GREMLIN Database
YRKQ - Sensor histidine kinase YrkQ
UniProt: P54444 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 432 (396)
Sequences: 46202 (39926)
Seq/√Len: 2006.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
381_S420_K4.1611.00
375_I424_V3.8161.00
302_V339_V3.6321.00
402_A406_S3.5741.00
413_H422_Y3.4781.00
379_H420_K3.3021.00
250_L271_A3.2541.00
327_H366_S2.9541.00
379_H422_Y2.9171.00
368_T379_H2.9011.00
377_E424_V2.8641.00
339_V408_M2.7771.00
327_H364_K2.7701.00
377_E422_Y2.7631.00
301_T338_N2.7551.00
254_K272_Y2.7541.00
359_A383_T2.6871.00
247_I276_L2.6541.00
370_V377_E2.6321.00
364_K383_T2.6241.00
384_I387_A2.6181.00
415_I422_Y2.6141.00
254_K269_A2.6041.00
415_I420_K2.5771.00
366_S381_S2.5671.00
414_S421_Y2.5461.00
329_S368_T2.5311.00
347_V405_M2.5251.00
301_T336_Y2.5021.00
416_Q419_S2.4171.00
370_V379_H2.4101.00
401_I412_F2.3531.00
368_T381_S2.3341.00
411_Q424_V2.3101.00
325_R364_K2.2581.00
405_M410_G2.2271.00
310_D345_G2.2221.00
247_I275_A2.2181.00
303_A306_E2.1691.00
300_E341_L2.1551.00
329_S366_S2.1481.00
247_I279_K2.0651.00
315_Q349_D2.0551.00
299_L338_N2.0341.00
279_K283_D1.9991.00
339_V344_L1.9631.00
413_H424_V1.9511.00
347_V404_M1.9321.00
198_D201_A1.9271.00
405_M423_I1.9151.00
372_D377_E1.8171.00
353_S357_K1.8151.00
319_L356_L1.8021.00
347_V401_I1.7801.00
359_A363_E1.7801.00
230_S234_E1.7711.00
228_S232_V1.7551.00
384_I388_D1.7531.00
404_M408_M1.7331.00
251_E272_Y1.7111.00
406_S411_Q1.6991.00
254_K265_D1.6651.00
348_F378_I1.6291.00
196_G201_A1.6121.00
182_I187_E1.6101.00
250_L272_Y1.6091.00
253_A268_V1.6011.00
305_K309_Y1.6001.00
382_N419_S1.5961.00
350_N401_I1.5941.00
363_E383_T1.5861.00
366_S383_T1.5701.00
177_H181_H1.5641.00
249_N267_Y1.5631.00
340_N343_E1.5611.00
222_E226_A1.5551.00
272_Y276_L1.5301.00
197_H201_A1.5191.00
246_L275_A1.5051.00
386_L389_I1.4911.00
52_S55_Y1.4881.00
310_D341_L1.4771.00
226_A230_S1.4521.00
314_D345_G1.4521.00
382_N418_N1.4481.00
343_E346_R1.4371.00
359_A365_I1.4361.00
177_H202_M1.4311.00
246_L271_A1.4301.00
91_F95_E1.4301.00
305_K369_F1.4281.00
247_I272_Y1.4131.00
204_A208_E1.4121.00
238_D346_R1.4001.00
341_L345_G1.3961.00
384_I389_I1.3941.00
180_I183_L1.3671.00
162_V166_I1.3641.00
378_I423_I1.3641.00
48_Y52_S1.3641.00
375_I411_Q1.3531.00
347_V423_I1.3441.00
303_A336_Y1.3411.00
297_A340_N1.3391.00
405_M412_F1.3391.00
309_Y328_I1.3291.00
183_L211_R1.3261.00
312_I328_I1.3231.00
343_E407_R1.3191.00
130_G134_I1.3161.00
56_I59_F1.3141.00
225_Q228_S1.3131.00
256_E264_K1.3121.00
