GREMLIN Database
YQEH - Uncharacterized protein YqeH
UniProt: P54453 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 366 (362)
Sequences: 896 (607)
Seq/√Len: 31.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
17_D20_G5.8991.00
149_V175_F5.1091.00
322_T350_T4.2771.00
260_G300_A4.1341.00
102_G121_M4.0851.00
320_A350_T4.0201.00
334_F351_A3.9861.00
124_E127_E3.4331.00
267_V350_T3.3861.00
100_L125_A3.2011.00
41_R47_E3.1001.00
256_L284_I2.9301.00
252_D270_E2.8191.00
317_E355_K2.8181.00
101_V149_V2.7771.00
272_S347_K2.7311.00
233_D311_E2.6081.00
6_C9_C2.5971.00
243_L280_N2.4921.00
256_L276_C2.4520.99
147_R182_E2.4460.99
36_C39_C2.4160.99
99_L134_D2.3820.99
190_I203_I2.3490.99
247_T275_I2.3210.99
75_I175_F2.2800.99
324_T348_K2.2700.99
15_T29_L2.2570.99
6_C10_G2.2550.99
266_Y272_S2.2530.99
123_R127_E2.1700.99
115_E119_Q2.1620.99
264_F351_A2.1580.99
258_F276_C2.0800.98
319_V355_K2.0480.98
320_A348_K2.0440.98
264_F340_V2.0120.98
77_D198_T1.9870.97
299_H302_E1.9170.97
177_N190_I1.9060.97
276_C284_I1.8690.96
69_D160_K1.8460.96
167_C221_N1.8290.96
11_V21_L1.8110.96
119_Q123_R1.7990.95
266_Y270_E1.7500.95
143_G178_R1.7500.95
118_I122_K1.7460.95
266_Y269_G1.7410.95
230_N233_D1.7220.94
119_Q126_K1.7050.94
80_D107_I1.6890.94
81_F121_M1.6870.94
152_A156_Y1.6790.93
76_V81_F1.6600.93
330_T361_V1.6300.92
35_I43_K1.6210.92
294_A298_K1.6160.92
89_L165_V1.5920.91
255_T265_D1.5880.91
111_S242_E1.5650.91
87_N90_Q1.5550.90
53_L57_D1.5550.90
294_A297_E1.5520.90
41_R45_Y1.5510.90
214_Y308_G1.5430.90
224_Q227_H1.5390.90
105_A114_R1.5240.89
253_Q289_L1.5220.89
78_I102_G1.5180.89
255_T289_L1.5080.89
164_V176_I1.4950.89
301_G307_P1.4880.88
67_E72_V1.4850.88
104_K177_N1.4840.88
184_S187_E1.4820.88
5_V12_T1.4620.87
14_Q22_G1.4500.87
176_I205_I1.4340.86
251_N271_R1.4230.86
80_D83_G1.4210.86
89_L98_I1.4140.86
122_K135_V1.4070.85
61_I201_D1.4000.85
122_K213_L1.3980.85
40_F45_Y1.3960.85
123_R363_R1.3890.84
249_Q286_R1.3750.84
183_V186_E1.3740.84
191_T198_T1.3720.84
268_S348_K1.3640.83
264_F274_F1.3470.83
18_K37_Q1.3460.83
166_G171_G1.3450.82
166_G172_K1.3450.82
80_D84_S1.3400.82
64_G67_E1.3130.81
28_S31_K1.3090.81
9_C14_Q1.2980.80
119_Q122_K1.2820.79
8_G198_T1.2750.79
291_N294_A1.2720.79
7_I35_I1.2700.79
21_L52_S1.2540.78
25_P37_Q1.2530.78
74_K85_W1.2460.77
241_K306_P1.2460.77
300_A312_M1.2460.77
233_D308_G1.2430.77
152_A155_H1.2360.77
136_F152_A1.2360.77
71_L99_L1.2340.77
81_F84_S1.2340.77
308_G311_E1.2260.76
9_C22_G1.2230.76
175_F221_N1.2070.75
133_V156_Y1.2000.75
332_I349_V1.1950.74
56_D72_V1.1900.74
254_Q286_R1.1890.74
164_V225_M1.1860.74
6_C22_G1.1770.73
322_T348_K1.1770.73
177_N191_T1.1750.73
38_R193_S1.1700.73
221_N224_Q1.1700.73
292_A296_Y1.1670.72
247_T256_L1.1550.72
130_L223_H1.1470.71
102_G137_L1.1460.71
79_F201_D1.1430.71
74_K175_F1.1380.71
230_N311_E1.1380.71
99_L133_V1.1050.68
