GREMLIN Database
YQEW - Uncharacterized protein YqeW
UniProt: P54463 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 307 (302)
Sequences: 2326 (1633)
Seq/√Len: 94.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
98_E276_H4.0841.00
90_N245_N3.6651.00
68_V85_M3.5951.00
62_S219_T3.5491.00
83_I297_Y3.4231.00
48_F91_V3.3411.00
83_I240_A3.3351.00
224_V242_V3.3141.00
42_D46_K3.2141.00
43_H46_K3.1691.00
98_E272_Q3.1471.00
91_V286_A3.0991.00
213_L249_V3.0721.00
174_L253_L2.9251.00
48_F290_L2.7361.00
98_E279_L2.6171.00
48_F286_A2.5601.00
297_Y301_H2.5461.00
91_V283_V2.5311.00
102_I272_Q2.5001.00
236_Q301_H2.4601.00
295_L299_L2.3761.00
216_N282_N2.3681.00
295_L298_R2.3521.00
272_Q276_H2.2411.00
219_T222_T2.2201.00
157_K161_D2.2051.00
44_P293_T2.1701.00
243_V303_L2.0901.00
298_R302_L2.0531.00
115_G118_F2.0461.00
292_L295_L1.9761.00
209_M277_F1.9741.00
10_L142_C1.9561.00
49_L52_I1.9451.00
7_F150_A1.8761.00
90_N241_H1.8571.00
67_I71_F1.8421.00
68_V237_T1.8131.00
302_L305_P1.7901.00
86_I237_T1.7611.00
221_I224_V1.7571.00
123_R126_L1.7321.00
217_I249_V1.7281.00
174_L249_V1.7241.00
121_T126_L1.7181.00
194_L211_V1.7101.00
12_L115_G1.7091.00
24_G135_G1.7081.00
224_V239_Y1.7051.00
182_A221_I1.7001.00
87_L244_F1.6691.00
248_G285_T1.6611.00
19_N23_K1.6281.00
241_H245_N1.6161.00
289_F292_L1.6131.00
64_F89_T1.5871.00
256_L260_T1.5791.00
250_A254_P1.5791.00
151_G154_T1.5771.00
78_S81_R1.5741.00
45_L290_L1.5721.00
239_Y304_I1.5691.00
59_Q188_S1.5611.00
115_G119_F1.5401.00
280_L284_V1.5351.00
279_L283_V1.5241.00
16_A20_M1.5151.00
278_S282_N1.5011.00
240_A300_I1.4831.00
258_A262_F1.4811.00
114_G118_F1.4801.00
290_L293_T1.4781.00
180_L184_I1.4651.00
57_I188_S1.4411.00
72_V237_T1.4210.99
144_S148_H1.4050.99
287_L291_P1.4000.99
11_I159_G1.3940.99
62_S185_H1.3820.99
220_C242_V1.3780.99
37_L50_I1.3540.99
184_I219_T1.3520.99
87_L286_A1.3490.99
198_M271_A1.3390.99
80_K297_Y1.3330.99
10_L149_L1.3060.99
54_F64_F1.2980.99
219_T241_H1.2980.99
299_L303_L1.2890.99
161_D164_Y1.2770.99
205_L273_K1.2690.99
44_P294_N1.2630.99
83_I293_T1.2590.99
96_T188_S1.2570.99
190_C215_S1.2510.99
24_G131_T1.2360.99
24_G28_M1.2310.98
216_N278_S1.2260.98
208_A274_I1.2230.98
242_V246_V1.2140.98
86_I241_H1.2110.98
255_F258_A1.2060.98
259_A263_V1.2050.98
223_A241_H1.1970.98
103_K106_I1.1910.98
195_M275_A1.1860.98
100_I192_G1.1840.98
204_G207_Q1.1820.98
112_L137_G1.1740.98
136_L142_C1.1720.98
