GREMLIN Database
SYGA - Glycine--tRNA ligase alpha subunit
UniProt: P54380 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 295 (281)
Sequences: 1020 (300)
Seq/√Len: 17.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
11_Q77_F5.0351.00
13_H94_D4.6521.00
35_S54_E4.5821.00
190_M194_Y4.2501.00
49_K81_I3.8831.00
88_I155_V3.5871.00
34_M117_N3.4191.00
46_E279_R3.3801.00
102_D105_E3.0980.99
72_Y200_T3.0690.99
211_Q215_T3.0370.99
94_D97_R2.9460.99
117_N120_L2.9280.99
191_M195_E2.8510.98
189_F192_A2.7830.98
71_L174_V2.5790.97
87_N91_L2.4760.96
29_K54_E2.4540.96
203_T226_N2.4530.96
6_M165_A2.4480.96
39_F272_A2.4320.96
80_I154_S2.4240.95
42_S150_C2.3230.94
212_L215_T2.2890.94
217_E263_R2.2730.94
2_N5_D2.2540.93
75_H189_F2.2520.93
28_E238_K2.2290.93
203_T223_Q2.2060.92
12_K16_S2.1090.91
106_H132_D2.1090.91
72_Y75_H2.1000.90
74_H200_T2.0830.90
34_M240_S2.0700.90
9_T98_A2.0580.89
192_A196_H2.0350.89
279_R282_L1.9970.88
136_I164_L1.9970.88
196_H234_D1.9890.88
97_R103_P1.9760.87
20_V183_F1.9600.87
150_C153_V1.9380.86
81_I88_I1.9070.85
178_E182_G1.8850.85
205_D222_K1.8780.85
6_M99_L1.8750.84
175_F186_K1.8470.84
2_N181_S1.8290.83
50_V154_S1.8200.83
53_V56_S1.8130.82
164_L168_I1.7900.82
137_T157_I1.7870.81
119_S261_I1.7470.80
43_I276_Y1.7390.80
75_H200_T1.7310.79
206_V251_A1.7120.78
198_V203_T1.6900.78
9_T12_K1.6870.77
62_G201_F1.6580.76
148_L276_Y1.6260.75
87_N157_I1.6240.75
97_R104_L1.6040.74
73_Q200_T1.5900.73
258_T262_A1.5880.73
103_P108_I1.5840.73
198_V202_E1.5770.72
45_P279_R1.5450.71
220_A236_V1.5230.70
178_E181_S1.5120.69
11_Q23_Q1.5020.69
89_Q110_F1.4920.68
216_Y235_Y1.4900.68
34_M237_L1.4820.67
194_Y198_V1.4500.66
191_M194_Y1.4240.64
178_E184_T1.4210.64
212_L216_Y1.4110.64
216_Y242_T1.4040.63
36_P234_D1.3990.63
26_D57_R1.3930.62
269_R273_K1.3830.62
87_N90_E1.3810.62
5_D9_T1.3620.61
2_N180_T1.3580.60
3_I161_I1.3450.60
208_M215_T1.3260.59
50_V80_I1.3190.58
25_Y234_D1.3150.58
117_N240_S1.3090.58
46_E282_L1.2860.56
92_Y96_L1.2730.55
42_S80_I1.2640.55
34_M120_L1.2470.54
13_H102_D1.2370.53
112_E144_Q1.2350.53
8_L11_Q1.2190.52
2_N178_E1.2040.51
227_G277_E1.1990.51
192_A230_H1.1970.51
4_Q28_E1.1830.50
123_A149_E1.1600.48
208_M212_L1.1480.48
274_T277_E1.1430.47
74_H189_F1.1410.47
114_N272_A1.1340.47
29_K237_L1.1320.47
102_D157_I1.1260.46
114_N262_A1.1110.45
7_I161_I1.1080.45
174_V202_E1.0780.43
54_E234_D1.0770.43
236_V271_V1.0610.42
123_A144_Q1.0560.42
209_L245_L1.0510.42
35_S234_D1.0480.42
17_Q87_N1.0370.41
43_I224_M1.0360.41
206_V210_F1.0090.39
111_V130_W1.0030.39
145_V164_L1.0020.39
273_K277_E0.9940.39
49_K87_N0.9880.38
147_G269_R0.9880.38
22_M150_C0.9850.38
220_A267_L0.9770.38
204_S245_L0.9760.37
3_I6_M0.9690.37
210_F214_S0.9640.37
177_L190_M0.9530.36
22_M35_S0.9530.36
196_H230_H0.9510.36
235_Y239_C0.9490.36
224_M270_K0.9430.36
204_S251_A0.9420.36
239_C258_T0.9420.36
114_N263_R0.9380.35
25_Y132_D0.9370.35
21_L51_A0.9360.35
29_K35_S0.9360.35
132_D219_E0.9270.35
22_M164_L0.9200.34
277_E280_E0.9160.34