181_K202_A1.1010.68
72_V365_L1.0950.68
258_F340_V1.0940.67
18_K23_Y1.0940.67
194_Q201_D1.0920.67
249_Q273_P1.0910.67
285_H299_H1.0910.67
287_T292_A1.0880.67
6_C14_Q1.0860.67
8_G77_D1.0800.66
82_N124_E1.0780.66
138_V149_V1.0750.66
146_I175_F1.0740.66
321_H353_A1.0730.66
223_H335_S1.0670.65
89_L290_E1.0640.65
232_K311_E1.0580.65
269_G274_F1.0480.64
150_I179_I1.0450.64
23_Y37_Q1.0450.64
241_K244_K1.0450.64
141_G240_K1.0430.64
65_I72_V1.0430.64
166_G169_N1.0430.64
75_I360_F1.0370.63
55_D222_N1.0350.63
269_G289_L1.0330.63
64_G160_K1.0280.63
106_D166_G1.0260.62
21_L194_Q1.0240.62
259_G282_L1.0240.62
85_W128_L1.0230.62
185_G189_I1.0140.61
215_D218_G1.0110.61
102_G266_Y1.0080.61
221_N352_Y1.0080.61
188_D332_I1.0050.61
323_F351_A1.0030.61
171_G215_D0.9980.60
172_K215_D0.9980.60
48_I238_S0.9930.60
79_F239_P0.9920.60
41_R46_N0.9910.60
106_D171_G0.9900.60
106_D172_K0.9900.60
199_T215_D0.9880.59
23_Y64_G0.9860.59
101_V138_V0.9790.59
95_G334_F0.9790.59
305_T312_M0.9750.58
122_K126_K0.9740.58
166_G215_D0.9700.58
70_S96_N0.9670.58
109_P216_T0.9660.58
172_K218_G0.9630.57
171_G218_G0.9630.57
123_R126_K0.9600.57
23_Y268_S0.9560.57
258_F278_M0.9490.56
301_G306_P0.9480.56
75_I136_F0.9480.56
77_D200_L0.9460.56
191_T207_L0.9370.55
258_F262_A0.9360.55
17_D309_K0.9350.55
88_G91_R0.9350.55
23_Y332_I0.9350.55
166_G218_G0.9340.55
229_V245_P0.9310.55
98_I230_N0.9310.55
285_H304_L0.9270.55
43_K295_L0.9270.55
18_K259_G0.9260.54
315_F318_L0.9220.54
115_E126_K0.9220.54
168_T220_I0.9200.54
198_T336_G0.9190.54
72_V93_V0.9180.54
138_V146_I0.9160.54
98_I115_E0.9070.53
169_N172_K0.9070.53
46_N121_M0.9030.53
52_S302_E0.8910.52
10_G14_Q0.8910.52
105_A332_I0.8840.51
91_R227_H0.8830.51
257_Y296_Y0.8820.51
193_S198_T0.8780.51
49_Q242_E0.8770.50
211_S264_F0.8740.50
9_C39_C0.8700.50
44_N250_L0.8690.50
267_V322_T0.8680.50
266_Y274_F0.8670.50
24_A37_Q0.8650.49
302_E309_K0.8650.49
24_A100_L0.8610.49
105_A144_Q0.8610.49
167_C175_F0.8610.49
100_L130_L0.8600.49
6_C39_C0.8540.49
257_Y287_T0.8430.48
134_D152_A0.8430.48
251_N364_S0.8420.48
301_G304_L0.8420.48
146_I182_E0.8370.47
229_V233_D0.8350.47
183_V189_I0.8330.47
22_G106_D0.8310.47
77_D336_G0.8300.47
22_G39_C0.8280.46
83_G120_W0.8270.46
57_D81_F0.8260.46
92_L179_I0.8260.46
109_P263_R0.8260.46
310_D317_E0.8240.46
213_L334_F0.8210.46
60_N294_A0.8200.46
166_G173_S0.8180.46
325_I330_T0.8170.46
147_R297_E0.8120.45
80_D260_G0.8100.45
250_L286_R0.8040.44
236_I281_E0.8030.44
95_G363_R0.8030.44
165_V168_T0.8020.44
70_S160_K0.8010.44
330_T364_S0.8000.44
76_V86_I0.7970.44
274_F342_V0.7970.44
263_R292_A0.7950.44
37_Q41_R0.7940.44
53_L58_F0.7930.44
103_N250_L0.7930.44
9_C23_Y0.7920.44
9_C36_C0.7920.44
10_G22_G0.7890.43
112_L117_L0.7890.43
21_L53_L0.7870.43
149_V253_Q0.7860.43
96_N130_L0.7850.43
129_G256_L0.7820.43
84_S170_V0.7820.43
63_H179_I0.7810.43
30_T64_G0.7780.42
332_I342_V0.7760.42
