GREMLIN Database
METK - S-adenosylmethionine synthase
UniProt: P54419 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 400 (380)
Sequences: 3083 (1258)
Seq/√Len: 64.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
142_N307_D5.6911.00
47_S56_S4.0341.00
333_G337_E3.7051.00
76_K89_A3.6531.00
33_I40_A3.3631.00
159_A180_T3.3581.00
185_E194_R3.2111.00
271_R310_E3.1271.00
32_E35_K2.9691.00
314_A323_V2.8861.00
14_T178_G2.8441.00
173_Y216_N2.8061.00
282_A366_Y2.6171.00
146_E153_S2.6051.00
247_I252_G2.5471.00
22_C48_V2.5461.00
196_D236_K2.5071.00
307_D334_K2.4391.00
77_E367_K2.4221.00
7_L183_T2.4011.00
39_N362_R2.3601.00
76_K90_E2.3221.00
343_V347_N2.2891.00
321_Q345_R2.2661.00
194_R232_D2.2521.00
161_R164_E2.2451.00
128_I283_T2.2441.00
210_L214_Q2.2331.00
44_C59_I2.2241.00
69_K73_Q2.2131.00
21_I78_I2.2111.00
293_A313_L2.2081.00
351_R354_G2.2061.00
387_T390_A2.2011.00
150_L154_L2.1971.00
55_V71_V2.1561.00
219_E223_N2.1521.00
33_I61_T2.1021.00
164_E168_E2.0671.00
104_D244_R2.0371.00
55_V67_I2.0221.00
296_V350_L2.0061.00
369_T382_L2.0021.00
26_S46_T1.9951.00
147_L387_T1.9811.00
41_R110_D1.9631.00
74_T367_K1.9521.00
360_D363_R1.9381.00
106_A110_D1.9361.00
36_K63_T1.9291.00
292_A350_L1.9141.00
198_I226_V1.8961.00
200_I217_I1.8821.00
81_T85_Y1.8781.00
218_K223_N1.8721.00
380_V383_P1.8641.00
300_I309_C1.7901.00
28_S367_K1.7691.00
197_A238_F1.7641.00
53_V75_I1.7521.00
295_Y388_D1.7501.00
24_Q28_S1.7190.99
24_Q370_A1.7100.99
201_S241_P1.6750.99
231_I237_Y1.6710.99
209_T212_Q1.6440.99
212_Q216_N1.6300.99
47_S54_L1.6230.99
14_T159_A1.6230.99
310_E330_F1.6180.99
160_R164_E1.5820.99
335_A343_V1.5780.99
342_E346_N1.5750.99
158_L200_I1.5670.99
24_Q74_T1.5620.99
15_E167_K1.5580.99
339_K342_E1.5550.99
15_E163_S1.5480.99
107_M242_T1.5440.99
202_T217_I1.5380.99
305_L393_L1.5340.99
159_A178_G1.5340.99
195_I226_V1.5230.99
369_T375_F1.5140.99
152_I156_H1.5090.99
108_G242_T1.4960.98
368_Q382_L1.4950.98
49_T99_D1.4890.98
15_E372_Y1.4860.98
271_R330_F1.4780.98
29_I44_C1.4770.98
295_Y358_M1.4750.98
56_S254_A1.4740.98
52_L93_A1.4270.98
296_V344_V1.4250.98
347_N396_E1.4180.98
215_R219_E1.4150.98
66_D69_K1.3640.97
8_F137_F1.3610.97
48_V53_V1.3610.97
353_A357_K1.3510.97
170_I220_H1.3390.97
28_S74_T1.3360.97
292_A358_M1.3240.97
75_I87_F1.3220.97
214_Q218_K1.3200.97
358_M389_K1.3170.97
336_S339_K1.3130.97
269_Y308_S1.3080.96
40_A62_S1.3030.96
