GREMLIN Database
YQED - Uncharacterized protein YqeD
UniProt: P54449 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 208 (175)
Sequences: 9623 (7079)
Seq/√Len: 535.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
84_I148_W3.9741.00
72_I164_V2.9351.00
147_R150_V2.7221.00
67_G70_N2.4451.00
120_F154_A2.3721.00
84_I152_F2.3681.00
80_M156_L2.3641.00
95_R112_E2.3641.00
195_I199_F2.3591.00
120_F150_V2.2141.00
124_L157_I2.1071.00
40_S62_N2.0791.00
181_I185_G1.9951.00
45_A85_L1.9671.00
67_G71_G1.8861.00
76_L160_I1.8861.00
118_N121_T1.8681.00
109_Q113_A1.7931.00
194_V198_K1.7491.00
112_E116_N1.7281.00
41_M74_I1.6661.00
94_F97_W1.6401.00
68_T72_I1.6361.00
88_F92_Y1.6091.00
176_N180_S1.5891.00
148_W152_F1.5851.00
75_T163_I1.5641.00
176_N179_L1.5471.00
72_I167_T1.5451.00
168_I172_N1.5391.00
90_A143_L1.5201.00
63_G170_G1.5191.00
91_R145_Q1.5181.00
41_M78_G1.5071.00
88_F148_W1.5071.00
196_Y200_P1.5021.00
183_I187_Y1.4971.00
41_M77_T1.4281.00
180_S184_Y1.4281.00
68_T168_I1.4271.00
80_M152_F1.4231.00
190_I193_L1.4021.00
37_V74_I1.3671.00
83_T155_S1.3611.00
196_Y199_F1.3591.00
149_H153_F1.3591.00
184_Y188_I1.3481.00
103_Q107_A1.3461.00
26_L30_K1.3441.00
29_I36_S1.3361.00
193_L197_K1.3321.00
69_A72_I1.3281.00
41_M45_A1.3271.00
198_K201_H1.3211.00
62_N71_G1.3131.00
70_N74_I1.3111.00
59_A75_T1.3011.00
178_L181_I1.3011.00
36_S66_F1.2931.00
75_T167_T1.2891.00
84_I88_F1.2811.00
69_A73_W1.2781.00
177_K180_S1.2721.00
45_A81_L1.2621.00
190_I194_V1.2451.00
90_A142_G1.2141.00
27_D30_K1.2131.00
70_N73_W1.1971.00
107_A110_S1.1841.00
123_V154_A1.1781.00
76_L156_L1.1711.00
71_G167_T1.1581.00
27_D31_A1.1541.00
189_L193_L1.1341.00
95_R99_R1.1301.00
74_I78_G1.1251.00
109_Q112_E1.1231.00
198_K202_L1.1191.00
121_T125_L1.1131.00
161_P164_V1.1121.00
128_L161_P1.1091.00
112_E145_Q1.1081.00
177_K181_I1.0921.00
197_K201_H1.0891.00
37_V70_N1.0871.00
40_S75_T1.0831.00
191_I195_I1.0811.00
72_I76_L1.0751.00
126_G137_M1.0651.00
123_V146_V1.0591.00
127_R155_S1.0571.00
179_L182_S1.0291.00
114_S122_A1.0281.00
192_M196_Y1.0201.00
112_E144_S1.0111.00
63_G167_T1.0111.00
59_A167_T1.0061.00
163_I167_T0.9961.00
66_F71_G0.9821.00
44_I48_V0.9821.00
149_H152_F0.9761.00
56_A166_V0.9711.00
44_I59_A0.9691.00
115_F141_C0.9651.00
73_W77_T0.9591.00
41_M81_L0.9571.00
152_F156_L0.9521.00
186_T190_I0.9501.00
199_F202_L0.9501.00
155_S159_K0.9461.00
59_A63_G0.9441.00
44_I47_D0.9401.00
178_L182_S0.9351.00
92_Y96_D0.9301.00
86_L139_V0.9301.00
72_I168_I0.9231.00
62_N75_T0.9231.00
194_V197_K0.9141.00
157_I160_I0.9051.00
150_V154_A0.8891.00
181_I184_Y0.8831.00
61_L64_A0.8781.00
68_T167_T0.8741.00
35_F39_F0.8721.00
32_G39_F0.8701.00
134_S159_K0.8611.00
124_L154_A0.8611.00
73_W76_L0.8581.00
99_R104_A0.8571.00
69_A168_I0.8511.00
120_F153_F0.8461.00
37_V67_G0.8391.00
104_A109_Q0.8361.00
28_A32_G0.8361.00
195_I198_K0.8241.00
103_Q106_P0.8181.00
138_N155_S0.8181.00
134_S162_N0.8171.00