6_C36_C0.7760.42
329_K364_S0.7700.42
267_V320_A0.7690.42
23_Y291_N0.7680.42
339_W365_L0.7670.42
253_Q325_I0.7650.41
275_I278_M0.7640.41
26_P64_G0.7630.41
249_Q254_Q0.7620.41
278_M284_I0.7620.41
70_S163_Y0.7600.41
76_V93_V0.7590.41
190_I207_L0.7580.41
8_G22_G0.7540.40
54_T57_D0.7540.40
285_H291_N0.7520.40
304_L307_P0.7470.40
6_C23_Y0.7470.40
265_D289_L0.7450.40
10_G39_C0.7420.40
175_F352_Y0.7420.40
291_N295_L0.7410.39
343_H348_K0.7400.39
80_D103_N0.7360.39
105_A143_G0.7360.39
185_G188_D0.7310.39
337_L357_V0.7300.39
17_D258_F0.7290.39
40_F44_N0.7280.38
178_R181_K0.7270.38
102_G105_A0.7270.38
332_I351_A0.7250.38
229_V237_L0.7230.38
130_L335_S0.7220.38
164_V282_L0.7220.38
281_E332_I0.7170.38
291_N298_K0.7170.38
22_G36_C0.7170.38
93_V98_I0.7110.37
199_T218_G0.7110.37
121_M266_Y0.7100.37
54_T59_L0.7090.37
115_E122_K0.7080.37
260_G338_G0.7040.37
117_L312_M0.7030.37
10_G23_Y0.7030.37
103_N220_I0.7000.36
171_G199_T0.7000.36
172_K199_T0.7000.36
256_L259_G0.7000.36
62_L238_S0.7000.36
179_I365_L0.6970.36
124_E312_M0.6970.36
353_A359_V0.6970.36
132_P353_A0.6960.36
13_I221_N0.6960.36
24_A89_L0.6950.36
108_L254_Q0.6940.36
138_V167_C0.6940.36
21_L101_V0.6930.36
136_F149_V0.6930.36
336_G339_W0.6920.36
102_G262_A0.6900.36
219_I232_K0.6890.35
77_D84_S0.6890.35
230_N308_G0.6880.35
175_F202_A0.6850.35
76_V100_L0.6830.35
141_G270_E0.6820.35
62_L275_I0.6820.35
35_I74_K0.6810.35
116_R120_W0.6810.35
153_I203_I0.6790.35
138_V143_G0.6780.35
151_D332_I0.6770.35
296_Y334_F0.6770.35
60_N264_F0.6750.34
76_V85_W0.6740.34
58_F62_L0.6740.34
229_V352_Y0.6730.34
30_T130_L0.6730.34
166_G199_T0.6710.34
7_I31_K0.6690.34
219_I265_D0.6680.34
17_D55_D0.6670.34
172_K217_P0.6670.34
171_G217_P0.6670.34
264_F334_F0.6650.34
10_G36_C0.6640.34
78_I194_Q0.6610.33
74_K89_L0.6610.33
102_G153_I0.6580.33
297_E309_K0.6570.33
177_N192_T0.6560.33
93_V96_N0.6560.33
63_H66_G0.6550.33
320_A352_Y0.6540.33
87_N98_I0.6520.33
94_G97_P0.6520.33
160_K228_Y0.6480.32
169_N199_T0.6480.32
63_H81_F0.6480.32
97_P228_Y0.6450.32
352_Y360_F0.6450.32
352_Y359_V0.6430.32
65_I93_V0.6390.32
166_G217_P0.6370.32
313_D321_H0.6370.32
174_T284_I0.6350.32
104_K191_T0.6340.31
96_N203_I0.6330.31
264_F348_K0.6330.31
200_L239_P0.6290.31
255_T310_D0.6270.31
157_R161_D0.6250.31
78_I108_L0.6250.31
12_T152_A0.6250.31
101_V136_F0.6240.31
146_I183_V0.6230.31
48_I74_K0.6230.31
146_I158_N0.6230.31
99_L156_Y0.6170.30
42_L224_Q0.6170.30
15_T24_A0.6170.30
111_S190_I0.6170.30
228_Y246_R0.6160.30
327_D342_V0.6160.30
308_G319_V0.6150.30
73_V101_V0.6150.30
137_L274_F0.6140.30
106_D215_D0.6140.30
258_F295_L0.6140.30
208_D211_S0.6140.30
123_R156_Y0.6140.30
135_V274_F0.6140.30
164_V246_R0.6130.30
248_F288_K0.6130.30
228_Y238_S0.6120.30
74_K81_F0.6110.30
105_A342_V0.6110.30
162_V197_G0.6090.30
91_R290_E0.6080.30
58_F295_L0.6070.30
234_L282_L0.6070.30
285_H292_A0.6040.29
