YQEW - BACSU - GREMLIN Contacts

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YQEW - Uncharacterized protein YqeW

UniProt:	P54463	Sequences: MLILISFTALILFFLAGMNMLRKGLISMAYSKIEERLLLFTDHPLKAFLISIVFTGILQSSSAFMVIVIGFVSAGVLSFKRTIPMILGTNVGSTFTTEFIAIKMDIVIWVLLIGGLLFFLTGRYPLKQLGTSFLGLGIIFFCISGFSHLAGPLTKLKTGADVLYHVNDSNWSALLIGMVLTAIIHSSSVCIGILMSFMNEGIIGLTQAMSVVLGSNIGTCITAVMAAVSGGYAAKQTAYAHVVFNVLGVALVLPFLTAATGFVEQLSPDPAQKIAHFSLLFNVVTALLFLPLTNLFYRLIHLLIPAK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	307 (302)
Sequences:	2326 (1633)
Seq/√Len:	94.0

ECOLI - YJBB
BACSU - YQEW

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
98_E	276_H	4.084	1.00
90_N	245_N	3.665	1.00
68_V	85_M	3.595	1.00
62_S	219_T	3.549	1.00
83_I	297_Y	3.423	1.00
48_F	91_V	3.341	1.00
83_I	240_A	3.335	1.00
224_V	242_V	3.314	1.00
42_D	46_K	3.214	1.00
43_H	46_K	3.169	1.00
98_E	272_Q	3.147	1.00
91_V	286_A	3.099	1.00
213_L	249_V	3.072	1.00
174_L	253_L	2.925	1.00
48_F	290_L	2.736	1.00
98_E	279_L	2.617	1.00
48_F	286_A	2.560	1.00
297_Y	301_H	2.546	1.00
91_V	283_V	2.531	1.00
102_I	272_Q	2.500	1.00
236_Q	301_H	2.460	1.00
295_L	299_L	2.376	1.00
216_N	282_N	2.368	1.00
295_L	298_R	2.352	1.00
272_Q	276_H	2.241	1.00
219_T	222_T	2.220	1.00
157_K	161_D	2.205	1.00
44_P	293_T	2.170	1.00
243_V	303_L	2.090	1.00
298_R	302_L	2.053	1.00
115_G	118_F	2.046	1.00
292_L	295_L	1.976	1.00
209_M	277_F	1.974	1.00
10_L	142_C	1.956	1.00
49_L	52_I	1.945	1.00
7_F	150_A	1.876	1.00
90_N	241_H	1.857	1.00
67_I	71_F	1.842	1.00
68_V	237_T	1.813	1.00
302_L	305_P	1.790	1.00
86_I	237_T	1.761	1.00
221_I	224_V	1.757	1.00
123_R	126_L	1.732	1.00
217_I	249_V	1.728	1.00
174_L	249_V	1.724	1.00
121_T	126_L	1.718	1.00
194_L	211_V	1.710	1.00
12_L	115_G	1.709	1.00
24_G	135_G	1.708	1.00
224_V	239_Y	1.705	1.00
182_A	221_I	1.700	1.00
87_L	244_F	1.669	1.00
248_G	285_T	1.661	1.00
19_N	23_K	1.628	1.00
241_H	245_N	1.616	1.00
289_F	292_L	1.613	1.00
64_F	89_T	1.587	1.00
256_L	260_T	1.579	1.00
250_A	254_P	1.579	1.00
151_G	154_T	1.577	1.00
78_S	81_R	1.574	1.00
45_L	290_L	1.572	1.00
239_Y	304_I	1.569	1.00
59_Q	188_S	1.561	1.00
115_G	119_F	1.540	1.00
280_L	284_V	1.535	1.00
279_L	283_V	1.524	1.00
16_A	20_M	1.515	1.00
278_S	282_N	1.501	1.00
240_A	300_I	1.483	1.00
258_A	262_F	1.481	1.00
114_G	118_F	1.480	1.00
