GREMLIN Database
YQEC - Putative 6-phosphogluconate dehydrogenase YqeC
UniProt: P54448 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 297 (276)
Sequences: 11437 (7361)
Seq/√Len: 443.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
145_E149_R3.6541.00
73_D102_R3.3841.00
138_H142_E3.3731.00
27_V47_T3.1171.00
40_K46_G2.9211.00
113_H140_A2.8711.00
2_K25_Q2.8551.00
113_H143_I2.7391.00
17_K42_Y2.7221.00
37_D41_A2.2701.00
48_T52_E2.2371.00
36_V46_G2.2331.00
4_G53_F2.2221.00
142_E145_E2.2121.00
107_M112_I2.1591.00
88_M144_V2.0261.00
13_I38_E1.9881.00
49_N52_E1.9431.00
24_H150_D1.9431.00
138_H159_Y1.9021.00
104_Y163_A1.8881.00
20_I44_A1.8871.00
80_S107_M1.8611.00
113_H137_D1.8561.00
65_V89_I1.8381.00
98_K253_D1.8251.00
18_Q21_D1.8231.00
22_R150_D1.7951.00
51_K55_S1.7911.00
250_T253_D1.7801.00
25_Q45_E1.7721.00
2_K27_V1.7671.00
34_A37_D1.7601.00
84_S87_D1.7471.00
32_N35_A1.7471.00
108_K137_D1.7071.00
105_N109_E1.6921.00
191_L203_V1.6851.00
137_D140_A1.6721.00
76_L89_I1.6551.00
132_F151_T1.6541.00
33_Q37_D1.6441.00
115_L136_G1.6051.00
28_G44_A1.6021.00
214_R219_G1.5991.00
277_F280_K1.5961.00
66_M92_A1.5911.00
88_M140_A1.5821.00
223_R227_K1.5781.00
237_I279_G1.5651.00
262_A266_M1.5571.00
199_D202_K1.5521.00
106_Q109_E1.5381.00
132_F152_A1.5321.00
104_Y108_K1.5111.00
102_R106_Q1.5101.00
141_W145_E1.5071.00
115_L144_V1.5001.00
117_A132_F1.4871.00
83_L87_D1.4821.00
18_Q129_G1.4771.00
64_W92_A1.4721.00
51_K82_L1.4481.00
55_S59_P1.4391.00
179_G183_A1.4181.00
141_W159_Y1.4161.00
37_D40_K1.4091.00
201_E205_R1.4031.00
123_M127_R1.4011.00
53_F60_P1.3951.00
160_A169_L1.3941.00
124_E128_H1.3911.00
263_M266_M1.3891.00
27_V45_E1.3801.00
70_G99_E1.3721.00
171_M246_W1.3711.00
27_V59_P1.3541.00
162_E165_S1.3481.00
61_R84_S1.3361.00
100_S114_Y1.3301.00
33_Q48_T1.3221.00
21_D42_Y1.3201.00
88_M143_I1.3121.00
59_P84_S1.3061.00
66_M119_T1.2941.00
107_M114_Y1.2881.00
80_S110_A1.2601.00
50_L82_L1.2551.00
17_K127_R1.2551.00
90_I144_V1.2501.00
192_E200_Y1.2421.00
14_N127_R1.2411.00
52_E55_S1.2301.00
252_L262_A1.2291.00
54_I82_L1.2271.00
78_D81_P1.2241.00
62_I88_M1.2081.00
4_G60_P1.2051.00
115_L141_W1.2021.00
16_G26_V1.2011.00
21_D127_R1.2001.00
178_Y240_S1.1901.00
208_N219_G1.1891.00
83_L112_I1.1891.00
265_L270_R1.1881.00
249_E253_D1.1851.00
73_D106_Q1.1821.00
280_K287_N1.1821.00
5_L15_I1.1661.00
62_I147_L1.1661.00
130_A155_N1.1651.00
251_A258_T1.1541.00
189_E193_N1.1491.00
237_I273_T1.1481.00
178_Y244_G1.1441.00
144_V148_F1.1431.00
101_I168_F1.1431.00
38_E41_A1.1421.00
257_A262_A1.1411.00
87_D112_I1.1391.00
92_A132_F1.1361.00
39_L44_A1.1291.00
194_S254_L1.1291.00
234_I237_I1.1271.00
5_L64_W1.1181.00
17_K21_D1.1171.00
67_V75_V1.1151.00
106_Q110_A1.1141.00
96_H99_E1.1141.00
81_P110_A1.1091.00
5_L16_G1.1051.00
241_S273_T1.0951.00
101_I105_N1.0871.00
89_I107_M1.0811.00
231_L234_I1.0801.00
70_G96_H1.0761.00
248_V262_A1.0701.00
134_V141_W1.0621.00
101_I163_A1.0591.00
