GREMLIN Database
YQEM - Putative methyltransferase YqeM
UniProt: P54458 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 247 (209)
Sequences: 7134 (5973)
Seq/√Len: 413.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
67_L84_Q3.3211.00
35_R56_E3.3031.00
58_T97_F3.2061.00
98_D128_K3.1481.00
123_V133_L2.9441.00
64_E84_Q2.8991.00
37_L97_F2.8881.00
47_S57_V2.8291.00
122_S125_R2.7211.00
70_A82_F2.6891.00
40_A106_S2.5901.00
67_L82_F2.4311.00
39_L123_V2.4181.00
41_C59_G2.2771.00
64_E68_S2.2211.00
88_R115_D2.1811.00
61_D67_L2.0861.00
56_E81_L2.0781.00
91_T122_S2.0571.00
58_T83_L2.0511.00
74_V82_F1.9971.00
36_I50_L1.9831.00
117_I211_N1.9731.00
60_I85_Q1.8731.00
48_I74_V1.8541.00
69_F72_Q1.8341.00
100_V127_L1.7811.00
48_I73_K1.7611.00
35_R128_K1.7211.00
100_V123_V1.7191.00
122_S126_V1.7101.00
119_T123_V1.6881.00
40_A102_I1.6731.00
90_I122_S1.6491.00
35_R95_G1.6421.00
47_S59_G1.6301.00
74_V78_Q1.6251.00
110_L119_T1.6201.00
11_D43_T1.6141.00
60_I90_I1.6041.00
127_L131_G1.5911.00
27_E53_K1.5781.00
35_R98_D1.5591.00
201_P204_E1.5241.00
96_Q128_K1.5171.00
19_Y22_W1.5091.00
39_L87_M1.5051.00
36_I55_F1.5041.00
74_V80_I1.4931.00
11_D73_K1.4771.00
59_G70_A1.4451.00
36_I101_V1.4421.00
87_M106_S1.4401.00
24_K53_K1.4201.00
206_E210_K1.4081.00
117_I121_K1.3961.00
118_E121_K1.3911.00
41_C70_A1.3841.00
24_K28_A1.3811.00
20_D49_R1.3771.00
58_T81_L1.3671.00
65_E68_S1.3291.00
41_C47_S1.3191.00
127_L133_L1.3171.00
51_A80_I1.3051.00
93_F126_V1.2921.00
46_I103_C1.2841.00
39_L119_T1.2841.00
124_F214_F1.2791.00
36_I99_A1.2751.00
207_E211_N1.2651.00
86_D89_E1.2601.00
26_I103_C1.2591.00
35_R58_T1.2401.00
48_I52_E1.2391.00
93_F96_Q1.2381.00
67_L71_Q1.2021.00
59_G82_F1.1941.00
100_V126_V1.1891.00
109_Y195_H1.1731.00
62_L86_D1.1711.00
47_S82_F1.1701.00
41_C61_D1.1681.00
49_R52_E1.1661.00
111_K115_D1.1631.00
37_L100_V1.1561.00
202_V206_E1.1501.00
30_L99_A1.1211.00
118_E122_S1.1051.00
74_V77_S1.0991.00
38_D101_V1.0821.00
204_E207_E1.0691.00
52_E78_Q1.0581.00
116_V208_M1.0551.00
91_T126_V1.0551.00
40_A87_M1.0541.00
35_R97_F1.0331.00
93_F97_F1.0321.00
71_Q75_S1.0271.00
34_G55_F1.0261.00
34_G99_A1.0251.00
91_T125_R1.0221.00
121_K125_R1.0201.00
146_V150_S1.0181.00
123_V127_L1.0181.00
115_D118_E1.0081.00
22_W26_I1.0011.00
117_I208_M1.0011.00
63_S66_M1.0011.00
137_V205_Y0.9761.00
43_T66_M0.9741.00
147_F150_S0.9681.00
69_F73_K0.9621.00
35_R96_Q0.9601.00
13_L16_H0.9571.00
38_D59_G0.9541.00
39_L60_I0.9531.00
75_S78_Q0.9511.00
146_V149_D0.9481.00
87_M110_L0.9421.00
207_E210_K0.9401.00
68_S71_Q0.9391.00
18_P22_W0.9351.00
171_E175_I0.9261.00
20_D24_K0.9261.00
94_D126_V0.9211.00
23_T27_E0.9161.00
107_L120_F0.9161.00
25_W28_A0.9161.00
49_R53_K0.9081.00
51_A78_Q0.9031.00
45_E49_R0.8941.00
203_E206_E0.8941.00
136_D139_S0.8941.00
45_E73_K0.8911.00
104_C109_Y0.8841.00
68_S72_Q0.8821.00
108_N138_H0.8791.00
21_Q24_K0.8741.00
168_G171_E0.8731.00
138_H141_F0.8691.00
206_E219_V0.8661.00
90_I126_V0.8661.00
96_Q126_V0.8651.00
113_K204_E0.8641.00
107_L116_V0.8631.00
97_F126_V0.8581.00
107_L110_L0.8481.00
22_W25_W0.8471.00
155_Q159_I0.8451.00
146_V151_T0.8361.00
51_A79_P0.8351.00
18_P21_Q0.8311.00
156_D159_I0.8311.00
202_V219_V0.8281.00
106_S110_L0.8221.00
104_C108_N0.8181.00
60_I83_L0.8151.00
94_D125_R0.8061.00
154_D158_D0.8021.00
145_E149_D0.8001.00
48_I82_F0.7951.00
155_Q160_S0.7901.00
176_H180_F0.7861.00
163_W166_F0.7851.00
34_G98_D0.7791.00
