GREMLIN Database
YBXI - Probable beta-lactamase YbxI
UniProt: P54427 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 267 (231)
Sequences: 674 (512)
Seq/√Len: 33.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
71_R174_E4.6641.00
242_T255_T4.3821.00
146_H153_E3.5341.00
88_Q193_V3.4891.00
183_A239_V3.2931.00
121_M201_M2.8561.00
115_H119_S2.8121.00
148_L189_F2.7271.00
126_I164_L2.6741.00
176_E241_V2.5851.00
83_A197_V2.5081.00
71_R171_S2.5031.00
88_Q190_D2.4941.00
115_H125_A2.4931.00
202_I210_T2.4901.00
142_K146_H2.3870.99
192_P196_I2.3860.99
49_T68_A2.2560.99
182_L194_M2.1900.99
185_E198_K2.1800.99
141_M145_L2.0690.98
83_A129_Y2.0460.98
81_V178_F2.0360.98
231_I264_L2.0140.98
67_R243_N1.9840.98
91_A136_I1.9810.98
141_M155_I1.9440.98
134_R160_D1.8170.96
49_T172_P1.8080.96
101_W106_R1.7650.96
88_Q144_W1.7120.95
129_Y200_M1.6870.94
157_G166_S1.6680.94
82_N133_A1.6610.94
203_Q213_G1.6450.94
228_V241_V1.6400.94
143_T147_T1.6240.93
102_D106_R1.6100.93
118_G199_R1.6000.93
81_V148_L1.5950.93
72_Q243_N1.5930.92
145_L155_I1.5840.92
204_E256_V1.5790.92
73_T167_S1.5760.92
89_V144_W1.5740.92
54_D236_G1.5540.92
78_F162_F1.5420.91
201_M212_Y1.5020.90
76_S79_K1.4970.90
213_G227_F1.4860.90
181_K186_E1.4780.89
231_I259_L1.4540.89
42_E261_K1.4500.88
185_E194_M1.4190.87
83_A121_M1.4150.87
133_A162_F1.4020.87
233_T236_G1.4000.87
141_M162_F1.3950.86
86_G136_I1.3950.86
198_K232_K1.3890.86
82_N141_M1.3830.86
75_Q217_T1.3830.86
73_T166_S1.3700.85
130_Q164_L1.3570.85
172_P243_N1.3530.85
40_D44_K1.3500.84
102_D112_N1.3460.84
115_H123_E1.3460.84
113_R123_E1.3410.84
120_A129_Y1.3320.84
98_V114_D1.3240.83
131_A135_D1.3170.83
182_L197_V1.3100.83
65_R69_N1.3090.83
113_R191_K1.2940.82
203_Q227_F1.2800.81
145_L164_L1.2630.80
193_V197_V1.2310.78
171_S174_E1.2240.78
50_F255_T1.2160.78
106_R112_N1.2160.78
156_S167_S1.1860.76
242_T251_A1.1660.75
113_R119_S1.1590.74
152_N168_L1.1530.74
185_E195_K1.1450.73
185_E191_K1.1360.73
55_L239_V1.1340.72
154_D157_G1.1340.72
51_I176_E1.1310.72
51_I241_V1.1290.72
130_Q160_D1.1270.72
151_G168_L1.1270.72
206_G209_Y1.1160.71
144_W189_F1.1090.71
75_Q166_S1.1060.71
96_Y116_T1.1040.70
130_Q159_I1.1020.70
140_R143_T1.1010.70
78_F133_A1.0940.70
150_Y175_Q1.0910.69
54_D238_Y1.0890.69
82_N162_F1.0790.69
249_T264_L1.0770.68
115_H127_W1.0760.68
70_Q186_E1.0700.68
190_D193_V1.0620.67
67_R172_P1.0470.66
87_L120_A1.0450.66
53_H92_V1.0450.66
205_E210_T1.0230.64
99_K128_Y1.0070.63
53_H60_T1.0000.63
83_A200_M0.9970.62
134_R164_L0.9940.62
67_R245_D0.9910.62
