GREMLIN Database
YPJB - Uncharacterized protein YpjB
UniProt: P54393 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 264 (246)
Sequences: 156 (134)
Seq/√Len: 8.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
139_K208_Q5.7811.00
225_P246_G3.4930.95
127_L215_F3.3210.93
187_I245_V3.2590.93
78_I82_T2.9980.89
123_L246_G2.6990.83
85_Y127_L2.6910.83
28_L207_L2.5760.80
35_S81_I2.5650.80
244_Y250_Y2.5130.78
157_F236_S2.3500.73
88_M247_Y2.3040.72
135_F167_S2.2870.71
235_G248_R2.2510.70
249_K252_A2.2360.69
38_V127_L2.2210.69
46_K49_E2.1510.66
244_Y249_K2.1080.65
57_F167_S2.0980.64
167_S234_T1.9400.58
123_L162_D1.9310.57
54_L238_I1.8880.56
93_K131_I1.8850.56
40_Q43_R1.8690.55
39_F107_A1.8490.54
31_L170_I1.8150.53
88_M106_A1.8120.52
184_I204_L1.8100.52
247_Y252_A1.8090.52
32_N114_D1.8040.52
101_Q186_V1.8000.52
228_L235_G1.7760.51
79_R128_E1.7640.50
112_L239_I1.7280.49
63_S144_K1.7230.49
180_V231_I1.7170.48
88_M132_M1.7010.48
129_K247_Y1.6740.47
76_A85_Y1.6610.46
57_F221_D1.6560.46
41_M49_E1.6510.46
86_N102_K1.6360.45
122_P236_S1.5990.43
165_Y234_T1.5980.43
111_M123_L1.5960.43
161_Y181_G1.5930.43
157_F184_I1.5830.43
122_P181_G1.5600.42
12_A81_I1.5550.42
81_I180_V1.5530.42
75_G78_I1.5170.40
228_L246_G1.5150.40
11_I255_N1.5000.39
61_L78_I1.4950.39
102_K203_R1.4860.39
156_E180_V1.4790.39
123_L150_F1.4690.38
133_E137_E1.4650.38
12_A113_M1.3930.35
127_L160_L1.3910.35
39_F252_A1.3680.34
126_S160_L1.3650.34
167_S238_I1.3610.34
221_D238_I1.3530.34
155_N165_Y1.3510.34
180_V251_K1.3500.34
44_Q52_Q1.3440.33
221_D227_L1.3390.33
39_F127_L1.3390.33
226_S249_K1.3340.33
38_V167_S1.3310.33
51_L93_K1.3190.32
81_I177_L1.3160.32
102_K248_R1.3060.32
51_L102_K1.3030.32
207_L219_E1.3020.32
117_D179_T1.3000.32
46_K106_A1.2960.32
85_Y109_F1.2900.31
92_L108_Q1.2650.30
89_V241_A1.2640.30
135_F249_K1.2590.30
124_W242_L1.2440.30
59_K140_R1.2410.30
8_C13_L1.2370.29
58_E62_K1.2350.29
39_F172_V1.2050.28
57_F79_R1.1980.28
97_T102_K1.1930.28
128_E229_W1.1850.28
35_S82_T1.1780.27
31_L57_F1.1770.27
118_N121_D1.1750.27
236_S253_E1.1670.27
220_E243_T1.1630.27
155_N168_L1.1620.27
28_L187_I1.1460.26
62_K162_D1.1380.26
88_M91_S1.1350.26
144_K180_V1.1340.26
92_L223_A1.1290.26
92_L173_S1.1270.26
57_F234_T1.1250.26
224_D230_V1.1190.25
125_G134_A1.1160.25
108_Q167_S1.1110.25
123_L186_V1.1100.25
222_D234_T1.1060.25
68_Q170_I1.1020.25
160_L214_V1.1010.25
126_S165_Y1.1000.25
9_L14_I1.0970.25
242_L250_Y1.0960.25
58_E238_I1.0910.25
153_K243_T1.0850.24
247_Y255_N1.0790.24
13_L20_A1.0790.24
87_D193_Q1.0760.24
10_L13_L1.0700.24
203_R227_L1.0700.24
61_L112_L1.0680.24
31_L224_D1.0650.24
109_F230_V1.0510.23
77_Q127_L1.0500.23
