YRKH - BACSU - GREMLIN Contacts

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YRKH - Uncharacterized protein YrkH

UniProt:	P54435	Sequences: MKHDRKGNDPKRSDKKIFNKEPLFILDVRNENDFSDWKIEGHDFDHLNVPYFDLLDGVEDILEKIPSDKEVLVVCAKEGSSVMVSEMLSEAGHSVSYLKGGMKAWSEHLEPVKVGDLKDGGEMYQFVRIGKGCLSYMVISNGEAAIIDATRMVNFFIDFAKGKGATITHVFDTHLHADHISGGRVIAEKTKATYWLPPKDAEEVEFDYQPLEEGNDIIIGNTTIKIQPIYSPGHTIGSTSFIVDDQYLLSGDILFIDSIGRPDLAGMAEDWVGDLRKTLYSRYKALSKDLIVLPAHFMIIDELNENGSVGKQLSTLFSENHGLNIADETEFRHLVTDHLPPQPNAYQEIRETNMGKISPDEEKQREMEIGPNRCAIR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	377 (363)
Sequences:	452 (291)
Seq/√Len:	15.3

BACSU - YRKH
HALSA - O54647 O54661 Q9HS22

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
65_I	71_V	6.204	1.00
78_E	97_Y	4.978	1.00
160_A	167_I	4.786	1.00
147_I	249_L	4.290	1.00
171_F	241_F	4.142	1.00
311_K	315_T	4.112	1.00
231_S	240_S	3.653	1.00
171_F	217_I	3.460	0.99
83_M	87_M	3.442	0.99
213_E	228_P	3.200	0.99
139_I	165_A	3.148	0.99
169_H	195_W	3.114	0.98
312_Q	315_T	3.086	0.98
34_F	39_I	2.993	0.98
100_G	104_A	2.821	0.97
273_G	328_E	2.799	0.97
288_K	314_S	2.796	0.97
257_D	298_M	2.767	0.97
298_M	321_H	2.762	0.97
123_M	138_V	2.758	0.97
52_F	79_G	2.300	0.91
122_E	163_K	2.283	0.91
333_H	337_D	2.259	0.90
72_L	78_E	2.230	0.89
137_M	167_I	2.227	0.89
138_V	147_I	2.220	0.89
113_K	116_D	2.211	0.89
54_L	57_G	2.202	0.89
157_I	189_K	2.193	0.89
146_I	160_A	2.160	0.88
14_D	17_I	2.094	0.86
78_E	82_V	2.089	0.86
304_N	308_S	2.075	0.86
8_N	78_E	2.071	0.86
231_S	278_T	2.040	0.85
176_H	179_H	2.027	0.84
10_P	78_E	2.019	0.84
20_K	42_H	2.015	0.84
285_A	330_E	1.953	0.82
183_G	194_Y	1.932	0.81
14_D	129_I	1.917	0.81
360_D	363_K	1.903	0.80
238_S	260_G	1.869	0.79
14_D	18_F	1.824	0.77
30_N	51_Y	1.795	0.76
74_V	98_L	1.779	0.75
33_D	66_P	1.776	0.75
145_A	171_F	1.768	0.75
240_S	253_I	1.732	0.73
150_T	156_F	1.728	0.73
52_F	55_L	1.720	0.73
79_G	84_V	1.717	0.73
325_I	334_L	1.694	0.72
257_D	321_H	1.681	0.71
51_Y	55_L	1.676	0.71
123_M	249_L	1.674	0.71
78_E	93_H	1.659	0.70
31_E	35_S	1.653	0.70
316_L	323_L	1.651	0.69
25_I	41_G	1.650	0.69
262_P	349_I	1.636	0.69
31_E	59_E	1.626	0.68
63_E	243_V	1.625	0.68
130_G	152_M	1.594	0.67
8_N	97_Y	1.590	0.66
211_L	228_P	1.586	0.66
238_S	253_I	1.582	0.66
167_I	217_I	1.558	0.65
