GREMLIN Database
YRKH - Uncharacterized protein YrkH
UniProt: P54435 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 377 (363)
Sequences: 452 (291)
Seq/√Len: 15.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
65_I71_V6.2041.00
78_E97_Y4.9781.00
160_A167_I4.7861.00
147_I249_L4.2901.00
171_F241_F4.1421.00
311_K315_T4.1121.00
231_S240_S3.6531.00
171_F217_I3.4600.99
83_M87_M3.4420.99
213_E228_P3.2000.99
139_I165_A3.1480.99
169_H195_W3.1140.98
312_Q315_T3.0860.98
34_F39_I2.9930.98
100_G104_A2.8210.97
273_G328_E2.7990.97
288_K314_S2.7960.97
257_D298_M2.7670.97
298_M321_H2.7620.97
123_M138_V2.7580.97
52_F79_G2.3000.91
122_E163_K2.2830.91
333_H337_D2.2590.90
72_L78_E2.2300.89
137_M167_I2.2270.89
138_V147_I2.2200.89
113_K116_D2.2110.89
54_L57_G2.2020.89
157_I189_K2.1930.89
146_I160_A2.1600.88
14_D17_I2.0940.86
78_E82_V2.0890.86
304_N308_S2.0750.86
8_N78_E2.0710.86
231_S278_T2.0400.85
176_H179_H2.0270.84
10_P78_E2.0190.84
20_K42_H2.0150.84
285_A330_E1.9530.82
183_G194_Y1.9320.81
14_D129_I1.9170.81
360_D363_K1.9030.80
238_S260_G1.8690.79
14_D18_F1.8240.77
30_N51_Y1.7950.76
74_V98_L1.7790.75
33_D66_P1.7760.75
145_A171_F1.7680.75
240_S253_I1.7320.73
150_T156_F1.7280.73
52_F55_L1.7200.73
79_G84_V1.7170.73
325_I334_L1.6940.72
257_D321_H1.6810.71
51_Y55_L1.6760.71
123_M249_L1.6740.71
78_E93_H1.6590.70
31_E35_S1.6530.70
316_L323_L1.6510.69
25_I41_G1.6500.69
262_P349_I1.6360.69
31_E59_E1.6260.68
63_E243_V1.6250.68
130_G152_M1.5940.67
8_N97_Y1.5900.66
211_L228_P1.5860.66
238_S253_I1.5820.66
167_I217_I1.5580.65
71_V315_T1.5430.64
72_L97_Y1.5240.63
82_V97_Y1.5140.63
16_K70_E1.5100.62
71_V93_H1.4850.61
79_G103_K1.4750.60
143_E168_T1.4650.60
8_N72_L1.4500.59
126_F159_F1.4490.59
7_G78_E1.4410.59
20_K93_H1.4300.58
172_D176_H1.4290.58
52_F84_V1.4200.57
147_I241_F1.4070.57
33_D97_Y1.4040.57
266_G320_N1.4040.57
76_A80_S1.4040.57
7_G97_Y1.3980.56
51_Y84_V1.3890.56
34_F38_K1.3870.56
15_K272_V1.3860.56
132_G368_E1.3820.55
253_I260_G1.3780.55
39_I74_V1.3770.55
123_M163_K1.3650.54
369_I376_I1.3450.53
173_T346_Y1.3410.53
258_S279_L1.3400.53
101_G105_W1.3380.53
193_T209_Q1.3270.52
154_N281_S1.3170.52
106_S131_K1.3140.51
17_I23_L1.3100.51
170_V183_G1.2960.50
304_N311_K1.2890.50
102_M132_G1.2870.50
211_L293_L1.2790.49
16_K21_E1.2760.49
146_I149_A1.2660.49
186_I311_K1.2620.49
17_I301_D1.2480.48
180_I324_N1.2220.46
51_Y79_G1.2090.46
277_K328_E1.2080.45
197_P340_P1.2040.45
216_D223_T1.1970.45
311_K321_H1.1960.45
78_E99_K1.1950.45
7_G35_S1.1950.45
286_L290_L1.1920.45
74_V154_N1.1900.44
102_M133_C1.1860.44
348_E363_K1.1810.44
191_K315_T1.1780.44
18_F267_M1.1750.44
172_D179_H1.1620.43
18_F129_I1.1570.43
130_G238_S1.1540.42
157_I190_T1.1520.42
22_P245_D1.1520.42
231_S253_I1.1410.42
154_N167_I1.1400.42
59_E83_M1.1390.42
77_K95_V1.1370.42
130_G135_S1.1340.41
164_G180_I1.1330.41
21_E360_D1.1250.41