354_G358_M1.3000.96
28_S70_T1.2950.96
347_N390_A1.2950.96
125_I357_K1.2940.96
292_A295_Y1.2770.96
62_S103_A1.2750.96
47_S254_A1.2730.96
389_K392_Q1.2700.96
73_Q77_E1.2660.96
232_D235_T1.2630.96
162_L178_G1.2620.96
33_I59_I1.2510.95
335_A339_K1.2510.95
283_T362_R1.2500.95
348_F389_K1.2360.95
333_G340_L1.2310.95
300_I305_L1.2250.95
175_R205_H1.2230.95
29_I67_I1.2210.95
368_Q380_V1.2180.95
75_I92_C1.2030.94
343_V396_E1.2010.94
231_I235_T1.2010.94
216_N220_H1.1970.94
81_T89_A1.1890.94
157_K160_R1.1890.94
208_I213_I1.1850.94
300_I306_A1.1710.93
185_E232_D1.1680.93
197_A236_K1.1650.93
82_R85_Y1.1620.93
346_N396_E1.1540.93
171_L216_N1.1530.93
51_G93_A1.1520.93
104_D246_V1.1480.93
161_R224_P1.1460.93
391_E394_R1.1420.93
210_L213_I1.1390.92
21_I48_V1.1320.92
52_L95_L1.1260.92
329_T340_L1.1200.92
67_I96_T1.1140.92
292_A296_V1.1120.92
343_V393_L1.1110.92
390_A394_R1.1080.91
165_V221_V1.1000.91
392_Q395_K1.0970.91
368_Q381_D1.0950.91
327_I344_V1.0950.91
343_V390_A1.0890.91
12_S156_H1.0860.91
167_K372_Y1.0770.90
151_P269_Y1.0740.90
328_N337_E1.0650.90
347_N392_Q1.0630.90
222_I237_Y1.0620.90
68_P96_T1.0530.89
161_R165_V1.0490.89
33_I65_V1.0480.89
313_L325_I1.0440.89
349_D354_G1.0310.88
64_Y67_I1.0310.88
5_R185_E1.0300.88
173_Y208_I1.0280.88
321_Q349_D1.0280.88
184_V195_I1.0270.88
70_T74_T1.0250.88
146_E157_K1.0160.87
368_Q383_P1.0130.87
125_I353_A1.0100.87
52_L97_S1.0070.87
187_D193_V1.0050.87
142_N334_K1.0050.87
14_T162_L1.0010.87
135_L290_A1.0010.87
328_N333_G0.9980.86
77_E167_K0.9890.86
73_Q76_K0.9880.86
82_R90_E0.9880.86
5_R187_D0.9860.86
32_E65_V0.9860.86
41_R60_T0.9850.86
300_I393_L0.9830.86
147_L302_A0.9820.86
220_H224_P0.9810.86
299_N390_A0.9800.85
379_D382_L0.9740.85
32_E36_K0.9650.85
165_V178_G0.9640.85
163_S372_Y0.9630.84
64_Y100_E0.9620.84
378_H381_D0.9570.84
69_K100_E0.9570.84
227_P230_L0.9540.84
375_F382_L0.9510.84
60_T106_A0.9500.84
60_T103_A0.9500.84
71_V74_T0.9460.83
107_M244_R0.9420.83
65_V70_T0.9390.83
126_E353_A0.9350.83
392_Q396_E0.9340.83
161_R220_H0.9310.82
53_V71_V0.9260.82
160_R382_L0.9250.82
313_L350_L0.9250.82
213_I216_N0.9240.82
74_T77_E0.9220.82
329_T337_E0.9200.82
24_Q367_K0.9180.81
381_D386_R0.9160.81
146_E378_H0.9140.81
54_L97_S0.9130.81
162_L202_T0.9110.81
327_I337_E0.9070.81
137_F262_I0.9020.80
320_A351_R0.9010.80
262_I272_H0.9000.80
370_A377_R0.9000.80
226_V231_I0.8990.80
211_E215_R0.8930.80
300_I344_V0.8920.80
