GREMLIN Database
RSME - Ribosomal RNA small subunit methyltransferase E
UniProt: P54461 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 256 (231)
Sequences: 4647 (3549)
Seq/√Len: 233.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
107_A152_M3.4701.00
136_A151_V3.4521.00
54_E68_I3.2701.00
114_A210_T3.0341.00
114_A212_A2.8071.00
54_E66_L2.8021.00
82_Y109_I2.7801.00
56_Q66_L2.6981.00
97_I136_A2.5171.00
170_C222_G2.4981.00
53_C65_C2.4971.00
52_K69_E2.4691.00
80_K198_S2.4571.00
107_A150_R2.4231.00
100_G108_F2.4031.00
49_F70_W2.3571.00
84_A160_L2.3491.00
172_V214_V2.3161.00
84_A200_L2.2591.00
88_P234_T2.2361.00
40_Q52_K2.1921.00
27_H31_N2.1791.00
156_S159_Q2.0491.00
40_Q54_E2.0401.00
115_R210_T2.0291.00
215_E219_E2.0041.00
201_I241_A1.9801.00
18_T64_S1.9451.00
174_Y214_V1.9271.00
57_S64_S1.9141.00
86_G113_A1.8611.00
158_Q216_R1.8261.00
110_P153_D1.8071.00
109_I152_M1.7661.00
25_E141_E1.7061.00
157_F217_L1.6991.00
26_V63_V1.6631.00
85_S238_P1.6381.00
18_T66_L1.6161.00
82_Y107_A1.6121.00
83_I100_G1.5981.00
94_E131_R1.5851.00
80_K107_A1.5821.00
80_K106_H1.5811.00
76_E147_E1.5631.00
113_A116_S1.5581.00
88_P96_I1.5581.00
218_T224_T1.5371.00
81_V242_L1.5221.00
20_S64_S1.5041.00
129_R133_T1.4791.00
41_I65_C1.4691.00
95_W239_L1.4561.00
20_S62_K1.4481.00
172_V217_L1.4411.00
211_E215_E1.4231.00
168_D198_S1.4171.00
35_M39_D1.3981.00
97_I132_W1.3911.00
244_A247_Y1.3851.00
95_W99_K1.3781.00
50_E146_N1.3711.00
42_I50_E1.3441.00
112_Q154_V1.3401.00
105_A108_F1.3321.00
29_I35_M1.3291.00
93_L110_P1.3251.00
202_V222_G1.3231.00
92_K96_I1.3121.00
84_A111_F1.2921.00
35_M55_L1.2891.00
111_F160_L1.2851.00
131_R135_I1.2831.00
40_Q68_I1.2601.00
215_E218_T1.2551.00
55_L63_V1.2531.00
30_V63_V1.2501.00
83_I105_A1.2501.00
140_A148_V1.2321.00
93_L132_W1.2311.00
29_I41_I1.2311.00
55_L65_C1.2271.00
240_Y243_S1.1981.00
169_K223_V1.1871.00
85_S96_I1.1791.00
172_V209_L1.1781.00
168_D200_L1.1761.00
53_C67_V1.1721.00
171_V225_C1.1641.00
103_L240_Y1.1631.00
23_G26_V1.1571.00
95_W98_Q1.1461.00
89_K117_V1.1451.00
18_T56_Q1.1441.00
98_Q102_E1.1441.00
24_E134_K1.1391.00
202_V217_L1.1391.00
55_L58_V1.1181.00
45_S48_G1.1081.00
161_L216_R1.1001.00
59_S62_K1.0991.00
29_I63_V1.0951.00
52_K68_I1.0941.00
126_K130_E1.0831.00
26_V30_V1.0821.00
77_L246_S1.0761.00
38_G54_E1.0761.00
216_R220_Q1.0631.00
100_G242_L1.0621.00
98_Q135_I1.0621.00
76_E145_R1.0591.00
85_S234_T1.0561.00
7_E11_Q1.0451.00
157_F161_L1.0421.00
52_K71_T1.0351.00
212_A215_E1.0321.00
