GREMLIN Database
ISPA - Farnesyl diphosphate synthase
UniProt: P54383 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 296 (265)
Sequences: 9755 (6668)
Seq/√Len: 409.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
57_L67_G3.5671.00
201_P204_D3.4341.00
192_I209_R3.2041.00
94_D104_K3.1171.00
188_G209_R2.8951.00
145_E192_I2.7471.00
171_T174_E2.5791.00
188_G213_S2.5141.00
180_E213_S2.5021.00
145_E196_I2.4331.00
95_L100_P2.4321.00
121_E124_K2.3761.00
192_I205_I2.3321.00
231_S234_K2.2281.00
238_R241_S2.1821.00
142_L193_A2.1601.00
266_H283_L2.0281.00
195_A208_L2.0231.00
56_V208_L2.0001.00
90_M159_Q1.9911.00
177_S181_R1.9551.00
265_V269_E1.9541.00
264_D268_K1.9461.00
56_V191_V1.9461.00
141_R205_I1.9271.00
19_Q69_P1.9241.00
19_Q72_C1.9051.00
107_G110_T1.8841.00
191_V212_S1.8531.00
12_R58_N1.8051.00
60_Y204_D1.8021.00
262_K265_V1.7791.00
210_T214_H1.7171.00
19_Q22_V1.7121.00
172_L254_L1.7071.00
206_E210_T1.6961.00
38_L42_Q1.6831.00
127_T143_V1.6521.00
84_H116_D1.6481.00
21_S38_L1.6421.00
200_A204_D1.6101.00
110_T160_V1.6031.00
17_E47_R1.5891.00
124_K148_S1.5871.00
57_L62_K1.5851.00
84_H115_G1.5811.00
266_H269_E1.5791.00
168_R174_E1.5701.00
69_P128_S1.5631.00
141_R202_E1.5541.00
128_S144_N1.5391.00
189_F193_A1.5291.00
254_L258_G1.5101.00
277_L280_Q1.4981.00
241_S245_N1.4861.00
195_A200_A1.4841.00
161_A177_S1.4641.00
260_K263_L1.4631.00
83_I102_N1.4551.00
141_R144_N1.4491.00
93_D241_S1.4431.00
141_R196_I1.4101.00
159_Q162_D1.4091.00
194_G198_A1.3891.00
188_G192_I1.3881.00
232_E239_V1.3731.00
230_G235_I1.3681.00
81_S155_M1.3641.00
55_A58_N1.3611.00
258_G261_H1.3591.00
18_N22_V1.3531.00
56_V60_Y1.3521.00
202_E206_E1.3521.00
43_A99_K1.3381.00
175_L179_H1.3121.00
54_L71_G1.3021.00
282_D285_Y1.3021.00
282_D286_E1.2981.00
145_E189_F1.2971.00
180_E217_I1.2771.00
87_L108_E1.2761.00
17_E20_L1.2501.00
186_L190_C1.2441.00
73_A126_I1.2411.00
232_E238_R1.2411.00
60_Y198_A1.2331.00
283_L286_E1.2231.00
19_Q23_Y1.2111.00
40_S102_N1.2071.00
70_V142_L1.2061.00
76_M125_L1.1921.00
15_T68_I1.1911.00
14_K17_E1.1831.00
144_N148_S1.1831.00
154_G181_R1.1821.00
161_A181_R1.1811.00
32_S107_G1.1701.00
142_L197_L1.1681.00
225_I229_E1.1621.00
268_K272_R1.1591.00
32_S164_E1.1561.00
185_K188_G1.1431.00
254_L257_E1.1381.00
34_K38_L1.1341.00
214_H269_E1.1291.00
36_S102_N1.1271.00
39_Y105_V1.1271.00
165_A178_I1.1241.00
226_L235_I1.1221.00
15_T65_K1.1151.00
281_K285_Y1.1111.00
165_A170_V1.1091.00
177_S180_E1.1081.00
195_A205_I1.1061.00
11_D15_T1.1031.00
271_K285_Y1.1021.00
172_L176_E1.0941.00
60_Y200_A1.0901.00
70_V193_A1.0891.00
204_D207_T1.0871.00
192_I196_I1.0871.00
54_L68_I1.0861.00
140_L144_N1.0791.00
149_A189_F1.0781.00
11_D14_K1.0771.00
283_L287_L1.0671.00
191_V208_L1.0651.00
16_I20_L1.0621.00
52_I191_V1.0601.00
60_Y194_G1.0541.00
13_K17_E1.0541.00
266_H270_A1.0501.00
21_S42_Q1.0491.00
267_I271_K1.0441.00