180_S183_I0.8161.00
79_S159_K0.8151.00
61_L65_V0.8141.00
179_L183_I0.8121.00
187_Y190_I0.8081.00
193_L196_Y0.8021.00
113_A117_K0.8001.00
164_V168_I0.7961.00
101_K104_A0.7941.00
62_N66_F0.7941.00
76_L80_M0.7941.00
76_L163_I0.7931.00
46_A51_P0.7821.00
150_V153_F0.7811.00
127_R138_N0.7781.00
83_T138_N0.7741.00
185_G189_L0.7681.00
113_A116_N0.7661.00
44_I58_I0.7651.00
153_F157_I0.7611.00
124_L161_P0.7581.00
83_T127_R0.7541.00
182_S185_G0.7531.00
38_L42_L0.7501.00
106_P110_S0.7491.00
81_L85_L0.7481.00
87_F151_F0.7461.00
97_W101_K0.7451.00
63_G71_G0.7421.00
56_A134_S0.7341.00
159_K162_N0.7331.00
59_A79_S0.7271.00
45_A78_G0.7251.00
125_L129_I0.7241.00
45_A48_V0.7221.00
98_A108_I0.7211.00
34_M38_L0.7191.00
188_I192_M0.7111.00
86_L135_L0.7101.00
176_N181_I0.7051.00
57_L61_L0.7001.00
53_V135_L0.6991.00
47_D82_G0.6931.00
137_M141_C0.6921.00
98_A102_V0.6921.00
51_P86_L0.6921.00
47_D135_L0.6901.00
80_M159_K0.6891.00
169_A173_F0.6881.00
114_S117_K0.6871.00
74_I77_T0.6871.00
177_K188_I0.6871.00
95_R98_A0.6751.00
154_A158_G0.6731.00
44_I78_G0.6711.00
182_S186_T0.6711.00
37_V41_M0.6621.00
185_G200_P0.6611.00
50_F86_L0.6601.00
47_D55_F0.6601.00
87_F148_W0.6581.00
169_A172_N0.6551.00
165_V169_A0.6511.00
187_Y191_I0.6491.00
59_A163_I0.6471.00
197_K200_P0.6461.00
88_F91_R0.6451.00
82_G86_L0.6441.00
124_L158_G0.6381.00
90_A139_V0.6381.00
126_G141_C0.6301.00
188_I191_I0.6261.00
76_L159_K0.6261.00
89_L93_S0.6231.00
68_T164_V0.6171.00
87_F91_R0.6121.00
176_N193_L0.6111.00
93_S96_D0.6091.00
97_W100_K0.6071.00
171_A174_T0.5981.00
83_T151_F0.5911.00
99_R109_Q0.5911.00
184_Y187_Y0.5840.99
176_N183_I0.5760.99
110_S114_S0.5730.99
111_Y144_S0.5720.99
120_F124_L0.5660.99
60_A64_A0.5620.99
153_F156_L0.5610.99
115_F119_A0.5580.99
47_D58_I0.5580.99
179_L190_I0.5570.99
52_I135_L0.5540.99
126_G132_I0.5540.99
80_M155_S0.5500.99
160_I164_V0.5450.99
165_V168_I0.5450.99
52_I55_F0.5450.99
64_A174_T0.5430.99
156_L160_I0.5420.99
77_T80_M0.5400.99
129_I132_I0.5380.99
42_L45_A0.5380.99
185_G188_I0.5380.99
171_A175_S0.5370.99
83_T148_W0.5350.99
28_A31_A0.5330.99
162_N166_V0.5300.99
119_A146_V0.5290.99
178_L190_I0.5280.99
177_K182_S0.5280.99
108_I112_E0.5260.99
32_G36_S0.5260.99
78_G82_G0.5210.99
46_A50_F0.5200.99
56_A60_A0.5190.99
120_F146_V0.5180.99
95_R145_Q0.5180.99
96_D99_R0.5110.99
72_I160_I0.5080.99
84_I155_S0.5080.99
99_R112_E0.5040.98
44_I55_F0.5020.98
110_S113_A0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4huqS 1 0.7308 36.9 0.92 Contact Map
2l2tA 2 0.1971 34.3 0.921 Contact Map
3ne5A 3 0.8846 31.3 0.923 Contact Map
2rddB 1 0.1538 26 0.926 Contact Map
3rlbA 1 0.7837 21.3 0.929 Contact Map
2m20A 2 0.1538 21.1 0.929 Contact Map
4dx5A 3 0.851 20.9 0.929 Contact Map
4dveA 3 0.7548 19.2 0.93 Contact Map
4a82A 2 0.8365 17.5 0.932 Contact Map
4x5mA 2 0.4375 17.4 0.932 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0076 seconds.