81_T90_E0.8910.80
241_P316_A0.8900.79
83_A251_Q0.8880.79
150_L184_V0.8850.79
32_E70_T0.8790.79
51_G97_S0.8780.79
338_E341_I0.8770.78
22_C53_V0.8760.78
333_G339_K0.8750.78
305_L340_L0.8730.78
162_L221_V0.8710.78
173_Y212_Q0.8660.78
128_I362_R0.8650.77
148_M376_G0.8620.77
93_A97_S0.8620.77
143_E308_S0.8610.77
217_I239_I0.8600.77
160_R379_D0.8600.77
162_L165_V0.8540.77
333_G336_S0.8530.76
139_Y269_Y0.8510.76
64_Y98_I0.8470.76
50_T99_D0.8460.76
369_T380_V0.8420.76
51_G68_P0.8410.75
142_N304_E0.8380.75
359_L383_P0.8380.75
341_I345_R0.8350.75
163_S167_K0.8310.75
126_E351_R0.8310.75
68_P97_S0.8250.74
41_R106_A0.8250.74
126_E321_Q0.8240.74
299_N387_T0.8210.74
218_K239_I0.8190.74
371_A377_R0.8180.73
199_V239_I0.8170.73
300_I343_V0.8150.73
136_M285_V0.8140.73
21_I75_I0.8130.73
185_E196_D0.8120.73
337_E341_I0.8060.72
15_E166_R0.8030.72
387_T394_R0.8010.72
153_S157_K0.8010.72
363_R381_D0.8000.72
21_I251_Q0.8000.72
34_L40_A0.7980.72
30_L42_V0.7970.71
76_K81_T0.7970.71
33_I63_T0.7950.71
365_I383_P0.7910.71
68_P93_A0.7910.71
191_K307_D0.7890.71
206_P246_V0.7880.71
54_L95_L0.7880.71
363_R383_P0.7860.70
379_D383_P0.7850.70
99_D254_A0.7830.70
187_D191_K0.7830.70
377_R382_L0.7820.70
329_T333_G0.7820.70
174_L202_T0.7810.70
350_L354_G0.7810.70
40_A61_T0.7800.70
83_A88_D0.7780.70
289_A313_L0.7780.70
325_I345_R0.7770.70
358_M388_D0.7760.69
161_R170_I0.7750.69
104_D108_G0.7740.69
199_V238_F0.7740.69
213_I217_I0.7720.69
201_S316_A0.7710.69
148_M152_I0.7690.69
40_A63_T0.7680.69
111_Q125_I0.7650.68
217_I221_V0.7640.68
142_N191_K0.7610.68
61_T64_Y0.7580.68
161_R225_V0.7560.67
347_N389_K0.7550.67
21_I25_I0.7530.67
282_A362_R0.7520.67
302_A387_T0.7500.67
282_A356_I0.7480.67
7_L196_D0.7470.66
175_R206_P0.7450.66
360_D386_R0.7440.66
171_L174_L0.7430.66
299_N388_D0.7400.66
165_V170_I0.7390.66
339_K346_N0.7360.65
388_D392_Q0.7330.65
335_A340_L0.7320.65
83_A91_T0.7300.65
356_I362_R0.7290.65
269_Y310_E0.7270.64
22_C47_S0.7270.64
211_E214_Q0.7240.64
190_N308_S0.7220.64
161_R168_E0.7210.64
160_R380_V0.7210.64
64_Y68_P0.7180.63
54_L93_A0.7160.63
218_K237_Y0.7160.63
368_Q379_D0.7150.63
91_T251_Q0.7140.63
6_R187_D0.7130.63
208_I216_N0.7120.63
14_T180_T0.7070.62
30_L55_V0.7070.62
162_L200_I0.7050.62
39_N62_S0.7040.62
224_P227_P0.7030.62
313_L351_R0.7030.62
33_I67_I0.7010.62
288_S355_I0.7010.62
309_C393_L0.7000.61
147_L151_P0.6990.61
339_K343_V0.6940.61