124_Y159_F1.1220.41
146_I186_I1.1220.41
84_V191_K1.1080.40
94_S218_I1.1060.40
270_D352_T1.0990.39
197_P350_R1.0970.39
147_I171_F1.0970.39
138_V215_N1.0960.39
51_Y56_D1.0920.39
194_Y293_L1.0920.39
147_I243_V1.0820.39
164_G319_E1.0730.38
14_D110_E1.0680.38
103_K362_E1.0670.38
79_G83_M1.0670.38
231_S276_R1.0650.38
256_I321_H1.0640.38
237_G320_N1.0600.37
22_P68_D1.0580.37
13_S85_S1.0530.37
162_G188_E1.0520.37
32_N65_I1.0510.37
9_D99_K1.0420.36
130_G211_L1.0420.36
265_A373_R1.0390.36
48_N51_Y1.0370.36
35_S216_D1.0330.36
52_F80_S1.0310.36
81_S97_Y1.0290.36
311_K319_E1.0290.36
236_I270_D1.0280.36
172_D181_S1.0260.36
49_V363_K1.0240.35
272_V332_R1.0220.35
265_A271_W1.0130.35
72_L96_S1.0080.35
153_V189_K1.0070.35
256_I298_M1.0070.35
91_A335_V1.0030.34
154_N218_I0.9990.34
86_E222_T0.9990.34
99_K219_I0.9990.34
170_V249_L0.9980.34
283_Y367_M0.9980.34
198_P212_E0.9950.34
235_T262_P0.9870.34
172_D272_V0.9870.34
72_L328_E0.9870.34
149_A365_R0.9820.33
138_V222_T0.9770.33
102_M106_S0.9770.33
200_D203_E0.9750.33
164_G318_S0.9680.33
8_N195_W0.9650.32
23_L72_L0.9620.32
114_V223_T0.9600.32
24_F66_P0.9580.32
40_E286_L0.9550.32
13_S72_L0.9530.32
69_K89_S0.9490.32
22_P94_S0.9420.31
150_T186_I0.9390.31
28_V33_D0.9370.31
31_E154_N0.9370.31
130_G341_P0.9370.31
164_G245_D0.9370.31
204_V208_Y0.9360.31
200_D350_R0.9340.31
253_I276_R0.9320.31
215_N221_N0.9310.31
8_N11_K0.9250.31
219_I277_K0.9200.30
266_G271_W0.9200.30
329_T361_E0.9140.30
100_G161_K0.9070.30
106_S371_P0.9050.30
263_D349_I0.9020.29
93_H97_Y0.8980.29
269_E272_V0.8910.29
37_W102_M0.8900.29
51_Y80_S0.8890.29
189_K348_E0.8880.29
202_E243_V0.8840.29
150_T311_K0.8830.29
125_Q294_P0.8820.29
235_T263_D0.8810.28
59_E170_V0.8790.28
238_S275_L0.8700.28
131_K260_G0.8690.28
298_M311_K0.8690.28
155_F167_I0.8670.28
60_D168_T0.8650.28
240_S260_G0.8650.28
92_G255_F0.8630.28
158_D161_K0.8600.27
304_N321_H0.8530.27
180_I286_L0.8530.27
133_C172_D0.8530.27
297_F320_N0.8490.27
243_V249_L0.8480.27
33_D70_E0.8480.27
35_S221_N0.8470.27
278_T297_F0.8470.27
30_N33_D0.8470.27
191_K358_S0.8460.27
60_D118_K0.8460.27
115_G123_M0.8460.27
133_C176_H0.8430.27
60_D329_T0.8430.27
178_D296_H0.8410.27
241_F287_S0.8400.27
125_Q264_L0.8390.27
112_V257_D0.8350.26
278_T359_P0.8350.26
246_Q278_T0.8330.26
211_L241_F0.8290.26
15_K19_N0.8240.26
89_S95_V0.8230.26
11_K25_I0.8220.26
48_N56_D0.8220.26
73_V214_G0.8210.26
265_A344_N0.8180.26
303_L309_V0.8180.26
216_D221_N0.8110.25
8_N93_H0.8110.25
32_N39_I0.8080.25
35_S67_S0.8060.25
102_M134_L0.8050.25
31_E240_S0.7980.25
196_L201_A0.7910.24
173_T287_S0.7830.24
106_S260_G0.7820.24
20_K47_L0.7760.24
162_G218_I0.7750.24
128_R264_L0.7730.24
217_I241_F0.7730.24
81_S219_I0.7700.24
19_N221_N0.7650.23
301_D329_T0.7650.23
201_A237_G0.7640.23
158_D168_T0.7640.23
8_N22_P0.7630.23
96_S119_D0.7610.23
146_I278_T0.7610.23
152_M365_R0.7580.23