161_A178_I1.0441.00
44_G47_R1.0411.00
261_H265_V1.0361.00
100_P104_K1.0361.00
175_L253_L1.0311.00
53_V74_V1.0301.00
228_L243_T1.0281.00
18_N21_S1.0231.00
16_I72_C1.0141.00
123_F147_I1.0101.00
70_V126_I1.0091.00
229_E260_K1.0081.00
203_E207_T1.0031.00
90_M113_L1.0031.00
228_L251_P0.9971.00
179_H217_I0.9931.00
95_L232_E0.9881.00
170_V174_E0.9871.00
37_M117_G0.9861.00
176_E180_E0.9861.00
176_E217_I0.9771.00
279_L282_D0.9691.00
92_D108_E0.9661.00
32_S35_K0.9631.00
87_L112_V0.9631.00
57_L198_A0.9621.00
101_T104_K0.9591.00
190_C194_G0.9581.00
100_P105_V0.9521.00
10_A14_K0.9471.00
77_I146_L0.9461.00
53_V67_G0.9351.00
207_T211_F0.9311.00
54_L67_G0.9301.00
103_H108_E0.9261.00
31_D35_K0.9261.00
165_A174_E0.9221.00
15_T18_N0.9171.00
124_K128_S0.9151.00
76_M121_E0.9141.00
14_K18_N0.9131.00
284_L288_C0.9101.00
222_R263_L0.9101.00
70_V197_L0.9011.00
39_Y106_F0.8981.00
17_E21_S0.8971.00
191_V211_F0.8951.00
102_N105_V0.8931.00
13_K51_L0.8871.00
146_L193_A0.8861.00
266_H271_K0.8831.00
188_G212_S0.8811.00
277_L281_K0.8801.00
235_I239_V0.8791.00
276_G280_Q0.8731.00
258_G262_K0.8691.00
126_I142_L0.8661.00
25_E34_K0.8661.00
167_N246_D0.8641.00
23_Y125_L0.8641.00
127_T144_N0.8631.00
124_K153_E0.8611.00
16_I54_L0.8581.00
261_H264_D0.8561.00
265_V268_K0.8521.00
23_Y128_S0.8511.00
206_E209_R0.8501.00
278_S281_K0.8481.00
259_A263_L0.8471.00
210_T213_S0.8461.00
47_R50_P0.8451.00
225_I256_L0.8421.00
58_N64_E0.8391.00
166_E248_S0.8321.00
255_S288_C0.8321.00
35_K39_Y0.8301.00
94_D103_H0.8301.00
162_D247_K0.8281.00
178_I247_K0.8281.00
23_Y69_P0.8281.00
273_L276_G0.8211.00
37_M118_L0.8181.00
209_R213_S0.8181.00
102_N106_F0.8171.00
192_I206_E0.8171.00
69_P129_H0.8131.00
16_I68_I0.8131.00
226_L230_G0.8111.00
164_E168_R0.8101.00
124_K144_N0.8091.00
196_I205_I0.8081.00
59_A208_L0.8061.00
72_C125_L0.8051.00
83_I111_A0.8031.00
50_P79_T0.8001.00
172_L250_Y0.7941.00
80_Y119_L0.7941.00
269_E273_L0.7941.00
145_E209_R0.7911.00
63_S66_D0.7911.00
62_K67_G0.7911.00
205_I209_R0.7871.00
99_K105_V0.7851.00
42_Q99_K0.7811.00
53_V71_G0.7801.00
213_S217_I0.7781.00
161_A165_A0.7751.00
81_S186_L0.7741.00
275_G285_Y0.7721.00
119_L156_V0.7681.00
15_T64_E0.7661.00
117_G156_V0.7631.00
39_Y99_K0.7611.00
172_L257_E0.7581.00
129_H139_R0.7491.00
52_I215_I0.7491.00
40_S83_I0.7481.00
130_V139_R0.7421.00
67_G197_L0.7421.00
223_D226_L0.7401.00
252_S271_K0.7381.00
49_R219_F0.7371.00
70_V129_H0.7351.00
15_T19_Q0.7321.00
12_R54_L0.7291.00
36_S110_T0.7291.00
173_E176_E0.7281.00
207_T276_G0.7281.00
221_I225_I0.7201.00
10_A13_K0.7151.00
78_H81_S0.7121.00
37_M114_A0.7121.00
53_V194_G0.7111.00
80_Y150_A0.7031.00
230_G234_K0.7001.00
227_D241_S0.6971.00
172_L253_L0.6961.00
219_F223_D0.6931.00
53_V190_C0.6931.00
222_R225_I0.6851.00
251_P254_L0.6831.00
120_T150_A0.6831.00
68_I72_C0.6821.00
180_E185_K0.6791.00
12_R15_T0.6781.00