343_E404_M1.3101.00
245_S274_K1.3041.00
303_A334_E1.3001.00
280_S342_E1.2961.00
34_T37_L1.2961.00
385_K388_D1.2851.00
316_I320_H1.2801.00
403_R406_S1.2791.00
253_A264_K1.2751.00
223_E227_E1.2721.00
414_S419_S1.2701.00
203_I207_I1.2691.00
182_I190_Y1.2671.00
180_I184_E1.2651.00
166_I170_L1.2421.00
245_S249_N1.2371.00
249_N270_N1.2341.00
187_E190_Y1.2331.00
250_L275_A1.2161.00
350_N353_S1.2141.00
174_K177_H1.2091.00
410_G425_L1.2081.00
305_K334_E1.2001.00
204_A207_I1.1871.00
131_R135_D1.1841.00
269_A273_G1.1791.00
299_L408_M1.1741.00
191_E212_K1.1721.00
318_I321_Q1.1721.00
307_V311_L1.1711.00
28_L31_Q1.1661.00
250_L254_K1.1641.00
311_L349_D1.1611.00
344_L408_M1.1521.00
240_R283_D1.1471.00
355_L365_I1.1451.00
231_L235_M1.1421.00
308_I369_F1.1341.00
330_G369_F1.1281.00
49_H53_A1.1271.00
110_E119_H1.1271.00
265_D269_A1.1221.00
210_L214_F1.1221.00
208_E211_R1.1071.00
145_L149_L1.1031.00
38_I41_Y1.1001.00
207_I210_L1.0981.00
311_L345_G1.0951.00
335_T376_F1.0831.00
179_E192_M1.0801.00
283_D287_A1.0781.00
311_L315_Q1.0741.00
245_S248_M1.0671.00
38_I42_L1.0601.00
176_I180_I1.0571.00
180_I207_I1.0491.00
177_H206_S1.0401.00
55_Y58_K1.0401.00
351_V421_Y1.0381.00
304_V378_I1.0341.00
250_L268_V1.0291.00
258_G264_K1.0281.00
302_V307_V1.0271.00
60_S64_S1.0221.00
266_R270_N1.0161.00
248_M252_F1.0151.00
181_H202_M1.0111.00
372_D375_I1.0111.00
257_G264_K1.0111.00
305_K330_G1.0101.00
349_D353_S1.0081.00
193_T208_E1.0041.00
194_I205_K1.0031.00
191_E208_E1.0011.00
167_R171_R1.0001.00
181_H185_G0.9991.00
29_T32_K0.9971.00
274_K277_Q0.9951.00
222_E225_Q0.9921.00
177_H180_I0.9901.00
180_I206_S0.9901.00
318_I353_S0.9841.00
345_G349_D0.9831.00
312_I316_I0.9801.00
125_F128_G0.9781.00
141_R145_L0.9781.00
324_F359_A0.9731.00
247_I251_E0.9711.00
306_E310_D0.9661.00
389_I392_E0.9661.00
90_I96_L0.9641.00
284_N343_E0.9631.00
307_V339_V0.9571.00
315_Q352_M0.9571.00
131_R137_F0.9551.00
207_I211_R0.9541.00
172_Y176_I0.9521.00
36_D40_G0.9481.00
51_E54_R0.9471.00
11_K198_D0.9451.00
169_S172_Y0.9421.00
297_A343_E0.9411.00
270_N274_K0.9401.00
314_D349_D0.9401.00
36_D39_E0.9361.00
48_Y51_E0.9341.00
130_G133_I0.9321.00
348_F352_M0.9321.00
51_E55_Y0.9261.00
39_E43_S0.9251.00
37_L41_Y0.9201.00
37_L40_G0.9171.00
241_T245_S0.9151.00
126_S129_E0.9141.00
412_F421_Y0.9121.00
342_E345_G0.9111.00
303_A335_T0.9101.00
351_V401_I0.9081.00
179_E190_Y0.9081.00
166_I169_S0.9051.00
348_F380_V0.9041.00
239_M278_L0.8991.00
33_I38_I0.8981.00
191_E211_R0.8981.00
59_F63_V0.8951.00
273_G310_D0.8901.00
