YQEH - BACSU - GREMLIN Contacts

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YQEH - Uncharacterized protein YqeH

UniProt:	P54453	Sequences: MEKVVCIGCGVTIQTEDKTGLGYAPPASLTKENVICQRCFRLKNYNEIQDVSLTDDDFLNILHGIGETDSLVVKIVDIFDFNGSWINGLQRLVGGNPILLVGNKADILPKSLKRERLIQWMKREAKELGLKPVDVFLVSAGRGQGIREVIDAIEHYRNGKDVYVVGCTNVGKSTFINRIIKEVSGEEDIITTSQFPGTTLDAIEIPLDDGSSLYDTPGIINNHQMAHYVNKKDLKILSPKKELKPRTFQLNDQQTLYFGGLARFDYVSGERSPFICYMPNELMIHRTKLENADALYEKHAGELLTPPGKDEMDEFPELVAHTFTIKDKKTDIVFSGLGWVTVHDADKKVTAYAPKGVHVFVRRSLI	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	366 (362)
Sequences:	896 (607)
Seq/√Len:	31.9

BACSU - YQEH

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
17_D	20_G	5.899	1.00
149_V	175_F	5.109	1.00
322_T	350_T	4.277	1.00
260_G	300_A	4.134	1.00
102_G	121_M	4.085	1.00
320_A	350_T	4.020	1.00
334_F	351_A	3.986	1.00
124_E	127_E	3.433	1.00
267_V	350_T	3.386	1.00
100_L	125_A	3.201	1.00
41_R	47_E	3.100	1.00
256_L	284_I	2.930	1.00
252_D	270_E	2.819	1.00
317_E	355_K	2.818	1.00
101_V	149_V	2.777	1.00
272_S	347_K	2.731	1.00
233_D	311_E	2.608	1.00
6_C	9_C	2.597	1.00
243_L	280_N	2.492	1.00
256_L	276_C	2.452	0.99
147_R	182_E	2.446	0.99
36_C	39_C	2.416	0.99
99_L	134_D	2.382	0.99
190_I	203_I	2.349	0.99
247_T	275_I	2.321	0.99
75_I	175_F	2.280	0.99
324_T	348_K	2.270	0.99
15_T	29_L	2.257	0.99
6_C	10_G	2.255	0.99
266_Y	272_S	2.253	0.99
123_R	127_E	2.170	0.99
115_E	119_Q	2.162	0.99
264_F	351_A	2.158	0.99
258_F	276_C	2.080	0.98
319_V	355_K	2.048	0.98
320_A	348_K	2.044	0.98
264_F	340_V	2.012	0.98
77_D	198_T	1.987	0.97
299_H	302_E	1.917	0.97
177_N	190_I	1.906	0.97
276_C	284_I	1.869	0.96
69_D	160_K	1.846	0.96
167_C	221_N	1.829	0.96
11_V	21_L	1.811	0.96
119_Q	123_R	1.799	0.95
266_Y	270_E	1.750	0.95
143_G	178_R	1.750	0.95
118_I	122_K	1.746	0.95
266_Y	269_G	1.741	0.95
230_N	233_D	1.722	0.94
119_Q	126_K	1.705	0.94
80_D	107_I	1.689	0.94
81_F	121_M	1.687	0.94
152_A	156_Y	1.679	0.93
76_V	81_F	1.660	0.93
330_T	361_V	1.630	0.92
35_I	43_K	1.621	0.92
294_A	298_K	1.616	0.92
89_L	165_V	1.592	0.91
255_T	265_D	1.588	0.91
111_S	242_E	1.565	0.91
87_N	90_Q	1.555	0.90
53_L	57_D	1.555	0.90
294_A	297_E	1.552	0.90
41_R	45_Y	1.551	0.90
214_Y	308_G	1.543	0.90
224_Q	227_H	1.539	0.90
105_A	114_R	1.524	0.89
253_Q	289_L	1.522	0.89