71_V	315_T	1.543	0.64
72_L	97_Y	1.524	0.63
82_V	97_Y	1.514	0.63
16_K	70_E	1.510	0.62
71_V	93_H	1.485	0.61
79_G	103_K	1.475	0.60
143_E	168_T	1.465	0.60
8_N	72_L	1.450	0.59
126_F	159_F	1.449	0.59
7_G	78_E	1.441	0.59
20_K	93_H	1.430	0.58
172_D	176_H	1.429	0.58
52_F	84_V	1.420	0.57
147_I	241_F	1.407	0.57
33_D	97_Y	1.404	0.57
266_G	320_N	1.404	0.57
76_A	80_S	1.404	0.57
7_G	97_Y	1.398	0.56
51_Y	84_V	1.389	0.56
34_F	38_K	1.387	0.56
15_K	272_V	1.386	0.56
132_G	368_E	1.382	0.55
253_I	260_G	1.378	0.55
39_I	74_V	1.377	0.55
123_M	163_K	1.365	0.54
369_I	376_I	1.345	0.53
173_T	346_Y	1.341	0.53
258_S	279_L	1.340	0.53
101_G	105_W	1.338	0.53
193_T	209_Q	1.327	0.52
154_N	281_S	1.317	0.52
106_S	131_K	1.314	0.51
17_I	23_L	1.310	0.51
170_V	183_G	1.296	0.50
304_N	311_K	1.289	0.50
102_M	132_G	1.287	0.50
211_L	293_L	1.279	0.49
16_K	21_E	1.276	0.49
146_I	149_A	1.266	0.49
186_I	311_K	1.262	0.49
17_I	301_D	1.248	0.48
180_I	324_N	1.222	0.46
51_Y	79_G	1.209	0.46
277_K	328_E	1.208	0.45
197_P	340_P	1.204	0.45
216_D	223_T	1.197	0.45
311_K	321_H	1.196	0.45
78_E	99_K	1.195	0.45
7_G	35_S	1.195	0.45
286_L	290_L	1.192	0.45
74_V	154_N	1.190	0.44
102_M	133_C	1.186	0.44
348_E	363_K	1.181	0.44
191_K	315_T	1.178	0.44
18_F	267_M	1.175	0.44
172_D	179_H	1.162	0.43
18_F	129_I	1.157	0.43
130_G	238_S	1.154	0.42
157_I	190_T	1.152	0.42
22_P	245_D	1.152	0.42
231_S	253_I	1.141	0.42
154_N	167_I	1.140	0.42
59_E	83_M	1.139	0.42
77_K	95_V	1.137	0.42
130_G	135_S	1.134	0.41
164_G	180_I	1.133	0.41
21_E	360_D	1.125	0.41
124_Y	159_F	1.122	0.41
146_I	186_I	1.122	0.41
84_V	191_K	1.108	0.40
94_S	218_I	1.106	0.40
270_D	352_T	1.099	0.39
197_P	350_R	1.097	0.39
147_I	171_F	1.097	0.39
138_V	215_N	1.096	0.39
51_Y	56_D	1.092	0.39
194_Y	293_L	1.092	0.39
147_I	243_V	1.082	0.39
164_G	319_E	1.073	0.38
14_D	110_E	1.068	0.38
103_K	362_E	1.067	0.38
79_G	83_M	1.067	0.38
231_S	276_R	1.065	0.38
256_I	321_H	1.064	0.38
237_G	320_N	1.060	0.37
22_P	68_D	1.058	0.37
13_S	85_S	1.053	0.37
162_G	188_E	1.052	0.37
32_N	65_I	1.051	0.37
9_D	99_K	1.042	0.36
130_G	211_L	1.042	0.36
265_A	373_R	1.039	0.36
48_N	51_Y	1.037	0.36
35_S	216_D	1.033	0.36
52_F	80_S	1.031	0.36
81_S	97_Y	1.029	0.36
311_K	319_E	1.029	0.36
236_I	270_D	1.028	0.36
172_D	181_S	1.026	0.36
49_V	363_K	1.024	0.35