290_L	293_T	1.478	1.00
180_L	184_I	1.465	1.00
57_I	188_S	1.441	1.00
72_V	237_T	1.421	0.99
144_S	148_H	1.405	0.99
287_L	291_P	1.400	0.99
11_I	159_G	1.394	0.99
62_S	185_H	1.382	0.99
220_C	242_V	1.378	0.99
37_L	50_I	1.354	0.99
184_I	219_T	1.352	0.99
87_L	286_A	1.349	0.99
198_M	271_A	1.339	0.99
80_K	297_Y	1.333	0.99
10_L	149_L	1.306	0.99
54_F	64_F	1.298	0.99
219_T	241_H	1.298	0.99
299_L	303_L	1.289	0.99
161_D	164_Y	1.277	0.99
205_L	273_K	1.269	0.99
44_P	294_N	1.263	0.99
83_I	293_T	1.259	0.99
96_T	188_S	1.257	0.99
190_C	215_S	1.251	0.99
24_G	131_T	1.236	0.99
24_G	28_M	1.231	0.98
216_N	278_S	1.226	0.98
208_A	274_I	1.223	0.98
242_V	246_V	1.214	0.98
86_I	241_H	1.211	0.98
255_F	258_A	1.206	0.98
259_A	263_V	1.205	0.98
223_A	241_H	1.197	0.98
103_K	106_I	1.191	0.98
195_M	275_A	1.186	0.98
100_I	192_G	1.184	0.98
204_G	207_Q	1.182	0.98
112_L	137_G	1.174	0.98
136_L	142_C	1.172	0.98
27_S	131_T	1.170	0.98
35_E	39_L	1.159	0.98
14_F	185_H	1.157	0.98
65_M	86_I	1.151	0.98
48_F	52_I	1.140	0.97
160_A	164_Y	1.139	0.97
62_S	221_I	1.130	0.97
49_L	53_V	1.127	0.97
79_F	82_T	1.127	0.97
258_A	261_G	1.123	0.97
179_V	183_I	1.118	0.97
62_S	188_S	1.114	0.97
233_A	236_Q	1.104	0.97
61_S	93_S	1.100	0.97
206_T	264_E	1.090	0.97
102_I	276_H	1.089	0.97
47_A	84_P	1.087	0.97
18_M	76_V	1.086	0.97
182_A	193_I	1.081	0.96
232_Y	305_P	1.079	0.96
257_T	260_T	1.078	0.96
194_L	210_S	1.074	0.96
65_M	241_H	1.068	0.96
84_P	293_T	1.054	0.96
78_S	82_T	1.045	0.96
287_L	290_L	1.039	0.96
112_L	141_F	1.036	0.96
198_M	270_P	1.035	0.96
222_T	241_H	1.034	0.95
80_K	294_N	1.028	0.95
93_S	187_S	1.022	0.95
101_A	272_Q	1.021	0.95
93_S	188_S	1.020	0.95
257_T	261_G	1.018	0.95
10_L	146_F	1.016	0.95
67_I	73_S	1.013	0.95
52_I	95_F	1.007	0.95
203_I	208_A	1.004	0.95
178_M	217_I	1.002	0.95
115_G	120_L	1.000	0.95
98_E	101_A	1.000	0.95
17_G	142_C	0.996	0.94
100_I	195_M	0.986	0.94
232_Y	304_I	0.986	0.94
194_L	215_S	0.970	0.94
93_S	96_T	0.967	0.94
240_A	297_Y	0.957	0.93
55_T	58_L	0.954	0.93
23_K	26_I	0.951	0.93
205_L	264_E	0.946	0.93
239_Y	300_I	0.941	0.93
174_L	217_I	0.938	0.92
270_P	273_K	0.937	0.92
137_G	141_F	0.932	0.92
116_L	121_T	0.927	0.92
113_I	117_L	0.927	0.92
216_N	223_A	0.925	0.92
252_V	284_V	0.925	0.92
97_T	191_I	0.925	0.92
187_S	278_S	0.922	0.92
54_F	58_L	0.921	0.92
56_G	95_F	0.911	0.91