78_I	102_G	1.518	0.89
255_T	289_L	1.508	0.89
164_V	176_I	1.495	0.89
301_G	307_P	1.488	0.88
67_E	72_V	1.485	0.88
104_K	177_N	1.484	0.88
184_S	187_E	1.482	0.88
5_V	12_T	1.462	0.87
14_Q	22_G	1.450	0.87
176_I	205_I	1.434	0.86
251_N	271_R	1.423	0.86
80_D	83_G	1.421	0.86
89_L	98_I	1.414	0.86
122_K	135_V	1.407	0.85
61_I	201_D	1.400	0.85
122_K	213_L	1.398	0.85
40_F	45_Y	1.396	0.85
123_R	363_R	1.389	0.84
249_Q	286_R	1.375	0.84
183_V	186_E	1.374	0.84
191_T	198_T	1.372	0.84
268_S	348_K	1.364	0.83
264_F	274_F	1.347	0.83
18_K	37_Q	1.346	0.83
166_G	171_G	1.345	0.82
166_G	172_K	1.345	0.82
80_D	84_S	1.340	0.82
64_G	67_E	1.313	0.81
28_S	31_K	1.309	0.81
9_C	14_Q	1.298	0.80
119_Q	122_K	1.282	0.79
8_G	198_T	1.275	0.79
291_N	294_A	1.272	0.79
7_I	35_I	1.270	0.79
21_L	52_S	1.254	0.78
25_P	37_Q	1.253	0.78
74_K	85_W	1.246	0.77
241_K	306_P	1.246	0.77
300_A	312_M	1.246	0.77
233_D	308_G	1.243	0.77
152_A	155_H	1.236	0.77
136_F	152_A	1.236	0.77
71_L	99_L	1.234	0.77
81_F	84_S	1.234	0.77
308_G	311_E	1.226	0.76
9_C	22_G	1.223	0.76
175_F	221_N	1.207	0.75
133_V	156_Y	1.200	0.75
332_I	349_V	1.195	0.74
56_D	72_V	1.190	0.74
254_Q	286_R	1.189	0.74
164_V	225_M	1.186	0.74
6_C	22_G	1.177	0.73
322_T	348_K	1.177	0.73
177_N	191_T	1.175	0.73
38_R	193_S	1.170	0.73
221_N	224_Q	1.170	0.73
292_A	296_Y	1.167	0.72
247_T	256_L	1.155	0.72
130_L	223_H	1.147	0.71
102_G	137_L	1.146	0.71
79_F	201_D	1.143	0.71
74_K	175_F	1.138	0.71
230_N	311_E	1.138	0.71
99_L	133_V	1.105	0.68
181_K	202_A	1.101	0.68
72_V	365_L	1.095	0.68
258_F	340_V	1.094	0.67
18_K	23_Y	1.094	0.67
194_Q	201_D	1.092	0.67
249_Q	273_P	1.091	0.67
285_H	299_H	1.091	0.67
287_T	292_A	1.088	0.67
6_C	14_Q	1.086	0.67
8_G	77_D	1.080	0.66
82_N	124_E	1.078	0.66
138_V	149_V	1.075	0.66
146_I	175_F	1.074	0.66
321_H	353_A	1.073	0.66
223_H	335_S	1.067	0.65
89_L	290_E	1.064	0.65
232_K	311_E	1.058	0.65
269_G	274_F	1.048	0.64
150_I	179_I	1.045	0.64
23_Y	37_Q	1.045	0.64
241_K	244_K	1.045	0.64
141_G	240_K	1.043	0.64
65_I	72_V	1.043	0.64
166_G	169_N	1.043	0.64
75_I	360_F	1.037	0.63
55_D	222_N	1.035	0.63
269_G	289_L	1.033	0.63
64_G	160_K	1.028	0.63
106_D	166_G	1.026	0.62
21_L	194_Q	1.024	0.62
259_G	282_L	1.024	0.62
85_W	128_L	1.023	0.62
185_G	189_I	1.014	0.61
215_D	218_G	1.011	0.61
102_G	266_Y	1.008	0.61
