5931.00
97_E138_L2.2001.00
54_L87_L2.1011.00
46_T49_E2.0401.00
101_R145_S2.0381.00
101_R142_L1.9711.00
4_L37_A1.9211.00
11_M26_V1.8871.00
58_L84_L1.8771.00
110_E129_K1.8631.00
29_V87_L1.7951.00
106_E110_E1.7641.00
102_T106_E1.7331.00
106_E129_K1.7251.00
29_V54_L1.7241.00
62_K88_E1.7201.00
85_D88_E1.7171.00
118_D121_K1.7151.00
13_L17_N1.6851.00
78_D82_K1.6721.00
101_R105_N1.6091.00
34_Q38_I1.5341.00
65_L81_Q1.5231.00
103_I130_V1.5141.00
93_E99_E1.4951.00
47_E50_E1.4761.00
73_R76_L1.4611.00
110_E125_A1.4471.00
19_E22_K1.4441.00
134_A139_I1.4081.00
98_E101_R1.4001.00
137_S141_K1.3891.00
9_Q12_K1.3731.00
21_D82_K1.3731.00
81_Q85_D1.3491.00
96_S99_E1.3461.00
33_L50_E1.3141.00
40_L43_D1.3081.00
121_K124_G1.3031.00
6_R10_D1.2941.00
11_M23_L1.2901.00
107_T111_V1.2891.00
65_L84_L1.2621.00
101_R146_Q1.2551.00
119_M143_V1.2471.00
36_E39_K1.2341.00
82_K85_D1.2281.00
35_N39_K1.2261.00
69_S74_L1.2261.00
108_I146_Q1.2201.00
107_T125_A1.2031.00
13_L16_K1.1981.00
9_Q13_L1.1921.00
138_L141_K1.1901.00
116_K144_S1.1811.00
108_I122_V1.1711.00
7_L26_V1.1621.00
43_D49_E1.1511.00
142_L146_Q1.1481.00
124_G128_P1.1441.00
103_I126_I1.1351.00
67_E71_A1.1171.00
21_D79_K1.1070.99
32_S57_E1.1070.99
103_I106_E1.0980.99
97_E101_R1.0860.99
36_E40_L1.0770.99
5_E9_Q1.0500.99
115_S118_D1.0500.99
32_S35_N1.0490.99
113_A118_D1.0360.99
100_L138_L1.0320.99
8_N30_K1.0250.99
125_A128_P1.0130.99
107_T126_I0.9990.99
78_D81_Q0.9920.99
111_V125_A0.9850.99
105_N109_A0.9790.99
102_T105_N0.9690.99
142_L145_S0.9500.98
57_E60_Q0.9430.98
67_E70_N0.9420.98
10_D13_L0.9410.98
69_S77_V0.9410.98
100_L139_I0.9380.98
94_Q133_K0.9360.98
61_R83_E0.9340.98
31_A35_N0.9330.98
63_D67_E0.9270.98
127_M131_K0.9110.98
125_A129_K0.9060.98
9_Q16_K0.9060.98
127_M136_G0.8950.98
24_T28_M0.8950.98
36_E56_R0.8910.98
97_E141_K0.8880.97
93_E96_S0.8770.97
141_K145_S0.8730.97
104_V146_Q0.8660.97
20_K79_K0.8590.97
140_N144_S0.8550.97
23_L27_R0.8330.96
11_M30_K0.8300.96
95_L103_I0.8230.96
58_L91_L0.8220.96
20_K23_L0.8130.96
100_L134_A0.8070.96
103_I129_K0.8040.95
56_R60_Q0.8010.95
77_V81_Q0.8010.95
111_V122_V0.7980.95
126_I130_V0.7840.95
107_T129_K0.7820.95
65_L80_V0.7820.95
65_L69_S0.7720.94
97_E142_L0.7710.94
30_K34_Q0.7710.94
77_V80_V0.7690.94
113_A122_V0.7690.94
126_I139_I0.7680.94
8_N12_K0.7660.94
65_L77_V0.7660.94
127_M140_N0.7510.94
104_V142_L0.7500.93
4_L33_L0.7390.93
5_E8_N0.7280.92
130_V139_I0.7220.92
12_K15_M0.7130.92
21_D24_T0.7100.91
99_E133_K0.7070.91
52_T55_S0.7040.91
6_R9_Q0.7000.91
36_E45_L0.6970.91
52_T131_K0.6910.90
29_V57_E0.6900.90
66_Q69_S0.6870.90
35_N38_I0.6760.89
68_F80_V0.6750.89
39_K42_K0.6750.89
130_V134_A0.6720.89
3_L50_E0.6710.89
36_E52_T0.6680.89
7_L33_L0.6590.88
25_V82_K0.6580.88
100_L130_V0.6490.87
25_V87_L0.6470.87
26_V30_K0.6450.87
103_I107_T0.6420.87
71_A74_L0.6400.87
93_E133_K0.6400.87
45_L53_V0.6380.86
28_M57_E0.6370.86
98_E102_T0.6350.86
38_I42_K0.6350.86
24_T83_E0.6340.86
106_E109_A0.6330.86
37_A43_D0.6290.86
14_Y26_V0.6280.86
45_L49_E0.6280.86
64_S68_F0.6230.85
138_L142_L0.6220.85
40_L49_E0.6190.85
116_K119_M0.6190.85
124_G127_M0.6140.84
8_N11_M0.6120.84
100_L142_L0.6110.84
6_R89_V0.6110.84
36_E53_V0.6060.84
65_L71_A0.5960.83
76_L80_V0.5940.82
31_A34_Q0.5920.82
20_K24_T0.5920.82
11_M27_R0.5870.82
111_V114_S0.5860.81
14_Y23_L0.5780.81
58_L87_L0.5730.80
88_E93_E0.5710.80
4_L8_N0.5690.80
4_L50_E0.5650.79
68_F71_A0.5640.79
119_M140_N0.5610.79
15_M23_L0.5600.79
79_K83_E0.5560.78
76_L79_K0.5530.78
127_M144_S0.5530.78
7_L30_K0.5500.77
21_D25_V0.5450.77
28_M83_E0.5380.76
85_D89_V0.5350.75
114_S118_D0.5340.75
103_I133_K0.5330.75
18_R23_L0.5330.75
67_E80_V0.5310.75
120_G124_G0.5310.75
55_S131_K0.5280.74
68_F76_L0.5250.74
37_A45_L0.5230.74
57_E83_E0.5220.74
130_V133_K0.5110.72
6_R47_E0.5090.72
48_D51_L0.5090.72
11_M15_M0.5080.72
137_S140_N0.5070.71
36_E43_D0.5070.71
61_R80_V0.5060.71
55_S94_Q0.5030.71
64_S83_E0.5020.71
51_L55_S0.5010.71
58_L62_K0.5010.71
111_V118_D0.5010.71
84_L88_E0.5000.70
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ng6A 1 0.9932 100 0.114 Contact Map
2d6fC 1 0.1959 99.7 0.585 Contact Map
1zq1C 1 0.2162 99.7 0.605 Contact Map
3al0B 1 0.9459 99.3 0.697 Contact Map
3h0lB 1 0.5541 99.2 0.703 Contact Map
3ip4B 1 0.9459 99.2 0.705 Contact Map
2hz7A 1 0 98.5 0.774 Contact Map
4r3zC 1 0 64.4 0.911 Contact Map
4h3sA 1 0 49 0.918 Contact Map
3aiiA 1 0 42.8 0.921 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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