GCST - BACSU - GREMLIN Contacts

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GCST - Aminomethyltransferase

UniProt:	P54378	Sequences: MLKRTPLFDLYKEYGGKTIDFGGWELPVQFSSIKKEHEAVRTAAGLFDVSHMGEVEVSGNDSLSFLQRLMTNDVSALTPGRAQYTAMCYPDGGTVDDLLIYQKGENRYLLVINASNIDKDLAWMKEHAAGDVQIDNQSDQIALLAVQGPKAEAILKNLTDADVSALKPFAFIDEADISGRKALISRTGYTGEDGYEIYCRSDDAMHIWKKIIDAGDAYGLIPCGLGARDTLRFEAKLPLYGQELTRDITPIEAGIGFAVKHKKESDFFGKSVLSEQKENGAKRKLVGLEMIEKGIPRHGYEVFQNGKSVGKVTTGTQSPTLGKNVGLALIDSETSEIGTVVDVEIRKKLVKAKVVKTPFYKR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	362 (352)
Sequences:	6837 (4427)
Seq/√Len:	236.0

ECOLI - GCST YGFZ
BACSU - GCST
HALSA - GCST Q9HM98
SULSO - Q97ZI7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
10_L	209_K	3.618	1.00
150_K	153_A	3.617	1.00
301_E	308_S	3.186	1.00
289_E	323_K	3.180	1.00
44_A	154_I	3.072	1.00
249_T	276_Q	3.009	1.00
56_E	107_R	2.826	1.00
342_D	349_L	2.786	1.00
275_E	279_N	2.632	1.00
8_F	12_K	2.568	1.00
302_V	328_A	2.526	1.00
288_L	326_G	2.526	1.00
43_A	150_K	2.499	1.00
12_K	18_T	2.494	1.00
38_E	42_T	2.440	1.00
142_A	204_A	2.420	1.00
61_D	64_S	2.307	1.00
340_V	351_K	2.300	1.00
45_G	223_C	2.182	1.00
291_I	353_K	2.146	1.00
40_V	45_G	2.128	1.00
13_E	209_K	2.127	1.00
168_P	171_F	2.107	1.00
58_S	107_R	2.085	1.00
344_E	349_L	2.059	1.00
289_E	353_K	2.054	1.00
303_F	349_L	2.054	1.00
299_G	311_K	2.024	1.00
215_G	220_L	2.007	1.00
304_Q	307_K	1.998	1.00
318_S	321_L	1.979	1.00
69_L	124_M	1.978	1.00
79_P	102_Q	1.974	1.00
242_Q	298_H	1.970	1.00
344_E	347_K	1.970	1.00
176_D	181_K	1.947	1.00
67_Q	73_D	1.941	1.00
340_V	353_K	1.936	1.00
9_D	12_K	1.932	1.00
342_D	351_K	1.926	1.00
9_D	13_E	1.923	1.00
341_V	352_A	1.914	1.00
266_D	270_K	1.869	1.00
309_V	334_T	1.795	1.00
270_K	274_S	1.792	1.00
39_A	43_A	1.781	1.00
4_R	25_E	1.764	1.00
39_A	221_I	1.760	1.00
10_L	14_Y	1.749	1.00
56_E	137_Q	1.741	1.00
200_R	203_D	1.738	1.00
9_D	205_M	1.715	1.00
203_D	206_H	1.701	1.00
104_G	107_R	1.690	1.00
157_N	214_A	1.689	1.00
10_L	13_E	1.679	1.00
307_K	331_D	1.669	1.00
61_D	131_D	1.662	1.00
55_V	121_L	1.638	1.00
38_E	320_T	1.627	1.00
63_L	108_Y	1.606	1.00
199_C	207_I	1.598	1.00
271_S	274_S	1.595	1.00
312_V	326_G	1.581	1.00
174_E	181_K	1.571	1.00
