GREMLIN Database
YQEK - Uncharacterized protein YqeK
UniProt: P54456 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 186 (179)
Sequences: 1400 (1139)
Seq/√Len: 85.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
121_K150_N3.6121.00
42_K99_D3.2191.00
15_T55_F3.0921.00
145_A152_A2.8581.00
42_K101_D2.6891.00
28_T131_P2.6681.00
38_A118_L2.6471.00
91_V106_I2.5381.00
108_Y120_E2.4691.00
26_M44_E2.4581.00
34_E40_S2.4141.00
38_A122_V2.4071.00
22_T47_A2.3961.00
26_M47_A2.3711.00
24_G132_N2.2971.00
29_A123_I2.2431.00
158_K179_Y2.2301.00
104_D113_R2.0381.00
16_E20_I2.0031.00
43_A119_L1.9691.00
113_R120_E1.9581.00
108_Y113_R1.8681.00
165_M180_N1.8671.00
43_A47_A1.8631.00
31_E146_E1.8381.00
53_A86_V1.8361.00
14_L22_T1.7881.00
164_L171_V1.7781.00
45_I102_I1.7751.00
49_F106_I1.7631.00
72_A82_W1.7361.00
30_I44_E1.7341.00
114_P177_L1.7161.00
125_V152_A1.7121.00
176_F180_N1.6971.00
157_I178_T1.6901.00
104_D120_E1.6631.00
73_H172_F1.6011.00
104_D108_Y1.5941.00
9_C95_A1.5721.00
65_I82_W1.5551.00
118_L149_L1.5451.00
144_L155_Q1.5261.00
33_A43_A1.4880.99
24_G130_E1.4760.99
7_L19_Y1.4340.99
92_Q98_Q1.4200.99
6_A45_I1.3970.99
179_Y183_V1.3460.99
61_M86_V1.3410.99
114_P178_T1.3380.99
54_K80_E1.3230.99
63_Q67_R1.3150.99
28_T129_I1.3030.99
135_F138_V1.3020.99
124_Y153_L1.2940.98
125_V156_S1.2820.98
68_E93_R1.2750.98
62_K66_A1.2550.98
141_V155_Q1.2540.98
143_K147_T1.2500.98
64_I86_V1.2480.98
20_I24_G1.2290.98
101_D120_E1.2180.98
30_I40_S1.1910.97
56_R60_E1.1820.97
158_K168_N1.1790.97
115_G181_W1.1580.97
92_Q100_E1.1430.97
49_F91_V1.1390.97
144_L152_A1.1350.96
124_Y157_I1.1160.96
28_T31_E1.1040.96
103_L107_R1.0930.96
138_V142_R1.0670.95
30_I43_A1.0610.95
128_Y156_S1.0540.95
53_A87_G1.0490.94
73_H76_D1.0430.94
11_K19_Y1.0270.94
27_N131_P1.0230.94
88_A103_L1.0190.94
42_K102_I1.0170.94
128_Y160_T1.0120.93
8_A12_Q1.0110.93
117_T120_E1.0100.93
101_D117_T1.0010.93
165_M176_F1.0010.93
180_N183_V0.9990.93
52_Y87_G0.9980.93
140_E143_K0.9870.92
76_D85_P0.9840.92
162_V166_K0.9750.92
84_A87_G0.9730.92
90_L94_E0.9660.92
128_Y135_F0.9560.91
147_T151_Q0.9520.91
100_E104_D0.9510.91
97_V102_I0.9480.91
53_A61_M0.9410.91
88_A107_R0.9380.90
22_T26_M0.9290.90
101_D104_D0.9250.90
10_V48_I0.9240.90
32_L36_F0.9210.90
38_A119_L0.9160.89
35_R146_E0.9140.89
7_L26_M0.9130.89
52_Y91_V0.9130.89
104_D107_R0.9110.89
108_Y117_T0.9020.89
64_I68_E0.8990.88
26_M30_I0.8980.88
137_G140_E0.8980.88
39_D42_K0.8940.88
58_K79_P0.8890.88
9_C94_E0.8860.88
6_A9_C0.8850.88
57_P60_E0.8820.88
125_V153_L0.8720.87
154_I183_V0.8700.87
140_E155_Q0.8610.86
91_V103_L0.8610.86
158_K162_V0.8550.86
30_I47_A0.8540.86
163_F167_K0.8410.85
23_V26_M0.8360.85
118_L122_V0.8320.84
59_E63_Q0.8270.84
121_K153_L0.8180.83
148_D151_Q0.8170.83
125_V145_A0.8150.83
145_A148_D0.8120.83
118_L121_K0.8110.83
154_I179_Y0.8100.83
9_C13_Q0.8100.83
31_E35_R0.8070.82
28_T146_E0.8050.82
133_R142_R0.8000.82
68_E89_Y0.7960.82
27_N31_E0.7830.81