221_N	352_Y	1.008	0.61
188_D	332_I	1.005	0.61
323_F	351_A	1.003	0.61
171_G	215_D	0.998	0.60
172_K	215_D	0.998	0.60
48_I	238_S	0.993	0.60
79_F	239_P	0.992	0.60
41_R	46_N	0.991	0.60
106_D	171_G	0.990	0.60
106_D	172_K	0.990	0.60
199_T	215_D	0.988	0.59
23_Y	64_G	0.986	0.59
101_V	138_V	0.979	0.59
95_G	334_F	0.979	0.59
305_T	312_M	0.975	0.58
122_K	126_K	0.974	0.58
166_G	215_D	0.970	0.58
70_S	96_N	0.967	0.58
109_P	216_T	0.966	0.58
172_K	218_G	0.963	0.57
171_G	218_G	0.963	0.57
123_R	126_K	0.960	0.57
23_Y	268_S	0.956	0.57
258_F	278_M	0.949	0.56
301_G	306_P	0.948	0.56
75_I	136_F	0.948	0.56
77_D	200_L	0.946	0.56
191_T	207_L	0.937	0.55
258_F	262_A	0.936	0.55
17_D	309_K	0.935	0.55
88_G	91_R	0.935	0.55
23_Y	332_I	0.935	0.55
166_G	218_G	0.934	0.55
229_V	245_P	0.931	0.55
98_I	230_N	0.931	0.55
285_H	304_L	0.927	0.55
43_K	295_L	0.927	0.55
18_K	259_G	0.926	0.54
315_F	318_L	0.922	0.54
115_E	126_K	0.922	0.54
168_T	220_I	0.920	0.54
198_T	336_G	0.919	0.54
72_V	93_V	0.918	0.54
138_V	146_I	0.916	0.54
98_I	115_E	0.907	0.53
169_N	172_K	0.907	0.53
46_N	121_M	0.903	0.53
52_S	302_E	0.891	0.52
10_G	14_Q	0.891	0.52
105_A	332_I	0.884	0.51
91_R	227_H	0.883	0.51
257_Y	296_Y	0.882	0.51
193_S	198_T	0.878	0.51
49_Q	242_E	0.877	0.50
211_S	264_F	0.874	0.50
9_C	39_C	0.870	0.50
44_N	250_L	0.869	0.50
267_V	322_T	0.868	0.50
266_Y	274_F	0.867	0.50
24_A	37_Q	0.865	0.49
302_E	309_K	0.865	0.49
24_A	100_L	0.861	0.49
105_A	144_Q	0.861	0.49
167_C	175_F	0.861	0.49
100_L	130_L	0.860	0.49
6_C	39_C	0.854	0.49
257_Y	287_T	0.843	0.48
134_D	152_A	0.843	0.48
251_N	364_S	0.842	0.48
301_G	304_L	0.842	0.48
146_I	182_E	0.837	0.47
229_V	233_D	0.835	0.47
183_V	189_I	0.833	0.47
22_G	106_D	0.831	0.47
77_D	336_G	0.830	0.47
22_G	39_C	0.828	0.46
83_G	120_W	0.827	0.46
57_D	81_F	0.826	0.46
92_L	179_I	0.826	0.46
109_P	263_R	0.826	0.46
310_D	317_E	0.824	0.46
213_L	334_F	0.821	0.46
60_N	294_A	0.820	0.46
166_G	173_S	0.818	0.46
325_I	330_T	0.817	0.46
147_R	297_E	0.812	0.45
80_D	260_G	0.810	0.45
250_L	286_R	0.804	0.44
236_I	281_E	0.803	0.44
95_G	363_R	0.803	0.44
165_V	168_T	0.802	0.44
70_S	160_K	0.801	0.44
330_T	364_S	0.800	0.44
76_V	86_I	0.797	0.44
274_F	342_V	0.797	0.44
263_R	292_A	0.795	0.44
37_Q	41_R	0.794	0.44
53_L	58_F	0.793	0.44
103_N	250_L	0.793	0.44
