GREMLIN Database
MTAB - Threonylcarbamoyladenosine tRNA methylthiotransferase MtaB
UniProt: P54462 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 451 (424)
Sequences: 7307 (4360)
Seq/√Len: 211.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
264_S311_E3.5441.00
264_S314_E3.5291.00
147_L181_A3.4111.00
185_V225_V3.4081.00
265_N278_E3.3911.00
380_E420_K3.1811.00
323_K369_E3.1341.00
240_D286_K3.0661.00
378_V420_K3.0451.00
281_A321_E3.0411.00
422_K434_Q2.9711.00
424_L434_Q2.9481.00
266_T311_E2.9471.00
220_T249_S2.8521.00
383_P408_F2.8251.00
244_E290_A2.7901.00
316_Y362_L2.6741.00
217_E221_R2.6561.00
354_E358_R2.6451.00
320_K365_Q2.4561.00
266_T270_R2.4541.00
317_N321_E2.4301.00
378_V422_K2.4241.00
216_S248_R2.3321.00
179_K182_Q2.2431.00
181_A192_I2.2381.00
281_A322_H2.2191.00
287_L294_L2.1991.00
104_K107_G2.1731.00
351_V354_E2.1661.00
8_T18_T2.1601.00
181_A218_L2.1401.00
256_L294_L2.1391.00
190_K226_K2.1371.00
282_D285_N2.0861.00
320_K362_L2.0861.00
334_K346_Q2.0461.00
244_E248_R2.0401.00
317_N320_K2.0041.00
309_E351_V1.9771.00
182_Q186_D1.9761.00
348_D351_V1.9541.00
312_F358_R1.9511.00
254_N401_D1.9341.00
380_E418_I1.9061.00
3_T31_E1.9041.00
210_N241_E1.9041.00
247_D290_A1.9011.00
331_P356_V1.8911.00
277_M314_E1.8871.00
414_M417_K1.8671.00
316_Y358_R1.8611.00
277_M281_A1.8491.00
375_E426_A1.8481.00
185_V222_V1.8241.00
285_N321_E1.8191.00
28_A110_D1.8011.00
174_P217_E1.7941.00
285_N289_K1.7891.00
210_N213_K1.7771.00
368_K372_S1.7751.00
313_M317_N1.7491.00
35_F38_T1.7441.00
262_S315_T1.7301.00
260_I318_F1.7281.00
323_K366_L1.7081.00
349_E352_K1.6931.00
279_F282_D1.6841.00
334_K341_A1.6661.00
276_T279_F1.6591.00
220_T251_K1.6411.00
370_Y373_Q1.6251.00
380_E401_D1.6231.00
156_F168_L1.6231.00
277_M317_N1.6111.00
313_M358_R1.6091.00
6_F18_T1.6071.00
308_T311_E1.6001.00
216_S249_S1.5971.00
220_T250_D1.5821.00
265_N277_M1.5721.00
226_K380_E1.5701.00
374_Y379_L1.5651.00
406_V423_I1.5521.00
267_V270_R1.5501.00
381_I398_G1.5501.00
216_S245_V1.5451.00
278_E282_D1.5401.00
309_E313_M1.5381.00
254_N293_G1.5321.00
383_P419_V1.5271.00
245_V249_S1.5071.00
4_V32_R1.4941.00
325_S370_Y1.4871.00
74_C95_I1.4661.00
311_E314_E1.4551.00
80_A96_V1.4291.00
243_I287_L1.4111.00
394_N399_Y1.4071.00
256_L287_L1.3981.00
48_T165_A1.3831.00
173_D176_E1.3761.00
314_E317_N1.3661.00
394_N400_T1.3651.00
277_M318_F1.3621.00
172_R180_Q1.3621.00
421_V433_G1.3611.00
179_K183_Q1.3601.00
21_I76_T1.3551.00
216_S241_E1.3521.00
158_T272_R1.3461.00
158_T304_F1.3461.00
101_D104_K1.3411.00
183_Q187_A1.3411.00
394_N398_G1.3391.00
215_L252_I1.3271.00
43_V74_C1.3261.00
246_L252_I1.3231.00
353_N357_H1.3201.00
240_D244_E1.3151.00
192_I225_V1.3021.00