183_H207_L1.0350.23
157_F186_V1.0300.23
182_K195_M1.0290.23
151_H207_L1.0200.22
160_L168_L1.0190.22
52_Q253_E1.0150.22
79_R106_A1.0140.22
17_N22_A0.9960.22
114_D245_V0.9920.22
177_L214_V0.9900.22
57_F229_W0.9880.21
81_I185_D0.9850.21
44_Q135_F0.9830.21
63_S137_E0.9800.21
112_L216_D0.9790.21
79_R229_W0.9740.21
110_R171_D0.9740.21
75_G207_L0.9700.21
167_S248_R0.9700.21
32_N249_K0.9530.20
187_I207_L0.9490.20
241_A245_V0.9470.20
66_K165_Y0.9430.20
63_S133_E0.9400.20
140_R250_Y0.9380.20
221_D229_W0.9370.20
81_I165_Y0.9360.20
44_Q217_R0.9300.20
61_L219_E0.9290.20
47_Y73_L0.9230.20
67_K177_L0.9230.20
94_Q119_R0.9190.20
54_L168_L0.9190.20
81_I107_A0.9180.20
32_N110_R0.9170.20
36_D157_F0.9100.19
133_E163_L0.9090.19
115_A122_P0.9070.19
35_S51_L0.9000.19
95_A140_R0.8980.19
95_A98_S0.8970.19
166_P244_Y0.8960.19
31_L226_S0.8960.19
79_R224_D0.8910.19
106_A128_E0.8870.19
23_A164_I0.8820.19
79_R234_T0.8760.18
113_M249_K0.8740.18
31_L79_R0.8690.18
36_D110_R0.8620.18
175_D245_V0.8570.18
14_I81_I0.8560.18
62_K154_W0.8480.18
28_L219_E0.8430.18
61_L82_T0.8420.18
101_Q240_T0.8390.18
135_F234_T0.8360.17
45_A123_L0.8320.17
158_I241_A0.8280.17
238_I248_R0.8180.17
44_Q233_T0.8160.17
15_F23_A0.8150.17
36_D118_N0.8130.17
132_M222_D0.8100.17
220_E225_P0.8100.17
95_A105_A0.8090.17
75_G109_F0.8080.17
210_D245_V0.8060.17
48_E122_P0.8030.17
54_L229_W0.8000.17
8_C136_T0.7960.16
183_H210_D0.7930.16
165_Y183_H0.7910.16
29_E198_S0.7870.16
142_V145_N0.7810.16
10_L16_Y0.7790.16
172_V182_K0.7790.16
42_T58_E0.7770.16
162_D228_L0.7660.16
45_A116_V0.7630.16
220_E252_A0.7590.16
179_T209_H0.7580.16
42_T131_I0.7540.16
111_M154_W0.7520.15
108_Q162_D0.7520.15
61_L250_Y0.7520.15
110_R166_P0.7480.15
121_D241_A0.7480.15
9_L46_K0.7430.15
39_F77_Q0.7420.15
31_L219_E0.7350.15
105_A130_P0.7330.15
54_L180_V0.7320.15
202_E239_I0.7320.15
88_M180_V0.7310.15
77_Q210_D0.7310.15
207_L247_Y0.7300.15
33_D140_R0.7290.15
8_C18_G0.7270.15
9_L186_V0.7220.15
235_G246_G0.7210.15
201_L205_S0.7140.15
85_Y165_Y0.7130.15
27_S99_D0.7130.15
123_L223_A0.7020.14
168_L214_V0.7010.14
163_L191_E0.6960.14
54_L114_D0.6950.14
51_L121_D0.6920.14
57_F223_A0.6840.14
138_L154_W0.6810.14
11_I14_I0.6780.14
24_E196_T0.6760.14
94_Q99_D0.6750.14
10_L214_V0.6730.14
226_S244_Y0.6720.14
99_D185_D0.6710.14
19_N168_L0.6690.14
173_S255_N0.6690.14
230_V238_I0.6660.14
58_E61_L0.6650.14
29_E246_G0.6640.14
161_Y234_T0.6640.14
75_G191_E0.6580.14
87_D108_Q0.6570.14
28_L152_E0.6560.13
101_Q243_T0.6550.13
80_Q139_K0.6550.13
50_A167_S0.6540.13
48_E249_K0.6520.13
109_F187_I0.6510.13
62_K78_I0.6460.13
65_E108_Q0.6430.13
43_R88_M0.6430.13
19_N248_R0.6430.13
40_Q158_I0.6400.13