9_C	23_Y	0.792	0.44
9_C	36_C	0.792	0.44
10_G	22_G	0.789	0.43
112_L	117_L	0.789	0.43
21_L	53_L	0.787	0.43
149_V	253_Q	0.786	0.43
96_N	130_L	0.785	0.43
129_G	256_L	0.782	0.43
84_S	170_V	0.782	0.43
63_H	179_I	0.781	0.43
30_T	64_G	0.778	0.42
332_I	342_V	0.776	0.42
6_C	36_C	0.776	0.42
329_K	364_S	0.770	0.42
267_V	320_A	0.769	0.42
23_Y	291_N	0.768	0.42
339_W	365_L	0.767	0.42
253_Q	325_I	0.765	0.41
275_I	278_M	0.764	0.41
26_P	64_G	0.763	0.41
249_Q	254_Q	0.762	0.41
278_M	284_I	0.762	0.41
70_S	163_Y	0.760	0.41
76_V	93_V	0.759	0.41
190_I	207_L	0.758	0.41
8_G	22_G	0.754	0.40
54_T	57_D	0.754	0.40
285_H	291_N	0.752	0.40
304_L	307_P	0.747	0.40
6_C	23_Y	0.747	0.40
265_D	289_L	0.745	0.40
10_G	39_C	0.742	0.40
175_F	352_Y	0.742	0.40
291_N	295_L	0.741	0.39
343_H	348_K	0.740	0.39
80_D	103_N	0.736	0.39
105_A	143_G	0.736	0.39
185_G	188_D	0.731	0.39
337_L	357_V	0.730	0.39
17_D	258_F	0.729	0.39
40_F	44_N	0.728	0.38
178_R	181_K	0.727	0.38
102_G	105_A	0.727	0.38
332_I	351_A	0.725	0.38
229_V	237_L	0.723	0.38
130_L	335_S	0.722	0.38
164_V	282_L	0.722	0.38
281_E	332_I	0.717	0.38
291_N	298_K	0.717	0.38
22_G	36_C	0.717	0.38
93_V	98_I	0.711	0.37
199_T	218_G	0.711	0.37
121_M	266_Y	0.710	0.37
54_T	59_L	0.709	0.37
115_E	122_K	0.708	0.37
260_G	338_G	0.704	0.37
117_L	312_M	0.703	0.37
10_G	23_Y	0.703	0.37
103_N	220_I	0.700	0.36
171_G	199_T	0.700	0.36
172_K	199_T	0.700	0.36
256_L	259_G	0.700	0.36
62_L	238_S	0.700	0.36
179_I	365_L	0.697	0.36
124_E	312_M	0.697	0.36
353_A	359_V	0.697	0.36
132_P	353_A	0.696	0.36
13_I	221_N	0.696	0.36
24_A	89_L	0.695	0.36
108_L	254_Q	0.694	0.36
138_V	167_C	0.694	0.36
21_L	101_V	0.693	0.36
136_F	149_V	0.693	0.36
336_G	339_W	0.692	0.36
102_G	262_A	0.690	0.36
219_I	232_K	0.689	0.35
77_D	84_S	0.689	0.35
230_N	308_G	0.688	0.35
175_F	202_A	0.685	0.35
76_V	100_L	0.683	0.35
141_G	270_E	0.682	0.35
62_L	275_I	0.682	0.35
35_I	74_K	0.681	0.35
116_R	120_W	0.681	0.35
153_I	203_I	0.679	0.35
138_V	143_G	0.678	0.35
151_D	332_I	0.677	0.35
296_Y	334_F	0.677	0.35
60_N	264_F	0.675	0.34
76_V	85_W	0.674	0.34
58_F	62_L	0.674	0.34
229_V	352_Y	0.673	0.34
30_T	130_L	0.673	0.34
166_G	199_T	0.671	0.34
7_I	31_K	0.669	0.34
219_I	265_D	0.668	0.34
17_D	55_D	0.667	0.34
172_K	217_P	0.667	0.34
171_G	217_P	0.667	0.34
264_F	334_F	0.665	0.34