299_L409_Q0.8901.00
49_H52_S0.8891.00
238_D350_N0.8881.00
402_A411_Q0.8841.00
53_A57_Q0.8831.00
200_L203_I0.8831.00
298_D340_N0.8821.00
403_R407_R0.8821.00
28_L32_K0.8801.00
201_A205_K0.8801.00
262_A265_D0.8781.00
130_G136_G0.8751.00
144_D148_A0.8741.00
201_A204_A0.8671.00
184_E209_D0.8661.00
62_Y66_N0.8661.00
181_H206_S0.8641.00
266_R269_A0.8641.00
352_M367_I0.8621.00
375_I426_R0.8611.00
259_E264_K0.8601.00
145_L148_A0.8601.00
159_L163_L0.8601.00
405_M425_L0.8551.00
269_A272_Y0.8541.00
308_I348_F0.8521.00
229_R292_N0.8521.00
96_L99_D0.8521.00
41_Y44_S0.8521.00
351_V412_F0.8521.00
206_S209_D0.8461.00
196_G204_A0.8451.00
227_E230_S0.8431.00
202_M205_K0.8421.00
276_L279_K0.8411.00
388_D391_P0.8411.00
277_Q345_G0.8391.00
280_S284_N0.8381.00
360_D363_E0.8371.00
35_D39_E0.8361.00
164_F168_Q0.8361.00
168_Q171_R0.8331.00
240_R279_K0.8331.00
237_H350_N0.8331.00
287_A346_R0.8331.00
347_V408_M0.8331.00
351_V423_I0.8321.00
299_L339_V0.8281.00
271_A275_A0.8281.00
286_F289_F0.8241.00
85_Y88_L0.8231.00
410_G423_I0.8211.00
130_G135_D0.8171.00
275_A279_K0.8161.00
86_I99_D0.8151.00
178_Q182_I0.8141.00
192_M208_E0.8131.00
203_I206_S0.8101.00
372_D424_V0.8101.00
308_I367_I0.8091.00
180_I203_I0.8081.00
264_K267_Y0.8051.00
401_I405_M0.8051.00
9_T167_R0.8041.00
311_L352_M0.8001.00
396_L400_S0.7991.00
325_R328_I0.7961.00
288_Y399_R0.7921.00
315_Q353_S0.7901.00
73_R77_G0.7881.00
223_E226_A0.7851.00
122_P131_R0.7831.00
317_A320_H0.7831.00
160_I164_F0.7811.00
37_L42_L0.7801.00
224_L228_S0.7801.00
235_M285_L0.7801.00
40_G43_S0.7791.00
379_H415_I0.7791.00
284_N346_R0.7791.00
346_R404_M0.7781.00
19_A23_S0.7771.00
351_V405_M0.7771.00
47_Y51_E0.7761.00
309_Y313_S0.7741.00
287_A343_E0.7721.00
190_Y193_T0.7701.00
387_A391_P0.7691.00
302_V341_L0.7661.00
179_E182_I0.7651.00
304_V337_I0.7641.00
385_K389_I0.7631.00
367_I380_V0.7601.00
382_N417_K0.7601.00
295_Y343_E0.7561.00
50_E53_A0.7551.00
256_E259_E0.7551.00
312_I326_V0.7481.00
252_F256_E0.7431.00
54_R58_K0.7431.00
55_Y62_Y0.7431.00
52_S56_I0.7411.00
224_L227_E0.7401.00
40_G44_S0.7401.00
57_Q60_S0.7381.00
324_F356_L0.7361.00
61_K65_E0.7351.00
163_L167_R0.7341.00
243_L282_S0.7311.00
237_H241_T0.7301.00
238_D242_P0.7291.00
297_A407_R0.7291.00
124_K127_D0.7291.00
313_S316_I0.7271.00
50_E54_R0.7271.00
171_R175_T0.7221.00
88_L96_L0.7221.00
232_V235_M0.7211.00
174_K178_Q0.7211.00
122_P126_S0.7161.00
400_S404_M0.7151.00
270_N273_G0.7141.00
181_H184_E0.7131.00
39_E42_L0.7131.00
91_F97_Q0.7131.00
69_S72_D0.7131.00