27_S131_T1.1700.98
35_E39_L1.1590.98
14_F185_H1.1570.98
65_M86_I1.1510.98
48_F52_I1.1400.97
160_A164_Y1.1390.97
62_S221_I1.1300.97
49_L53_V1.1270.97
79_F82_T1.1270.97
258_A261_G1.1230.97
179_V183_I1.1180.97
62_S188_S1.1140.97
233_A236_Q1.1040.97
61_S93_S1.1000.97
206_T264_E1.0900.97
102_I276_H1.0890.97
47_A84_P1.0870.97
18_M76_V1.0860.97
182_A193_I1.0810.96
232_Y305_P1.0790.96
257_T260_T1.0780.96
194_L210_S1.0740.96
65_M241_H1.0680.96
84_P293_T1.0540.96
78_S82_T1.0450.96
287_L290_L1.0390.96
112_L141_F1.0360.96
198_M270_P1.0350.96
222_T241_H1.0340.95
80_K294_N1.0280.95
93_S187_S1.0220.95
101_A272_Q1.0210.95
93_S188_S1.0200.95
257_T261_G1.0180.95
10_L146_F1.0160.95
67_I73_S1.0130.95
52_I95_F1.0070.95
203_I208_A1.0040.95
178_M217_I1.0020.95
115_G120_L1.0000.95
98_E101_A1.0000.95
17_G142_C0.9960.94
100_I195_M0.9860.94
232_Y304_I0.9860.94
194_L215_S0.9700.94
93_S96_T0.9670.94
240_A297_Y0.9570.93
55_T58_L0.9540.93
23_K26_I0.9510.93
205_L264_E0.9460.93
239_Y300_I0.9410.93
174_L217_I0.9380.92
270_P273_K0.9370.92
137_G141_F0.9320.92
116_L121_T0.9270.92
113_I117_L0.9270.92
216_N223_A0.9250.92
252_V284_V0.9250.92
97_T191_I0.9250.92
187_S278_S0.9220.92
54_F58_L0.9210.92
56_G95_F0.9110.91
9_A12_L0.9090.91
65_M234_A0.9070.91
24_G132_S0.9020.91
71_F76_V0.9010.91
82_T89_T0.8970.91
9_A13_F0.8970.91
143_I196_S0.8970.91
173_A211_V0.8930.91
224_V227_A0.8790.90
278_S281_F0.8780.90
66_V222_T0.8750.90
261_G264_E0.8660.89
247_L292_L0.8620.89
44_P47_A0.8600.89
65_M223_A0.8590.89
79_F237_T0.8580.89
80_K301_H0.8560.89
87_L289_F0.8550.89
243_V299_L0.8540.88
300_I303_L0.8520.88
188_S191_I0.8500.88
158_T161_D0.8500.88
151_G299_L0.8470.88
255_F260_T0.8380.88
240_A296_F0.8350.87
191_I195_M0.8340.87
143_I192_G0.8330.87
66_V223_A0.8330.87
157_K160_A0.8320.87
261_G265_Q0.8320.87
191_I215_S0.8310.87
10_L145_G0.8290.87
220_C245_N0.8190.86
69_I72_V0.8190.86
230_G235_K0.8170.86
14_F62_S0.8150.86
114_G117_L0.8150.86
132_S183_I0.8130.86
114_G130_G0.8120.86
44_P290_L0.8080.86
205_L209_M0.7970.85
298_R301_H0.7960.85
156_L160_A0.7920.84
32_K35_E0.7910.84
48_F87_L0.7890.84
258_A263_V0.7850.84
97_T244_F0.7830.84
24_G152_P0.7800.84
251_L288_L0.7750.83
109_W242_V0.7720.83
27_S236_Q0.7680.83
184_I190_C0.7650.82
300_I305_P0.7650.82
83_I87_L0.7650.82
255_F262_F0.7650.82
284_V288_L0.7640.82
5_I110_V0.7620.82
170_N210_S0.7610.82
5_I156_L0.7580.82
175_L179_V0.7520.81
255_F301_H0.7490.81