278_E282_L0.9070.34
4_Q238_K0.8890.33
114_N177_L0.8880.33
60_A117_N0.8850.32
5_D101_I0.8840.32
51_A77_F0.8820.32
117_N139_F0.8810.32
214_S264_V0.8720.32
228_L231_P0.8710.32
109_R130_W0.8690.32
191_M282_L0.8680.32
111_V128_E0.8660.31
146_G272_A0.8620.31
114_N150_C0.8610.31
134_M167_Y0.8560.31
187_D274_T0.8540.31
242_T245_L0.8460.30
56_S74_H0.8420.30
117_N264_V0.8420.30
194_Y200_T0.8410.30
29_K72_Y0.8380.30
12_K101_I0.8310.30
56_S71_L0.8290.29
211_Q214_S0.8280.29
97_R102_D0.8250.29
84_S151_K0.8220.29
227_G274_T0.8180.29
222_K226_N0.8170.29
81_I155_V0.8170.29
5_D8_L0.8150.29
75_H192_A0.8110.29
2_N168_I0.8080.28
202_E230_H0.8040.28
197_S233_Y0.8030.28
149_E262_A0.7970.28
13_H191_M0.7940.28
43_I148_L0.7870.27
39_F131_L0.7860.27
114_N196_H0.7860.27
57_R119_S0.7730.27
132_D255_T0.7700.27
24_A112_E0.7620.26
39_F268_A0.7620.26
266_N269_R0.7580.26
256_E263_R0.7570.26
123_A258_T0.7560.26
129_V146_G0.7560.26
137_T169_Q0.7470.25
9_T207_D0.7460.25
114_N258_T0.7460.25
94_D98_A0.7420.25
148_L236_V0.7330.25
168_I206_V0.7320.25
254_V269_R0.7310.25
190_M224_M0.7270.25
101_I108_I0.7260.25
123_A147_G0.7260.25
60_A99_L0.7250.24
72_Y194_Y0.7250.24
60_A74_H0.7220.24
173_N271_V0.7200.24
60_A200_T0.7180.24
175_F201_F0.7180.24
111_V134_M0.7170.24
29_K56_S0.7170.24
216_Y239_C0.7170.24
42_S145_V0.7160.24
17_Q94_D0.7140.24
171_K178_E0.7110.24
229_V278_E0.7090.24
99_L157_I0.7070.24
125_L264_V0.7060.24
11_Q21_L0.7050.24
62_G175_F0.7030.23
208_M218_K0.7020.23
137_T219_E0.7020.23
142_F201_F0.7010.23
17_Q91_L0.7010.23
237_L242_T0.7010.23
91_L125_L0.7000.23
261_I264_V0.6980.23
77_F168_I0.6970.23
114_N131_L0.6960.23
22_M37_Y0.6920.23
12_K15_S0.6910.23
52_Y237_L0.6910.23
131_L239_C0.6900.23
165_A201_F0.6890.23
84_S236_V0.6800.22
154_S272_A0.6750.22
6_M170_D0.6740.22
214_S260_Y0.6730.22
150_C203_T0.6720.22
27_V35_S0.6700.22
195_E230_H0.6700.22
24_A144_Q0.6690.22
210_F260_Y0.6670.22
39_F168_I0.6660.22
131_L236_V0.6650.22
149_E153_V0.6650.22
232_A271_V0.6650.22
153_V263_R0.6650.22
29_K236_V0.6640.22
164_L170_D0.6610.22
191_M279_R0.6590.22
149_E245_L0.6560.21
40_L48_W0.6540.21
95_S159_Y0.6530.21
136_I206_V0.6520.21
37_Y166_S0.6500.21
46_E280_E0.6490.21
173_N176_D0.6490.21
57_R201_F0.6480.21
51_A99_L0.6470.21
12_K91_L0.6470.21
34_M74_H0.6460.21
39_F179_W0.6430.21
203_T234_D0.6430.21
80_I180_T0.6420.21
13_H91_L0.6420.21
101_I183_F0.6350.21
41_R48_W0.6330.21
210_F252_I0.6330.21
184_T267_L0.6330.21
155_V239_C0.6310.20
136_I179_W0.6310.20
90_E144_Q0.6300.20
179_W275_Y0.6300.20
240_S264_V0.6300.20
75_H171_K0.6290.20
60_A120_L0.6270.20
221_I225_D0.6250.20
39_F223_Q0.6250.20
145_V150_C0.6240.20
150_C155_V0.6230.20
154_S250_G0.6230.20
2_N91_L0.6210.20
196_H229_V0.6200.20
240_S268_A0.6180.20
125_L233_Y0.6170.20
17_Q81_I0.6160.20
242_T269_R0.6150.20
56_S75_H0.6140.20
56_S251_A0.6130.20
165_A177_L0.6110.20
91_L94_D0.6100.20
132_D178_E0.6100.20
132_D179_W0.6070.20
27_V105_E0.6060.19
208_M222_K0.6060.19
35_S209_L0.6040.19
22_M80_I0.6040.19
205_D218_K0.6000.19