85_I148_L0.9890.62
96_Y118_G0.9880.62
101_W112_N0.9810.61
144_W148_L0.9750.61
127_W160_D0.9710.60
125_A128_Y0.9650.60
141_M159_I0.9620.60
104_V112_N0.9600.59
160_D164_L0.9590.59
131_A134_R0.9500.59
83_A201_M0.9500.59
166_S169_T0.9370.58
72_Q224_L0.9330.57
154_D158_G0.9300.57
202_I212_Y0.9300.57
67_R72_Q0.9290.57
175_Q228_V0.9280.57
157_G165_Q0.9180.56
117_L120_A0.9140.56
56_Q236_G0.9050.55
187_L194_M0.9040.55
172_P189_F0.9030.55
212_Y218_R0.9020.55
126_I217_T0.8990.54
81_V85_I0.8990.54
249_T253_N0.8920.54
72_Q172_P0.8890.54
154_D166_S0.8860.53
121_M125_A0.8760.52
91_A97_D0.8740.52
179_L228_V0.8730.52
41_D142_K0.8660.52
47_D66_K0.8650.52
130_Q243_N0.8620.51
114_D119_S0.8600.51
194_M230_F0.8590.51
85_I136_I0.8460.50
80_V228_V0.8440.50
45_D105_K0.8440.50
154_D167_S0.8420.50
234_E264_L0.8400.49
88_Q101_W0.8390.49
53_H262_Y0.8360.49
128_Y227_F0.8360.49
75_Q218_R0.8340.49
161_Q165_Q0.8330.49
139_E149_S0.8300.49
191_K195_K0.8300.49
95_E196_I0.8290.48
257_D261_K0.8210.48
64_N227_F0.8170.47
100_R114_D0.8120.47
36_K262_Y0.8110.47
166_S218_R0.8030.46
112_N201_M0.8020.46
133_A141_M0.8010.46
76_S214_K0.8000.46
109_E211_L0.7940.46
120_A162_F0.7930.45
132_L164_L0.7910.45
42_E62_V0.7860.45
161_Q182_L0.7840.45
252_K256_V0.7830.45
117_L129_Y0.7810.44
79_K214_K0.7800.44
127_W230_F0.7770.44
149_S153_E0.7770.44
84_L189_F0.7740.44
248_G251_A0.7720.44
78_F126_I0.7700.44
43_F48_G0.7570.42
81_V189_F0.7520.42
79_K215_T0.7510.42
55_L180_E0.7500.42
87_L129_Y0.7480.42
40_D257_D0.7430.41
175_Q179_L0.7420.41
170_I198_K0.7400.41
55_L237_S0.7380.41
82_N129_Y0.7180.39
142_K153_E0.7170.39
45_D69_N0.7160.39
62_V127_W0.7160.39
256_V260_K0.7150.39
128_Y251_A0.7150.39
105_K109_E0.7140.39
159_I164_L0.7140.39
141_M160_D0.7100.39
217_T251_A0.7040.38
191_K235_H0.7020.38
140_R144_W0.7020.38
51_I68_A0.7020.38
166_S217_T0.7010.38
212_Y230_F0.6960.38
183_A212_Y0.6960.38
79_K129_Y0.6950.37
112_N115_H0.6920.37
121_M197_V0.6910.37
116_T119_S0.6890.37
52_L176_E0.6870.37
54_D95_E0.6870.37
119_S123_E0.6870.37
75_Q251_A0.6870.37
103_G114_D0.6870.37
80_V122_R0.6860.37
211_L244_V0.6810.36
51_I173_L0.6780.36
183_A198_K0.6740.36
37_M262_Y0.6700.36
99_K135_D0.6680.35
92_V200_M0.6670.35
41_D207_D0.6620.35
208_H256_V0.6620.35
210_T232_K0.6620.35
176_E212_Y0.6560.34
85_I135_D0.6560.34
126_I133_A0.6530.34
111_W126_I0.6500.34
176_E179_L0.6470.34
152_N156_S0.6450.34
253_N257_D0.6440.34
85_I141_M0.6430.33
119_S125_A0.6420.33
182_L230_F0.6380.33
127_W168_L0.6360.33
90_K140_R0.6350.33
55_L115_H0.6310.33
166_S213_G0.6250.32