212_A245_V1.2981.00
357_H361_A1.2921.00
270_R343_M1.2791.00
178_I217_E1.2771.00
156_F164_W1.2771.00
213_K241_E1.2751.00
323_K370_Y1.2731.00
65_I94_D1.2681.00
425_K432_E1.2611.00
395_M409_K1.2561.00
172_R176_E1.2561.00
68_N71_G1.2481.00
270_R311_E1.2451.00
293_G377_E1.2441.00
319_I359_L1.2391.00
48_T54_D1.2271.00
374_Y377_E1.2251.00
349_E353_N1.2201.00
300_V319_I1.2191.00
310_E314_E1.2141.00
372_S375_E1.2141.00
329_V356_V1.2131.00
362_L366_L1.2031.00
213_K217_E1.2011.00
178_I182_Q1.1941.00
203_G206_M1.1911.00
331_P353_N1.1891.00
46_T75_V1.1871.00
245_V252_I1.1861.00
423_I431_N1.1841.00
183_Q186_D1.1821.00
223_E251_K1.1791.00
61_I75_V1.1731.00
419_V435_F1.1691.00
282_D286_K1.1681.00
339_P342_R1.1631.00
291_L294_L1.1621.00
99_T102_R1.1581.00
55_K59_Q1.1571.00
270_R304_F1.1501.00
3_T38_T1.1471.00
286_K289_K1.1461.00
209_Y213_K1.1371.00
270_R306_G1.1331.00
363_S366_L1.1281.00
272_R339_P1.1271.00
218_L228_I1.1261.00
161_I165_A1.1191.00
331_P349_E1.1171.00
228_I251_K1.1151.00
309_E358_R1.1141.00
6_F43_V1.1091.00
361_A365_Q1.1091.00
51_N55_K1.1071.00
413_D417_K1.1071.00
226_K251_K1.0841.00
283_R286_K1.0841.00
209_Y217_E1.0821.00
185_V226_K1.0821.00
133_E136_V1.0821.00
313_M316_Y1.0791.00
302_V312_F1.0781.00
265_N276_T1.0721.00
172_R177_V1.0691.00
249_S252_I1.0651.00
319_I327_L1.0641.00
284_L296_V1.0621.00
346_Q352_K1.0611.00
379_L423_I1.0601.00
220_T245_V1.0551.00
310_E313_M1.0521.00
154_N168_L1.0501.00
329_V360_I1.0501.00
300_V327_L1.0491.00
246_L291_L1.0481.00
284_L322_H1.0461.00
365_Q369_E1.0461.00
7_H60_V1.0451.00
81_Q98_G1.0431.00
95_I112_Y1.0401.00
25_F109_I1.0391.00
97_V108_Y1.0271.00
372_S426_A1.0261.00
323_K373_Q1.0251.00
396_F410_G1.0151.00
362_L365_Q1.0151.00
298_S324_F1.0131.00
145_A184_L1.0131.00
199_T230_I1.0111.00
83_S86_E1.0101.00
134_L137_P1.0091.00
255_H403_Y1.0071.00
158_T339_P1.0071.00
72_V112_Y1.0041.00
76_T97_V1.0021.00
399_Y405_K1.0011.00
111_Q116_R0.9991.00
174_P178_I0.9981.00
265_N314_E0.9961.00
241_E244_E0.9941.00
306_G345_D0.9941.00
375_E425_K0.9891.00
95_I108_Y0.9881.00
243_I290_A0.9881.00
82_T165_A0.9871.00
46_T57_S0.9871.00
132_E135_D0.9861.00
247_D291_L0.9731.00
288_K323_K0.9701.00
327_L363_S0.9691.00
176_E179_K0.9681.00
211_F242_V0.9661.00
190_K418_I0.9651.00
396_F413_D0.9641.00
316_Y320_K0.9621.00
87_I93_V0.9621.00
312_F359_L0.9581.00
161_I164_W0.9571.00
379_L400_T0.9491.00
147_L177_V0.9491.00
368_K426_A0.9450.99
185_V224_G0.9430.99
371_A404_M0.9420.99
395_M398_G0.9370.99
42_Y71_G0.9340.99
6_F22_W0.9330.99
182_Q223_E0.9270.99
72_V113_R0.9270.99
5_A36_E0.9250.99
150_Q169_L0.9230.99
302_V356_V0.9190.99
4_V30_Y0.9180.99
107_G111_Q0.9180.99
286_K290_A0.9150.99
243_I291_L0.9130.99