9_A	12_L	0.909	0.91
65_M	234_A	0.907	0.91
24_G	132_S	0.902	0.91
71_F	76_V	0.901	0.91
82_T	89_T	0.897	0.91
9_A	13_F	0.897	0.91
143_I	196_S	0.897	0.91
173_A	211_V	0.893	0.91
224_V	227_A	0.879	0.90
278_S	281_F	0.878	0.90
66_V	222_T	0.875	0.90
261_G	264_E	0.866	0.89
247_L	292_L	0.862	0.89
44_P	47_A	0.860	0.89
65_M	223_A	0.859	0.89
79_F	237_T	0.858	0.89
80_K	301_H	0.856	0.89
87_L	289_F	0.855	0.89
243_V	299_L	0.854	0.88
300_I	303_L	0.852	0.88
188_S	191_I	0.850	0.88
158_T	161_D	0.850	0.88
151_G	299_L	0.847	0.88
255_F	260_T	0.838	0.88
240_A	296_F	0.835	0.87
191_I	195_M	0.834	0.87
143_I	192_G	0.833	0.87
66_V	223_A	0.833	0.87
157_K	160_A	0.832	0.87
261_G	265_Q	0.832	0.87
191_I	215_S	0.831	0.87
10_L	145_G	0.829	0.87
220_C	245_N	0.819	0.86
69_I	72_V	0.819	0.86
230_G	235_K	0.817	0.86
14_F	62_S	0.815	0.86
114_G	117_L	0.815	0.86
132_S	183_I	0.813	0.86
114_G	130_G	0.812	0.86
44_P	290_L	0.808	0.86
205_L	209_M	0.797	0.85
298_R	301_H	0.796	0.85
156_L	160_A	0.792	0.84
32_K	35_E	0.791	0.84
48_F	87_L	0.789	0.84
258_A	263_V	0.785	0.84
97_T	244_F	0.783	0.84
24_G	152_P	0.780	0.84
251_L	288_L	0.775	0.83
109_W	242_V	0.772	0.83
27_S	236_Q	0.768	0.83
184_I	190_C	0.765	0.82
300_I	305_P	0.765	0.82
83_I	87_L	0.765	0.82
255_F	262_F	0.765	0.82
284_V	288_L	0.764	0.82
5_I	110_V	0.762	0.82
170_N	210_S	0.761	0.82
5_I	156_L	0.758	0.82
175_L	179_V	0.752	0.81
255_F	301_H	0.749	0.81
52_I	56_G	0.748	0.81
55_T	61_S	0.747	0.81
98_E	275_A	0.747	0.81
104_M	107_V	0.745	0.81
210_S	256_L	0.744	0.81
294_N	297_Y	0.743	0.80
295_L	302_L	0.740	0.80
180_L	190_C	0.738	0.80
232_Y	236_Q	0.738	0.80
170_N	173_A	0.726	0.79
163_L	166_V	0.726	0.79
294_N	298_R	0.724	0.79
187_S	219_T	0.723	0.79
232_Y	235_K	0.722	0.79
261_G	287_L	0.721	0.78
174_L	178_M	0.720	0.78
98_E	102_I	0.718	0.78
35_E	266_L	0.718	0.78
260_T	264_E	0.718	0.78
87_L	293_T	0.717	0.78
195_M	271_A	0.716	0.78
108_I	141_F	0.712	0.78
70_G	73_S	0.711	0.77
77_L	81_R	0.708	0.77
220_C	223_A	0.706	0.77
289_F	296_F	0.705	0.77
22_R	73_S	0.704	0.77
41_T	85_M	0.697	0.76
185_H	188_S	0.694	0.76
58_L	188_S	0.693	0.76
209_M	260_T	0.692	0.76
44_P	84_P	0.691	0.75
113_I	118_F	0.690	0.75
11_I	146_F	0.688	0.75
249_V	254_P	0.686	0.75
216_N	241_H	0.686	0.75
55_T	64_F	0.685	0.75
44_P	210_S	0.685	0.75
194_L	212_V	0.684	0.75
219_T	282_N	0.683	0.75