123_W	127_H	1.557	1.00
11_Y	30_F	1.552	1.00
154_I	220_L	1.551	1.00
58_S	135_D	1.550	1.00
4_R	8_F	1.544	1.00
56_E	135_D	1.542	1.00
303_F	308_S	1.513	1.00
162_D	165_A	1.502	1.00
205_M	209_K	1.501	1.00
208_W	222_P	1.500	1.00
63_L	102_Q	1.484	1.00
81_R	171_F	1.471	1.00
14_Y	222_P	1.468	1.00
301_E	344_E	1.460	1.00
303_F	344_E	1.458	1.00
121_L	125_K	1.445	1.00
82_A	99_L	1.443	1.00
288_L	328_A	1.442	1.00
60_N	131_D	1.440	1.00
343_V	352_A	1.435	1.00
86_A	258_A	1.428	1.00
37_H	230_T	1.427	1.00
137_Q	141_I	1.425	1.00
58_S	133_Q	1.421	1.00
117_I	136_N	1.419	1.00
46_L	212_I	1.413	1.00
122_A	126_E	1.408	1.00
70_M	100_I	1.406	1.00
286_V	330_I	1.405	1.00
55_V	112_I	1.401	1.00
178_S	210_K	1.389	1.00
210_K	213_D	1.380	1.00
180_R	203_D	1.372	1.00
46_L	144_L	1.371	1.00
6_P	142_A	1.363	1.00
252_E	283_R	1.363	1.00
71_T	88_C	1.353	1.00
103_K	107_R	1.346	1.00
128_A	134_I	1.328	1.00
70_M	85_T	1.325	1.00
327_L	357_T	1.322	1.00
69_L	127_H	1.313	1.00
214_A	219_G	1.312	1.00
158_L	211_I	1.306	1.00
43_A	221_I	1.303	1.00
146_V	155_L	1.297	1.00
89_Y	246_R	1.297	1.00
63_L	75_S	1.286	1.00
304_Q	334_T	1.285	1.00
142_A	201_S	1.282	1.00
110_L	124_M	1.273	1.00
43_A	219_G	1.272	1.00
16_G	26_L	1.272	1.00
233_F	316_T	1.261	1.00
86_A	255_I	1.258	1.00
251_I	261_H	1.248	1.00
177_I	182_A	1.248	1.00
57_V	110_L	1.246	1.00
10_L	205_M	1.246	1.00
317_Q	322_G	1.246	1.00
302_V	343_V	1.245	1.00
288_L	352_A	1.244	1.00
35_K	221_I	1.240	1.00
266_D	271_S	1.239	1.00
331_D	334_T	1.237	1.00
19_I	28_V	1.232	1.00
7_L	144_L	1.229	1.00
65_F	132_V	1.225	1.00
248_I	329_L	1.215	1.00
135_D	140_Q	1.212	1.00
102_Q	105_E	1.209	1.00
74_V	100_I	1.207	1.00
330_I	341_V	1.200	1.00
306_G	349_L	1.195	1.00
101_Y	172_I	1.189	1.00
79_P	104_G	1.186	1.00
175_A	184_I	1.181	1.00
291_I	351_K	1.178	1.00
253_A	329_L	1.172	1.00
153_A	156_K	1.166	1.00
251_I	281_A	1.165	1.00
251_I	273_L	1.160	1.00
339_T	354_V	1.158	1.00
121_L	134_I	1.152	1.00
8_F	25_E	1.149	1.00
67_Q	75_S	1.140	1.00
62_S	108_Y	1.132	1.00
271_S	275_E	1.125	1.00
86_A	94_T	1.119	1.00
336_E	339_T	1.116	1.00
265_S	270_K	1.115	1.00
252_E	276_Q	1.109	1.00
233_F	314_T	1.109	1.00
245_T	248_I	1.109	1.00
34_K	38_E	1.108	1.00
309_V	341_V	1.097	1.00
277_K	280_G	1.091	1.00