167_S244_Y0.6400.13
115_A187_I0.6380.13
29_E87_D0.6380.13
156_E164_I0.6380.13
132_M216_D0.6370.13
102_K224_D0.6370.13
10_L159_S0.6340.13
78_I206_L0.6340.13
181_G208_Q0.6320.13
185_D233_T0.6310.13
65_E115_A0.6290.13
238_I242_L0.6270.13
16_Y22_A0.6250.13
8_C16_Y0.6230.13
45_A66_K0.6230.13
145_N148_T0.6210.13
38_V164_I0.6180.13
85_Y234_T0.6170.13
145_N217_R0.6160.13
162_D208_Q0.6140.13
87_D211_L0.6130.13
77_Q172_V0.6110.13
42_T90_R0.6090.13
168_L177_L0.6080.13
12_A17_N0.6060.13
62_K123_L0.6050.13
242_L246_G0.6050.13
209_H240_T0.6050.13
74_T180_V0.6050.13
81_I210_D0.6040.12
118_N229_W0.6030.12
128_E158_I0.6010.12
57_F219_E0.6010.12
242_L249_K0.6010.12
43_R107_A0.5980.12
109_F249_K0.5970.12
115_A183_H0.5930.12
40_Q176_Q0.5900.12
184_I194_Q0.5900.12
54_L171_D0.5890.12
109_F233_T0.5850.12
82_T107_A0.5840.12
234_T237_I0.5810.12
158_I196_T0.5810.12
120_S138_L0.5780.12
82_T109_F0.5780.12
79_R221_D0.5770.12
57_F230_V0.5670.12
18_G149_S0.5660.12
225_P229_W0.5660.12
80_Q194_Q0.5660.12
118_N128_E0.5650.12
221_D224_D0.5640.12
90_R108_Q0.5630.12
112_L117_D0.5630.12
113_M134_A0.5620.12
13_L24_E0.5600.12
40_Q235_G0.5580.12
53_V220_E0.5560.12
9_L196_T0.5550.12
168_L207_L0.5550.12
42_T184_I0.5550.12
57_F224_D0.5520.12
55_E255_N0.5500.12
105_A116_V0.5470.11
160_L165_Y0.5470.11
86_N94_Q0.5460.11
50_A245_V0.5460.11
153_K214_V0.5450.11
38_V173_S0.5420.11
22_A115_A0.5410.11
105_A201_L0.5390.11
34_L181_G0.5390.11
241_A249_K0.5370.11
114_D242_L0.5360.11
74_T133_E0.5360.11
80_Q208_Q0.5350.11
151_H236_S0.5330.11
128_E224_D0.5310.11
151_H243_T0.5300.11
61_L226_S0.5300.11
226_S252_A0.5280.11
72_M178_E0.5280.11
39_F43_R0.5260.11
171_D229_W0.5260.11
163_L167_S0.5250.11
220_E236_S0.5240.11
126_S135_F0.5210.11
52_Q101_Q0.5210.11
44_Q152_E0.5190.11
115_A242_L0.5190.11
140_R214_V0.5170.11
110_R161_Y0.5170.11
28_L253_E0.5120.11
132_M235_G0.5110.11
67_K81_I0.5100.11
122_P248_R0.5090.11
54_L234_T0.5090.11
250_Y253_E0.5080.11
61_L191_E0.5070.11
45_A99_D0.5060.11
114_D247_Y0.5060.11
86_N93_K0.5050.11
78_I191_E0.5050.11
167_S215_F0.5030.11
243_T250_Y0.5020.11
110_R234_T0.5020.11
57_F75_G0.5020.11
40_Q204_L0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2micA 2 0.1553 32.1 0.959 Contact Map
3zbiC 1 0.1061 29.7 0.96 Contact Map
3n71A 1 0.678 16.5 0.964 Contact Map
2f95B 2 0.0758 16.4 0.964 Contact Map
2w2uA 1 0.2803 15.6 0.964 Contact Map
3v57A 1 0.4773 15.2 0.965 Contact Map
2w84A 1 0.2045 14.3 0.965 Contact Map
3ezhA 3 0.3712 12.8 0.966 Contact Map
4uy3A 1 0.2462 9.5 0.968 Contact Map
2m3eA 1 0.1553 9.2 0.968 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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