GREMLIN Database
PRMA - Ribosomal protein L11 methyltransferase
UniProt: P54460 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 311 (252)
Sequences: 2493 (1823)
Seq/√Len: 114.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
265_L269_G3.9201.00
166_I192_A3.5121.00
243_D266_K3.5041.00
160_P302_E3.3931.00
194_A201_V3.1821.00
167_Q301_M2.8931.00
184_T214_A2.7651.00
180_I242_H2.6701.00
281_K305_V2.5711.00
163_V301_M2.5331.00
278_G300_S2.3201.00
122_K143_E2.3181.00
178_K200_S2.2961.00
130_V147_E2.2681.00
171_R297_E2.2421.00
168_A308_I2.2071.00
132_T149_D2.1841.00
176_G199_E2.1611.00
174_Q177_D2.1551.00
282_Q286_E2.1481.00
298_I307_I2.1151.00
113_A116_K2.0641.00
173_V177_D2.0611.00
255_L287_A2.0531.00
200_S228_Q2.0481.00
194_A226_I2.0421.00
270_H310_K2.0021.00
179_V193_A2.0011.00
202_H242_H1.9871.00
168_A306_S1.9561.00
255_L283_E1.9241.00
255_L284_V1.9131.00
285_K289_E1.9081.00
245_I265_L1.8761.00
300_S305_V1.8691.00
287_A290_Q1.8581.00
233_N236_D1.8331.00
294_T310_K1.8311.00
281_K298_I1.8301.00
284_V287_A1.7951.00
119_H134_E1.7781.00
281_K307_I1.7721.00
127_F166_I1.7711.00
108_E113_A1.7491.00
300_S303_D1.7081.00
112_T115_K1.6971.00
214_A229_V1.6491.00
295_I298_I1.6491.00
262_Y293_F1.6221.00
278_G303_D1.6041.00
281_K300_S1.5971.00
124_S170_E1.5951.00
161_T274_S1.5771.00
203_A227_A1.5721.00
288_L309_A1.5541.00
203_A229_V1.5491.00
281_K285_K1.5431.00
265_L293_F1.5251.00
250_L280_K1.5121.00
249_I253_V1.5071.00
126_K144_L1.4651.00
130_V145_I1.4471.00
136_Y143_E1.4471.00
203_A214_A1.4161.00
258_T284_V1.4111.00
296_V310_K1.3861.00
172_F308_I1.3841.00
128_T136_Y1.3791.00
172_F272_I1.3721.00
190_S201_V1.3651.00
127_F192_A1.3641.00
167_Q299_L1.3631.00
246_V272_I1.3631.00
125_E170_E1.3531.00
126_K170_E1.3521.00
216_L219_K1.3411.00
258_T288_L1.3371.00
144_L195_M1.3371.00
245_I261_A1.2961.00
124_S167_Q1.2920.99
254_I271_F1.2820.99
129_I166_I1.2760.99
280_K283_E1.2580.99
208_P231_Q1.2510.99
171_R299_L1.2430.99
194_A227_A1.2410.99
208_P212_E1.2350.99
202_H230_K1.2330.99
179_V201_V1.2280.99
194_A223_V1.2260.99
287_A291_A1.2140.99
270_H308_I1.2070.99
179_V246_V1.2020.99
285_K298_I1.1980.99
178_K199_E1.1970.99
128_T143_E1.1920.99
169_L174_Q1.1880.99
260_Q263_S1.1740.99
286_E289_E1.1740.99
279_H303_D1.1730.99
184_T190_S1.1680.99
179_V198_A1.1580.99
146_I192_A1.1540.99
244_V270_H1.1340.99
295_I307_I1.1320.99
201_V227_A1.1290.99
212_E216_L1.1270.99
190_S227_A1.1180.99
254_I273_T1.1080.98
209_V213_S1.0760.98
179_V244_V1.0670.98
295_I309_A1.0650.98
187_G214_A1.0640.98
131_P150_P1.0540.98
136_Y145_I1.0520.98
115_K133_W1.0490.98
164_L250_L1.0440.98
125_E171_R1.0430.98
164_L306_S1.0410.98
60_E63_I1.0400.98
259_S287_A1.0370.98
245_I264_L1.0360.98
219_K224_S1.0360.98
73_F76_E1.0340.98
123_I163_V1.0330.98
75_G79_D1.0320.98