40_S79_T0.6750.99
120_T156_V0.6720.99
255_S259_A0.6670.99
36_S114_A0.6610.99
214_H266_H0.6600.99
181_R185_K0.6600.99
141_R145_E0.6570.99
250_Y254_L0.6560.99
69_P125_L0.6550.99
183_T219_F0.6490.99
20_L42_Q0.6470.99
214_H217_I0.6460.99
32_S110_T0.6430.99
30_P34_K0.6400.99
274_I281_K0.6390.99
145_E149_A0.6390.99
19_Q68_I0.6390.99
49_R78_H0.6380.99
276_G281_K0.6360.99
155_M187_L0.6330.99
31_D34_K0.6320.99
170_V248_S0.6300.99
272_R275_G0.6300.99
202_E205_I0.6290.99
87_L109_A0.6270.99
83_I87_L0.6210.99
83_I114_A0.6210.99
69_P72_C0.6200.99
90_M156_V0.6200.99
125_L128_S0.6160.99
83_I118_L0.6160.99
235_I238_R0.6150.99
43_A79_T0.6150.99
211_F214_H0.6150.99
270_A284_L0.6110.99
46_K219_F0.6110.99
274_I277_L0.6100.99
109_A163_M0.6100.99
127_T147_I0.6090.99
178_I181_R0.6090.99
281_K284_L0.6050.99
187_L215_I0.6050.99
193_A197_L0.6040.99
156_V163_M0.6030.99
210_T273_L0.5990.99
230_G239_V0.5970.99
267_I284_L0.5960.99
29_M177_S0.5950.99
145_E148_S0.5950.99
74_V190_C0.5940.99
281_K288_C0.5930.99
201_P206_E0.5930.99
227_D235_I0.5930.99
160_V164_E0.5920.99
175_L250_Y0.5920.99
74_V193_A0.5910.99
120_T123_F0.5900.99
21_S25_E0.5900.99
157_G181_R0.5870.99
57_L197_L0.5860.99
173_E177_S0.5840.99
90_M163_M0.5830.99
62_K194_G0.5790.98
273_L280_Q0.5750.98
66_D129_H0.5750.98
119_L150_A0.5750.98
162_D166_E0.5730.98
270_A273_L0.5710.98
184_A217_I0.5690.98
77_I122_S0.5680.98
121_E153_E0.5670.98
259_A287_L0.5630.98
185_K213_S0.5620.98
232_E235_I0.5590.98
241_S244_T0.5590.98
256_L268_K0.5580.98
154_G157_G0.5570.98
182_K220_Q0.5570.98
200_A205_I0.5560.98
49_R82_L0.5560.98
60_Y208_L0.5550.98
195_A212_S0.5550.98
128_S148_S0.5530.98
211_F288_C0.5530.98
65_K68_I0.5520.98
259_A262_K0.5500.98
183_T187_L0.5500.98
261_H268_K0.5470.98
93_D238_R0.5410.98
207_T210_T0.5410.98
154_G180_E0.5410.98
221_I262_K0.5400.98
77_I150_A0.5390.98
257_E260_K0.5360.97
165_A168_R0.5350.97
123_F126_I0.5320.97
270_A274_I0.5300.97
92_D103_H0.5260.97
176_E221_I0.5230.97
80_Y120_T0.5230.97
108_E112_V0.5220.97
36_S106_F0.5210.97
48_L187_L0.5210.97
283_L288_C0.5210.97
93_D227_D0.5200.97
260_K264_D0.5190.97
61_G64_E0.5190.97
254_L262_K0.5150.97
37_M40_S0.5140.97
262_K266_H0.5120.97
54_L58_N0.5120.97
53_V57_L0.5100.97
121_E125_L0.5090.97
76_M118_L0.5070.96
266_H273_L0.5060.96
41_L76_M0.5060.96
25_E38_L0.5020.96
140_L143_V0.5010.96
263_L267_I0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ts7A 2 0.9561 100 0.117 Contact Map
3ucaA 2 0.9189 100 0.119 Contact Map
3pdeA 2 0.9561 100 0.119 Contact Map
3oyrA 2 0.9527 100 0.121 Contact Map
1rtrA 2 0.9257 100 0.123 Contact Map
2h8oA 2 0.9291 100 0.124 Contact Map
3lsnA 2 0.9392 100 0.124 Contact Map
4kkmA 2 0.9358 100 0.128 Contact Map
1rqjA 2 0.9932 100 0.129 Contact Map
4f62A 2 0.8986 100 0.13 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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