272_V	332_R	1.022	0.35
265_A	271_W	1.013	0.35
72_L	96_S	1.008	0.35
153_V	189_K	1.007	0.35
256_I	298_M	1.007	0.35
91_A	335_V	1.003	0.34
154_N	218_I	0.999	0.34
86_E	222_T	0.999	0.34
99_K	219_I	0.999	0.34
170_V	249_L	0.998	0.34
283_Y	367_M	0.998	0.34
198_P	212_E	0.995	0.34
235_T	262_P	0.987	0.34
172_D	272_V	0.987	0.34
72_L	328_E	0.987	0.34
149_A	365_R	0.982	0.33
138_V	222_T	0.977	0.33
102_M	106_S	0.977	0.33
200_D	203_E	0.975	0.33
164_G	318_S	0.968	0.33
8_N	195_W	0.965	0.32
23_L	72_L	0.962	0.32
114_V	223_T	0.960	0.32
24_F	66_P	0.958	0.32
40_E	286_L	0.955	0.32
13_S	72_L	0.953	0.32
69_K	89_S	0.949	0.32
22_P	94_S	0.942	0.31
150_T	186_I	0.939	0.31
28_V	33_D	0.937	0.31
31_E	154_N	0.937	0.31
130_G	341_P	0.937	0.31
164_G	245_D	0.937	0.31
204_V	208_Y	0.936	0.31
200_D	350_R	0.934	0.31
253_I	276_R	0.932	0.31
215_N	221_N	0.931	0.31
8_N	11_K	0.925	0.31
219_I	277_K	0.920	0.30
266_G	271_W	0.920	0.30
329_T	361_E	0.914	0.30
100_G	161_K	0.907	0.30
106_S	371_P	0.905	0.30
263_D	349_I	0.902	0.29
93_H	97_Y	0.898	0.29
269_E	272_V	0.891	0.29
37_W	102_M	0.890	0.29
51_Y	80_S	0.889	0.29
189_K	348_E	0.888	0.29
202_E	243_V	0.884	0.29
150_T	311_K	0.883	0.29
125_Q	294_P	0.882	0.29
235_T	263_D	0.881	0.28
59_E	170_V	0.879	0.28
238_S	275_L	0.870	0.28
131_K	260_G	0.869	0.28
298_M	311_K	0.869	0.28
155_F	167_I	0.867	0.28
60_D	168_T	0.865	0.28
240_S	260_G	0.865	0.28
92_G	255_F	0.863	0.28
158_D	161_K	0.860	0.27
304_N	321_H	0.853	0.27
180_I	286_L	0.853	0.27
133_C	172_D	0.853	0.27
297_F	320_N	0.849	0.27
243_V	249_L	0.848	0.27
33_D	70_E	0.848	0.27
35_S	221_N	0.847	0.27
278_T	297_F	0.847	0.27
30_N	33_D	0.847	0.27
191_K	358_S	0.846	0.27
60_D	118_K	0.846	0.27
115_G	123_M	0.846	0.27
133_C	176_H	0.843	0.27
60_D	329_T	0.843	0.27
178_D	296_H	0.841	0.27
241_F	287_S	0.840	0.27
125_Q	264_L	0.839	0.27
112_V	257_D	0.835	0.26
278_T	359_P	0.835	0.26
246_Q	278_T	0.833	0.26
211_L	241_F	0.829	0.26
15_K	19_N	0.824	0.26
89_S	95_V	0.823	0.26
11_K	25_I	0.822	0.26
48_N	56_D	0.822	0.26
73_V	214_G	0.821	0.26
265_A	344_N	0.818	0.26
303_L	309_V	0.818	0.26
216_D	221_N	0.811	0.25
8_N	93_H	0.811	0.25
32_N	39_I	0.808	0.25
35_S	67_S	0.806	0.25
102_M	134_L	0.805	0.25
31_E	240_S	0.798	0.25
196_L	201_A	0.791	0.24
173_T	287_S	0.783	0.24
106_S	260_G	0.782	0.24
20_K	47_L	0.776	0.24