258_T291_A1.0270.97
182_V204_Y1.0260.97
172_F270_H1.0160.97
286_E290_Q1.0140.97
271_F309_A1.0100.97
112_T116_K1.0050.97
215_R219_K1.0010.97
129_I146_I0.9940.97
58_P61_G0.9890.97
191_I223_V0.9870.97
180_I264_L0.9750.96
218_L227_A0.9610.96
284_V307_I0.9580.96
266_K269_G0.9530.96
163_V167_Q0.9520.96
285_K295_I0.9490.96
223_V227_A0.9450.96
111_A114_W0.9400.96
114_W118_Y0.9370.96
78_V82_K0.9350.96
241_E263_S0.9230.95
132_T220_L0.9210.95
195_M222_K0.9170.95
114_W117_Y0.9110.95
95_L98_N0.9080.95
79_D83_E0.9070.95
261_A293_F0.9070.95
194_A218_L0.8950.94
122_K128_T0.8900.94
232_N237_G0.8870.94
278_G305_V0.8850.94
254_I288_L0.8800.94
121_V158_T0.8730.94
165_C272_I0.8730.94
126_K143_E0.8700.93
127_F196_L0.8700.93
111_A115_K0.8690.93
195_M199_E0.8650.93
148_M186_S0.8620.93
74_L77_T0.8610.93
178_K240_G0.8570.93
241_E266_K0.8540.93
120_P134_E0.8530.93
202_H240_G0.8530.93
78_V102_I0.8470.93
180_I240_G0.8390.92
232_N235_L0.8370.92
78_V100_I0.8360.92
131_P134_E0.8330.92
259_S291_A0.8330.92
109_E112_T0.8320.92
164_L299_L0.8300.92
299_L306_S0.8300.92
244_V272_I0.8280.92
273_T307_I0.8260.92
118_Y129_I0.8260.92
211_V229_V0.8220.91
180_I245_I0.8200.91
277_I280_K0.8100.91
282_Q285_K0.8070.91
219_K222_K0.8070.91
152_M213_S0.8040.90
186_S251_A0.8000.90
262_Y265_L0.7970.90
111_A117_Y0.7910.90
153_A210_A0.7800.89
259_S290_Q0.7790.89
273_T309_A0.7760.89
54_P57_Y0.7760.89
285_K307_I0.7750.89
241_E264_L0.7740.89
133_W150_P0.7710.89
202_H228_Q0.7670.88
140_H143_E0.7630.88
252_E255_L0.7610.88
218_L223_V0.7610.88
146_I195_M0.7610.88
190_S203_A0.7580.88
234_L237_G0.7580.88
253_V288_L0.7570.88
122_K125_E0.7570.88
132_T147_E0.7550.87
194_A224_S0.7480.87
209_V212_E0.7470.87
36_L61_G0.7470.87
86_N89_L0.7430.87
251_A284_V0.7400.86
121_V188_I0.7390.86
177_D244_V0.7360.86
124_S143_E0.7310.86
283_E286_E0.7300.86
229_V232_N0.7240.85
174_Q244_V0.7230.85
247_A254_I0.7220.85
213_S250_L0.7160.85
213_S216_L0.7140.84
178_K242_H0.7110.84
131_P149_D0.7110.84
178_K241_E0.7080.84
285_K309_A0.7040.84
191_I252_E0.7030.84
270_H296_V0.7020.83
296_V299_L0.7000.83
272_I308_I0.6950.83
147_E222_K0.6950.83
194_A225_D0.6910.82
169_L196_L0.6910.82
70_V104_E0.6880.82
282_Q289_E0.6860.82
84_T87_N0.6850.82
124_S146_I0.6850.82
73_F77_T0.6840.82
129_I192_A0.6840.82
276_I280_K0.6810.82
260_Q264_L0.6750.81
276_I305_V0.6730.81
178_K266_K0.6710.81
173_V244_V0.6710.81
169_L193_A0.6690.80
80_G84_T0.6600.79
130_V148_M0.6580.79
79_D82_K0.6570.79
76_E80_G0.6550.79
261_A273_T0.6540.79
182_V235_L0.6540.79
192_A195_M0.6530.79
249_I254_I0.6520.79
195_M226_I0.6520.79
135_E147_E0.6510.79
130_V134_E0.6490.78
128_T137_T0.6470.78
137_T145_I0.6470.78
258_T287_A0.6450.78
152_M209_V0.6440.78
169_L172_F0.6430.78
190_S218_L0.6400.77
173_V246_V0.6350.77
118_Y148_M0.6330.77
164_L194_A0.6330.77