367_K370_A0.6930.61
85_Y89_A0.6930.61
165_V171_L0.6890.60
173_Y213_I0.6880.60
141_C147_L0.6870.60
158_L180_T0.6860.60
51_G83_A0.6860.60
49_T97_S0.6850.60
29_I71_V0.6830.60
84_K90_E0.6830.60
347_N393_L0.6830.60
141_C148_M0.6830.60
103_A107_M0.6780.59
378_H386_R0.6780.59
187_D190_N0.6770.59
378_H382_L0.6760.59
295_Y299_N0.6760.59
159_A162_L0.6740.59
360_D383_P0.6720.58
270_A310_E0.6720.58
295_Y389_K0.6710.58
104_D247_I0.6690.58
104_D242_T0.6680.58
128_I353_A0.6660.58
180_T200_I0.6640.57
165_V174_L0.6600.57
393_L396_E0.6590.57
295_Y347_N0.6570.57
103_A247_I0.6570.57
359_L369_T0.6560.56
197_A323_V0.6520.56
68_P99_D0.6510.56
308_S330_F0.6500.56
21_I87_F0.6480.56
50_T251_Q0.6470.55
85_Y205_H0.6460.55
88_D92_C0.6440.55
362_R366_Y0.6410.55
96_T99_D0.6400.55
320_A352_P0.6390.55
232_D238_F0.6370.54
135_L269_Y0.6360.54
303_A393_L0.6350.54
93_A96_T0.6350.54
172_P205_H0.6350.54
327_I341_I0.6340.54
184_V230_L0.6340.54
299_N302_A0.6340.54
238_F323_V0.6310.54
209_T213_I0.6290.53
391_E395_K0.6290.53
111_Q353_A0.6290.53
265_T272_H0.6290.53
223_N231_I0.6280.53
101_Q105_I0.6270.53
136_M313_L0.6250.53
161_R221_V0.6240.53
68_P71_V0.6230.53
73_Q367_K0.6230.53
160_R368_Q0.6190.52
126_E354_G0.6190.52
139_Y308_S0.6190.52
87_F92_C0.6180.52
309_C344_V0.6180.52
126_E357_K0.6180.52
14_T165_V0.6170.52
111_Q126_E0.6160.52
51_G64_Y0.6150.52
60_T110_D0.6150.52
333_G341_I0.6140.52
372_Y377_R0.6120.51
151_P192_P0.6120.51
305_L309_C0.6120.51
194_R235_T0.6120.51
305_L333_G0.6090.51
168_E171_L0.6090.51
300_I329_T0.6090.51
345_R349_D0.6070.51
87_F91_T0.6070.51
222_I235_T0.6060.51
295_Y387_T0.6030.50
105_I109_V0.6020.50
364_P368_Q0.6010.50
145_K306_A0.5990.50
329_T332_S0.5980.50
128_I356_I0.5970.50
300_I340_L0.5950.49
110_D242_T0.5940.49
51_G95_L0.5940.49
56_S96_T0.5930.49
36_K61_T0.5930.49
343_V392_Q0.5920.49
171_L213_I0.5920.49
195_I231_I0.5910.49
326_S344_V0.5900.49
104_D107_M0.5900.49
341_I344_V0.5890.49
349_D357_K0.5890.49
305_L344_V0.5880.49
155_A178_G0.5870.48
336_S340_L0.5870.48
71_V92_C0.5850.48
33_I62_S0.5850.48
226_V230_L0.5820.48
292_A355_I0.5790.48
53_V92_C0.5770.47
206_P244_R0.5760.47
203_Q248_G0.5740.47
51_G94_V0.5740.47
36_K62_S0.5740.47
8_F269_Y0.5730.47
162_L174_L0.5730.47
134_G275_G0.5710.47
308_S328_N0.5710.47
49_T68_P0.5690.46
390_A396_E0.5680.46
265_T268_G0.5670.46
321_Q351_R0.5660.46
137_F312_Q0.5640.46
14_T163_S0.5630.46
136_M315_Y0.5620.46
