GREMLIN Database
NADD - Nicotinate-nucleotide adenylyltransferase
UniProt: P54455 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 189 (184)
Sequences: 4110 (2989)
Seq/√Len: 220.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
74_L78_E3.9681.00
33_E71_K3.3771.00
26_L69_S2.9571.00
118_K121_E2.9391.00
12_D51_T2.6591.00
36_F70_F2.5421.00
5_G31_L2.5181.00
29_A129_I2.4391.00
90_S121_E2.3621.00
14_P60_L2.3601.00
58_E61_K2.3141.00
55_H184_N2.3021.00
55_H180_Y2.1671.00
89_V126_I2.1561.00
55_H58_E1.9801.00
57_V74_L1.9331.00
23_N67_N1.9231.00
169_T173_I1.9031.00
22_A36_F1.9011.00
53_S77_M1.8901.00
122_L128_F1.8611.00
59_M180_Y1.8501.00
35_W73_E1.8471.00
90_S118_K1.8441.00
52_D55_H1.8321.00
3_K100_Q1.7961.00
93_K125_L1.7681.00
79_R87_D1.7681.00
62_L180_Y1.7641.00
158_M162_R1.7521.00
14_P63_A1.7501.00
89_V122_L1.7351.00
4_I99_D1.7351.00
75_V91_L1.7281.00
161_E165_S1.7281.00
57_V72_L1.7121.00
103_F128_F1.7001.00
64_I72_L1.6681.00
175_D178_K1.5931.00
163_F169_T1.5841.00
86_F118_K1.5701.00
60_L72_L1.5511.00
86_F90_S1.5421.00
178_K182_E1.5041.00
25_V104_I1.4851.00
36_F64_I1.4631.00
113_L122_L1.4551.00
67_N171_Y1.4291.00
60_L64_I1.3511.00
44_H115_K1.3471.00
35_W101_L1.3281.00
65_Q176_K1.3241.00
100_Q127_Q1.3041.00
169_T178_K1.3011.00
5_G104_I1.2941.00
102_F129_I1.2891.00
10_T42_P1.2841.00
127_Q145_L1.2641.00
35_W96_Y1.2631.00
75_V95_R1.2621.00
58_E62_L1.2481.00
12_D49_D1.2341.00
158_M161_E1.2311.00
57_V61_K1.2191.00
79_R91_L1.2171.00
12_D50_Y1.2001.00
21_M131_V1.1861.00
86_F125_L1.1701.00
121_E125_L1.1681.00
62_L176_K1.1561.00
16_N174_P1.1391.00
113_L123_L1.1381.00
110_I130_G1.1291.00
61_K74_L1.1261.00
179_K183_E1.1241.00
91_L95_R1.1231.00
113_L119_L1.1221.00
35_W71_K1.1201.00
162_R167_K1.1091.00
85_T103_F1.1031.00
112_Y115_K1.0971.00
37_M75_V1.0921.00
7_F21_M1.0771.00
40_Q80_E1.0721.00
20_L152_F1.0711.00
170_D178_K1.0711.00
75_V79_R1.0691.00
86_F117_Y1.0621.00
43_P83_S1.0491.00
134_P151_E1.0481.00
170_D175_D1.0431.00
91_L94_Q1.0391.00
37_M73_E1.0231.00
159_I173_I0.9981.00
123_L128_F0.9901.00
87_D90_S0.9891.00
180_Y184_N0.9881.00
19_L174_P0.9871.00
132_K148_D0.9811.00
45_K156_S0.9781.00
23_N26_L0.9741.00
14_P59_M0.9731.00
25_V131_V0.9631.00
26_L34_I0.9561.00
154_V172_L0.9531.00
40_Q77_M0.9431.00
51_T186_L0.9401.00
3_K102_F0.9341.00
24_E28_Q0.9291.00
86_F121_E0.9210.99
51_T55_H0.9180.99
6_I37_M0.9120.99
96_Y101_L0.9070.99
20_L23_N0.9010.99
109_M112_Y0.8980.99
29_A145_L0.8960.99
25_V147_A0.8960.99
180_Y186_L0.8910.99
121_E124_N0.8910.99
55_H59_M0.8870.99
75_V92_L0.8780.99
31_L104_I0.8690.99
6_I89_V0.8650.99
132_K151_E0.8580.99
90_S125_L0.8540.99
19_L171_Y0.8530.99
173_I178_K0.8480.99
93_K101_L0.8460.99
4_I101_L0.8430.99
14_P36_F0.8360.99
28_Q148_D0.8310.99
131_V149_V0.8300.99
20_L24_E0.8250.99
57_V77_M0.8200.99
19_L63_A0.8080.99
44_H112_Y0.8020.99
40_Q43_P0.8020.99
102_F127_Q0.7920.98
87_D117_Y0.7920.98
127_Q143_P0.7830.98
67_N70_F0.7820.98
81_G87_D0.7780.98
85_T89_V0.7740.98
40_Q53_S0.7720.98
168_P171_Y0.7690.98
