GREMLIN Database
FOLD - Bifunctional protein FolD
UniProt: P54382 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 283 (276)
Sequences: 4749 (2914)
Seq/√Len: 175.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
22_E279_K3.9681.00
150_K181_E3.4121.00
83_D112_R3.1821.00
160_E201_K3.1681.00
244_E247_G3.0991.00
75_E108_A2.9461.00
194_N197_E2.8261.00
14_E151_K2.7101.00
160_E198_H2.6871.00
81_I84_Q2.6771.00
164_V215_I2.6101.00
34_G65_K2.4671.00
7_D10_E2.4671.00
79_L112_R2.3181.00
31_V92_H2.2621.00
157_S182_N2.2451.00
209_V214_F2.2291.00
222_E251_K2.1671.00
67_D81_I2.1621.00
83_D87_Q2.1131.00
56_A267_I2.1001.00
16_R59_T2.0691.00
217_A247_G2.0601.00
73_L78_L2.0381.00
205_L220_I2.0281.00
213_N244_E2.0201.00
27_K32_T2.0141.00
137_F277_S1.9121.00
175_G187_Y1.9021.00
216_S219_Q1.8561.00
34_G63_N1.8511.00
147_E150_K1.8311.00
5_I245_F1.8101.00
225_V253_S1.8101.00
157_S191_R1.8051.00
220_I248_A1.7971.00
122_F169_I1.7901.00
161_V178_L1.7751.00
42_D47_H1.7661.00
146_V181_E1.7631.00
156_L204_I1.7491.00
96_V109_V1.7411.00
245_F255_I1.7271.00
199_T205_L1.7161.00
20_A24_E1.7091.00
196_T200_K1.6921.00
147_E272_H1.6801.00
48_S239_L1.6671.00
198_H201_K1.6661.00
19_L275_V1.6441.00
234_L238_K1.6171.00
11_T152_T1.6001.00
60_M271_A1.5801.00
203_D221_K1.5721.00
226_V243_V1.5561.00
131_L176_Q1.5501.00
243_V248_A1.5281.00
138_L177_L1.5281.00
216_S244_E1.5261.00
39_L47_H1.5221.00
179_L187_Y1.4921.00
147_E269_M1.4441.00
16_R56_A1.4291.00
69_F73_L1.4251.00
159_K193_E1.4201.00
199_T219_Q1.4191.00
147_E151_K1.3991.00
4_T254_F1.3801.00
197_E201_K1.3751.00
216_S247_G1.3721.00
163_V174_V1.3701.00
69_F81_I1.3571.00
75_E79_L1.3571.00
155_D159_K1.3571.00
143_H276_K1.3531.00
205_L215_I1.3521.00
75_E105_S1.3271.00
74_T77_E1.3261.00
162_V188_C1.3251.00
25_E29_Q1.3171.00
143_H272_H1.3161.00
18_Q151_K1.3161.00
246_E249_K1.3071.00
48_S52_G1.3021.00
6_I152_T1.3011.00
188_C198_H1.3011.00
19_L60_M1.2911.00
221_K224_A1.2851.00
65_K91_F1.2821.00
21_K24_E1.2741.00
154_I254_F1.2741.00
217_A251_K1.2721.00
213_N240_C1.2641.00
166_R182_N1.2611.00
54_K66_L1.2581.00
23_V62_M1.2531.00
217_A248_A1.2441.00
11_T151_K1.2441.00
188_C192_T1.2271.00
15_K19_L1.2231.00
63_N91_F1.2191.00
188_C195_I1.2111.00
36_A67_D1.2091.00
42_D71_S1.2041.00
162_V202_A1.1981.00
63_N90_E1.1831.00
54_K58_E1.1771.00
9_K13_R1.1671.00
166_R190_S1.1591.00
213_N246_E1.1541.00
51_R55_K1.1481.00
105_S108_A1.1461.00
39_L68_Q1.1431.00
162_V198_H1.1431.00
98_L110_I1.1391.00
62_M275_V1.1371.00
127_V131_L1.1331.00
36_A91_F1.1321.00
13_R17_E1.1321.00
25_E28_K1.1171.00
220_I224_A1.1111.00
75_E104_I1.1041.00
196_T219_Q1.1031.00
65_K88_D1.1001.00
200_K251_K1.0971.00
17_E20_A1.0941.00
17_E21_K1.0891.00
72_S77_E1.0861.00
36_A85_Y1.0851.00
24_E28_K1.0801.00
182_N191_R1.0761.00
32_T63_N1.0581.00
248_A255_I1.0511.00
159_K204_I1.0491.00
211_R214_F1.0471.00
47_H68_Q1.0441.00
10_E14_E1.0420.99
76_A80_S1.0400.99
209_V232_N1.0390.99