73_D99_E1.0581.00
10_K123_M1.0551.00
105_N108_K1.0521.00
27_V60_P1.0491.00
30_D35_A1.0351.00
64_W147_L1.0341.00
20_I43_G1.0271.00
51_K78_D1.0261.00
92_A151_T1.0261.00
104_Y137_D1.0221.00
245_K265_L1.0181.00
47_T52_E1.0111.00
176_I187_G1.0091.00
202_K205_R1.0071.00
249_E252_L0.9971.00
38_E42_Y0.9751.00
115_L134_V0.9731.00
64_W90_I0.9671.00
172_I191_L0.9601.00
8_L39_L0.9591.00
149_R157_Y0.9581.00
47_T53_F0.9571.00
137_D162_E0.9571.00
77_R81_P0.9551.00
83_L89_I0.9491.00
33_Q46_G0.9481.00
120_S173_H0.9481.00
188_F204_A0.9421.00
216_W220_L0.9411.00
245_K249_E0.9391.00
71_I74_A0.9391.00
172_I187_G0.9341.00
120_S133_M0.9341.00
116_D164_G0.9341.00
77_R106_Q0.9281.00
76_L79_V0.9271.00
266_M270_R0.9261.00
72_V95_S0.9211.00
168_F194_S0.9211.00
160_A165_S0.9201.00
31_V71_I0.9201.00
101_I162_E0.9181.00
273_T278_T0.9181.00
76_L107_M0.9151.00
88_M113_H0.9131.00
136_G141_W0.9101.00
85_K111_G0.9091.00
73_D103_R0.9081.00
34_A38_E0.9031.00
179_G260_V0.9031.00
99_E102_R0.8981.00
142_E159_Y0.8981.00
13_I17_K0.8871.00
18_Q151_T0.8861.00
270_R274_D0.8861.00
100_S167_H0.8841.00
201_E226_A0.8841.00
62_I143_I0.8791.00
133_M206_V0.8731.00
5_L26_V0.8721.00
280_K284_A0.8701.00
241_S265_L0.8691.00
95_S99_E0.8661.00
193_N256_T0.8651.00
102_R105_N0.8631.00
96_H249_E0.8631.00
168_F250_T0.8601.00
15_I151_T0.8541.00
241_S270_R0.8531.00
160_A206_V0.8501.00
8_L28_G0.8411.00
35_A38_E0.8371.00
2_K61_R0.8341.00
182_A260_V0.8321.00
204_A208_N0.8301.00
19_F64_W0.8221.00
146_P149_R0.8191.00
3_I24_H0.8191.00
20_I42_Y0.8161.00
271_S275_D0.8021.00
63_L79_V0.8001.00
90_I117_A0.8001.00
140_A143_I0.7981.00
193_N254_L0.7951.00
80_S112_I0.7931.00
270_R273_T0.7911.00
277_F287_N0.7911.00
27_V53_F0.7891.00
135_G166_G0.7891.00
180_M184_I0.7881.00
65_V72_V0.7881.00
169_L198_F0.7871.00
116_D166_G0.7871.00
101_I164_G0.7841.00
141_W157_Y0.7791.00
91_E114_Y0.7781.00
175_G261_I0.7731.00
113_H139_E0.7721.00
68_P71_I0.7711.00
210_G213_I0.7701.00
98_K101_I0.7691.00
245_K270_R0.7681.00
260_V264_S0.7681.00
94_N246_W0.7671.00
53_F59_P0.7671.00
204_A222_E0.7651.00
159_Y162_E0.7641.00
175_G247_T0.7641.00
67_V71_I0.7631.00
15_I92_A0.7631.00
62_I90_I0.7631.00
198_F203_V0.7631.00
140_A144_V0.7611.00
201_E227_K0.7571.00
15_I66_M0.7551.00
222_E226_A0.7511.00
65_V76_L0.7491.00
145_E157_Y0.7391.00
148_F157_Y0.7391.00
5_L66_M0.7391.00
250_T254_L0.7381.00
115_L140_A0.7371.00
248_V265_L0.7361.00
28_G36_V0.7341.00
185_G285_L0.7311.00
213_I216_W0.7261.00
208_N214_R0.7261.00
24_H147_L0.7251.00
103_R114_Y0.7231.00
232_D235_K0.7221.00
122_G125_G0.7211.00
55_S82_L0.7181.00
234_I239_H0.7161.00
252_L265_L0.7121.00
272_L277_F0.7061.00
19_F26_V0.7061.00
52_E59_P0.7051.00
176_I183_A0.7031.00
80_S106_Q0.6991.00
13_I42_Y0.6991.00
31_V35_A0.6981.00
63_L83_L0.6931.00
6_I29_Y0.6921.00
176_I184_I0.6911.00
114_Y163_A0.6901.00
33_Q36_V0.6791.00
72_V93_G0.6781.00
3_I19_F0.6781.00
139_E142_E0.6761.00
117_A134_V0.6761.00
3_I147_L0.6761.00
