GREMLIN Database
YQEF - Uncharacterized lipoprotein YqeF
UniProt: P54451 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 243 (189)
Sequences: 7927 (5985)
Seq/√Len: 435.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
138_T190_L3.7791.00
117_R181_D3.4741.00
121_V186_L3.2261.00
92_L127_S2.9401.00
121_V185_R2.8961.00
27_A33_T2.8211.00
125_E186_L2.7561.00
76_A96_F2.6561.00
81_Q126_E2.5521.00
73_T119_N2.4611.00
183_S190_L2.1121.00
77_R122_Y2.0851.00
71_Q79_R2.0681.00
92_L132_I2.0141.00
117_R178_I2.0081.00
28_F76_A1.9641.00
193_N231_V1.9321.00
25_V93_F1.9021.00
121_V125_E1.8411.00
229_R233_E1.8381.00
32_N223_M1.8151.00
139_C176_N1.7001.00
223_M231_V1.6791.00
24_D62_D1.6631.00
230_I233_E1.6601.00
128_R186_L1.6361.00
192_D195_K1.6231.00
27_A93_F1.6121.00
180_R190_L1.6081.00
36_S69_G1.6021.00
136_L179_T1.5921.00
133_K189_P1.5651.00
234_G237_D1.5181.00
127_S132_I1.5111.00
39_D225_P1.5111.00
34_R69_G1.5101.00
177_D181_D1.4751.00
126_E130_H1.4401.00
73_T116_F1.4341.00
117_R121_V1.4271.00
33_T67_G1.4271.00
124_I136_L1.4141.00
47_Q225_P1.3861.00
98_T221_N1.3811.00
191_V238_G1.3801.00
226_K229_R1.3621.00
112_S115_R1.3531.00
52_I229_R1.3481.00
120_L179_T1.3411.00
136_L183_S1.3411.00
138_T192_D1.3401.00
73_T123_F1.3351.00
124_I188_V1.3251.00
178_I181_D1.3221.00
196_H234_G1.3121.00
80_F127_S1.3101.00
117_R185_R1.2971.00
32_N98_T1.2901.00
23_E61_L1.2781.00
124_I186_L1.2721.00
77_R119_N1.2691.00
124_I182_V1.2651.00
56_A236_Q1.2501.00
138_T180_R1.2501.00
77_R126_E1.2291.00
116_F179_T1.2281.00
23_E90_K1.2281.00
75_D78_L1.2231.00
137_M235_I1.2131.00
122_Y126_E1.2111.00
94_I123_F1.2091.00
80_F123_F1.2081.00
116_F175_Y1.1921.00
182_V186_L1.1881.00
68_I79_R1.1861.00
73_T120_L1.1801.00
135_I191_V1.1541.00
93_F137_M1.1421.00
71_Q75_D1.1331.00
48_Q51_N1.1321.00
115_R118_E1.1251.00
140_I223_M1.1241.00
56_A233_E1.1171.00
232_Y236_Q1.1021.00
27_A50_V1.0961.00
74_E115_R1.0911.00
52_I232_Y1.0791.00
194_W198_I1.0741.00
91_Y135_I1.0721.00
113_K174_S1.0721.00
180_R184_K1.0701.00
195_K198_I1.0691.00
118_E121_V1.0571.00
127_S134_P1.0511.00
118_E122_Y1.0481.00
169_R173_N1.0411.00
120_L124_I1.0381.00
33_T95_M1.0371.00
136_L182_V1.0351.00
91_Y133_K1.0281.00
172_H176_N1.0231.00
171_W174_S1.0221.00
116_F178_I1.0191.00
122_Y125_E1.0081.00
121_V182_V1.0061.00
73_T96_F1.0051.00
126_E129_K1.0001.00
230_I234_G0.9951.00
170_K174_S0.9871.00
30_D97_G0.9811.00
38_W225_P0.9751.00
26_V89_P0.9691.00
119_N123_F0.9691.00
125_E129_K0.9641.00
24_D64_L0.9591.00
173_N177_D0.9571.00
81_Q85_L0.9451.00
114_Q118_E0.9451.00
52_I56_A0.9441.00
131_G134_P0.9251.00
89_P132_I0.9251.00
137_M193_N0.9221.00
74_E78_L0.9111.00
113_K117_R0.9091.00
181_D185_R0.9051.00
85_L130_H0.9021.00
47_Q52_I0.8991.00
115_R119_N0.8931.00
72_T75_D0.8801.00
73_T77_R0.8791.00
66_A87_Q0.8761.00
76_A123_F0.8741.00
95_M140_I0.8731.00
195_K199_E0.8681.00
176_N180_R0.8631.00
216_I220_G0.8611.00
25_V63_I0.8611.00
125_E128_R0.8601.00
124_I134_P0.8491.00
79_R83_D0.8461.00
191_V235_I0.8411.00
81_Q86_D0.8291.00
82_T85_L0.8291.00
140_I197_F0.8221.00
141_P197_F0.8151.00
135_I189_P0.8131.00
74_E119_N0.8111.00
228_A231_V0.8081.00
183_S188_V0.8081.00