31_V278_A1.0320.99
161_V183_A1.0300.99
21_K25_E1.0190.99
38_I85_Y1.0160.99
196_T218_D1.0110.99
42_D68_Q1.0050.99
6_I254_F1.0000.99
79_L108_A0.9980.99
234_L240_C0.9980.99
212_A234_L0.9890.99
57_A271_A0.9830.99
47_H51_R0.9800.99
86_N114_S0.9790.99
111_E124_P0.9710.99
56_A271_A0.9710.99
80_S84_Q0.9700.99
67_D84_Q0.9680.99
143_H147_E0.9650.99
144_G265_M0.9580.99
57_A62_M0.9530.99
15_K268_T0.9500.99
145_I229_V0.9400.99
77_E80_S0.9330.99
58_E63_N0.9310.99
172_K179_L0.9310.99
6_I11_T0.9310.99
129_K134_E0.9260.99
164_V209_V0.9170.99
184_T192_T0.9100.99
247_G250_E0.9070.99
50_V97_Q0.9060.99
52_G55_K0.9030.99
190_S209_V0.9030.99
152_T254_F0.9010.99
19_L268_T0.8990.99
79_L83_D0.8960.98
16_R268_T0.8960.98
133_G172_K0.8940.98
56_A60_M0.8880.98
18_Q272_H0.8870.98
9_K260_G0.8820.98
84_Q88_D0.8800.98
11_T14_E0.8800.98
156_L183_A0.8790.98
164_V205_L0.8740.98
11_T148_L0.8730.98
125_L129_K0.8690.98
22_E275_V0.8680.98
104_I109_V0.8670.98
138_L143_H0.8660.98
149_L152_T0.8650.98
35_L119_V0.8640.98
135_D276_K0.8640.98
186_T198_H0.8640.98
225_V254_F0.8620.98
146_V156_L0.8600.98
92_H278_A0.8590.98
234_L237_G0.8570.98
85_Y94_I0.8550.98
232_N240_C0.8500.98
34_G91_F0.8490.98
15_K269_M0.8470.98
55_K59_T0.8460.98
37_V64_F0.8450.98
79_L109_V0.8420.98
197_E200_K0.8410.98
215_I219_Q0.8370.98
168_N172_K0.8340.98
160_E186_T0.8330.98
67_D85_Y0.8300.97
14_E18_Q0.8170.97
96_V113_I0.8120.97
54_K68_Q0.8080.97
182_N189_H0.8070.97
182_N190_S0.8060.97
148_L256_T0.8050.97
36_A65_K0.8020.97
264_P267_I0.8010.97
18_Q21_K0.7950.97
146_V150_K0.7950.97
26_L30_G0.7910.97
160_E193_E0.7910.97
143_H269_M0.7900.97
107_K134_E0.7900.97
248_A251_K0.7880.97
123_H126_N0.7870.97
245_F249_K0.7860.97
148_L265_M0.7850.97
213_N234_L0.7790.96
272_H276_K0.7740.96
130_M138_L0.7700.96
6_I227_I0.7690.96
196_T199_T0.7690.96
140_C269_M0.7670.96
212_A240_C0.7650.96
145_I227_I0.7640.96
73_L81_I0.7610.96
212_A231_V0.7590.96
206_V229_V0.7590.96
207_V243_V0.7560.96
233_R239_L0.7520.96
164_V207_V0.7510.96
207_V232_N0.7490.95
13_R59_T0.7470.95
24_E27_K0.7380.95
79_L104_I0.7370.95
19_L23_V0.7250.95
223_G252_A0.7250.95
62_M271_A0.7240.95
18_Q147_E0.7230.94
12_A16_R0.7200.94
174_V206_V0.7160.94
22_E272_H0.7130.94
23_V26_L0.7110.94
14_E17_E0.7110.94
82_I109_V0.7110.94
48_S231_V0.7070.94
125_L136_T0.7060.94
48_S51_R0.7030.94
26_L31_V0.7030.94
52_G267_I0.7020.94
37_V54_K0.6970.93
70_D73_L0.6920.93
107_K111_E0.6890.93
157_S193_E0.6840.93
18_Q22_E0.6830.93
154_I225_V0.6830.93
111_E129_K0.6790.92
40_I78_L0.6780.92
26_L275_V0.6730.92
166_R189_H0.6700.92
26_L278_A0.6680.92
98_L106_E0.6670.92
146_V161_V0.6650.92
163_V185_V0.6640.92
85_Y91_F0.6630.92
78_L109_V0.6620.91
269_M272_H0.6620.91
78_L104_I0.6600.91
55_K58_E0.6600.91
57_A64_F0.6570.91
19_L22_E0.6570.91
38_I81_I0.6520.91
4_T152_T0.6490.91
154_I204_I0.6490.91
54_K64_F0.6490.91
228_D241_G0.6490.91
77_E81_I0.6480.91
124_P132_L0.6480.91
149_L156_L0.6470.91
178_L206_V0.6430.90
94_I113_I0.6410.90