147_L192_I0.9090.99
298_S327_L0.9090.99
293_G373_Q0.9080.99
221_R249_S0.9040.99
309_E354_E0.8990.99
60_V63_R0.8980.99
264_S267_V0.8970.99
356_V360_I0.8970.99
246_L256_L0.8960.99
22_W32_R0.8950.99
190_K417_K0.8930.99
407_V430_Y0.8930.99
44_I61_I0.8860.99
175_E179_K0.8840.99
406_V433_G0.8820.99
3_T33_R0.8770.99
181_A222_V0.8760.99
30_Y41_V0.8720.99
319_I324_F0.8710.99
215_L249_S0.8700.99
361_A364_D0.8690.99
131_Y134_L0.8680.99
220_T252_I0.8670.99
270_R345_D0.8650.99
8_T45_N0.8640.99
324_F327_L0.8610.99
368_K371_A0.8600.99
393_E398_G0.8590.99
363_S367_A0.8530.99
182_Q217_E0.8510.99
9_L57_S0.8460.99
184_L189_Y0.8450.99
155_N198_H0.8420.99
174_P202_Y0.8400.99
137_P140_T0.8370.99
212_A241_E0.8370.99
279_F283_R0.8340.99
54_D83_S0.8330.99
4_V26_K0.8320.99
4_V22_W0.8310.99
343_M346_Q0.8290.99
174_P209_Y0.8290.99
93_V96_V0.8290.99
110_D114_E0.8280.99
254_N291_L0.8280.99
72_V95_I0.8270.99
226_K418_I0.8250.99
266_T314_E0.8240.99
427_G432_E0.8220.99
131_Y136_V0.8220.99
367_A371_A0.8210.99
212_A239_T0.8190.99
13_V197_I0.8170.99
304_F343_M0.8170.99
171_S205_D0.8150.98
410_G413_D0.8150.98
255_H297_T0.8140.98
9_L60_V0.8130.98
386_A396_F0.8080.98
281_A285_N0.8080.98
358_R362_L0.8060.98
175_E207_K0.8060.98
222_V225_V0.8040.98
341_A346_Q0.8020.98
238_I283_R0.8020.98
318_F322_H0.8020.98
297_T326_E0.8000.98
220_T228_I0.7970.98
75_V93_V0.7960.98
364_D429_P0.7950.98
143_T384_E0.7950.98
386_A412_E0.7930.98
41_V72_V0.7930.98
111_Q115_E0.7930.98
33_R39_A0.7890.98
423_I433_G0.7890.98
154_N204_E0.7880.98
263_G314_E0.7880.98
393_E400_T0.7870.98
145_A189_Y0.7850.98
260_I280_F0.7840.98
302_V352_K0.7840.98
366_L369_E0.7830.98
178_I218_L0.7830.98
409_K434_Q0.7830.98
320_K366_L0.7810.98
267_V311_E0.7800.98
312_F316_Y0.7800.98
169_L201_G0.7800.98
133_E176_E0.7780.98
302_V359_L0.7770.98
42_Y70_D0.7760.98
393_E399_Y0.7760.98
156_F272_R0.7760.98
42_Y64_A0.7760.98
175_E217_E0.7750.98
260_I300_V0.7750.98
382_I418_I0.7750.98
243_I286_K0.7750.98
366_L370_Y0.7750.98
36_E42_Y0.7670.98
410_G414_M0.7670.98
244_E247_D0.7670.98
81_Q84_P0.7650.98
295_A325_S0.7630.98
136_V139_F0.7630.98
295_A402_N0.7620.98
227_R253_V0.7610.98
185_V223_E0.7600.98
147_L184_L0.7600.98
278_E281_A0.7590.98
41_V74_C0.7540.98
381_I421_V0.7530.97
22_W26_K0.7530.97
215_L242_V0.7520.97
313_M320_K0.7520.97
300_V359_L0.7510.97
256_L296_V0.7500.97
28_A107_G0.7500.97
280_F324_F0.7500.97
24_L106_L0.7450.97
132_E136_V0.7440.97
374_Y402_N0.7440.97
327_L366_L0.7400.97
213_K216_S0.7360.97
25_F43_V0.7340.97
319_I366_L0.7310.97
408_F421_V0.7300.97
230_I246_L0.7280.97
334_K352_K0.7260.97
33_R38_T0.7240.97
178_I222_V0.7240.97
306_G346_Q0.7230.97
30_Y110_D0.7230.97
400_T406_V0.7230.97