290_E298_K0.6030.29
323_F332_I0.6000.29
274_F365_L0.5990.29
62_L356_G0.5980.29
36_C218_G0.5980.29
327_D343_H0.5970.29
8_G191_T0.5970.29
126_K131_K0.5970.29
237_L365_L0.5930.29
323_F358_H0.5890.28
202_A214_Y0.5880.28
240_K281_E0.5850.28
124_E128_L0.5830.28
77_D80_D0.5830.28
67_E152_A0.5830.28
109_P177_N0.5810.28
323_F357_V0.5810.28
38_R198_T0.5810.28
52_S297_E0.5800.28
168_T193_S0.5790.28
4_V75_I0.5790.28
151_D154_E0.5780.28
106_D218_G0.5780.28
114_R349_V0.5780.28
68_T342_V0.5770.28
220_I227_H0.5750.27
227_H354_P0.5740.27
102_G291_N0.5720.27
225_M323_F0.5700.27
105_A137_L0.5690.27
74_K214_Y0.5690.27
169_N215_D0.5690.27
198_T263_R0.5680.27
63_H88_G0.5670.27
108_L331_D0.5670.27
146_I184_S0.5670.27
287_T291_N0.5640.27
176_I207_L0.5630.27
191_T263_R0.5630.27
8_G255_T0.5620.27
142_R182_E0.5610.27
88_G168_T0.5600.26
68_T101_V0.5600.26
270_E274_F0.5590.26
183_V343_H0.5570.26
250_L287_T0.5570.26
146_I260_G0.5550.26
18_K264_F0.5550.26
176_I229_V0.5550.26
78_I357_V0.5540.26
86_I170_V0.5540.26
85_W214_Y0.5500.26
234_L239_P0.5500.26
45_Y249_Q0.5490.26
90_Q125_A0.5490.26
24_A85_W0.5480.26
153_I162_V0.5480.26
69_D277_Y0.5480.26
150_I175_F0.5460.26
330_T349_V0.5460.26
219_I315_F0.5440.25
75_I283_M0.5430.25
119_Q209_D0.5430.25
195_F205_I0.5420.25
77_D109_P0.5420.25
311_E315_F0.5420.25
34_V319_V0.5420.25
252_D266_Y0.5410.25
76_V192_T0.5400.25
70_S93_V0.5400.25
135_V145_G0.5390.25
35_I48_I0.5340.25
75_I167_C0.5340.25
92_L131_K0.5330.25
41_R180_I0.5330.25
29_L129_G0.5330.25
140_A356_G0.5330.25
290_E364_S0.5320.25
176_I195_F0.5300.25
90_Q128_L0.5300.25
106_D169_N0.5290.25
169_N218_G0.5290.25
325_I361_V0.5280.25
158_N178_R0.5280.25
187_E365_L0.5260.24
109_P265_D0.5250.24
272_S346_D0.5230.24
8_G200_L0.5230.24
124_E279_P0.5210.24
310_D313_D0.5200.24
7_I204_E0.5190.24
218_G338_G0.5190.24
110_K340_V0.5190.24
110_K244_K0.5170.24
85_W258_F0.5130.24
162_V263_R0.5120.24
42_L272_S0.5110.23
331_D339_W0.5110.23
70_S94_G0.5100.23
48_I202_A0.5090.23
231_K258_F0.5080.23
174_T191_T0.5070.23
124_E360_F0.5070.23
164_V264_F0.5060.23
117_L235_K0.5060.23
12_T21_L0.5050.23
134_D156_Y0.5050.23
81_F124_E0.5040.23
84_S198_T0.5030.23
50_D74_K0.5030.23
265_D292_A0.5020.23
15_T204_E0.5020.23
44_N363_R0.5020.23
64_G78_I0.5020.23
173_S215_D0.5010.23
196_P362_R0.5000.23
8_G267_V0.5000.23
195_F219_I0.5000.23
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3h2yA 1 0.8415 100 0.347 Contact Map
3ec1A 1 0.8497 100 0.38 Contact Map
1pujA 1 0.6202 99.9 0.778 Contact Map
3cnlA 1 0.6011 99.9 0.808 Contact Map
2yv5A 1 0.735 99.8 0.81 Contact Map
1mkyA 1 0.8087 99.8 0.814 Contact Map
1u0lA 1 0.6694 99.8 0.818 Contact Map
4dcuA 1 0.8115 99.8 0.824 Contact Map
2rcnA 2 0.6503 99.8 0.828 Contact Map
1t9hA 1 0.6475 99.8 0.828 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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