GREMLIN Database
PSIE - Protein PsiE homolog
UniProt: P54445 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 138 (123)
Sequences: 184 (124)
Seq/√Len: 11.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
117_M121_A4.7541.00
27_L31_A2.7810.92
74_L126_F2.4020.85
60_G123_I2.2660.81
22_L86_P2.2160.79
15_Q130_N2.2070.79
98_V122_M2.1850.78
43_F59_L2.1210.76
79_F92_Y2.0420.73
68_Y102_I2.0200.73
40_I115_W1.9870.71
37_T74_L1.9590.70
74_L81_S1.9540.70
70_E106_H1.8460.65
78_Y93_I1.7920.63
86_P89_Y1.7660.62
68_Y77_K1.7470.61
85_F103_I1.7270.60
11_P14_L1.7040.59
68_Y89_Y1.6920.58
79_F104_I1.6620.57
71_F119_I1.6340.56
104_I112_T1.6110.54
61_E115_W1.4730.48
91_I99_I1.4560.47
78_Y92_Y1.4520.47
56_Y118_A1.4440.46
125_G131_R1.4250.45
82_D121_A1.3740.43
91_I98_V1.3560.42
29_L103_I1.3560.42
88_R120_L1.3560.42
31_A38_W1.3390.41
85_F102_I1.3330.41
68_Y85_F1.3120.40
19_N79_F1.3100.40
20_V124_C1.3030.40
55_Y63_L1.2610.38
38_W123_I1.2550.37
15_Q18_L1.2400.37
37_T65_F1.2320.36
22_L75_I1.2270.36
101_L115_W1.2140.36
98_V126_F1.2080.35
22_L113_F1.2070.35
120_L124_C1.1990.35
32_L61_E1.1990.35
73_A120_L1.1840.34
118_A126_F1.1780.34
54_S115_W1.1360.32
58_M65_F1.1250.32
13_L27_L1.1110.31
21_C114_W1.1000.31
9_K128_I1.0800.30
10_V31_A1.0790.30
107_D124_C1.0650.29
120_L130_N1.0640.29
41_V63_L1.0590.29
53_D121_A1.0560.29
27_L57_E1.0560.29
14_L26_A1.0440.28
79_F83_F1.0290.28
30_S107_D1.0200.28
63_L82_D1.0200.28
13_L116_A1.0140.27
99_I125_G1.0130.27
7_F116_A1.0060.27
79_F90_F0.9840.26
66_F97_A0.9810.26
24_F113_F0.9770.26
98_V129_A0.9670.26
78_Y85_F0.9640.25
85_F92_Y0.9540.25
78_Y89_Y0.9490.25
27_L42_L0.9470.25
62_L72_I0.9240.24
124_C129_A0.9240.24
18_L112_T0.9230.24
19_N85_F0.9180.24
77_K85_F0.9080.23
54_S122_M0.9060.23
74_L129_A0.9040.23
34_I58_M0.8970.23
24_F53_D0.8920.23
74_L90_F0.8720.22
79_F85_F0.8690.22
22_L89_Y0.8690.22
32_L128_I0.8680.22
36_E64_I0.8670.22
65_F69_F0.8480.21
22_L95_I0.8390.21
86_P96_T0.8380.21
45_Y62_L0.8370.21
79_F102_I0.8270.21
113_F128_I0.8160.20
109_A115_W0.8160.20
98_V118_A0.8110.20
16_A20_V0.8090.20
108_Q113_F0.8070.20
30_S34_I0.7970.20
87_L94_G0.7960.20
53_D57_E0.7890.20
90_F112_T0.7860.19
59_L126_F0.7850.19
27_L110_I0.7820.19
35_S101_L0.7810.19
24_F46_K0.7770.19
77_K86_P0.7730.19
56_Y81_S0.7700.19
28_A37_T0.7700.19
57_E128_I0.7650.19
13_L17_L0.7640.19
85_F89_Y0.7560.19
20_V110_I0.7520.18
70_E97_A0.7510.18
77_K93_I0.7460.18
75_I103_I0.7290.18
25_L34_I0.7210.18
14_L83_F0.7210.18
78_Y86_P0.7150.17
91_I126_F0.7100.17
118_A123_I0.7040.17
90_F106_H0.7030.17
25_L115_W0.6990.17
42_L123_I0.6990.17
40_I61_E0.6970.17
18_L69_F0.6970.17
33_L64_I0.6880.17
20_V54_S0.6760.16
76_I104_I0.6610.16
20_V25_L0.6600.16
77_K83_F0.6600.16
11_P99_I0.6570.16
17_L104_I0.6550.16
70_E77_K0.6540.16
76_I116_A0.6490.16
12_Y20_V0.6480.16
83_F90_F0.6430.15
34_I38_W0.6410.15
24_F41_V0.6350.15
68_Y79_F0.6270.15
84_H100_R0.6260.15
68_Y92_Y0.6240.15
16_A58_M0.6240.15
74_L87_L0.6230.15
115_W122_M0.6190.15
32_L65_F0.6180.15
14_L105_D0.6170.15
92_Y102_I0.6170.15
20_V46_K0.6130.15
39_Y125_G0.6110.15
100_R119_I0.6100.15
61_E98_V0.6040.15
69_F73_A0.5950.14
111_S122_M0.5880.14
77_K92_Y0.5850.14
34_I123_I0.5790.14
45_Y121_A0.5760.14
70_E73_A0.5730.14
82_D128_I0.5730.14
17_L110_I0.5710.14
17_L58_M0.5680.14
14_L106_H0.5610.13
25_L37_T0.5590.13
45_Y131_R0.5570.13
40_I114_W0.5540.13
19_N92_Y0.5530.13
30_S50_N0.5530.13
31_A58_M0.5410.13
83_F92_Y0.5400.13
80_K117_M0.5390.13
19_N93_I0.5390.13
30_S108_Q0.5380.13
77_K90_F0.5370.13
74_L128_I0.5260.13
97_A119_I0.5260.13
31_A80_K0.5250.13
45_Y72_I0.5210.13
91_I129_A0.5190.13
43_F61_E0.5190.13
8_K27_L0.5150.12
88_R127_F0.5120.12
8_K41_V0.5030.12
37_T81_S0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4hw9A 3 0.6739 10.2 0.946 Contact Map
5ajiA 3 0.7391 8.2 0.949 Contact Map
1zrtD 1 0.3333 3.4 0.957 Contact Map
3j2wE 1 0.3333 2.4 0.96 Contact Map
3l1lA 2 0.8913 1.7 0.963 Contact Map
1rklA 1 0.2609 1.7 0.963 Contact Map
2mfrA 1 0.2971 1.6 0.964 Contact Map
1qleD 1 0.2609 1.4 0.966 Contact Map
4pn8A 3 0.1667 1.3 0.966 Contact Map
2hacA 2 0.2391 1.3 0.966 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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