38_P60_L0.7690.98
12_D47_N0.7620.98
123_L144_L0.7610.98
129_I145_L0.7570.98
22_A70_F0.7570.98
62_L177_V0.7530.98
162_R168_P0.7460.98
3_K32_D0.7450.98
107_A136_F0.7430.98
162_R172_L0.7420.98
74_L77_M0.7380.97
21_M149_V0.7360.97
19_L64_I0.7360.97
92_L96_Y0.7340.97
23_N27_Y0.7340.97
27_Y167_K0.7280.97
107_A132_K0.7280.97
58_E180_Y0.7250.97
64_I70_F0.7230.97
21_M25_V0.7210.97
42_P45_K0.7210.97
79_R83_S0.7200.97
24_E150_P0.7160.97
134_P153_E0.7080.97
89_V125_L0.7060.97
37_M92_L0.7020.97
10_T50_Y0.7020.97
3_K30_G0.7000.97
12_D160_R0.6990.97
23_N168_P0.6970.96
4_I35_W0.6920.96
31_L102_F0.6910.96
36_F60_L0.6910.96
110_I144_L0.6890.96
16_N173_I0.6870.96
163_F173_I0.6830.96
129_I147_A0.6810.96
37_M88_T0.6810.96
27_Y168_P0.6780.96
63_A177_V0.6780.96
66_S176_K0.6770.96
59_M177_V0.6750.96
76_E83_S0.6750.96
16_N171_Y0.6730.96
168_P178_K0.6700.96
17_G152_F0.6680.96
9_G15_H0.6640.95
6_I92_L0.6610.95
47_N50_Y0.6610.95
54_F58_E0.6590.95
51_T59_M0.6560.95
44_H109_M0.6560.95
113_L128_F0.6520.95
163_F178_K0.6480.95
16_N20_L0.6480.95
76_E88_T0.6420.94
20_L172_L0.6380.94
85_T122_L0.6360.94
54_F74_L0.6310.94
7_F103_F0.6300.94
171_Y175_D0.6280.94
162_R169_T0.6260.94
35_W92_L0.6260.94
105_I109_M0.6220.93
93_K126_I0.6210.93
57_V60_L0.6200.93
107_A135_G0.6200.93
104_I129_I0.6190.93
132_K149_V0.6190.93
25_V129_I0.6180.93
42_P109_M0.6180.93
32_D99_D0.6150.93
16_N154_V0.6100.93
154_V159_I0.6090.93
10_T39_N0.6080.93
63_A66_S0.6060.93
22_A34_I0.6050.93
15_H84_Y0.6010.92
34_I104_I0.6000.92
43_P82_P0.5980.92
41_I82_P0.5980.92
176_K179_K0.5940.92
105_I110_I0.5940.92
158_M172_L0.5890.92
90_S94_Q0.5890.92
107_A111_E0.5890.92
4_I33_E0.5870.91
179_K182_E0.5850.91
24_E149_V0.5840.91
62_L65_Q0.5830.91
78_E95_R0.5810.91
7_F22_A0.5730.90
17_G154_V0.5720.90
152_F158_M0.5660.90
77_M80_E0.5650.90
53_S57_V0.5570.89
20_L150_P0.5550.89
20_L171_Y0.5480.88
10_T44_H0.5470.88
23_N70_F0.5470.88
39_N83_S0.5460.88
107_A138_V0.5430.88
181_V186_L0.5410.88
25_V29_A0.5400.88
25_V149_V0.5380.87
92_L101_L0.5350.87
93_K100_Q0.5340.87
86_F119_L0.5310.87
100_Q143_P0.5300.87
16_N152_F0.5250.86
96_Y99_D0.5240.86
93_K98_N0.5240.86
89_V93_K0.5240.86
119_L128_F0.5230.86
132_K146_F0.5220.86
39_N43_P0.5210.86
159_I172_L0.5180.85
7_F36_F0.5170.85
44_H119_L0.5160.85
29_A147_A0.5150.85
86_F89_V0.5130.85
22_A60_L0.5080.84
6_I101_L0.5080.84
34_I70_F0.5070.84
119_L123_L0.5060.84
16_N159_I0.5060.84
161_E164_K0.5030.84
111_E114_P0.5030.84
7_F20_L0.5030.84
24_E131_V0.5000.83
63_A174_P0.5000.83
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1k4mA 3 0.9894 100 0.222 Contact Map
4x0eA 1 0.9735 100 0.236 Contact Map
1kqnA 3 0.9788 100 0.244 Contact Map
1yumA 4 0.9947 100 0.25 Contact Map
2qtrA 2 1 100 0.267 Contact Map
1kamA 3 0.9683 100 0.267 Contact Map
4wsoA 1 0.9841 100 0.273 Contact Map
1nupA 4 0.9894 100 0.277 Contact Map
2h29A 2 0.9947 100 0.277 Contact Map
3h05A 2 0.836 100 0.366 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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