GREMLIN Database
YQEN - Uncharacterized protein YqeN
UniProt: P54459 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 347 (292)
Sequences: 11255 (7320)
Seq/√Len: 428.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
230_K233_E4.1661.00
152_T172_E3.4901.00
156_V168_T3.4021.00
156_V171_A3.3771.00
147_N150_E3.3291.00
165_T201_E3.1841.00
203_T206_D2.9871.00
167_G170_A2.6661.00
204_L208_K2.6431.00
167_G201_E2.6361.00
316_Y320_T2.4991.00
169_E204_L2.4031.00
152_T156_V2.2951.00
6_W10_K2.2931.00
226_I258_Q2.2461.00
87_T97_H2.2371.00
157_N161_T2.2091.00
154_F182_L2.1831.00
20_L143_A2.1631.00
313_V317_E2.1481.00
159_A189_I2.0811.00
167_G203_T2.0321.00
31_T143_A2.0321.00
152_T171_A2.0241.00
146_L182_L1.9941.00
173_H204_L1.9711.00
156_V160_K1.9361.00
164_K193_C1.9291.00
155_T185_I1.9141.00
58_P61_Q1.9131.00
151_T185_I1.9011.00
205_D209_M1.8741.00
166_I171_A1.8541.00
289_V293_M1.8541.00
159_A166_I1.8391.00
267_Y301_E1.8301.00
243_K319_K1.8151.00
315_D319_K1.7901.00
61_Q64_A1.7841.00
266_K301_E1.7781.00
50_S65_D1.7671.00
15_H18_Y1.7091.00
152_T175_V1.7091.00
294_D298_L1.7041.00
158_L186_F1.6941.00
151_T175_V1.6801.00
153_D157_N1.6641.00
75_R114_V1.6461.00
64_A68_T1.6331.00
33_S51_V1.6241.00
108_S112_Y1.6111.00
277_Q280_S1.6061.00
205_D208_K1.5961.00
300_S303_E1.5881.00
265_T293_M1.5861.00
225_K233_E1.5411.00
63_I66_A1.5371.00
155_T171_A1.5351.00
153_D156_V1.5311.00
21_Y140_M1.5251.00
61_Q65_D1.5141.00
224_N228_N1.5141.00
170_A207_V1.4981.00
64_A67_E1.4881.00
175_V185_I1.4871.00
239_Y243_K1.4871.00
50_S76_R1.4751.00
257_N261_L1.4641.00
39_V114_V1.4521.00
148_A176_L1.4441.00
223_I259_F1.4381.00
168_T172_E1.4251.00
7_K10_K1.4161.00
290_K294_D1.4011.00
148_A152_T1.4011.00
70_P112_Y1.3971.00
148_A172_E1.3941.00
225_K237_I1.3891.00
57_D61_Q1.3831.00
259_F307_I1.3831.00
171_A175_V1.3821.00
236_Q240_D1.3661.00
154_F157_N1.3641.00
152_T168_T1.3491.00
227_V299_F1.3461.00
58_P63_I1.3341.00
258_Q295_Q1.3341.00
188_E191_K1.3291.00
310_Q314_M1.3261.00
178_V185_I1.3201.00
148_A175_V1.3181.00
104_S107_Q1.3081.00
277_Q281_N1.3071.00
7_K11_K1.3041.00
170_A204_L1.3011.00
312_A315_D1.2961.00
49_L79_I1.2881.00
57_D60_D1.2861.00
313_V316_Y1.2671.00
309_E313_V1.2661.00
150_E153_D1.2601.00
173_H208_K1.2421.00
224_N291_L1.2331.00
77_L116_V1.2311.00
173_H176_L1.2241.00
19_C138_A1.2181.00
173_H177_L1.2131.00
206_D209_M1.2091.00
233_E237_I1.2071.00
308_I312_A1.2011.00
276_K280_S1.2001.00
149_K153_D1.1991.00
214_S217_Q1.1981.00
290_K293_M1.1871.00
174_L188_E1.1741.00
238_F242_L1.1721.00
172_E176_L1.1641.00
88_G97_H1.1551.00
196_I206_D1.1431.00
151_T182_L1.1371.00
223_I258_Q1.1361.00
60_D101_A1.1331.00
48_N69_F1.1241.00
79_I118_L1.1171.00
246_E250_K1.1161.00
21_Y142_E1.1151.00
231_R235_L1.1141.00
219_I223_I1.1121.00
265_T296_A1.1101.00
190_Q194_T1.1081.00
287_F290_K1.1061.00
253_A315_D1.0931.00
51_V81_K1.0881.00
149_K152_T1.0821.00
288_R291_L1.0821.00
220_F224_N1.0761.00
276_K281_N1.0621.00
309_E312_A1.0591.00
260_R293_M1.0471.00
293_M297_R1.0461.00
305_R309_E1.0421.00
242_L248_P1.0401.00
20_L31_T1.0371.00
288_R312_A1.0361.00
216_E220_F1.0231.00
262_I304_L1.0211.00
128_K131_T1.0151.00