162_G	218_I	0.775	0.24
128_R	264_L	0.773	0.24
217_I	241_F	0.773	0.24
81_S	219_I	0.770	0.24
19_N	221_N	0.765	0.23
301_D	329_T	0.765	0.23
201_A	237_G	0.764	0.23
158_D	168_T	0.764	0.23
8_N	22_P	0.763	0.23
96_S	119_D	0.761	0.23
146_I	278_T	0.761	0.23
152_M	365_R	0.758	0.23
258_S	350_R	0.757	0.23
88_L	105_W	0.756	0.23
228_P	239_T	0.753	0.23
162_G	329_T	0.748	0.23
138_V	190_T	0.747	0.23
250_S	260_G	0.746	0.23
166_T	361_E	0.744	0.23
130_G	184_R	0.741	0.22
104_A	108_H	0.740	0.22
21_E	108_H	0.739	0.22
12_R	223_T	0.738	0.22
197_P	200_D	0.737	0.22
70_E	318_S	0.736	0.22
148_D	173_T	0.735	0.22
52_F	56_D	0.734	0.22
125_Q	128_R	0.734	0.22
76_A	79_G	0.732	0.22
189_K	291_I	0.732	0.22
9_D	64_K	0.731	0.22
251_G	255_F	0.731	0.22
147_I	284_K	0.730	0.22
57_G	62_L	0.726	0.22
72_L	98_L	0.725	0.22
66_P	237_G	0.720	0.22
172_D	255_F	0.719	0.22
60_D	122_E	0.718	0.22
158_D	215_N	0.718	0.22
100_G	103_K	0.717	0.22
30_N	297_F	0.716	0.21
15_K	35_S	0.714	0.21
48_N	66_P	0.712	0.21
81_S	204_V	0.711	0.21
327_D	332_R	0.709	0.21
48_N	68_D	0.709	0.21
32_N	358_S	0.704	0.21
201_A	340_P	0.700	0.21
368_E	371_P	0.697	0.21
13_S	19_N	0.697	0.21
123_M	269_E	0.697	0.21
81_S	105_W	0.693	0.21
35_S	94_S	0.693	0.21
93_H	137_M	0.691	0.21
168_T	180_I	0.691	0.21
78_E	98_L	0.691	0.21
111_P	115_G	0.687	0.20
269_E	277_K	0.686	0.20
35_S	78_E	0.684	0.20
177_A	261_R	0.683	0.20
26_L	135_S	0.682	0.20
145_A	215_N	0.682	0.20
221_N	289_D	0.680	0.20
321_H	324_N	0.680	0.20
221_N	305_E	0.677	0.20
224_I	295_A	0.677	0.20
8_N	165_A	0.677	0.20
116_D	146_I	0.677	0.20
28_V	84_V	0.676	0.20
175_L	237_G	0.676	0.20
72_L	82_V	0.675	0.20
60_D	139_I	0.673	0.20
27_D	101_G	0.673	0.20
131_K	210_P	0.673	0.20
158_D	186_I	0.671	0.20
95_V	158_D	0.669	0.20
153_V	185_V	0.669	0.20
272_V	345_A	0.669	0.20
171_F	224_I	0.669	0.20
22_P	209_Q	0.667	0.20
229_I	286_L	0.666	0.20
83_M	89_S	0.665	0.20
145_A	217_I	0.660	0.19
199_K	236_I	0.659	0.19
51_Y	237_G	0.659	0.19
156_F	349_I	0.659	0.19
22_P	47_L	0.658	0.19
135_S	156_F	0.658	0.19
259_I	279_L	0.657	0.19
134_L	172_D	0.656	0.19
208_Y	260_G	0.655	0.19
94_S	357_I	0.655	0.19
149_A	156_F	0.655	0.19
229_I	321_H	0.655	0.19
52_F	77_K	0.655	0.19
123_M	247_Y	0.651	0.19
9_D	149_A	0.650	0.19
18_F	186_I	0.649	0.19
36_D	84_V	0.648	0.19
344_N	373_R	0.645	0.19