6_I50_L0.6751.00
67_V72_V0.6721.00
134_V148_F0.6711.00
272_L284_A0.6701.00
224_A229_A0.6691.00
176_I180_M0.6671.00
158_L206_V0.6651.00
180_M215_S0.6631.00
148_F152_A0.6631.00
184_I218_M0.6611.00
169_L203_V0.6601.00
99_E103_R0.6571.00
13_I39_L0.6571.00
20_I26_V0.6551.00
85_K110_A0.6551.00
176_I207_W0.6531.00
236_G272_L0.6521.00
271_S274_D0.6521.00
222_E225_F0.6480.99
181_M282_V0.6480.99
11_M15_I0.6460.99
231_L280_K0.6450.99
189_E192_E0.6440.99
180_M217_L0.6430.99
135_G159_Y0.6420.99
36_V40_K0.6410.99
74_A77_R0.6390.99
95_S167_H0.6390.99
145_E159_Y0.6340.99
230_K287_N0.6330.99
95_S100_S0.6310.99
235_K239_H0.6250.99
45_E59_P0.6240.99
241_S245_K0.6240.99
60_P63_L0.6200.99
245_K252_L0.6200.99
16_G28_G0.6190.99
37_D46_G0.6160.99
84_S112_I0.6160.99
273_T276_T0.6150.99
190_V258_T0.6140.99
172_I190_V0.6120.99
179_G264_S0.6120.99
74_A78_D0.6120.99
125_G130_A0.6110.99
30_D33_Q0.6110.99
248_V252_L0.6110.99
216_W219_G0.6100.99
6_I53_F0.6100.99
117_A148_F0.6090.99
72_V99_E0.6090.99
284_A287_N0.6080.99
171_M247_T0.6050.99
168_F198_F0.6050.99
51_K81_P0.6020.99
65_V91_E0.5980.99
237_I278_T0.5970.99
17_K20_I0.5960.99
51_K77_R0.5950.99
72_V91_E0.5940.99
50_L54_I0.5880.99
29_Y50_L0.5870.99
96_H246_W0.5860.99
134_V157_Y0.5850.99
8_L16_G0.5840.99
208_N218_M0.5830.99
97_Y168_F0.5810.99
30_D71_I0.5800.99
14_N123_M0.5790.99
9_G68_P0.5780.99
63_L87_D0.5770.99
125_G128_H0.5720.99
240_S269_Y0.5700.99
206_V209_H0.5680.99
76_L103_R0.5670.99
62_I144_V0.5600.99
79_V83_L0.5590.99
2_K59_P0.5570.98
75_V78_D0.5560.98
156_G209_H0.5550.98
55_S84_S0.5540.98
17_K38_E0.5530.98
205_R226_A0.5530.98
72_V103_R0.5520.98
91_E100_S0.5520.98
189_E256_T0.5510.98
205_R222_E0.5500.98
36_V39_L0.5500.98
138_H141_W0.5480.98
213_I218_M0.5430.98
50_L53_F0.5410.98
191_L200_Y0.5370.98
50_L79_V0.5360.98
138_H145_E0.5340.98
64_W151_T0.5340.98
221_T224_A0.5340.98
270_R276_T0.5330.98
147_L150_D0.5330.98
146_P150_D0.5320.98
90_I148_F0.5300.98
30_D36_V0.5300.98
14_N129_G0.5260.98
260_V263_M0.5210.98
18_Q22_R0.5200.98
2_K60_P0.5190.98
173_H210_G0.5180.98
14_N18_Q0.5170.98
203_V207_W0.5170.98
11_M66_M0.5160.97
225_F286_R0.5160.97
100_S163_A0.5150.97
64_W148_F0.5140.97
185_G225_F0.5140.97
18_Q126_A0.5110.97
103_R106_Q0.5100.97
143_I146_P0.5090.97
190_V251_A0.5080.97
61_R87_D0.5050.97
28_G40_K0.5050.97
165_S168_F0.5050.97
139_E143_I0.5030.97
16_G39_L0.5030.97
98_K102_R0.5000.97
266_M271_S0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3pduA 4 0.9461 100 0.363 Contact Map
3pefA 5 0.9461 100 0.366 Contact Map
4e21A 4 0.9461 100 0.367 Contact Map
3dojA 3 0.9529 100 0.368 Contact Map
3obbA 4 0.9495 100 0.369 Contact Map
3ckyA 4 0.9663 100 0.373 Contact Map
3zgyA 2 0.9495 100 0.373 Contact Map
3g0oA 3 0.9394 100 0.374 Contact Map
1vpdA 1 0.9663 100 0.375 Contact Map
2gf2A 4 0.9562 100 0.376 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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