60_A258_T0.5990.19
117_N220_A0.5980.19
3_I125_L0.5960.19
278_E281_K0.5950.19
220_A264_V0.5940.19
108_I128_E0.5940.19
34_M60_A0.5900.19
131_L179_W0.5890.19
255_T279_R0.5880.19
43_I191_M0.5880.19
211_Q218_K0.5870.19
200_T261_I0.5870.19
108_I236_V0.5860.19
66_E205_D0.5840.19
3_I177_L0.5840.19
27_V60_A0.5840.19
34_M114_N0.5830.19
7_I23_Q0.5820.19
77_F125_L0.5810.19
8_L21_L0.5810.19
74_H167_Y0.5770.18
60_A72_Y0.5750.18
191_M278_E0.5750.18
131_L272_A0.5740.18
41_R234_D0.5740.18
200_T245_L0.5740.18
137_T155_V0.5720.18
34_M234_D0.5720.18
88_I145_V0.5680.18
16_S98_A0.5680.18
155_V220_A0.5660.18
145_V206_V0.5660.18
248_A251_A0.5650.18
2_N6_M0.5640.18
214_S218_K0.5640.18
117_N214_S0.5640.18
54_E189_F0.5630.18
119_S177_L0.5630.18
148_L153_V0.5620.18
157_I266_N0.5620.18
43_I132_D0.5620.18
116_E234_D0.5610.18
270_K273_K0.5610.18
26_D119_S0.5600.18
274_T278_E0.5600.18
53_V222_K0.5580.18
34_M264_V0.5580.18
48_W112_E0.5580.18
71_L197_S0.5570.18
106_H167_Y0.5550.18
32_G56_S0.5530.18
217_E238_K0.5510.17
62_G176_D0.5500.17
153_V181_S0.5480.17
184_T262_A0.5470.17
2_N239_C0.5450.17
8_L252_I0.5450.17
194_Y281_K0.5440.17
154_S172_E0.5430.17
37_Y117_N0.5430.17
45_P152_P0.5430.17
207_D277_E0.5430.17
169_Q178_E0.5420.17
183_F207_D0.5410.17
80_I164_L0.5400.17
73_Q189_F0.5390.17
164_L196_H0.5380.17
84_S152_P0.5370.17
250_G262_A0.5370.17
17_Q49_K0.5360.17
57_R261_I0.5360.17
119_S122_C0.5350.17
34_M150_C0.5340.17
171_K216_Y0.5330.17
136_I237_L0.5330.17
90_E97_R0.5330.17
2_N164_L0.5320.17
154_S171_K0.5320.17
10_L14_W0.5300.17
136_I207_D0.5280.17
216_Y220_A0.5270.17
42_S276_Y0.5270.17
219_E222_K0.5250.17
20_V54_E0.5240.17
72_Y189_F0.5240.17
60_A119_S0.5220.16
9_T170_D0.5220.16
119_S243_F0.5210.16
30_G33_T0.5210.16
81_I154_S0.5210.16
26_D179_W0.5200.16
260_Y264_V0.5180.16
20_V218_K0.5170.16
195_E279_R0.5170.16
69_N171_K0.5170.16
54_E161_I0.5150.16
117_N204_S0.5150.16
197_S251_A0.5150.16
167_Y174_V0.5140.16
123_A223_Q0.5140.16
212_L239_C0.5140.16
13_H87_N0.5130.16
186_K279_R0.5130.16
194_Y275_Y0.5120.16
18_G36_P0.5120.16
128_E260_Y0.5120.16
103_P222_K0.5110.16
183_F187_D0.5090.16
262_A266_N0.5080.16
44_G81_I0.5080.16
137_T275_Y0.5080.16
196_H271_V0.5070.16
141_Y169_Q0.5060.16
49_K80_I0.5060.16
43_I80_I0.5050.16
230_H271_V0.5050.16
227_G281_K0.5040.16
145_V195_E0.5040.16
175_F197_S0.5040.16
15_S49_K0.5040.16
13_H22_M0.5040.16
23_Q72_Y0.5030.16
50_V102_D0.5030.16
104_L273_K0.5030.16
221_I270_K0.5030.16
40_L146_G0.5000.16
221_I224_M0.5000.16
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1j5wA 2 0.9492 100 0.003 Contact Map
3rf1A 2 0.9492 100 0.016 Contact Map
2zzeA 1 0.9153 100 0.703 Contact Map
2ztgA 1 0.9424 100 0.712 Contact Map
3wqyA 2 0.9288 100 0.795 Contact Map
3hy0A 1 0.8576 96.8 0.956 Contact Map
4cs4A 2 0.6034 96.4 0.959 Contact Map
1yfsA 1 0.8746 96 0.96 Contact Map
3dsqA 2 0.5898 95.9 0.961 Contact Map
3l4gA 2 0.6542 84.7 0.971 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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