102_E236_T1.0301.00
105_A242_L1.0301.00
167_F200_L1.0301.00
202_V209_L1.0121.00
134_K138_E1.0021.00
169_K199_L0.9971.00
99_K235_E0.9851.00
85_S203_F0.9781.00
158_Q212_A0.9681.00
216_R219_E0.9601.00
83_I96_I0.9561.00
51_A70_W0.9491.00
27_H32_V0.9461.00
164_M170_C0.9451.00
170_C200_L0.9411.00
4_Y33_M0.9401.00
44_C50_E0.9341.00
37_E57_S0.9301.00
108_F149_P0.9231.00
17_P66_L0.9141.00
173_A241_A0.9071.00
101_T149_P0.9061.00
30_V58_V0.9041.00
155_H163_R0.9031.00
159_Q162_Q0.9021.00
87_L112_Q0.8990.99
25_E137_K0.8960.99
99_K102_E0.8930.99
98_Q138_E0.8930.99
95_W235_E0.8920.99
160_L200_L0.8870.99
26_V58_V0.8860.99
175_E231_I0.8860.99
44_C146_N0.8810.99
103_L243_S0.8800.99
4_Y29_I0.8790.99
240_Y246_S0.8710.99
97_I108_F0.8710.99
152_M163_R0.8710.99
199_L245_I0.8700.99
92_K98_Q0.8680.99
3_R42_I0.8660.99
203_F238_P0.8660.99
162_Q165_Q0.8640.99
92_K235_E0.8600.99
75_R146_N0.8580.99
14_E17_P0.8550.99
21_I29_I0.8530.99
155_H159_Q0.8530.99
240_Y244_A0.8520.99
129_R151_V0.8500.99
19_F65_C0.8460.99
50_E73_E0.8370.99
167_F198_S0.8280.99
133_T150_R0.8260.99
36_N39_D0.8260.99
28_H141_E0.8230.99
203_F234_T0.8230.99
22_T26_V0.8210.99
43_C65_C0.8160.99
42_I52_K0.8140.99
155_H160_L0.8080.99
84_A109_I0.8080.99
45_S49_F0.8060.99
99_K239_L0.8060.99
160_L202_V0.8010.99
49_F72_N0.7940.99
158_Q162_Q0.7930.99
76_E230_R0.7820.99
41_I53_C0.7730.98
43_C53_C0.7650.98
21_I26_V0.7620.98
165_Q168_D0.7570.98
22_T25_E0.7560.98
4_Y28_H0.7560.98
175_E208_G0.7540.98
82_Y200_L0.7500.98
73_E146_N0.7500.98
101_T136_A0.7450.98
169_K197_S0.7420.98
103_L236_T0.7410.98
88_P93_L0.7360.98
137_K141_E0.7350.98
168_D197_S0.7330.98
109_I155_H0.7330.98
113_A209_L0.7310.98
174_Y224_T0.7310.98
209_L214_V0.7280.98
94_E135_I0.7270.98
133_T137_K0.7230.98
177_S180_Q0.7200.98
97_I151_V0.7170.98
140_A149_P0.7150.97
4_Y25_E0.7140.97
85_S108_F0.7100.97
56_Q64_S0.7070.97
50_E71_T0.7050.97
93_L97_I0.7020.97
142_Q233_R0.7020.97
110_P154_V0.6990.97
30_V55_L0.6930.97
100_G105_A0.6910.97
110_P155_H0.6890.97
50_E75_R0.6810.97
111_F202_V0.6770.96
160_L217_L0.6770.96
4_Y43_C0.6720.96
85_S93_L0.6690.96
176_E211_E0.6680.96
145_R230_R0.6650.96
6_I43_C0.6610.96
3_R50_E0.6600.96
7_E133_T0.6600.96
4_Y141_E0.6580.96
51_A67_V0.6580.96
194_P197_S0.6560.96
86_G209_L0.6530.96
128_K135_I0.6450.95
58_V63_V0.6410.95
126_K153_D0.6400.95
90_G118_V0.6360.95
126_K129_R0.6330.95
42_I71_T0.6310.95
29_I55_L0.6310.95
83_I242_L0.6300.95
77_L106_H0.6280.95
200_L222_G0.6240.94
26_V29_I0.6210.94