55_Y60_S0.7121.00
249_N274_K0.7081.00
254_K268_V0.7071.00
200_L204_A0.7031.00
62_Y65_E0.7031.00
142_Y145_L0.7011.00
249_N271_A0.7001.00
323_H361_P0.6971.00
357_K391_P0.6971.00
311_L314_D0.6941.00
324_F328_I0.6931.00
304_V376_F0.6931.00
357_K393_S0.6891.00
131_R134_I0.6891.00
47_Y50_E0.6871.00
238_D400_S0.6861.00
183_L210_L0.6861.00
365_I380_V0.6861.00
211_R214_F0.6831.00
319_L365_I0.6801.00
130_G138_Y0.6791.00
238_D281_L0.6771.00
35_D38_I0.6751.00
317_A321_Q0.6741.00
190_Y194_I0.6741.00
173_L176_I0.6721.00
142_Y146_A0.6711.00
192_M204_A0.6671.00
267_Y271_A0.6661.00
306_E341_L0.6651.00
401_I404_M0.6631.00
86_I89_T0.6631.00
310_D314_D0.6621.00
184_E213_A0.6601.00
377_E413_H0.6581.00
176_I204_A0.6581.00
203_I208_E0.6561.00
125_F129_E0.6561.00
226_A229_R0.6531.00
61_K64_S0.6521.00
245_S270_N0.6511.00
319_L323_H0.6511.00
268_V272_Y0.6491.00
346_R349_D0.6481.00
302_V338_N0.6481.00
91_F94_Q0.6471.00
225_Q229_R0.6461.00
99_D102_Y0.6451.00
335_T371_S0.6441.00
122_P129_E0.6431.00
320_H323_H0.6431.00
369_F376_F0.6431.00
329_S370_V0.6421.00
355_L380_V0.6411.00
176_I179_E0.6401.00
182_I185_G0.6401.00
203_I210_L0.6381.00
74_K77_G0.6371.00
344_L425_L0.6361.00
307_V344_L0.6361.00
272_Y275_A0.6331.00
56_I63_V0.6321.00
179_E208_E0.6321.00
182_I186_G0.6321.00
274_K314_D0.6321.00
384_I391_P0.6311.00
34_T39_E0.6291.00
244_T248_M0.6281.00
416_Q420_K0.6281.00
352_M365_I0.6271.00
315_Q356_L0.6271.00
77_G81_K0.6271.00
168_Q172_Y0.6261.00
249_N253_A0.6261.00
234_E238_D0.6261.00
175_T179_E0.6241.00
413_H423_I0.6231.00
319_L326_V0.6231.00
58_K61_K0.6221.00
319_L324_F0.6221.00
387_A390_T0.6201.00
10_K14_L0.6191.00
209_D213_A0.6191.00
267_Y270_N0.6191.00
124_K129_E0.6181.00
309_Y330_G0.6171.00
75_A78_E0.6151.00
34_T38_I0.6151.00
276_L280_S0.6141.00
381_S417_K0.6131.00
141_R144_D0.6121.00
360_D383_T0.6111.00
146_A149_L0.6101.00
102_Y105_S0.6061.00
249_N275_A0.6051.00
253_A267_Y0.6031.00
231_L238_D0.6011.00
48_Y56_I0.5991.00
309_Y312_I0.5991.00
25_V29_T0.5981.00
173_L177_H0.5951.00
135_D138_Y0.5951.00
210_L213_A0.5951.00
204_A211_R0.5941.00
312_I367_I0.5941.00
279_K282_S0.5931.00
405_M411_Q0.5921.00
100_S103_S0.5921.00
27_F31_Q0.5911.00
251_E254_K0.5911.00
57_Q61_K0.5911.00
137_F140_S0.5901.00
17_M20_A0.5891.00
256_E267_Y0.5891.00
59_F62_Y0.5881.00
313_S317_A0.5851.00
399_R403_R0.5831.00
58_K62_Y0.5801.00
197_H204_A0.5791.00
343_E408_M0.5791.00
233_T236_S0.5771.00
60_S63_V0.5751.00
134_I137_F0.5751.00
148_A152_L0.5751.00
52_S59_F0.5701.00
152_L156_L0.5701.00