199_C	204_A	1.081	1.00
118_D	122_A	1.076	1.00
78_T	81_R	1.076	1.00
206_H	210_K	1.070	1.00
180_R	206_H	1.069	1.00
119_K	246_R	1.069	1.00
152_E	193_D	1.068	1.00
65_F	124_M	1.066	1.00
31_S	35_K	1.063	1.00
38_E	322_G	1.061	1.00
345_I	350_V	1.059	1.00
4_R	9_D	1.052	1.00
341_V	354_V	1.050	1.00
304_Q	309_V	1.049	1.00
144_L	208_W	1.049	1.00
79_P	105_E	1.041	1.00
338_G	353_K	1.037	1.00
102_Q	108_Y	1.037	1.00
256_G	277_K	1.034	1.00
116_N	119_K	1.032	1.00
288_L	343_V	1.030	1.00
63_L	74_V	1.028	1.00
57_V	124_M	1.027	1.00
123_W	268_F	1.025	1.00
232_R	314_T	1.025	1.00
337_I	356_K	1.025	1.00
287_G	359_F	1.023	1.00
289_E	355_V	1.017	1.00
44_A	220_L	1.016	1.00
87_M	124_M	1.015	1.00
261_H	277_K	1.015	1.00
157_N	219_G	1.013	1.00
303_F	342_D	1.013	1.00
57_V	62_S	1.009	1.00
290_M	352_A	1.005	1.00
73_D	76_A	1.005	1.00
127_H	268_F	1.004	1.00
146_V	154_I	1.000	1.00
272_V	276_Q	0.997	1.00
303_F	306_G	0.991	1.00
35_K	38_E	0.985	1.00
152_E	195_Y	0.985	1.00
100_I	108_Y	0.982	1.00
8_F	18_T	0.980	1.00
291_I	340_V	0.980	1.00
94_T	244_L	0.976	1.00
150_K	219_G	0.975	1.00
304_Q	342_D	0.967	1.00
68_R	268_F	0.965	1.00
238_P	244_L	0.959	1.00
276_Q	281_A	0.947	1.00
137_Q	140_Q	0.946	1.00
100_I	110_L	0.944	1.00
154_I	214_A	0.940	1.00
136_N	139_D	0.939	1.00
56_E	109_L	0.937	1.00
6_P	201_S	0.927	1.00
32_S	35_K	0.926	1.00
274_S	278_E	0.925	1.00
33_I	226_G	0.924	1.00
334_T	339_T	0.915	1.00
147_Q	194_G	0.912	1.00
308_S	311_K	0.910	1.00
292_E	351_K	0.910	1.00
180_R	207_I	0.909	1.00
210_K	214_A	0.904	1.00
29_Q	33_I	0.904	1.00
72_N	260_K	0.902	1.00
296_P	300_Y	0.899	1.00
199_C	203_D	0.897	1.00
54_E	141_I	0.896	1.00
11_Y	27_P	0.893	0.99
7_L	204_A	0.893	0.99
281_A	332_S	0.891	0.99
72_N	85_T	0.886	0.99
261_H	267_F	0.885	0.99
103_K	183_L	0.882	0.99
284_K	332_S	0.882	0.99
5_T	8_F	0.878	0.99
209_K	213_D	0.876	0.99
46_L	208_W	0.868	0.99
66_L	108_Y	0.862	0.99
18_T	25_E	0.859	0.99
37_H	231_L	0.859	0.99
152_E	164_S	0.856	0.99
60_N	106_N	0.852	0.99
89_Y	95_V	0.852	0.99
49_V	145_A	0.849	0.99
212_I	222_P	0.849	0.99
162_D	166_L	0.845	0.99
166_L	171_F	0.843	0.99
249_T	252_E	0.843	0.99
46_L	146_V	0.842	0.99
176_D	179_G	0.842	0.99
24_W	117_I	0.840	0.99
70_M	87_M	0.837	0.99
90_P	268_F	0.830	0.99
53_G	117_I	0.828	0.99