175_L	350_R	0.643	0.19
186_I	276_R	0.642	0.19
13_S	250_S	0.641	0.19
65_I	295_A	0.640	0.19
154_N	328_E	0.639	0.19
289_D	360_D	0.639	0.19
144_A	165_A	0.637	0.19
213_E	318_S	0.636	0.19
174_H	233_G	0.636	0.19
130_G	342_Q	0.635	0.19
256_I	304_N	0.632	0.18
184_R	188_E	0.632	0.18
292_V	330_E	0.630	0.18
215_N	245_D	0.629	0.18
123_M	145_A	0.628	0.18
37_W	132_G	0.627	0.18
30_N	79_G	0.627	0.18
298_M	304_N	0.626	0.18
50_P	355_G	0.622	0.18
242_I	286_L	0.622	0.18
115_G	185_V	0.621	0.18
138_V	229_I	0.620	0.18
72_L	218_I	0.619	0.18
35_S	166_T	0.618	0.18
10_P	108_H	0.617	0.18
94_S	241_F	0.616	0.18
19_N	25_I	0.616	0.18
249_L	293_L	0.615	0.18
258_S	352_T	0.613	0.18
217_I	358_S	0.612	0.18
102_M	368_E	0.611	0.18
239_T	341_P	0.611	0.18
31_E	79_G	0.610	0.18
24_F	54_L	0.610	0.18
142_G	219_I	0.608	0.18
250_S	273_G	0.607	0.18
131_K	183_G	0.607	0.18
9_D	167_I	0.607	0.18
235_T	261_R	0.606	0.18
78_E	176_H	0.606	0.18
256_I	311_K	0.606	0.18
12_R	123_M	0.606	0.18
216_D	228_P	0.605	0.18
137_M	165_A	0.605	0.18
129_I	298_M	0.604	0.18
177_A	353_N	0.603	0.17
98_L	215_N	0.602	0.17
17_I	243_V	0.602	0.17
81_S	101_G	0.602	0.17
209_Q	282_R	0.602	0.17
245_D	281_S	0.602	0.17
131_K	134_L	0.602	0.17
69_K	168_T	0.600	0.17
25_I	123_M	0.600	0.17
189_K	217_I	0.599	0.17
231_S	238_S	0.599	0.17
36_D	231_S	0.597	0.17
94_S	211_L	0.595	0.17
109_L	113_K	0.593	0.17
67_S	93_H	0.593	0.17
370_G	374_C	0.593	0.17
15_K	63_E	0.592	0.17
161_K	361_E	0.592	0.17
190_T	245_D	0.592	0.17
263_D	266_G	0.592	0.17
113_K	117_L	0.592	0.17
17_I	356_K	0.591	0.17
23_L	55_L	0.591	0.17
148_D	174_H	0.590	0.17
141_N	329_T	0.590	0.17
140_S	166_T	0.590	0.17
93_H	154_N	0.589	0.17
37_W	133_C	0.589	0.17
204_V	242_I	0.587	0.17
78_E	96_S	0.587	0.17
99_K	318_S	0.586	0.17
60_D	277_K	0.586	0.17
215_N	218_I	0.584	0.17
48_N	237_G	0.583	0.17
82_V	277_K	0.583	0.17
185_V	361_E	0.582	0.17
317_F	344_N	0.582	0.17
193_T	197_P	0.578	0.17
52_F	83_M	0.576	0.17
131_K	135_S	0.575	0.17
67_S	71_V	0.575	0.17
176_H	296_H	0.575	0.17
63_E	162_G	0.575	0.17
98_L	165_A	0.574	0.17
108_H	129_I	0.574	0.17
99_K	295_A	0.574	0.17
25_I	300_I	0.572	0.16
157_I	209_Q	0.571	0.16
77_K	80_S	0.571	0.16
342_Q	350_R	0.571	0.16
25_I	52_F	0.570	0.16
133_C	179_H	0.568	0.16
227_Q	242_I	0.568	0.16
240_S	313_L	0.568	0.16