137_F268_G0.5610.45
342_E345_R0.5610.45
270_A350_L0.5600.45
49_T55_V0.5600.45
113_L126_E0.5590.45
22_C56_S0.5580.45
36_K65_V0.5570.45
165_V220_H0.5570.45
67_I98_I0.5560.45
203_Q245_F0.5560.45
92_C309_C0.5550.45
125_I351_R0.5540.45
148_M377_R0.5530.45
366_Y383_P0.5530.45
148_M192_P0.5510.44
8_F312_Q0.5510.44
296_V311_V0.5500.44
25_I48_V0.5490.44
68_P83_A0.5480.44
150_L192_P0.5470.44
270_A311_V0.5460.44
125_I358_M0.5460.44
223_N228_E0.5450.44
173_Y205_H0.5440.44
153_S160_R0.5440.44
50_T87_F0.5430.43
150_L230_L0.5430.43
190_N193_V0.5410.43
99_D251_Q0.5400.43
153_S198_I0.5380.43
145_K153_S0.5380.43
66_D100_E0.5380.43
68_P95_L0.5380.43
216_N219_E0.5380.43
304_E394_R0.5380.43
105_I129_G0.5370.43
151_P186_Y0.5370.43
380_V386_R0.5360.43
171_L208_I0.5360.43
178_G221_V0.5360.43
171_L217_I0.5360.43
309_C387_T0.5350.42
36_K64_Y0.5350.42
67_I71_V0.5350.42
9_T183_T0.5330.42
125_I354_G0.5330.42
88_D91_T0.5320.42
187_D192_P0.5320.42
22_C254_A0.5320.42
173_Y220_H0.5310.42
309_C329_T0.5290.42
209_T215_R0.5280.42
305_L332_S0.5280.42
85_Y251_Q0.5280.42
207_E244_R0.5270.42
29_I222_I0.5270.42
344_V348_F0.5260.41
38_P362_R0.5250.41
236_K321_Q0.5230.41
64_Y93_A0.5230.41
141_C269_Y0.5220.41
60_T100_E0.5210.41
370_A382_L0.5210.41
22_C141_C0.5200.41
152_I155_A0.5200.41
319_V352_P0.5200.41
183_T197_A0.5190.41
363_R380_V0.5190.41
7_L185_E0.5190.41
340_L393_L0.5180.41
85_Y88_D0.5170.40
25_I53_V0.5160.40
83_A87_F0.5140.40
135_L311_V0.5140.40
296_V348_F0.5120.40
49_T56_S0.5120.40
48_V99_D0.5110.40
178_G200_I0.5110.40
145_K378_H0.5110.40
344_V350_L0.5100.40
87_F162_L0.5080.39
101_Q129_G0.5070.39
6_R326_S0.5070.39
8_F262_I0.5060.39
344_V347_N0.5060.39
242_T319_V0.5060.39
293_A325_I0.5050.39
113_L125_I0.5050.39
112_A126_E0.5040.39
106_A111_Q0.5030.39
26_S261_I0.5020.39
72_R92_C0.5020.39
8_F148_M0.5020.39
44_C98_I0.5010.39
33_I64_Y0.5000.39
194_R234_E0.5000.39
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3s82A 4 0.92 100 0.071 Contact Map
3so4A 4 0.935 100 0.083 Contact Map
3imlA 2 0.9175 100 0.085 Contact Map
1p7lA 4 0.9575 100 0.094 Contact Map
4odjA 2 0.945 100 0.099 Contact Map
2p02A 2 0.9425 100 0.102 Contact Map
4le5A 2 0.93 100 0.105 Contact Map
4l7iA 3 0.8375 100 0.386 Contact Map
4l4qA 3 0.85 98.8 0.938 Contact Map
2ogkA 4 0.1675 53.6 0.979 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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