65_K103_S0.6300.76
242_H245_I0.6280.76
118_Y132_T0.6250.76
150_P197_E0.6250.76
169_L272_I0.6230.75
111_A152_M0.6210.75
169_L246_V0.6190.75
252_E283_E0.6170.75
212_E215_R0.6170.75
122_K140_H0.6160.75
283_E287_A0.6140.74
85_I88_L0.6120.74
218_L229_V0.6110.74
118_Y253_V0.6100.74
149_D251_A0.6080.74
151_G280_K0.6080.74
136_Y146_I0.6080.74
69_P73_F0.6050.73
150_P198_A0.6040.73
118_Y204_Y0.6020.73
192_A196_L0.6010.73
137_T142_D0.6010.73
204_Y232_N0.6000.73
211_V214_A0.6000.73
147_E220_L0.5990.73
82_K86_N0.5990.73
168_A299_L0.5970.72
108_E111_A0.5960.72
86_N294_T0.5940.72
151_G213_S0.5930.72
228_Q231_Q0.5930.72
111_A156_T0.5920.72
169_L244_V0.5920.72
247_A271_F0.5910.72
210_A247_A0.5890.71
114_W150_P0.5880.71
132_T213_S0.5870.71
254_I284_V0.5850.71
164_L168_A0.5840.71
167_Q302_E0.5830.71
250_L253_V0.5830.71
180_I241_E0.5820.70
177_D243_D0.5820.70
66_A105_V0.5800.70
108_E112_T0.5780.70
261_A271_F0.5740.69
262_Y291_A0.5730.69
234_L260_Q0.5730.69
83_E310_K0.5710.69
130_V152_M0.5690.69
113_A117_Y0.5680.69
150_P164_L0.5670.69
124_S128_T0.5650.68
137_T143_E0.5630.68
258_T271_F0.5610.68
178_K202_H0.5610.68
255_L258_T0.5580.67
182_V257_F0.5550.67
265_L271_F0.5550.67
110_W191_I0.5520.66
195_M223_V0.5510.66
125_E167_Q0.5500.66
126_K196_L0.5500.66
130_V136_Y0.5480.66
76_E239_E0.5470.66
89_L95_L0.5460.66
210_A214_A0.5450.65
182_V261_A0.5430.65
127_F144_L0.5420.65
109_E251_A0.5410.65
211_V231_Q0.5400.65
131_P276_I0.5380.64
114_W253_V0.5380.64
242_H269_G0.5370.64
59_D168_A0.5360.64
151_G250_L0.5340.64
289_E295_I0.5340.64
204_Y237_G0.5330.64
276_I284_V0.5320.64
214_A220_L0.5310.63
165_C250_L0.5310.63
284_V292_G0.5280.63
75_G78_V0.5280.63
292_G295_I0.5280.63
130_V184_T0.5250.63
251_A283_E0.5220.62
66_A158_T0.5220.62
214_A247_A0.5180.62
66_A302_E0.5170.61
114_W158_T0.5170.61
148_M151_G0.5160.61
121_V206_L0.5140.61
168_A297_E0.5130.61
115_K131_P0.5130.61
264_L268_G0.5110.61
173_V198_A0.5100.60
258_T292_G0.5100.60
133_W151_G0.5090.60
199_E310_K0.5090.60
179_V238_I0.5090.60
148_M213_S0.5080.60
133_W145_I0.5060.60
235_L238_I0.5050.60
150_P191_I0.5040.60
110_W217_N0.5040.60
120_P210_A0.5030.59
241_E267_E0.5030.59
118_Y257_F0.5000.59
207_D253_V0.5000.59
210_A213_S0.5000.59
97_R201_V0.5000.59
123_I166_I0.5000.59
164_L274_S0.5000.59
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2nxcA 1 0.7974 100 0.434 Contact Map
3grzA 2 0.6238 100 0.656 Contact Map
3b3jA 1 0.5305 100 0.724 Contact Map
3gczA 1 0.6109 100 0.726 Contact Map
4pwyA 2 0.6238 99.9 0.739 Contact Map
3bzbA 1 0.5241 99.9 0.75 Contact Map
1u2zA 1 0.9068 99.9 0.761 Contact Map
3dmgA 1 0.9164 99.9 0.763 Contact Map
3lcvB 1 0.717 99.9 0.764 Contact Map
3gnlA 1 0.4855 99.9 0.775 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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