10_G	36_C	0.664	0.34
78_I	194_Q	0.661	0.33
74_K	89_L	0.661	0.33
102_G	153_I	0.658	0.33
297_E	309_K	0.657	0.33
177_N	192_T	0.656	0.33
93_V	96_N	0.656	0.33
63_H	66_G	0.655	0.33
320_A	352_Y	0.654	0.33
87_N	98_I	0.652	0.33
94_G	97_P	0.652	0.33
160_K	228_Y	0.648	0.32
169_N	199_T	0.648	0.32
63_H	81_F	0.648	0.32
97_P	228_Y	0.645	0.32
352_Y	360_F	0.645	0.32
352_Y	359_V	0.643	0.32
65_I	93_V	0.639	0.32
166_G	217_P	0.637	0.32
313_D	321_H	0.637	0.32
174_T	284_I	0.635	0.32
104_K	191_T	0.634	0.31
96_N	203_I	0.633	0.31
264_F	348_K	0.633	0.31
200_L	239_P	0.629	0.31
255_T	310_D	0.627	0.31
157_R	161_D	0.625	0.31
78_I	108_L	0.625	0.31
12_T	152_A	0.625	0.31
101_V	136_F	0.624	0.31
146_I	183_V	0.623	0.31
48_I	74_K	0.623	0.31
146_I	158_N	0.623	0.31
99_L	156_Y	0.617	0.30
42_L	224_Q	0.617	0.30
15_T	24_A	0.617	0.30
111_S	190_I	0.617	0.30
228_Y	246_R	0.616	0.30
327_D	342_V	0.616	0.30
308_G	319_V	0.615	0.30
73_V	101_V	0.615	0.30
137_L	274_F	0.614	0.30
106_D	215_D	0.614	0.30
258_F	295_L	0.614	0.30
208_D	211_S	0.614	0.30
123_R	156_Y	0.614	0.30
135_V	274_F	0.614	0.30
164_V	246_R	0.613	0.30
248_F	288_K	0.613	0.30
228_Y	238_S	0.612	0.30
74_K	81_F	0.611	0.30
105_A	342_V	0.611	0.30
162_V	197_G	0.609	0.30
91_R	290_E	0.608	0.30
58_F	295_L	0.607	0.30
234_L	282_L	0.607	0.30
285_H	292_A	0.604	0.29
290_E	298_K	0.603	0.29
323_F	332_I	0.600	0.29
274_F	365_L	0.599	0.29
62_L	356_G	0.598	0.29
36_C	218_G	0.598	0.29
327_D	343_H	0.597	0.29
8_G	191_T	0.597	0.29
126_K	131_K	0.597	0.29
237_L	365_L	0.593	0.29
323_F	358_H	0.589	0.28
202_A	214_Y	0.588	0.28
240_K	281_E	0.585	0.28
124_E	128_L	0.583	0.28
77_D	80_D	0.583	0.28
67_E	152_A	0.583	0.28
109_P	177_N	0.581	0.28
323_F	357_V	0.581	0.28
38_R	198_T	0.581	0.28
52_S	297_E	0.580	0.28
168_T	193_S	0.579	0.28
4_V	75_I	0.579	0.28
151_D	154_E	0.578	0.28
106_D	218_G	0.578	0.28
114_R	349_V	0.578	0.28
68_T	342_V	0.577	0.28
220_I	227_H	0.575	0.27
227_H	354_P	0.574	0.27
102_G	291_N	0.572	0.27
225_M	323_F	0.570	0.27
105_A	137_L	0.569	0.27
74_K	214_Y	0.569	0.27
169_N	215_D	0.569	0.27
198_T	263_R	0.568	0.27
63_H	88_G	0.567	0.27
108_L	331_D	0.567	0.27
146_I	184_S	0.567	0.27
287_T	291_N	0.564	0.27
176_I	207_L	0.563	0.27
191_T	263_R	0.563	0.27
8_G	255_T	0.562	0.27
142_R	182_E	0.561	0.27
88_G	168_T	0.560	0.26