150_Q196_G0.7220.97
159_F275_Y0.7210.97
19_E23_Q0.7170.97
383_P396_F0.7150.97
383_P421_V0.7150.97
267_V304_F0.7130.97
239_T242_V0.7120.96
263_G280_F0.7110.96
5_A33_R0.7100.96
381_I406_V0.7100.96
374_Y404_M0.7090.96
212_A242_V0.7090.96
238_I242_V0.7090.96
368_K428_Y0.7090.96
65_I71_G0.7070.96
201_G236_S0.7030.96
315_T359_L0.7020.96
72_V109_I0.7010.96
58_R62_R0.7000.96
316_Y359_L0.6990.96
387_F407_V0.6990.96
385_E397_V0.6980.96
5_A39_A0.6980.96
52_T55_K0.6980.96
369_E372_S0.6970.96
206_M209_Y0.6960.96
21_I105_M0.6940.96
207_K210_N0.6940.96
74_C97_V0.6940.96
148_K151_E0.6890.96
388_K394_N0.6880.96
112_Y115_E0.6860.96
18_T22_W0.6850.96
347_V352_K0.6840.96
144_R193_V0.6840.96
12_K402_N0.6840.96
424_L433_G0.6800.95
240_D243_I0.6790.95
164_W339_P0.6780.95
319_I363_S0.6760.95
370_Y374_Y0.6760.95
5_A42_Y0.6750.95
358_R361_A0.6740.95
28_A106_L0.6710.95
373_Q377_E0.6710.95
374_Y378_V0.6710.95
12_K195_T0.6710.95
386_A393_E0.6700.95
64_A71_G0.6700.95
360_I363_S0.6690.95
198_H237_Q0.6690.95
236_S274_K0.6680.95
223_E226_K0.6670.95
414_M435_F0.6670.95
336_T341_A0.6660.95
16_Y148_K0.6650.95
155_N201_G0.6630.95
227_R418_I0.6620.95
325_S404_M0.6620.95
18_T45_N0.6590.95
201_G237_Q0.6590.95
304_F340_A0.6580.95
64_A68_N0.6560.94
8_T15_H0.6560.94
112_Y116_R0.6560.94
105_M109_I0.6550.94
26_K32_R0.6550.94
387_F394_N0.6540.94
17_E151_E0.6530.94
224_G251_K0.6510.94
85_A88_M0.6500.94
130_V133_E0.6480.94
115_E118_P0.6470.94
281_A318_F0.6460.94
26_K31_E0.6460.94
23_Q27_E0.6450.94
225_V251_K0.6430.94
202_Y209_Y0.6430.94
98_G102_R0.6410.94
395_M407_V0.6410.94
200_G233_I0.6410.94
182_Q222_V0.6380.94
130_V134_L0.6370.94
164_W337_G0.6360.94
135_D138_A0.6350.93
263_G315_T0.6340.93
52_T333_S0.6320.93
136_V140_T0.6320.93
395_M400_T0.6320.93
381_I433_G0.6310.93
396_F415_I0.6310.93
9_L44_I0.6300.93
146_S193_V0.6290.93
263_G277_M0.6290.93
64_A70_D0.6290.93
62_R90_I0.6290.93
408_F435_F0.6290.93
133_E137_P0.6280.93
65_I92_G0.6270.93
75_V87_I0.6260.93
364_D428_Y0.6260.93
319_I362_L0.6250.93
129_R132_E0.6240.93
158_T270_R0.6230.93
309_E355_R0.6220.93
256_L291_L0.6210.93
177_V214_L0.6180.93
132_E137_P0.6170.92
147_L194_L0.6160.92
266_T306_G0.6160.92
179_K186_D0.6150.92
266_T269_K0.6140.92
266_T310_E0.6120.92
200_G259_P0.6120.92
253_V401_D0.6120.92
211_F230_I0.6100.92
315_T319_I0.6090.92
263_G318_F0.6070.92
174_P213_K0.6040.92
44_I57_S0.6040.92
59_Q62_R0.6040.92
5_A34_D0.6030.92
412_E417_K0.6010.91
397_V400_T0.6010.91
48_T82_T0.6000.91
44_I64_A0.5980.91
56_K59_Q0.5980.91
378_V433_G0.5970.91
149_I199_T0.5960.91
35_F64_A0.5960.91
13_V16_Y0.5910.91
90_I93_V0.5910.91
240_D290_A0.5900.91
211_F215_L0.5890.91
24_L27_E0.5850.90
149_I214_L0.5840.90