286_P289_V1.0151.00
286_P290_K1.0151.00
83_P115_F1.0031.00
46_D73_G1.0031.00
177_L211_V1.0021.00
318_M321_G1.0001.00
155_T189_I1.0001.00
53_D56_E0.9961.00
35_I116_V0.9891.00
173_H207_V0.9891.00
245_N248_P0.9881.00
311_L315_D0.9851.00
224_N295_Q0.9821.00
279_A287_F0.9771.00
66_A78_V0.9771.00
145_E179_N0.9761.00
135_K140_M0.9761.00
232_T236_Q0.9751.00
15_H139_F0.9751.00
266_K304_L0.9641.00
226_I298_L0.9631.00
48_N74_E0.9601.00
255_I295_Q0.9591.00
23_K26_Y0.9551.00
151_T155_T0.9511.00
59_L63_I0.9491.00
240_D244_Q0.9431.00
157_N160_K0.9371.00
155_T175_V0.9361.00
303_E307_I0.9351.00
262_I266_K0.9291.00
229_R303_E0.9281.00
256_S308_I0.9261.00
247_E250_K0.9211.00
12_G39_V0.9171.00
174_L207_V0.9121.00
259_F311_L0.9021.00
237_I240_D0.9011.00
125_D128_K0.8961.00
8_S15_H0.8921.00
317_E321_G0.8891.00
306_L310_Q0.8871.00
261_L264_Q0.8861.00
14_V114_V0.8861.00
36_R77_L0.8841.00
32_V36_R0.8771.00
265_T292_A0.8721.00
80_V117_L0.8701.00
107_Q137_H0.8701.00
314_M318_M0.8701.00
207_V211_V0.8651.00
104_S108_S0.8631.00
107_Q133_A0.8581.00
223_I257_N0.8561.00
144_K147_N0.8561.00
35_I39_V0.8511.00
241_L251_I0.8481.00
171_A185_I0.8481.00
103_E133_A0.8471.00
34_R37_Q0.8471.00
243_K315_D0.8471.00
29_Q81_K0.8401.00
263_L304_L0.8401.00
310_Q313_V0.8361.00
221_E224_N0.8341.00
222_L226_I0.8341.00
154_F158_L0.8301.00
258_Q261_L0.8261.00
48_N65_D0.8241.00
166_I170_A0.8221.00
181_H184_S0.8221.00
225_K230_K0.8201.00
221_E237_I0.8151.00
224_N227_V0.8121.00
234_S238_F0.8091.00
60_D63_I0.8051.00
47_F54_L0.8041.00
39_V75_R0.8031.00
188_E211_V0.8021.00
223_I226_I0.7901.00
100_S131_T0.7861.00
166_I202_I0.7851.00
217_Q220_F0.7841.00
63_I105_Y0.7831.00
266_K270_E0.7831.00
52_F58_P0.7821.00
223_I227_V0.7811.00
23_K181_H0.7811.00
312_A316_Y0.7791.00
248_P251_I0.7781.00
293_M296_A0.7771.00
294_D297_R0.7721.00
100_S103_E0.7701.00
100_S104_S0.7661.00
46_D54_L0.7651.00
256_S311_L0.7651.00
218_N221_E0.7611.00
291_L295_Q0.7581.00
29_Q33_S0.7571.00
264_Q268_F0.7571.00
215_L218_N0.7571.00
260_R264_Q0.7561.00
261_L292_A0.7541.00
222_L251_I0.7511.00
83_P117_L0.7471.00
217_Q221_E0.7411.00
207_V210_L0.7401.00
133_A137_H0.7391.00
221_E233_E0.7361.00
284_V288_R0.7321.00
291_L294_D0.7301.00
231_R234_S0.7291.00
218_N240_D0.7281.00
250_K253_A0.7271.00
252_M314_M0.7271.00
126_E131_T0.7261.00
66_A113_T0.7251.00
269_A297_R0.7211.00
247_E251_I0.7191.00
57_D62_A0.7191.00
259_F304_L0.7131.00
276_K279_A0.7091.00
224_N298_L0.7091.00
158_L161_T0.7071.00
191_K194_T0.7061.00
219_I250_K0.7041.00
86_L98_N0.7041.00
263_L298_L0.6991.00
221_E240_D0.6951.00
264_Q267_Y0.6951.00
288_R315_D0.6941.00
78_V113_T0.6921.00
77_L114_V0.6921.00
159_A193_C0.6901.00
68_T71_F0.6901.00
170_A174_L0.6841.00
204_L207_V0.6831.00
83_P130_L0.6821.00
103_E107_Q0.6771.00
18_Y141_M0.6741.00
58_P66_A0.6731.00
314_M317_E0.6721.00
235_L239_Y0.6711.00
249_I253_A0.6711.00
65_D76_R0.6691.00
33_S37_Q0.6681.00
235_L241_L0.6651.00
158_L162_E0.6621.00
220_F258_Q0.6621.00
255_I258_Q0.6611.00
164_K200_E0.6600.99
285_H288_R0.6600.99
250_K254_L0.6590.99
25_T28_L0.6580.99
51_V79_I0.6560.99
80_V83_P0.6540.99
237_I241_L0.6530.99
87_T98_N0.6530.99