257_T	267_S	0.682	0.74
37_L	41_T	0.680	0.74
59_Q	93_S	0.680	0.74
264_E	267_S	0.680	0.74
63_A	136_L	0.679	0.74
263_V	267_S	0.675	0.74
164_Y	168_D	0.672	0.73
258_A	265_Q	0.668	0.73
267_S	273_K	0.665	0.73
215_S	256_L	0.665	0.73
13_F	141_F	0.664	0.73
74_A	281_F	0.663	0.72
5_I	279_L	0.662	0.72
262_F	265_Q	0.662	0.72
301_H	305_P	0.662	0.72
151_G	155_K	0.662	0.72
20_M	138_I	0.661	0.72
137_G	140_F	0.661	0.72
184_I	258_A	0.660	0.72
246_V	250_A	0.659	0.72
213_L	253_L	0.659	0.72
64_F	237_T	0.657	0.72
155_K	298_R	0.657	0.72
39_L	42_D	0.655	0.71
90_N	216_N	0.651	0.71
94_T	222_T	0.650	0.71
259_A	267_S	0.650	0.71
220_C	244_F	0.649	0.71
130_G	133_F	0.648	0.71
72_V	177_G	0.647	0.71
16_A	131_T	0.647	0.71
57_I	299_L	0.647	0.71
16_A	22_R	0.644	0.70
245_N	285_T	0.638	0.70
74_A	140_F	0.636	0.69
191_I	212_V	0.634	0.69
28_M	223_A	0.633	0.69
296_F	300_I	0.632	0.69
21_L	63_A	0.631	0.69
77_L	176_I	0.630	0.69
222_T	226_A	0.630	0.69
26_I	142_C	0.629	0.68
130_G	191_I	0.629	0.68
55_T	222_T	0.629	0.68
17_G	135_G	0.627	0.68
41_T	77_L	0.627	0.68
146_F	220_C	0.624	0.68
52_I	85_M	0.622	0.68
213_L	248_G	0.622	0.68
264_E	268_P	0.621	0.67
91_V	248_G	0.620	0.67
11_I	14_F	0.620	0.67
97_T	188_S	0.619	0.67
48_F	64_F	0.618	0.67
17_G	172_S	0.617	0.67
264_E	273_K	0.616	0.67
117_L	121_T	0.616	0.67
19_N	47_A	0.614	0.67
73_S	230_G	0.612	0.66
41_T	66_V	0.612	0.66
132_S	136_L	0.611	0.66
199_N	271_A	0.610	0.66
63_A	71_F	0.610	0.66
91_V	216_N	0.610	0.66
216_N	248_G	0.606	0.66
203_I	213_L	0.605	0.65
299_L	302_L	0.604	0.65
96_T	99_F	0.604	0.65
187_S	245_N	0.603	0.65
111_L	136_L	0.602	0.65
58_L	64_F	0.601	0.65
291_P	294_N	0.601	0.65
42_D	47_A	0.600	0.65
58_L	62_S	0.600	0.65
121_T	127_K	0.597	0.64
248_G	286_A	0.597	0.64
103_K	107_V	0.596	0.64
47_A	289_F	0.595	0.64
255_F	261_G	0.594	0.64
222_T	282_N	0.592	0.64
269_D	272_Q	0.591	0.64
25_L	213_L	0.587	0.63
114_G	121_T	0.583	0.63
17_G	138_I	0.582	0.62
72_V	82_T	0.581	0.62
37_L	77_L	0.580	0.62
55_T	96_T	0.577	0.62
280_L	283_V	0.577	0.62
17_G	64_F	0.576	0.62
108_I	137_G	0.575	0.62
158_T	179_V	0.575	0.62
73_S	233_A	0.575	0.62
179_V	261_G	0.574	0.61
94_T	279_L	0.571	0.61
100_I	189_V	0.570	0.61
94_T	98_E	0.570	0.61
216_N	281_F	0.566	0.60
65_M	136_L	0.565	0.60
66_V	69_I	0.565	0.60
61_S	187_S	0.565	0.60
141_F	145_G	0.563	0.60