155_N274_K0.5830.90
212_A216_S0.5830.90
110_D113_R0.5830.90
331_P352_K0.5810.90
353_N356_V0.5810.90
266_T308_T0.5800.90
395_M399_Y0.5800.90
216_S221_R0.5800.90
185_V251_K0.5790.90
4_V25_F0.5770.90
225_V228_I0.5760.90
33_R36_E0.5760.90
115_E121_G0.5750.90
174_P214_L0.5740.90
113_R116_R0.5740.90
372_S425_K0.5740.90
210_N239_T0.5740.90
371_A426_A0.5730.89
225_V418_I0.5730.89
5_A35_F0.5710.89
84_P88_M0.5700.89
185_V228_I0.5700.89
424_L432_E0.5690.89
7_H44_I0.5680.89
20_A24_L0.5680.89
313_M354_E0.5670.89
302_V331_P0.5650.89
215_L218_L0.5650.89
46_T61_I0.5640.89
370_Y404_M0.5620.89
329_V359_L0.5620.89
408_F419_V0.5620.89
52_T56_K0.5610.88
326_E367_A0.5600.88
97_V101_D0.5600.88
319_I323_K0.5590.88
141_D189_Y0.5580.88
386_A410_G0.5580.88
127_K132_E0.5580.88
133_E138_A0.5580.88
375_E378_V0.5580.88
128_A131_Y0.5570.88
49_V161_I0.5570.88
421_V424_L0.5560.88
394_N397_V0.5550.88
300_V315_T0.5550.88
65_I70_D0.5550.88
350_N354_E0.5550.88
192_I218_L0.5540.88
312_F319_I0.5530.88
86_E89_A0.5530.88
154_N169_L0.5530.88
329_V363_S0.5520.88
200_G237_Q0.5510.88
260_I324_F0.5510.88
413_D435_F0.5510.88
185_V189_Y0.5500.87
65_I73_I0.5500.87
383_P398_G0.5470.87
194_L218_L0.5470.87
26_K29_G0.5450.87
180_Q184_L0.5450.87
201_G259_P0.5430.87
386_A394_N0.5410.87
351_V355_R0.5390.86
143_T382_I0.5390.86
222_V226_K0.5380.86
159_F272_R0.5330.86
149_I177_V0.5330.86
128_A132_E0.5320.86
240_D283_R0.5310.86
155_N236_S0.5300.86
232_S255_H0.5290.85
191_E229_R0.5290.85
72_V94_D0.5290.85
426_A431_N0.5280.85
88_M96_V0.5280.85
404_M431_N0.5280.85
371_A431_N0.5280.85
397_V405_K0.5270.85
245_V248_R0.5270.85
100_Q103_E0.5260.85
395_M432_E0.5260.85
244_E286_K0.5260.85
155_N165_A0.5240.85
67_Q71_G0.5240.85
215_L220_T0.5220.85
367_A428_Y0.5180.84
241_E245_V0.5170.84
105_M108_Y0.5170.84
131_Y135_D0.5170.84
106_L109_I0.5150.84
43_V95_I0.5150.84
285_N322_H0.5140.84
185_V192_I0.5140.84
52_T59_Q0.5110.83
375_E423_I0.5090.83
82_T336_T0.5090.83
354_E357_H0.5080.83
413_D419_V0.5070.83
54_D82_T0.5070.83
407_V432_E0.5070.83
332_Y340_A0.5060.83
412_E435_F0.5060.83
215_L228_I0.5050.83
196_G199_T0.5050.83
265_N282_D0.5010.82
8_T14_N0.5000.82
15_H19_E0.5000.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4jc0A 1 0.9202 100 0.355 Contact Map
2qgqA 1 0.5898 100 0.558 Contact Map
1oltA 1 0.745 100 0.774 Contact Map
4u0oB 1 0.5898 99.9 0.823 Contact Map
4wcxA 1 0.7849 99.9 0.84 Contact Map
3iixA 1 0.7295 99.9 0.844 Contact Map
2yx0A 1 0.6519 99.9 0.848 Contact Map
3t7vA 1 0.7095 99.8 0.851 Contact Map
1r30A 2 0.6541 99.8 0.855 Contact Map
1tv8A 2 0.6408 99.8 0.857 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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