76_A	320_N	0.566	0.16
348_E	357_I	0.566	0.16
153_V	157_I	0.566	0.16
124_Y	247_Y	0.565	0.16
230_Y	279_L	0.560	0.16
26_L	94_S	0.560	0.16
53_D	335_V	0.560	0.16
58_V	162_G	0.560	0.16
149_A	277_K	0.560	0.16
47_L	64_K	0.558	0.16
10_P	72_L	0.555	0.16
135_S	293_L	0.554	0.16
174_H	261_R	0.551	0.16
204_V	207_D	0.550	0.16
38_K	321_H	0.550	0.16
228_P	312_Q	0.550	0.16
31_E	48_N	0.549	0.16
111_P	114_V	0.542	0.16
309_V	327_D	0.541	0.16
102_M	176_H	0.541	0.16
56_D	79_G	0.541	0.16
25_I	348_E	0.539	0.15
193_T	277_K	0.538	0.15
13_S	47_L	0.535	0.15
250_S	323_L	0.534	0.15
55_L	79_G	0.534	0.15
9_D	35_S	0.533	0.15
171_F	281_S	0.533	0.15
277_K	282_R	0.533	0.15
258_S	359_P	0.531	0.15
174_H	178_D	0.531	0.15
183_G	266_G	0.530	0.15
49_V	334_L	0.528	0.15
62_L	155_F	0.528	0.15
131_K	342_Q	0.525	0.15
201_A	346_Y	0.525	0.15
81_S	100_G	0.524	0.15
307_G	335_V	0.524	0.15
262_P	271_W	0.524	0.15
161_K	329_T	0.524	0.15
190_T	358_S	0.523	0.15
138_V	161_K	0.522	0.15
15_K	191_K	0.521	0.15
115_G	146_I	0.521	0.15
76_A	362_E	0.520	0.15
197_P	239_T	0.520	0.15
242_I	346_Y	0.519	0.15
144_A	368_E	0.518	0.15
64_K	361_E	0.518	0.15
22_P	60_D	0.516	0.15
315_T	318_S	0.516	0.15
36_D	369_I	0.515	0.15
103_K	229_I	0.515	0.15
134_L	179_H	0.514	0.15
301_D	319_E	0.514	0.15
71_V	359_P	0.513	0.15
98_L	101_G	0.511	0.15
368_E	373_R	0.511	0.15
48_N	240_S	0.511	0.15
33_D	73_V	0.510	0.15
25_I	205_E	0.510	0.15
211_L	294_P	0.510	0.15
78_E	172_D	0.510	0.15
101_G	355_G	0.509	0.15
47_L	185_V	0.508	0.15
277_K	315_T	0.507	0.15
135_S	200_D	0.507	0.15
109_L	114_V	0.506	0.15
98_L	105_W	0.506	0.15
34_F	171_F	0.505	0.15
12_R	20_K	0.505	0.15
60_D	94_S	0.503	0.14
59_E	167_I	0.502	0.14
254_L	265_A	0.502	0.14
283_Y	339_L	0.501	0.14
58_V	278_T	0.501	0.14
30_N	84_V	0.500	0.14

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3tp9A	2	0.679	100	0.668	Contact Map
4efzA	2	0.6631	100	0.689	Contact Map
3r2uA	4	0.6844	100	0.691	Contact Map
4yslA	2	0.6684	100	0.697	Contact Map
4ysbA	2	0.5889	100	0.717	Contact Map
4chlA	2	0.6127	100	0.722	Contact Map
2gcuA	3	0.6101	100	0.731	Contact Map
1qh5A	1	0.5995	100	0.745	Contact Map
2qedA	1	0.5968	100	0.759	Contact Map
2p18A	1	0.6631	100	0.76	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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