160_D	176_D	0.822	0.99
125_K	128_A	0.816	0.99
39_A	223_C	0.815	0.99
248_I	283_R	0.810	0.99
94_T	253_A	0.807	0.99
66_L	74_V	0.805	0.99
143_L	198_Y	0.803	0.99
142_A	199_C	0.802	0.99
84_Y	97_D	0.800	0.99
156_K	161_A	0.799	0.99
159_T	163_V	0.798	0.99
178_S	206_H	0.797	0.99
14_Y	209_K	0.795	0.99
87_M	98_L	0.793	0.99
161_A	173_D	0.793	0.99
85_T	100_I	0.791	0.99
95_V	119_K	0.791	0.99
178_S	182_A	0.790	0.99
166_L	173_D	0.783	0.99
292_E	350_V	0.781	0.99
261_H	274_S	0.779	0.99
252_E	282_K	0.779	0.99
282_K	332_S	0.776	0.99
335_S	339_T	0.775	0.99
251_I	256_G	0.772	0.99
14_Y	208_W	0.772	0.99
267_F	274_S	0.771	0.98
186_R	193_D	0.770	0.98
121_L	136_N	0.768	0.98
304_Q	341_V	0.768	0.98
159_T	177_I	0.768	0.98
275_E	278_E	0.768	0.98
13_E	205_M	0.767	0.98
214_A	220_L	0.766	0.98
63_L	67_Q	0.764	0.98
68_R	266_D	0.764	0.98
168_P	172_I	0.761	0.98
296_P	324_N	0.759	0.98
184_I	197_I	0.758	0.98
57_V	134_I	0.755	0.98
318_S	325_V	0.753	0.98
12_K	25_E	0.752	0.98
76_A	83_Q	0.750	0.98
184_I	195_Y	0.747	0.98
71_T	259_V	0.744	0.98
302_V	341_V	0.743	0.98
156_K	164_S	0.741	0.98
88_C	273_L	0.740	0.98
245_T	311_K	0.740	0.98
174_E	183_L	0.737	0.98
70_M	74_V	0.732	0.98
65_F	128_A	0.731	0.98
14_Y	30_F	0.731	0.98
58_S	106_N	0.727	0.98
330_I	354_V	0.725	0.98
249_T	272_V	0.725	0.98
197_I	211_I	0.724	0.98
61_D	129_A	0.723	0.98
39_A	219_G	0.722	0.98
182_A	197_I	0.721	0.98
40_V	231_L	0.719	0.98
285_L	327_L	0.716	0.98
55_V	124_M	0.714	0.98
338_G	354_V	0.713	0.98
82_A	101_Y	0.711	0.97
254_G	284_K	0.711	0.97
155_L	163_V	0.711	0.97
67_Q	263_K	0.707	0.97
122_A	125_K	0.706	0.97
215_G	219_G	0.705	0.97
94_T	243_E	0.703	0.97
112_I	120_D	0.702	0.97
107_R	174_E	0.701	0.97
71_T	86_A	0.701	0.97
54_E	198_Y	0.699	0.97
296_P	343_V	0.697	0.97
288_L	341_V	0.696	0.97
55_V	134_I	0.695	0.97
40_V	223_C	0.693	0.97
251_I	259_V	0.693	0.97
140_Q	200_R	0.692	0.97
261_H	270_K	0.692	0.97
169_F	237_L	0.692	0.97
151_A	193_D	0.691	0.97
290_M	324_N	0.689	0.97
212_I	220_L	0.689	0.97
301_E	311_K	0.686	0.97
69_L	123_W	0.686	0.97
37_H	320_T	0.684	0.97
206_H	209_K	0.684	0.97
355_V	359_F	0.683	0.97
103_K	109_L	0.681	0.97
146_V	197_I	0.681	0.97
273_L	276_Q	0.681	0.97
77_L	83_Q	0.680	0.97
283_R	331_D	0.679	0.97