10_Y13_L0.7781.00
102_I106_S0.7701.00
107_L135_F0.7691.00
47_S51_A0.7661.00
36_I57_V0.7631.00
25_W29_S0.7561.00
178_M181_F0.7561.00
172_L176_H0.7561.00
157_E160_S0.7551.00
9_V13_L0.7491.00
43_T69_F0.7451.00
125_R128_K0.7431.00
48_I78_Q0.7421.00
113_K117_I0.7391.00
47_S80_I0.7331.00
26_I134_L0.7241.00
19_Y23_T0.7241.00
155_Q158_D0.7201.00
61_D82_F0.7201.00
117_I212_C0.7141.00
177_D181_F0.7071.00
175_I178_M0.7061.00
173_S176_H0.7051.00
153_A157_E0.6991.00
85_Q122_S0.6961.00
11_D16_H0.6931.00
99_A132_I0.6901.00
40_A62_L0.6881.00
114_N117_I0.6851.00
88_R118_E0.6841.00
120_F124_F0.6811.00
113_K198_R0.6771.00
38_D41_C0.6761.00
17_A20_D0.6741.00
10_Y14_M0.6720.99
173_S177_D0.6690.99
75_S79_P0.6680.99
174_V178_M0.6680.99
46_I101_V0.6650.99
95_G126_V0.6620.99
71_Q81_L0.6610.99
116_V120_F0.6600.99
62_L84_Q0.6590.99
159_I162_I0.6580.99
61_D66_M0.6570.99
120_F133_L0.6560.99
38_D104_C0.6540.99
203_E207_E0.6520.99
47_S50_L0.6510.99
85_Q91_T0.6500.99
96_Q125_R0.6490.99
144_A147_F0.6470.99
71_Q74_V0.6470.99
17_A23_T0.6470.99
171_E176_H0.6430.99
11_D14_M0.6340.99
145_E152_F0.6290.99
46_I50_L0.6280.99
171_E174_V0.6220.99
107_L137_V0.6200.99
100_V131_G0.6180.99
87_M102_I0.6180.99
85_Q90_I0.6110.99
43_T73_K0.6110.99
62_L87_M0.6090.99
104_C138_H0.6080.99
23_T26_I0.6070.99
210_K216_L0.6060.99
113_K208_M0.6050.99
113_K207_E0.6030.99
26_I30_L0.6000.99
195_H199_T0.5990.99
64_E71_Q0.5990.99
177_D194_T0.5990.99
208_M212_C0.5980.99
95_G125_R0.5970.99
8_S69_F0.5960.99
17_A21_Q0.5940.99
174_V177_D0.5940.99
187_A191_F0.5930.99
157_E163_W0.5930.99
56_E95_G0.5920.99
148_P151_T0.5910.99
39_L100_V0.5910.99
107_L119_T0.5890.99
38_D57_V0.5880.99
108_N137_V0.5870.99
37_L126_V0.5830.99
109_Y116_V0.5820.99
95_G128_K0.5820.99
166_F169_S0.5820.99
102_I116_V0.5810.99
144_A150_S0.5790.98
89_E122_S0.5790.98
20_D23_T0.5790.98
91_T94_D0.5790.98
90_I93_F0.5770.98
176_H179_S0.5770.98
88_R119_T0.5770.98
216_L219_V0.5710.98
103_C108_N0.5700.98
198_R204_E0.5670.98
184_N187_A0.5640.98
125_R129_P0.5630.98
9_V14_M0.5610.98
145_E148_P0.5600.98
191_F195_H0.5600.98
119_T122_S0.5600.98
46_I49_R0.5580.98
33_K98_D0.5580.98
176_H181_F0.5560.98
120_F135_F0.5550.98
180_F183_W0.5500.98
154_D159_I0.5490.98
11_D69_F0.5440.98
44_G57_V0.5410.98
72_Q75_S0.5400.98
132_I217_H0.5400.98
71_Q82_F0.5370.98
25_W220_T0.5350.98
108_N200_F0.5340.97
27_E31_P0.5340.97
14_M19_Y0.5340.97
102_I135_F0.5330.97
38_D102_I0.5310.97
188_Y195_H0.5300.97
199_T202_V0.5260.97
144_A149_D0.5250.97
161_Y165_S0.5240.97
186_E189_D0.5240.97
22_W103_C0.5240.97
179_S183_W0.5220.97
147_F151_T0.5210.97
87_M119_T0.5180.97
172_L175_I0.5170.97
85_Q89_E0.5150.97
167_A172_L0.5120.97
175_I180_F0.5120.97
139_S142_K0.5110.97
61_D84_Q0.5080.97
136_D140_S0.5070.97
36_I54_G0.5060.97
22_W29_S0.5060.97
141_F145_E0.5030.96
106_S109_Y0.5020.96
38_D46_I0.5010.96
108_N136_D0.5010.96
200_F208_M0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1y8cA 1 0.9717 100 0.333 Contact Map
3d2lA 1 0.9717 100 0.346 Contact Map
4hgzA 4 0.9271 100 0.384 Contact Map
3thrA 3 0.9798 100 0.407 Contact Map
1wznA 4 0.9312 100 0.41 Contact Map
3bxoA 2 0.915 100 0.42 Contact Map
5bszA 3 0.9312 100 0.427 Contact Map
3pfgA 2 0.9271 100 0.436 Contact Map
3g2mA 2 0.8785 100 0.44 Contact Map
1ri5A 1 0.8502 100 0.454 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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