153_L157_I0.7780.80
144_L151_Q0.7770.80
165_M179_Y0.7760.80
158_K183_V0.7730.80
19_Y23_V0.7700.79
5_E8_A0.7680.79
68_E86_V0.7680.79
89_Y93_R0.7600.79
58_K62_K0.7540.78
92_Q103_L0.7540.78
128_Y141_V0.7500.78
30_I34_E0.7420.77
154_I182_L0.7340.76
111_S172_F0.7320.76
31_E34_E0.7240.75
84_A107_R0.7220.75
36_F149_L0.7190.75
87_G91_V0.7180.74
26_M48_I0.7130.74
13_Q56_R0.7060.73
174_D177_L0.7060.73
53_A90_L0.7030.73
6_A95_A0.7000.73
82_W86_V0.6920.72
156_S159_N0.6900.72
158_K165_M0.6850.71
18_R54_K0.6820.71
108_Y111_S0.6810.71
81_L111_S0.6740.70
24_G27_N0.6670.69
104_D117_T0.6660.69
91_V95_A0.6660.69
155_Q158_K0.6630.68
97_V103_L0.6550.68
67_R93_R0.6540.67
176_F179_Y0.6530.67
165_M183_V0.6530.67
55_F84_A0.6530.67
20_I23_V0.6530.67
113_R117_T0.6520.67
46_A119_L0.6500.67
135_F159_N0.6460.67
75_L170_P0.6350.65
78_N81_L0.6300.65
52_Y65_I0.6290.64
24_G84_A0.6250.64
70_M86_V0.6250.64
27_N34_E0.6230.64
36_F145_A0.6230.64
112_G178_T0.6210.63
31_E36_F0.6170.63
14_L55_F0.6160.63
120_E123_I0.6140.63
161_M176_F0.6140.63
89_Y92_Q0.6110.62
10_V47_A0.6110.62
155_Q159_N0.6080.62
85_P107_R0.6060.62
11_K16_E0.6050.61
13_Q95_A0.6020.61
111_S174_D0.6010.61
116_M120_E0.5990.61
116_M133_R0.5970.60
36_F147_T0.5960.60
125_V129_I0.5950.60
20_I132_N0.5900.60
61_M80_E0.5880.59
65_I79_P0.5850.59
108_Y174_D0.5830.59
164_L169_Q0.5810.58
85_P88_A0.5800.58
91_V97_V0.5770.58
45_I97_V0.5710.57
171_V176_F0.5710.57
53_A56_R0.5680.57
63_Q70_M0.5680.57
68_E72_A0.5670.57
46_A102_I0.5660.56
137_G159_N0.5660.56
24_G131_P0.5620.56
29_A46_A0.5570.55
74_L77_H0.5570.55
119_L123_I0.5550.55
62_K79_P0.5540.55
89_Y107_R0.5520.55
157_I182_L0.5470.54
148_D152_A0.5440.53
24_G28_T0.5440.53
56_R86_V0.5420.53
6_A49_F0.5410.53
53_A91_V0.5390.53
63_Q73_H0.5370.53
36_F152_A0.5370.53
60_E63_Q0.5360.52
9_C87_G0.5360.52
25_V45_I0.5350.52
112_G116_M0.5330.52
70_M85_P0.5310.52
76_D81_L0.5310.52
10_V13_Q0.5270.51
49_F95_A0.5250.51
32_L129_I0.5220.51
153_L182_L0.5220.51
23_V48_I0.5220.51
39_D139_D0.5210.50
82_W110_T0.5180.50
9_C91_V0.5140.49
111_S178_T0.5140.49
26_M95_A0.5130.49
57_P61_M0.5130.49
22_T52_Y0.5120.49
6_A10_V0.5120.49
74_L86_V0.5100.49
12_Q177_L0.5100.49
154_I158_K0.5080.49
111_S157_I0.5080.49
128_Y159_N0.5080.49
144_L147_T0.5080.49
54_K79_P0.5060.48
98_Q103_L0.5050.48
24_G138_V0.5040.48
17_H92_Q0.5030.48
66_A75_L0.5020.48
114_P174_D0.5000.48
46_A105_A0.5000.48
89_Y100_E0.5000.48
44_E47_A0.5000.48
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ccgA 2 1 100 0.464 Contact Map
2o08A 2 1 100 0.466 Contact Map
2ogiA 2 1 100 0.466 Contact Map
4s1bA 2 0.8978 99.7 0.716 Contact Map
4r8zA 2 0.9194 99.6 0.734 Contact Map
2pq7A 2 0.6452 99.6 0.741 Contact Map
3m1tA 1 0.914 99.5 0.751 Contact Map
3dtoA 2 0.8065 99.5 0.758 Contact Map
4mcwA 2 0.8978 99.5 0.758 Contact Map
3b57A 2 0.8172 99.5 0.759 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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