258_S350_R0.7570.23
88_L105_W0.7560.23
228_P239_T0.7530.23
162_G329_T0.7480.23
138_V190_T0.7470.23
250_S260_G0.7460.23
166_T361_E0.7440.23
130_G184_R0.7410.22
104_A108_H0.7400.22
21_E108_H0.7390.22
12_R223_T0.7380.22
197_P200_D0.7370.22
70_E318_S0.7360.22
148_D173_T0.7350.22
52_F56_D0.7340.22
125_Q128_R0.7340.22
76_A79_G0.7320.22
189_K291_I0.7320.22
9_D64_K0.7310.22
251_G255_F0.7310.22
147_I284_K0.7300.22
57_G62_L0.7260.22
72_L98_L0.7250.22
66_P237_G0.7200.22
172_D255_F0.7190.22
60_D122_E0.7180.22
158_D215_N0.7180.22
100_G103_K0.7170.22
30_N297_F0.7160.21
15_K35_S0.7140.21
48_N66_P0.7120.21
81_S204_V0.7110.21
327_D332_R0.7090.21
48_N68_D0.7090.21
32_N358_S0.7040.21
201_A340_P0.7000.21
368_E371_P0.6970.21
13_S19_N0.6970.21
123_M269_E0.6970.21
81_S105_W0.6930.21
35_S94_S0.6930.21
93_H137_M0.6910.21
168_T180_I0.6910.21
78_E98_L0.6910.21
111_P115_G0.6870.20
269_E277_K0.6860.20
35_S78_E0.6840.20
177_A261_R0.6830.20
26_L135_S0.6820.20
145_A215_N0.6820.20
221_N289_D0.6800.20
321_H324_N0.6800.20
221_N305_E0.6770.20
224_I295_A0.6770.20
8_N165_A0.6770.20
116_D146_I0.6770.20
28_V84_V0.6760.20
175_L237_G0.6760.20
72_L82_V0.6750.20
60_D139_I0.6730.20
27_D101_G0.6730.20
131_K210_P0.6730.20
158_D186_I0.6710.20
95_V158_D0.6690.20
153_V185_V0.6690.20
272_V345_A0.6690.20
171_F224_I0.6690.20
22_P209_Q0.6670.20
229_I286_L0.6660.20
83_M89_S0.6650.20
145_A217_I0.6600.19
199_K236_I0.6590.19
51_Y237_G0.6590.19
156_F349_I0.6590.19
22_P47_L0.6580.19
135_S156_F0.6580.19
259_I279_L0.6570.19
134_L172_D0.6560.19
208_Y260_G0.6550.19
94_S357_I0.6550.19
149_A156_F0.6550.19
229_I321_H0.6550.19
52_F77_K0.6550.19
123_M247_Y0.6510.19
9_D149_A0.6500.19
18_F186_I0.6490.19
36_D84_V0.6480.19
344_N373_R0.6450.19
175_L350_R0.6430.19
186_I276_R0.6420.19
13_S250_S0.6410.19
65_I295_A0.6400.19
154_N328_E0.6390.19
289_D360_D0.6390.19
144_A165_A0.6370.19
213_E318_S0.6360.19
174_H233_G0.6360.19
130_G342_Q0.6350.19
256_I304_N0.6320.18
184_R188_E0.6320.18
292_V330_E0.6300.18
215_N245_D0.6290.18
123_M145_A0.6280.18
37_W132_G0.6270.18
30_N79_G0.6270.18
298_M304_N0.6260.18
50_P355_G0.6220.18
242_I286_L0.6220.18
115_G185_V0.6210.18
138_V229_I0.6200.18
72_L218_I0.6190.18
35_S166_T0.6180.18
10_P108_H0.6170.18
94_S241_F0.6160.18
19_N25_I0.6160.18
249_L293_L0.6150.18
258_S352_T0.6130.18
217_I358_S0.6120.18
102_M368_E0.6110.18
239_T341_P0.6110.18
31_E79_G0.6100.18
24_F54_L0.6100.18
142_G219_I0.6080.18
250_S273_G0.6070.18
131_K183_G0.6070.18
9_D167_I0.6070.18
235_T261_R0.6060.18
78_E176_H0.6060.18
256_I311_K0.6060.18
12_R123_M0.6060.18
216_D228_P0.6050.18
137_M165_A0.6050.18
129_I298_M0.6040.18
177_A353_N0.6030.17
98_L215_N0.6020.17
17_I243_V0.6020.17
81_S101_G0.6020.17
209_Q282_R0.6020.17
245_D281_S0.6020.17
131_K134_L0.6020.17
69_K168_T0.6000.17
25_I123_M0.6000.17
189_K217_I0.5990.17
231_S238_S0.5990.17
36_D231_S0.5970.17
