GREMLIN Database
YPJA - Uncharacterized protein YpjA
UniProt: P54392 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 185 (174)
Sequences: 361 (265)
Seq/√Len: 20.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
51_A58_A4.0101.00
6_L10_F3.8831.00
10_F46_L3.8821.00
6_L50_L3.6971.00
27_T35_V3.3391.00
64_L125_A3.2871.00
6_L46_L3.0490.99
18_Y21_L2.9510.99
8_I103_A2.4470.97
30_R33_I2.2600.95
48_V62_E2.2510.95
74_L102_F2.2350.95
131_H157_Y2.2250.95
66_L170_A2.2100.95
80_N94_G2.0620.92
67_V167_I2.0130.91
157_Y161_W1.9910.91
78_A158_G1.9160.89
13_T43_F1.8750.88
67_V122_L1.8280.86
68_T128_W1.8040.86
131_H161_W1.7850.85
95_Y98_I1.7820.85
111_Y114_Y1.7620.84
109_V165_F1.7580.84
48_V51_A1.7500.84
60_L120_W1.7410.84
48_V111_Y1.6890.82
70_V109_V1.6700.81
26_E144_Q1.6370.80
21_L25_L1.6110.78
14_V61_L1.6050.78
70_V108_G1.5790.77
130_L164_I1.5770.77
7_A11_L1.5570.76
142_M145_Y1.5300.75
14_V18_Y1.5250.74
122_L171_Y1.5140.74
67_V129_T1.5080.74
71_K133_D1.4750.72
28_P141_M1.4540.71
31_F135_I1.4530.71
60_L124_I1.4490.70
130_L163_S1.4330.70
90_L95_Y1.4220.69
28_P49_L1.4100.68
9_N107_Q1.4060.68
47_F61_L1.3790.67
68_T129_T1.3710.66
70_V169_L1.3510.65
46_L50_L1.3460.65
126_A167_I1.3310.64
81_F98_I1.3230.63
84_L94_G1.3210.63
47_F51_A1.2780.60
91_P95_Y1.2580.59
48_V52_F1.2350.58
117_F174_V1.2330.58
10_F50_L1.2300.57
36_P97_L1.2120.56
157_Y160_F1.2110.56
70_V166_S1.2100.56
139_F154_E1.1920.55
47_F92_W1.1880.55
28_P166_S1.1830.54
120_W124_I1.1570.53
80_N84_L1.1500.52
10_F174_V1.1490.52
163_S167_I1.1210.50
46_L54_M1.1200.50
131_H138_L1.0880.48
23_Q104_M1.0780.48
81_F85_A1.0440.45
86_V150_D1.0380.45
95_Y118_S1.0350.45
49_L110_L1.0330.45
51_A59_P1.0310.45
118_S121_H1.0050.43
111_Y130_L1.0040.43
48_V114_Y1.0010.43
69_L107_Q0.9920.42
3_I55_K0.9920.42
23_Q35_V0.9840.42
82_L87_T0.9640.40
122_L167_I0.9630.40
135_I139_F0.9620.40
33_I168_A0.9500.40
111_Y159_T0.9500.40
102_F119_F0.9490.39
171_Y175_V0.9370.39
59_P130_L0.9360.39
70_V173_L0.9280.38
95_Y171_Y0.9260.38
50_L57_N0.9210.38
23_Q100_S0.9190.38
131_H141_M0.9160.37
61_L133_D0.9080.37
66_L169_L0.9010.37
17_Y79_M0.8990.36
76_A80_N0.8960.36
103_A164_I0.8960.36
6_L53_L0.8960.36
29_A153_T0.8890.36
142_M152_M0.8850.36
66_L108_G0.8830.35
103_A170_A0.8760.35
83_V147_M0.8730.35
84_L145_Y0.8670.34
89_D124_I0.8610.34
53_L116_R0.8610.34
168_A172_F0.8610.34
38_S65_A0.8610.34
33_I134_V0.8590.34
102_F106_V0.8550.34
7_A153_T0.8530.34
78_A82_L0.8490.33
135_I141_M0.8390.33
84_L108_G0.8360.33
44_F69_L0.8300.32
95_Y117_F0.8210.32
148_L151_Y0.8140.31
8_I107_Q0.8130.31
16_G136_D0.8100.31
110_L115_F0.8090.31
62_E111_Y0.8060.31
30_R107_Q0.7980.31
138_L157_Y0.7960.30
146_S149_S0.7930.30
123_A126_A0.7920.30
15_Y19_W0.7920.30
51_A57_N0.7900.30
18_Y77_V0.7890.30
89_D106_V0.7820.30
51_A120_W0.7760.29
94_G145_Y0.7700.29
169_L175_V0.7680.29
119_F127_V0.7650.29
31_F141_M0.7650.29