284_K	335_S	0.679	0.97
41_R	234_E	0.678	0.97
180_R	200_R	0.678	0.97
101_Y	185_S	0.677	0.97
95_V	246_R	0.676	0.97
66_L	70_M	0.674	0.97
54_E	143_L	0.671	0.96
146_V	220_L	0.670	0.96
14_Y	212_I	0.669	0.96
10_L	212_I	0.662	0.96
17_K	29_Q	0.661	0.96
123_W	126_E	0.660	0.96
90_P	127_H	0.658	0.96
16_G	28_V	0.657	0.96
172_I	183_L	0.657	0.96
276_Q	280_G	0.655	0.96
10_L	208_W	0.655	0.96
296_P	352_A	0.653	0.96
57_V	65_F	0.653	0.96
317_Q	324_N	0.649	0.96
267_F	273_L	0.647	0.96
141_I	200_R	0.646	0.96
65_F	68_R	0.644	0.95
71_T	258_A	0.643	0.95
243_E	285_L	0.640	0.95
77_L	81_R	0.638	0.95
49_V	143_L	0.637	0.95
161_A	175_A	0.635	0.95
155_L	195_Y	0.631	0.95
47_F	223_C	0.629	0.95
181_K	203_D	0.628	0.95
159_T	162_D	0.628	0.95
153_A	157_N	0.627	0.95
252_E	281_A	0.625	0.95
286_V	335_S	0.624	0.95
230_T	316_T	0.623	0.95
300_Y	343_V	0.621	0.95
186_R	195_Y	0.619	0.94
223_C	227_A	0.619	0.94
66_L	110_L	0.618	0.94
41_R	231_L	0.613	0.94
52_M	111_V	0.611	0.94
72_N	83_Q	0.610	0.94
89_Y	93_G	0.610	0.94
283_R	311_K	0.609	0.94
43_A	220_L	0.608	0.94
51_H	225_L	0.605	0.94
91_D	247_D	0.604	0.94
304_Q	339_T	0.603	0.94
124_M	134_I	0.603	0.94
70_M	83_Q	0.601	0.94
190_T	194_G	0.600	0.93
287_G	357_T	0.600	0.93
240_Y	244_L	0.599	0.93
290_M	343_V	0.598	0.93
109_L	141_I	0.597	0.93
11_Y	18_T	0.596	0.93
29_Q	32_S	0.595	0.93
109_L	198_Y	0.595	0.93
233_F	325_V	0.595	0.93
315_G	324_N	0.595	0.93
46_L	220_L	0.591	0.93
117_I	139_D	0.591	0.93
64_S	75_S	0.590	0.93
36_E	224_G	0.589	0.93
163_V	166_L	0.589	0.93
177_I	180_R	0.588	0.93
230_T	318_S	0.588	0.93
57_V	66_L	0.588	0.93
332_S	335_S	0.587	0.93
95_V	123_W	0.585	0.93
53_G	112_I	0.580	0.92
34_K	319_P	0.579	0.92
236_K	357_T	0.579	0.92
272_V	275_E	0.579	0.92
289_E	325_V	0.579	0.92
330_I	335_S	0.579	0.92
98_L	110_L	0.578	0.92
286_V	354_V	0.578	0.92
85_T	98_L	0.578	0.92
56_E	103_K	0.577	0.92
103_K	172_I	0.576	0.92
259_V	267_F	0.576	0.92
102_Q	107_R	0.576	0.92
50_S	142_A	0.575	0.92
64_S	68_R	0.574	0.92
144_L	204_A	0.573	0.92
243_E	248_I	0.572	0.92
182_A	199_C	0.571	0.92
41_R	320_T	0.570	0.92
73_D	260_K	0.570	0.92
43_A	154_I	0.568	0.91
91_D	246_R	0.568	0.91
16_G	19_I	0.568	0.91
261_H	273_L	0.567	0.91
65_F	129_A	0.567	0.91
61_D	132_V	0.566	0.91
128_A	132_V	0.566	0.91