19_F43_C0.6200.94
135_I138_E0.6200.94
53_C68_I0.6190.94
82_Y152_M0.6180.94
125_A129_R0.6170.94
3_R44_C0.6170.94
84_A202_V0.6160.94
92_K95_W0.6140.94
115_R207_G0.6130.94
112_Q125_A0.6120.94
161_L220_Q0.6100.94
176_E214_V0.6100.94
37_E58_V0.6100.94
161_L164_M0.6090.94
160_L164_M0.6080.94
57_S62_K0.6070.94
127_K132_W0.6050.94
42_I144_Y0.6030.93
88_P92_K0.6030.93
100_G239_L0.6030.93
99_K236_T0.6020.93
139_A143_S0.6000.93
162_Q220_Q0.5980.93
169_K196_G0.5930.93
232_L237_A0.5910.93
86_G116_S0.5890.93
159_Q163_R0.5880.93
161_L217_L0.5860.92
103_L239_L0.5840.92
88_P118_V0.5830.92
87_L110_P0.5820.92
174_Y211_E0.5780.92
38_G56_Q0.5780.92
133_T151_V0.5770.92
234_T238_P0.5750.92
209_L213_E0.5740.92
209_L217_L0.5710.91
203_F241_A0.5690.91
173_A225_C0.5680.91
174_Y226_G0.5680.91
143_S146_N0.5670.91
109_I160_L0.5650.91
102_E139_A0.5640.91
27_H30_V0.5630.91
144_Y176_E0.5630.91
3_R144_Y0.5600.91
116_S205_P0.5590.91
217_L222_G0.5580.91
112_Q156_S0.5570.90
172_V224_T0.5570.90
98_Q236_T0.5550.90
245_I248_Q0.5550.90
82_Y106_H0.5550.90
125_A154_V0.5540.90
132_W154_V0.5520.90
242_L246_S0.5500.90
101_T139_A0.5500.90
164_M222_G0.5480.90
163_R166_D0.5470.90
133_T148_V0.5460.90
25_E43_C0.5440.89
21_I65_C0.5440.89
140_A145_R0.5430.89
13_I45_S0.5430.89
81_V245_I0.5430.89
193_L196_G0.5420.89
107_A163_R0.5390.89
110_P132_W0.5390.89
119_K128_K0.5370.89
92_K99_K0.5360.89
129_R136_A0.5360.89
59_S64_S0.5340.89
130_E134_K0.5330.88
83_I203_F0.5320.88
244_A248_Q0.5320.88
25_E28_H0.5300.88
82_Y167_F0.5290.88
96_I100_G0.5290.88
74_N146_N0.5280.88
21_I63_V0.5260.88
131_R138_E0.5240.88
28_H32_V0.5230.88
89_K116_S0.5220.87
112_Q116_S0.5220.87
101_T138_E0.5220.87
81_V199_L0.5220.87
129_R153_D0.5210.87
12_Q47_D0.5180.87
111_F209_L0.5170.87
13_I51_A0.5160.87
132_W136_A0.5150.87
179_K223_V0.5150.87
69_E219_E0.5130.87
92_K234_T0.5120.86
87_L154_V0.5120.86
173_A226_G0.5070.86
15_E68_I0.5060.86
170_C202_V0.5040.86
95_W234_T0.5030.85
180_Q186_F0.5020.85
26_V62_K0.5000.85
33_M231_I0.5000.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vhkA 3 0.9531 100 0.063 Contact Map
1vhyA 2 0.9492 100 0.081 Contact Map
4e8bA 2 0.9453 100 0.087 Contact Map
4l69A 2 0.9336 100 0.094 Contact Map
4j3cA 2 0.9219 100 0.105 Contact Map
3kw2A 2 0.9258 100 0.121 Contact Map
2egvA 2 0.8867 100 0.128 Contact Map
1v6zA 2 0.8828 100 0.134 Contact Map
1z85A 2 0.8438 100 0.161 Contact Map
2qmmA 2 0.7266 99.9 0.677 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0082 seconds.