94_S211_L0.5950.17
109_L113_K0.5930.17
67_S93_H0.5930.17
370_G374_C0.5930.17
15_K63_E0.5920.17
161_K361_E0.5920.17
190_T245_D0.5920.17
263_D266_G0.5920.17
113_K117_L0.5920.17
17_I356_K0.5910.17
23_L55_L0.5910.17
148_D174_H0.5900.17
141_N329_T0.5900.17
140_S166_T0.5900.17
93_H154_N0.5890.17
37_W133_C0.5890.17
204_V242_I0.5870.17
78_E96_S0.5870.17
99_K318_S0.5860.17
60_D277_K0.5860.17
215_N218_I0.5840.17
48_N237_G0.5830.17
82_V277_K0.5830.17
185_V361_E0.5820.17
317_F344_N0.5820.17
193_T197_P0.5780.17
52_F83_M0.5760.17
131_K135_S0.5750.17
67_S71_V0.5750.17
176_H296_H0.5750.17
63_E162_G0.5750.17
98_L165_A0.5740.17
108_H129_I0.5740.17
99_K295_A0.5740.17
25_I300_I0.5720.16
157_I209_Q0.5710.16
77_K80_S0.5710.16
342_Q350_R0.5710.16
25_I52_F0.5700.16
133_C179_H0.5680.16
227_Q242_I0.5680.16
240_S313_L0.5680.16
76_A320_N0.5660.16
348_E357_I0.5660.16
153_V157_I0.5660.16
124_Y247_Y0.5650.16
230_Y279_L0.5600.16
26_L94_S0.5600.16
53_D335_V0.5600.16
58_V162_G0.5600.16
149_A277_K0.5600.16
47_L64_K0.5580.16
10_P72_L0.5550.16
135_S293_L0.5540.16
174_H261_R0.5510.16
204_V207_D0.5500.16
38_K321_H0.5500.16
228_P312_Q0.5500.16
31_E48_N0.5490.16
111_P114_V0.5420.16
309_V327_D0.5410.16
102_M176_H0.5410.16
56_D79_G0.5410.16
25_I348_E0.5390.15
193_T277_K0.5380.15
13_S47_L0.5350.15
250_S323_L0.5340.15
55_L79_G0.5340.15
9_D35_S0.5330.15
171_F281_S0.5330.15
277_K282_R0.5330.15
258_S359_P0.5310.15
174_H178_D0.5310.15
183_G266_G0.5300.15
49_V334_L0.5280.15
62_L155_F0.5280.15
131_K342_Q0.5250.15
201_A346_Y0.5250.15
81_S100_G0.5240.15
307_G335_V0.5240.15
262_P271_W0.5240.15
161_K329_T0.5240.15
190_T358_S0.5230.15
138_V161_K0.5220.15
15_K191_K0.5210.15
115_G146_I0.5210.15
76_A362_E0.5200.15
197_P239_T0.5200.15
242_I346_Y0.5190.15
144_A368_E0.5180.15
64_K361_E0.5180.15
22_P60_D0.5160.15
315_T318_S0.5160.15
36_D369_I0.5150.15
103_K229_I0.5150.15
134_L179_H0.5140.15
301_D319_E0.5140.15
71_V359_P0.5130.15
98_L101_G0.5110.15
368_E373_R0.5110.15
48_N240_S0.5110.15
33_D73_V0.5100.15
25_I205_E0.5100.15
211_L294_P0.5100.15
78_E172_D0.5100.15
101_G355_G0.5090.15
47_L185_V0.5080.15
277_K315_T0.5070.15
135_S200_D0.5070.15
109_L114_V0.5060.15
98_L105_W0.5060.15
34_F171_F0.5050.15
12_R20_K0.5050.15
60_D94_S0.5030.14
59_E167_I0.5020.14
254_L265_A0.5020.14
283_Y339_L0.5010.14
58_V278_T0.5010.14
30_N84_V0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tp9A 2 0.679 100 0.668 Contact Map
4efzA 2 0.6631 100 0.689 Contact Map
3r2uA 4 0.6844 100 0.691 Contact Map
4yslA 2 0.6684 100 0.697 Contact Map
4ysbA 2 0.5889 100 0.717 Contact Map
4chlA 2 0.6127 100 0.722 Contact Map
2gcuA 3 0.6101 100 0.731 Contact Map
1qh5A 1 0.5995 100 0.745 Contact Map
2qedA 1 0.5968 100 0.759 Contact Map
2p18A 1 0.6631 100 0.76 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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