230_K236_Q0.6520.99
257_N289_V0.6510.99
261_L265_T0.6500.99
48_N70_P0.6470.99
125_D131_T0.6450.99
203_T207_V0.6450.99
146_L150_E0.6440.99
265_T268_F0.6430.99
188_E192_L0.6430.99
126_E135_K0.6420.99
266_K300_S0.6400.99
174_L185_I0.6400.99
160_K166_I0.6390.99
249_I280_S0.6380.99
167_G204_L0.6370.99
169_E172_E0.6350.99
233_E236_Q0.6340.99
63_I67_E0.6330.99
66_A105_Y0.6330.99
285_H292_A0.6330.99
218_N222_L0.6320.99
279_A284_V0.6310.99
262_I296_A0.6310.99
107_Q136_K0.6280.99
105_Y108_S0.6270.99
175_V180_G0.6260.99
252_M256_S0.6250.99
285_H289_V0.6240.99
206_D210_L0.6190.99
282_L290_K0.6190.99
299_F303_E0.6180.99
249_I276_K0.6180.99
256_S260_R0.6160.99
48_N52_F0.6130.99
178_V181_H0.6100.99
56_E105_Y0.6080.99
255_I259_F0.6080.99
69_F74_E0.6070.99
306_L309_E0.6060.99
60_D64_A0.6060.99
46_D49_L0.6030.99
296_A307_I0.6010.99
260_R263_L0.6010.99
287_F291_L0.6010.99
248_P252_M0.5930.99
240_D243_K0.5910.99
270_E297_R0.5910.99
101_A104_S0.5900.99
30_E33_S0.5900.99
213_R217_Q0.5880.99
259_F299_F0.5860.99
125_D130_L0.5860.99
241_L246_E0.5850.99
132_K135_K0.5820.99
259_F263_L0.5820.99
65_D69_F0.5820.99
60_D66_A0.5810.99
296_A300_S0.5800.99
75_R112_Y0.5800.99
48_N51_V0.5800.99
201_E206_D0.5790.99
238_F295_Q0.5770.99
253_A257_N0.5750.99
317_E322_K0.5740.99
238_F241_L0.5730.99
228_N298_L0.5710.99
189_I193_C0.5700.99
288_R292_A0.5700.99
303_E306_L0.5690.99
197_G200_E0.5670.98
14_V39_V0.5660.98
242_L284_V0.5660.98
154_F186_F0.5650.98
296_A308_I0.5650.98
220_F223_I0.5620.98
258_Q262_I0.5600.98
134_L138_A0.5590.98
67_E108_S0.5590.98
239_Y318_M0.5590.98
159_A171_A0.5570.98
127_R140_M0.5570.98
26_Y143_A0.5560.98
32_V118_L0.5530.98
48_N54_L0.5520.98
203_T210_L0.5510.98
162_E193_C0.5510.98
299_F304_L0.5490.98
80_V102_L0.5490.98
215_L246_E0.5470.98
12_G75_R0.5470.98
263_L308_I0.5460.98
101_A105_Y0.5440.98
195_F210_L0.5440.98
149_K172_E0.5440.98
246_E249_I0.5410.98
24_E27_L0.5410.98
278_I290_K0.5400.98
59_L62_A0.5400.98
246_E251_I0.5380.98
85_F100_S0.5370.98
46_D56_E0.5350.98
301_E305_R0.5330.98
258_Q298_L0.5310.98
262_I292_A0.5310.98
81_K118_L0.5300.98
261_L284_V0.5300.98
219_I227_V0.5300.98
36_R79_I0.5290.98
192_L207_V0.5290.98
105_Y115_F0.5270.98
285_H291_L0.5250.97
279_A282_L0.5250.97
251_I254_L0.5240.97
159_A164_K0.5220.97
212_A215_L0.5190.97
185_I189_I0.5180.97
193_C196_I0.5170.97
28_L118_L0.5170.97
221_E225_K0.5160.97
216_E219_I0.5160.97
262_I295_Q0.5160.97
295_Q299_F0.5150.97
46_D52_F0.5140.97
29_Q183_S0.5120.97
256_S276_K0.5120.97
279_A289_V0.5050.97
268_F293_M0.5040.97
34_R38_T0.5040.97
182_L185_I0.5030.97
254_L257_N0.5030.97
19_C83_P0.5010.97
116_V143_A0.5000.97
166_I169_E0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zh9B 1 0.9769 100 0.225 Contact Map
1jr3D 1 0.9452 100 0.299 Contact Map
1jr3A 3 0.9222 100 0.385 Contact Map
1a5tA 2 0.83 100 0.43 Contact Map
1sxjD 1 0.8357 100 0.469 Contact Map
2chqA 3 0.8271 100 0.471 Contact Map
1iqpA 5 0.83 100 0.474 Contact Map
3u61B 3 0.8012 100 0.487 Contact Map
1sxjB 1 0.8242 100 0.503 Contact Map
1sxjC 1 0.8386 100 0.503 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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