302_V	352_A	0.566	0.91
147_Q	190_T	0.565	0.91
244_L	248_I	0.564	0.91
297_R	300_Y	0.562	0.91
285_L	329_L	0.559	0.91
11_Y	14_Y	0.558	0.91
7_L	11_Y	0.558	0.91
177_I	207_I	0.557	0.91
344_E	348_K	0.555	0.91
84_Y	187_T	0.555	0.91
251_I	277_K	0.555	0.91
189_Y	239_L	0.554	0.90
66_L	124_M	0.553	0.90
54_E	138_S	0.552	0.90
67_Q	265_S	0.552	0.90
30_F	222_P	0.551	0.90
294_G	324_N	0.550	0.90
193_D	235_A	0.550	0.90
338_G	341_V	0.549	0.90
88_C	94_T	0.549	0.90
240_Y	246_R	0.547	0.90
159_T	178_S	0.546	0.90
274_S	277_K	0.546	0.90
185_S	198_Y	0.546	0.90
337_I	357_T	0.541	0.89
47_F	147_Q	0.541	0.89
87_M	120_D	0.539	0.89
250_P	273_L	0.539	0.89
151_A	154_I	0.538	0.89
112_I	121_L	0.536	0.89
118_D	136_N	0.536	0.89
53_G	136_N	0.535	0.89
250_P	259_V	0.535	0.89
69_L	268_F	0.534	0.89
4_R	12_K	0.530	0.88
318_S	323_K	0.529	0.88
256_G	284_K	0.529	0.88
323_K	353_K	0.529	0.88
44_A	146_V	0.529	0.88
342_D	350_V	0.528	0.88
91_D	272_V	0.528	0.88
51_H	114_A	0.527	0.88
296_P	326_G	0.526	0.88
279_N	282_K	0.526	0.88
172_I	185_S	0.525	0.88
57_V	100_I	0.524	0.88
82_A	187_T	0.524	0.88
31_S	221_I	0.523	0.88
154_I	157_N	0.523	0.88
201_S	204_A	0.523	0.88
117_I	138_S	0.520	0.87
70_M	77_L	0.520	0.87
68_R	130_G	0.518	0.87
64_S	67_Q	0.518	0.87
9_D	25_E	0.516	0.87
69_L	87_M	0.516	0.87
125_K	134_I	0.516	0.87
78_T	171_F	0.513	0.87
46_L	211_I	0.513	0.87
166_L	170_A	0.511	0.87
309_V	331_D	0.511	0.87
61_D	128_A	0.510	0.86
175_A	181_K	0.509	0.86
345_I	348_K	0.508	0.86
127_H	130_G	0.508	0.86
239_L	242_Q	0.507	0.86
158_L	210_K	0.507	0.86
238_P	243_E	0.505	0.86
82_A	185_S	0.504	0.86
101_Y	111_V	0.502	0.86
251_I	276_Q	0.502	0.86
172_I	175_A	0.502	0.86
46_L	222_P	0.501	0.86
151_A	195_Y	0.500	0.85

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1yx2A	1	0.9945	100	0.086	Contact Map
1v5vA	2	0.9917	100	0.112	Contact Map
1wosA	1	0.9834	100	0.113	Contact Map
2gagA	1	0.9945	100	0.113	Contact Map
1pj5A	3	0.9834	100	0.124	Contact Map
4pabA	1	0.989	100	0.125	Contact Map
3girA	1	0.9696	100	0.125	Contact Map
1wsrA	2	0.9807	100	0.135	Contact Map
3tfiA	2	0.9696	100	0.146	Contact Map
1vloA	1	0.9503	100	0.15	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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