127_V155_I0.7600.29
17_Y40_T0.7590.28
42_T62_E0.7550.28
134_V138_L0.7520.28
32_L141_M0.7510.28
147_M150_D0.7490.28
13_T42_T0.7470.28
8_I114_Y0.7450.28
22_P25_L0.7400.27
52_F108_G0.7300.27
19_W96_M0.7280.27
82_L145_Y0.7240.27
17_Y43_F0.7240.27
84_L102_F0.7230.27
46_L51_A0.7230.27
35_V104_M0.7210.26
47_F58_A0.7190.26
159_T167_I0.7190.26
12_G97_L0.7180.26
116_R139_F0.7170.26
131_H160_F0.7090.26
51_A56_R0.7070.26
11_L33_I0.7050.26
59_P62_E0.6990.25
29_A74_L0.6920.25
24_L72_Y0.6880.25
93_E148_L0.6830.25
65_A71_K0.6810.25
140_D153_T0.6740.24
55_K106_V0.6720.24
92_W98_I0.6710.24
99_A102_F0.6690.24
123_A169_L0.6680.24
90_L130_L0.6640.24
138_L161_W0.6560.23
86_V151_Y0.6540.23
109_V169_L0.6530.23
156_G160_F0.6520.23
149_S152_M0.6470.23
42_T68_T0.6410.23
143_P146_S0.6400.23
64_L103_A0.6400.23
8_I32_L0.6350.22
127_V131_H0.6330.22
19_W97_L0.6300.22
51_A54_M0.6280.22
169_L172_F0.6280.22
80_N83_V0.6250.22
19_W111_Y0.6240.22
52_F166_S0.6220.22
85_A99_A0.6180.22
27_T36_P0.6170.22
125_A129_T0.6160.22
34_F105_A0.6150.21
96_M100_S0.6140.21
38_S104_M0.6140.21
81_F173_L0.6130.21
12_G104_M0.6130.21
10_F89_D0.6120.21
45_F105_A0.6100.21
62_E115_F0.6070.21
29_A115_F0.6060.21
115_F129_T0.6030.21
18_Y24_L0.6010.21
83_V145_Y0.5980.21
61_L123_A0.5970.21
12_G23_Q0.5930.21
147_M170_A0.5910.20
131_H135_I0.5900.20
22_P26_E0.5890.20
28_P83_V0.5890.20
97_L100_S0.5860.20
5_V45_F0.5840.20
19_W76_A0.5820.20
140_D152_M0.5820.20
48_V57_N0.5800.20
8_I91_P0.5800.20
32_L42_T0.5800.20
129_T159_T0.5750.20
80_N145_Y0.5750.20
30_R140_D0.5750.20
163_S166_S0.5730.20
145_Y161_W0.5730.20
85_A149_S0.5720.20
134_V160_F0.5700.20
66_L109_V0.5700.20
131_H134_V0.5690.20
13_T44_F0.5690.20
110_L114_Y0.5650.19
91_P99_A0.5600.19
97_L104_M0.5600.19
46_L61_L0.5570.19
29_A126_A0.5560.19
78_A127_V0.5560.19
119_F122_L0.5540.19
141_M145_Y0.5520.19
50_L102_F0.5520.19
2_L53_L0.5450.19
36_P104_M0.5430.18
10_F124_I0.5420.18
125_A139_F0.5420.18
13_T104_M0.5350.18
159_T166_S0.5320.18
15_Y96_M0.5320.18
7_A99_A0.5260.18
94_G125_A0.5230.18
12_G36_P0.5210.18
76_A111_Y0.5200.18
67_V175_V0.5200.18
42_T100_S0.5180.18
52_F122_L0.5170.17
59_P139_F0.5150.17
22_P147_M0.5140.17
111_Y115_F0.5140.17
19_W45_F0.5130.17
9_N12_G0.5120.17
47_F173_L0.5110.17
129_T133_D0.5110.17
11_L21_L0.5080.17
68_T133_D0.5050.17
32_L166_S0.5020.17
57_N135_I0.5010.17
50_L164_I0.5000.17
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2jp3A 1 0.2865 9.3 0.963 Contact Map
2l6wA 2 0.2108 6.8 0.965 Contact Map
2m20A 2 0.2 5.1 0.967 Contact Map
2kluA 1 0.2054 5 0.967 Contact Map
2mkvA 1 0.3243 3.7 0.969 Contact Map
3wguG 1 0.1838 3.5 0.969 Contact Map
4qndA 2 0.2378 3.4 0.97 Contact Map
2kv5A 1 0.1784 3.1 0.97 Contact Map
2l2tA 2 0.227 2.6 0.971 Contact Map
2jwaA 2 0.2162 2.4 0.972 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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