51_N54_K0.8071.00
176_N179_T0.8061.00
28_F83_D0.8051.00
98_T139_C0.8011.00
18_E21_G0.7991.00
124_I128_R0.7911.00
175_Y179_T0.7911.00
93_F135_I0.7911.00
226_K230_I0.7891.00
102_A221_N0.7891.00
95_M98_T0.7861.00
182_V185_R0.7851.00
234_G238_G0.7811.00
68_I71_Q0.7761.00
34_R67_G0.7701.00
28_F80_F0.7701.00
215_L230_I0.7661.00
177_D180_R0.7651.00
196_H199_E0.7571.00
24_D87_Q0.7571.00
33_T235_I0.7551.00
26_V66_A0.7521.00
30_D95_M0.7501.00
80_F83_D0.7491.00
98_T142_I0.7481.00
24_D90_K0.7461.00
114_Q117_R0.7441.00
26_V64_L0.7421.00
52_I55_T0.7411.00
98_T102_A0.7331.00
169_R172_H0.7281.00
25_V91_Y0.7261.00
120_L182_V0.7241.00
117_R182_V0.7141.00
181_D184_K0.7091.00
174_S177_D0.6971.00
114_Q174_S0.6941.00
93_F235_I0.6881.00
27_A53_L0.6881.00
49_W52_I0.6861.00
180_R192_D0.6861.00
23_E91_Y0.6821.00
100_D119_N0.6791.00
28_F123_F0.6771.00
101_A175_Y0.6651.00
182_V188_V0.6641.00
111_V115_R0.6591.00
98_T140_I0.6591.00
189_P238_G0.6581.00
140_I176_N0.6581.00
77_R118_E0.6571.00
49_W228_A0.6561.00
114_Q178_I0.6561.00
85_L126_E0.6540.99
186_L189_P0.6500.99
119_N122_Y0.6470.99
136_L188_V0.6460.99
135_I238_G0.6450.99
35_G228_A0.6440.99
25_V61_L0.6420.99
33_T93_F0.6390.99
116_F120_L0.6380.99
83_D86_D0.6380.99
134_P188_V0.6380.99
69_G102_A0.6360.99
50_V54_K0.6340.99
170_K173_N0.6230.99
57_E60_N0.6220.99
137_M231_V0.6210.99
101_A142_I0.6210.99
22_Y60_N0.6200.99
113_K178_I0.6190.99
27_A67_G0.6180.99
57_E61_L0.6160.99
67_G79_R0.6120.99
77_R81_Q0.6120.99
197_F200_A0.6080.99
95_M223_M0.6060.99
104_L109_P0.6030.99
95_M137_M0.6020.99
101_A116_F0.6010.99
26_V92_L0.6010.99
138_T179_T0.5970.99
66_A83_D0.5960.99
120_L136_L0.5950.99
179_T182_V0.5940.99
31_S222_H0.5890.99
141_P144_E0.5890.99
28_F66_A0.5890.99
61_L90_K0.5880.99
67_G123_F0.5870.99
53_L236_Q0.5870.99
179_T183_S0.5830.99
225_P229_R0.5770.99
27_A63_I0.5770.99
36_S228_A0.5760.99
213_S216_I0.5710.99
214_G226_K0.5700.99
215_L218_P0.5680.99
176_N194_W0.5660.99
200_A204_K0.5630.98
223_M228_A0.5600.98
35_G48_Q0.5590.98
178_I182_V0.5580.98
49_W235_I0.5540.98
81_Q84_V0.5510.98
96_F120_L0.5500.98
164_P169_R0.5500.98
32_N95_M0.5490.98
142_I168_A0.5480.98
49_W54_K0.5460.98
55_T229_R0.5450.98
102_A168_A0.5450.98
173_N176_N0.5440.98
111_V116_F0.5430.98
201_D204_K0.5400.98
77_R123_F0.5390.98
80_F126_E0.5380.98
101_A172_H0.5360.98
67_G227_G0.5280.98
168_A171_W0.5240.98
142_I221_N0.5200.97
26_V87_Q0.5190.97
101_A171_W0.5180.97
53_L56_A0.5160.97
66_A84_V0.5150.97
52_I228_A0.5120.97
71_Q96_F0.5110.97
47_Q51_N0.5110.97
123_F126_E0.5090.97
143_I146_N0.5090.97
197_F201_D0.5090.97
96_F101_A0.5090.97
38_W47_Q0.5030.97
199_E202_G0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4jggA 1 0.7284 100 0.348 Contact Map
4jhlA 5 0.8313 100 0.369 Contact Map
4q9aA 2 0.8519 100 0.373 Contact Map
3rjtA 2 0.8272 100 0.377 Contact Map
4rw0A 1 0.7449 100 0.379 Contact Map
2o14A 1 0.9012 100 0.379 Contact Map
3milA 2 0.8477 100 0.382 Contact Map
1k7cA 1 0.7984 100 0.392 Contact Map
1ivnA 2 0.7284 100 0.392 Contact Map
4q7qA 1 0.893 100 0.395 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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