52_I56_G0.7480.81
55_T61_S0.7470.81
98_E275_A0.7470.81
104_M107_V0.7450.81
210_S256_L0.7440.81
294_N297_Y0.7430.80
295_L302_L0.7400.80
180_L190_C0.7380.80
232_Y236_Q0.7380.80
170_N173_A0.7260.79
163_L166_V0.7260.79
294_N298_R0.7240.79
187_S219_T0.7230.79
232_Y235_K0.7220.79
261_G287_L0.7210.78
174_L178_M0.7200.78
98_E102_I0.7180.78
35_E266_L0.7180.78
260_T264_E0.7180.78
87_L293_T0.7170.78
195_M271_A0.7160.78
108_I141_F0.7120.78
70_G73_S0.7110.77
77_L81_R0.7080.77
220_C223_A0.7060.77
289_F296_F0.7050.77
22_R73_S0.7040.77
41_T85_M0.6970.76
185_H188_S0.6940.76
58_L188_S0.6930.76
209_M260_T0.6920.76
44_P84_P0.6910.75
113_I118_F0.6900.75
11_I146_F0.6880.75
249_V254_P0.6860.75
216_N241_H0.6860.75
55_T64_F0.6850.75
44_P210_S0.6850.75
194_L212_V0.6840.75
219_T282_N0.6830.75
257_T267_S0.6820.74
37_L41_T0.6800.74
59_Q93_S0.6800.74
264_E267_S0.6800.74
63_A136_L0.6790.74
263_V267_S0.6750.74
164_Y168_D0.6720.73
258_A265_Q0.6680.73
267_S273_K0.6650.73
215_S256_L0.6650.73
13_F141_F0.6640.73
74_A281_F0.6630.72
5_I279_L0.6620.72
262_F265_Q0.6620.72
301_H305_P0.6620.72
151_G155_K0.6620.72
20_M138_I0.6610.72
137_G140_F0.6610.72
184_I258_A0.6600.72
246_V250_A0.6590.72
213_L253_L0.6590.72
64_F237_T0.6570.72
155_K298_R0.6570.72
39_L42_D0.6550.71
90_N216_N0.6510.71
94_T222_T0.6500.71
259_A267_S0.6500.71
220_C244_F0.6490.71
130_G133_F0.6480.71
72_V177_G0.6470.71
16_A131_T0.6470.71
57_I299_L0.6470.71
16_A22_R0.6440.70
245_N285_T0.6380.70
74_A140_F0.6360.69
191_I212_V0.6340.69
28_M223_A0.6330.69
296_F300_I0.6320.69
21_L63_A0.6310.69
77_L176_I0.6300.69
222_T226_A0.6300.69
26_I142_C0.6290.68
130_G191_I0.6290.68
55_T222_T0.6290.68
17_G135_G0.6270.68
41_T77_L0.6270.68
146_F220_C0.6240.68
52_I85_M0.6220.68
213_L248_G0.6220.68
264_E268_P0.6210.67
91_V248_G0.6200.67
11_I14_F0.6200.67
97_T188_S0.6190.67
48_F64_F0.6180.67
17_G172_S0.6170.67
264_E273_K0.6160.67
117_L121_T0.6160.67
19_N47_A0.6140.67
73_S230_G0.6120.66
41_T66_V0.6120.66
132_S136_L0.6110.66
199_N271_A0.6100.66
63_A71_F0.6100.66
91_V216_N0.6100.66
216_N248_G0.6060.66
203_I213_L0.6050.65
299_L302_L0.6040.65
96_T99_F0.6040.65
187_S245_N0.6030.65
111_L136_L0.6020.65
58_L64_F0.6010.65
291_P294_N0.6010.65
42_D47_A0.6000.65
58_L62_S0.6000.65
121_T127_K0.5970.64
248_G286_A0.5970.64
103_K107_V0.5960.64
47_A289_F0.5950.64
255_F261_G0.5940.64
222_T282_N0.5920.64
269_D272_Q0.5910.64
25_L213_L0.5870.63
114_G121_T0.5830.63