68_T	101_V	0.560	0.26
270_E	274_F	0.559	0.26
183_V	343_H	0.557	0.26
250_L	287_T	0.557	0.26
146_I	260_G	0.555	0.26
18_K	264_F	0.555	0.26
176_I	229_V	0.555	0.26
78_I	357_V	0.554	0.26
86_I	170_V	0.554	0.26
85_W	214_Y	0.550	0.26
234_L	239_P	0.550	0.26
45_Y	249_Q	0.549	0.26
90_Q	125_A	0.549	0.26
24_A	85_W	0.548	0.26
153_I	162_V	0.548	0.26
69_D	277_Y	0.548	0.26
150_I	175_F	0.546	0.26
330_T	349_V	0.546	0.26
219_I	315_F	0.544	0.25
75_I	283_M	0.543	0.25
119_Q	209_D	0.543	0.25
195_F	205_I	0.542	0.25
77_D	109_P	0.542	0.25
311_E	315_F	0.542	0.25
34_V	319_V	0.542	0.25
252_D	266_Y	0.541	0.25
76_V	192_T	0.540	0.25
70_S	93_V	0.540	0.25
135_V	145_G	0.539	0.25
35_I	48_I	0.534	0.25
75_I	167_C	0.534	0.25
92_L	131_K	0.533	0.25
41_R	180_I	0.533	0.25
29_L	129_G	0.533	0.25
140_A	356_G	0.533	0.25
290_E	364_S	0.532	0.25
176_I	195_F	0.530	0.25
90_Q	128_L	0.530	0.25
106_D	169_N	0.529	0.25
169_N	218_G	0.529	0.25
325_I	361_V	0.528	0.25
158_N	178_R	0.528	0.25
187_E	365_L	0.526	0.24
109_P	265_D	0.525	0.24
272_S	346_D	0.523	0.24
8_G	200_L	0.523	0.24
124_E	279_P	0.521	0.24
310_D	313_D	0.520	0.24
7_I	204_E	0.519	0.24
218_G	338_G	0.519	0.24
110_K	340_V	0.519	0.24
110_K	244_K	0.517	0.24
85_W	258_F	0.513	0.24
162_V	263_R	0.512	0.24
42_L	272_S	0.511	0.23
331_D	339_W	0.511	0.23
70_S	94_G	0.510	0.23
48_I	202_A	0.509	0.23
231_K	258_F	0.508	0.23
174_T	191_T	0.507	0.23
124_E	360_F	0.507	0.23
164_V	264_F	0.506	0.23
117_L	235_K	0.506	0.23
12_T	21_L	0.505	0.23
134_D	156_Y	0.505	0.23
81_F	124_E	0.504	0.23
84_S	198_T	0.503	0.23
50_D	74_K	0.503	0.23
265_D	292_A	0.502	0.23
15_T	204_E	0.502	0.23
44_N	363_R	0.502	0.23
64_G	78_I	0.502	0.23
173_S	215_D	0.501	0.23
196_P	362_R	0.500	0.23
8_G	267_V	0.500	0.23
195_F	219_I	0.500	0.23

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3h2yA	1	0.8415	100	0.347	Contact Map
3ec1A	1	0.8497	100	0.38	Contact Map
1pujA	1	0.6202	99.9	0.778	Contact Map
3cnlA	1	0.6011	99.9	0.808	Contact Map
2yv5A	1	0.735	99.8	0.81	Contact Map
1mkyA	1	0.8087	99.8	0.814	Contact Map
1u0lA	1	0.6694	99.8	0.818	Contact Map
4dcuA	1	0.8115	99.8	0.824	Contact Map
2rcnA	2	0.6503	99.8	0.828	Contact Map
1t9hA	1	0.6475	99.8	0.828	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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