158_F162_V0.5691.00
252_F267_Y0.5691.00
296_E299_L0.5671.00
76_F79_W0.5671.00
15_L19_A0.5671.00
305_K332_L0.5661.00
263_S267_Y0.5641.00
284_N342_E0.5641.00
288_Y403_R0.5631.00
16_I19_A0.5621.00
18_V21_I0.5621.00
67_E70_T0.5621.00
335_T369_F0.5611.00
230_S403_R0.5601.00
175_T178_Q0.5601.00
278_L282_S0.5591.00
381_S416_Q0.5591.00
307_V345_G0.5591.00
89_T93_D0.5591.00
14_L17_M0.5591.00
172_Y175_T0.5571.00
172_Y177_H0.5561.00
410_G426_R0.5561.00
236_S242_P0.5551.00
244_T247_I0.5551.00
337_I376_F0.5531.00
229_R234_E0.5531.00
188_L211_R0.5521.00
187_E191_E0.5511.00
173_L203_I0.5501.00
246_L274_K0.5501.00
239_M242_P0.5481.00
198_D202_M0.5481.00
305_K335_T0.5471.00
248_M275_A0.5471.00
54_R57_Q0.5471.00
199_E203_I0.5421.00
189_D211_R0.5421.00
136_G139_S0.5411.00
120_S123_V0.5411.00
149_L153_G0.5401.00
322_E356_L0.5401.00
32_K144_D0.5401.00
70_T73_R0.5391.00
343_E347_V0.5371.00
286_F290_L0.5371.00
318_I322_E0.5371.00
200_L207_I0.5371.00
186_G190_Y0.5361.00
236_S286_F0.5361.00
55_Y63_V0.5361.00
366_S369_F0.5361.00
386_L390_T0.5351.00
184_E188_L0.5341.00
170_L174_K0.5331.00
246_L250_L0.5321.00
171_R174_K0.5321.00
9_T13_A0.5321.00
322_E359_A0.5301.00
146_A150_D0.5291.00
232_V236_S0.5291.00
319_L322_E0.5281.00
21_I25_V0.5281.00
229_R233_T0.5281.00
55_Y59_F0.5261.00
194_I197_H0.5251.00
147_F150_D0.5241.00
369_F378_I0.5231.00
175_T193_T0.5211.00
56_I60_S0.5211.00
178_Q181_H0.5211.00
18_V25_V0.5201.00
63_V66_N0.5201.00
252_F257_G0.5201.00
202_M206_S0.5191.00
99_D103_S0.5191.00
256_E263_S0.5181.00
72_D75_A0.5171.00
264_K268_V0.5171.00
243_L278_L0.5161.00
322_E361_P0.5161.00
238_D274_K0.5161.00
337_I425_L0.5151.00
398_E421_Y0.5121.00
101_I104_E0.5111.00
305_K333_P0.5111.00
235_M239_M0.5101.00
194_I204_A0.5091.00
180_I210_L0.5081.00
122_P125_F0.5071.00
352_M356_L0.5061.00
308_I311_L0.5051.00
195_K201_A0.5041.00
242_P278_L0.5031.00
236_S241_T0.5031.00
198_D204_A0.5021.00
257_G265_D0.5021.00
130_G137_F0.5021.00
133_I137_F0.5011.00
310_D313_S0.5011.00
9_T174_K0.5001.00
371_S376_F0.5001.00
67_E71_S0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4i5sA 2 0.6019 100 0.408 Contact Map
4bixA 2 0.4931 100 0.445 Contact Map
4ctiA 2 0.5255 100 0.491 Contact Map
3a0rA 2 0.7292 100 0.525 Contact Map
4q20A 2 0.4954 100 0.528 Contact Map
2q8gA 2 0.6644 100 0.536 Contact Map
4mpcA 2 0.6736 100 0.54 Contact Map
4gczA 2 0.7894 100 0.542 Contact Map
3jz3A 2 0.3657 100 0.548 Contact Map
4r39A 1 0.4653 100 0.549 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0132 seconds.