17_G138_I0.5820.62
72_V82_T0.5810.62
37_L77_L0.5800.62
55_T96_T0.5770.62
280_L283_V0.5770.62
17_G64_F0.5760.62
108_I137_G0.5750.62
158_T179_V0.5750.62
73_S233_A0.5750.62
179_V261_G0.5740.61
94_T279_L0.5710.61
100_I189_V0.5700.61
94_T98_E0.5700.61
216_N281_F0.5660.60
65_M136_L0.5650.60
66_V69_I0.5650.60
61_S187_S0.5650.60
141_F145_G0.5630.60
37_L130_G0.5630.60
118_F134_L0.5620.60
91_V128_Q0.5620.60
151_G228_V0.5610.60
259_A287_L0.5600.60
226_A234_A0.5590.59
212_V277_F0.5580.59
189_V282_N0.5580.59
272_Q277_F0.5580.59
207_Q242_V0.5550.59
117_L130_G0.5540.59
267_S276_H0.5540.59
53_V56_G0.5530.59
7_F193_I0.5530.59
272_Q279_L0.5530.59
71_F279_L0.5510.58
239_Y242_V0.5490.58
47_A58_L0.5490.58
110_V279_L0.5480.58
11_I19_N0.5470.58
124_Y263_V0.5460.58
175_L178_M0.5430.57
220_C293_T0.5420.57
148_H151_G0.5410.57
18_M41_T0.5410.57
34_E143_I0.5390.57
262_F268_P0.5390.57
22_R26_I0.5380.57
58_L196_S0.5380.57
69_I227_A0.5380.57
87_L285_T0.5360.56
238_A275_A0.5340.56
90_N96_T0.5330.56
16_A26_I0.5320.56
6_S148_H0.5310.56
200_E204_G0.5300.55
239_Y303_L0.5300.55
244_F247_L0.5290.55
250_A302_L0.5280.55
23_K27_S0.5280.55
8_T28_M0.5280.55
74_A86_I0.5280.55
269_D296_F0.5270.55
8_T267_S0.5260.55
72_V193_I0.5260.55
28_M132_S0.5250.55
170_N253_L0.5240.55
215_S285_T0.5240.55
62_S184_I0.5210.54
181_T188_S0.5210.54
283_V287_L0.5200.54
131_T134_L0.5200.54
206_T210_S0.5200.54
6_S161_D0.5190.54
66_V281_F0.5190.54
6_S36_R0.5160.53
22_R146_F0.5150.53
173_A194_L0.5150.53
53_V164_Y0.5140.53
170_N195_M0.5130.53
53_V269_D0.5120.53
87_L245_N0.5120.53
228_V231_G0.5110.53
255_F268_P0.5110.53
187_S222_T0.5100.53
231_G234_A0.5090.52
163_L213_L0.5090.52
100_I127_K0.5080.52
189_V192_G0.5080.52
148_H250_A0.5080.52
215_S219_T0.5070.52
78_S83_I0.5060.52
257_T265_Q0.5060.52
157_K163_L0.5040.52
24_G34_E0.5030.52
66_V226_A0.5020.51
69_I234_A0.5020.51
182_A220_C0.5000.51
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4f35D 2 0.7003 51.6 0.954 Contact Map
4rp9A 2 0.4984 14.6 0.965 Contact Map
4wgvA 2 0.4691 11.7 0.967 Contact Map
3v5uA 1 0.4332 7.3 0.97 Contact Map
4o6yA 2 0.2215 7.2 0.97 Contact Map
2dmxA 1 0.1336 4.5 0.973 Contact Map
4humA 1 0.5049 3.8 0.974 Contact Map
2ej7A 1 0.1336 3.7 0.974 Contact Map
1pw4A 1 0.4723 3.7 0.974 Contact Map
3w4tA 1 0.4951 3.3 0.974 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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