95_E199_R0.6240.32
199_R202_I0.6240.32
69_N173_L0.6240.32
122_R193_V0.6240.32
130_Q134_R0.6240.32
84_L182_L0.6210.32
55_L238_Y0.6200.32
180_E184_K0.6170.32
41_D57_K0.6160.31
239_V255_T0.6130.31
165_Q224_L0.6130.31
129_Y162_F0.6100.31
107_E111_W0.6090.31
81_V145_L0.6090.31
86_G128_Y0.6080.31
93_R248_G0.6070.31
73_T169_T0.6050.31
103_G112_N0.6050.31
92_V97_D0.6040.31
108_F121_M0.5990.30
62_V65_R0.5970.30
35_S261_K0.5950.30
93_R234_E0.5940.30
56_Q235_H0.5930.30
224_L243_N0.5910.30
66_K177_T0.5900.30
55_L58_D0.5890.30
49_T62_V0.5880.30
87_L162_F0.5850.29
121_M200_M0.5840.29
87_L193_V0.5820.29
87_L117_L0.5810.29
171_S175_Q0.5800.29
168_L172_P0.5790.29
104_V131_A0.5770.29
146_H155_I0.5770.29
186_E237_S0.5760.29
246_D251_A0.5750.29
100_R207_D0.5740.29
195_K198_K0.5720.28
83_A186_E0.5710.28
48_G63_Y0.5690.28
51_I203_Q0.5690.28
48_G87_L0.5670.28
211_L231_I0.5640.28
89_V136_I0.5630.28
85_I162_F0.5630.28
188_P191_K0.5620.28
101_W115_H0.5620.28
156_S254_I0.5620.28
37_M42_E0.5600.28
175_Q229_G0.5600.28
134_R162_F0.5600.28
153_E173_L0.5590.28
61_F233_T0.5580.27
173_L190_D0.5580.27
231_I247_S0.5570.27
91_A135_D0.5570.27
77_T80_V0.5560.27
80_V192_P0.5540.27
148_L203_Q0.5540.27
101_W104_V0.5530.27
142_K155_I0.5530.27
116_T250_K0.5520.27
103_G106_R0.5510.27
94_D196_I0.5470.27
86_G95_E0.5460.27
229_G240_F0.5450.27
77_T229_G0.5430.26
150_Y228_V0.5410.26
123_E127_W0.5390.26
226_W229_G0.5350.26
148_L194_M0.5330.26
113_R143_T0.5320.26
204_E263_G0.5300.26
75_Q165_Q0.5290.26
83_A120_A0.5290.26
121_M251_A0.5270.25
179_L239_V0.5260.25
148_L178_F0.5240.25
128_Y258_I0.5220.25
97_D227_F0.5220.25
91_A140_R0.5210.25
103_G111_W0.5200.25
217_T246_D0.5200.25
209_Y230_F0.5180.25
254_I258_I0.5160.25
59_Q64_N0.5160.25
85_I89_V0.5140.25
106_R111_W0.5130.25
204_E209_Y0.5130.25
133_A187_L0.5130.25
82_N132_L0.5110.24
50_F201_M0.5100.24
76_S215_T0.5100.24
97_D156_S0.5070.24
166_S251_A0.5070.24
166_S227_F0.5060.24
150_Y229_G0.5060.24
91_A132_L0.5020.24
136_I140_R0.5010.24
53_H238_Y0.5000.24
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4s2pA 2 0.8801 100 0.573 Contact Map
4iedA 1 0.8914 100 0.574 Contact Map
4zdxA 1 0.8727 100 0.575 Contact Map
1xkzA 2 0.9139 100 0.582 Contact Map
1nrfA 1 0.8914 100 0.586 Contact Map
1k38A 2 0.8614 100 0.588 Contact Map
2iwbA 1 0.8951 100 0.59 Contact Map
4oh0A 1 0.8764 100 0.592 Contact Map
2x02A 2 0.8876 100 0.599 Contact Map
4jf5A 1 0.8764 100 0.602 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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