37_L	130_G	0.563	0.60
118_F	134_L	0.562	0.60
91_V	128_Q	0.562	0.60
151_G	228_V	0.561	0.60
259_A	287_L	0.560	0.60
226_A	234_A	0.559	0.59
212_V	277_F	0.558	0.59
189_V	282_N	0.558	0.59
272_Q	277_F	0.558	0.59
207_Q	242_V	0.555	0.59
117_L	130_G	0.554	0.59
267_S	276_H	0.554	0.59
53_V	56_G	0.553	0.59
7_F	193_I	0.553	0.59
272_Q	279_L	0.553	0.59
71_F	279_L	0.551	0.58
239_Y	242_V	0.549	0.58
47_A	58_L	0.549	0.58
110_V	279_L	0.548	0.58
11_I	19_N	0.547	0.58
124_Y	263_V	0.546	0.58
175_L	178_M	0.543	0.57
220_C	293_T	0.542	0.57
148_H	151_G	0.541	0.57
18_M	41_T	0.541	0.57
34_E	143_I	0.539	0.57
262_F	268_P	0.539	0.57
22_R	26_I	0.538	0.57
58_L	196_S	0.538	0.57
69_I	227_A	0.538	0.57
87_L	285_T	0.536	0.56
238_A	275_A	0.534	0.56
90_N	96_T	0.533	0.56
16_A	26_I	0.532	0.56
6_S	148_H	0.531	0.56
200_E	204_G	0.530	0.55
239_Y	303_L	0.530	0.55
244_F	247_L	0.529	0.55
250_A	302_L	0.528	0.55
23_K	27_S	0.528	0.55
8_T	28_M	0.528	0.55
74_A	86_I	0.528	0.55
269_D	296_F	0.527	0.55
8_T	267_S	0.526	0.55
72_V	193_I	0.526	0.55
28_M	132_S	0.525	0.55
170_N	253_L	0.524	0.55
215_S	285_T	0.524	0.55
62_S	184_I	0.521	0.54
181_T	188_S	0.521	0.54
283_V	287_L	0.520	0.54
131_T	134_L	0.520	0.54
206_T	210_S	0.520	0.54
6_S	161_D	0.519	0.54
66_V	281_F	0.519	0.54
6_S	36_R	0.516	0.53
22_R	146_F	0.515	0.53
173_A	194_L	0.515	0.53
53_V	164_Y	0.514	0.53
170_N	195_M	0.513	0.53
53_V	269_D	0.512	0.53
87_L	245_N	0.512	0.53
228_V	231_G	0.511	0.53
255_F	268_P	0.511	0.53
187_S	222_T	0.510	0.53
231_G	234_A	0.509	0.52
163_L	213_L	0.509	0.52
100_I	127_K	0.508	0.52
189_V	192_G	0.508	0.52
148_H	250_A	0.508	0.52
215_S	219_T	0.507	0.52
78_S	83_I	0.506	0.52
257_T	265_Q	0.506	0.52
157_K	163_L	0.504	0.52
24_G	34_E	0.503	0.52
66_V	226_A	0.502	0.51
69_I	234_A	0.502	0.51
182_A	220_C	0.500	0.51

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4f35D	2	0.7003	51.6	0.954	Contact Map
4rp9A	2	0.4984	14.6	0.965	Contact Map
4wgvA	2	0.4691	11.7	0.967	Contact Map
3v5uA	1	0.4332	7.3	0.97	Contact Map
4o6yA	2	0.2215	7.2	0.97	Contact Map
2dmxA	1	0.1336	4.5	0.973	Contact Map
4humA	1	0.5049	3.8	0.974	Contact Map
2ej7A	1	0.1336	3.7	0.974	Contact Map
1pw4A	1	0.4723	3.7	0.974	Contact Map
3w4tA	1	0.4951	3.3	0.974	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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