27_K31_V0.6400.90
224_A253_S0.6380.90
176_Q179_L0.6370.90
207_V215_I0.6360.90
223_G253_S0.6350.90
133_G180_N0.6340.90
163_V178_L0.6330.90
142_P174_V0.6310.89
226_V248_A0.6310.89
149_L154_I0.6300.89
65_K90_E0.6280.89
73_L104_I0.6280.89
161_V174_V0.6270.89
108_A112_R0.6260.89
11_T147_E0.6260.89
37_V66_L0.6250.89
48_S233_R0.6250.89
23_V60_M0.6250.89
53_K97_Q0.6230.89
205_L226_V0.6230.89
10_E13_R0.6200.89
127_V132_L0.6200.89
148_L264_P0.6190.89
224_A252_A0.6180.88
7_D260_G0.6160.88
23_V275_V0.6160.88
115_P123_H0.6140.88
215_I220_I0.6120.88
23_V27_K0.6110.88
52_G231_V0.6100.88
80_S83_D0.6100.88
196_T216_S0.6100.88
98_L122_F0.6060.87
20_A59_T0.6050.87
124_P127_V0.6040.87
26_L32_T0.6040.87
16_R60_M0.6030.87
22_E25_E0.6020.87
162_V199_T0.6020.87
119_V277_S0.6000.87
45_A233_R0.5940.86
211_R216_S0.5920.86
13_R16_R0.5900.86
50_V53_K0.5900.86
119_V274_T0.5890.86
15_K272_H0.5860.86
246_E250_E0.5850.86
82_I86_N0.5830.85
220_I252_A0.5830.85
148_L262_V0.5820.85
58_E62_M0.5810.85
8_G12_A0.5800.85
156_L181_E0.5790.85
15_K147_E0.5780.85
228_D259_P0.5760.85
87_Q114_S0.5720.84
167_S258_V0.5710.84
217_A250_E0.5700.84
164_V199_T0.5690.84
243_V255_I0.5690.84
184_T188_C0.5680.84
190_S211_R0.5670.84
126_N136_T0.5660.84
40_I100_L0.5640.83
170_V174_V0.5610.83
249_K255_I0.5590.83
78_L100_L0.5590.83
227_I262_V0.5550.83
157_S190_S0.5540.82
132_L168_N0.5500.82
115_P125_L0.5460.81
39_L50_V0.5460.81
271_A274_T0.5450.81
231_V239_L0.5450.81
179_L189_H0.5440.81
6_I151_K0.5440.81
44_P48_S0.5420.81
52_G56_A0.5410.81
38_I96_V0.5390.81
148_L152_T0.5380.81
122_F127_V0.5380.81
34_G90_E0.5360.80
162_V205_L0.5360.80
5_I249_K0.5350.80
231_V258_V0.5350.80
44_P233_R0.5340.80
38_I82_I0.5340.80
212_A232_N0.5330.80
172_K180_N0.5330.80
130_M135_D0.5330.80
129_K132_L0.5320.80
46_S97_Q0.5310.80
199_T215_I0.5310.80
53_K264_P0.5290.79
67_D73_L0.5280.79
149_L178_L0.5270.79
159_K225_V0.5270.79
222_E253_S0.5260.79
175_G179_L0.5250.79
17_E59_T0.5240.79
23_V30_G0.5240.79
151_K154_I0.5230.79
200_K218_D0.5230.79
111_E134_E0.5230.79
166_R191_R0.5190.78
176_Q180_N0.5190.78
93_G277_S0.5190.78
50_V95_L0.5190.78
56_A59_T0.5180.78
130_M136_T0.5180.78
190_S214_F0.5150.78
165_G230_G0.5150.78
199_T220_I0.5130.77
235_E238_K0.5130.77
154_I159_K0.5120.77
231_V234_L0.5110.77
29_Q87_Q0.5110.77
129_K136_T0.5050.76
213_N216_S0.5030.76
172_K176_Q0.5020.76
146_V149_L0.5020.76
57_A60_M0.5020.76
100_L104_I0.5000.76
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4cjxA 2 0.9965 100 0.277 Contact Map
2c2xA 2 0.9823 100 0.277 Contact Map
4a5oA 2 1 100 0.284 Contact Map
3l07A 2 0.9965 100 0.288 Contact Map
1b0aA 2 0.9965 100 0.293 Contact Map
4a26A 2 0.9965 100 0.297 Contact Map
3p2oA 2 0.9894 100 0.31 Contact Map
4b4uA 2 0.9929 100 0.314 Contact Map
1a4iA 2 1 100 0.327 Contact Map
1edzA 2 0.9435 100 0.416 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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