GREMLIN Database
GCST - Aminomethyltransferase
UniProt: P54378 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 362 (352)
Sequences: 6837 (4427)
Seq/√Len: 236.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
10_L209_K3.6181.00
150_K153_A3.6171.00
301_E308_S3.1861.00
289_E323_K3.1801.00
44_A154_I3.0721.00
249_T276_Q3.0091.00
56_E107_R2.8261.00
342_D349_L2.7861.00
275_E279_N2.6321.00
8_F12_K2.5681.00
302_V328_A2.5261.00
288_L326_G2.5261.00
43_A150_K2.4991.00
12_K18_T2.4941.00
38_E42_T2.4401.00
142_A204_A2.4201.00
61_D64_S2.3071.00
340_V351_K2.3001.00
45_G223_C2.1821.00
291_I353_K2.1461.00
40_V45_G2.1281.00
13_E209_K2.1271.00
168_P171_F2.1071.00
58_S107_R2.0851.00
344_E349_L2.0591.00
289_E353_K2.0541.00
303_F349_L2.0541.00
299_G311_K2.0241.00
215_G220_L2.0071.00
304_Q307_K1.9981.00
318_S321_L1.9791.00
69_L124_M1.9781.00
79_P102_Q1.9741.00
242_Q298_H1.9701.00
344_E347_K1.9701.00
176_D181_K1.9471.00
67_Q73_D1.9411.00
340_V353_K1.9361.00
9_D12_K1.9321.00
342_D351_K1.9261.00
9_D13_E1.9231.00
341_V352_A1.9141.00
266_D270_K1.8691.00
309_V334_T1.7951.00
270_K274_S1.7921.00
39_A43_A1.7811.00
4_R25_E1.7641.00
39_A221_I1.7601.00
10_L14_Y1.7491.00
56_E137_Q1.7411.00
200_R203_D1.7381.00
9_D205_M1.7151.00
203_D206_H1.7011.00
104_G107_R1.6901.00
157_N214_A1.6891.00
10_L13_E1.6791.00
307_K331_D1.6691.00
61_D131_D1.6621.00
55_V121_L1.6381.00
38_E320_T1.6271.00
63_L108_Y1.6061.00
199_C207_I1.5981.00
271_S274_S1.5951.00
312_V326_G1.5811.00
174_E181_K1.5711.00
123_W127_H1.5571.00
11_Y30_F1.5521.00
154_I220_L1.5511.00
58_S135_D1.5501.00
4_R8_F1.5441.00
56_E135_D1.5421.00
303_F308_S1.5131.00
162_D165_A1.5021.00
205_M209_K1.5011.00
208_W222_P1.5001.00
63_L102_Q1.4841.00
81_R171_F1.4711.00
14_Y222_P1.4681.00
301_E344_E1.4601.00
303_F344_E1.4581.00
121_L125_K1.4451.00
82_A99_L1.4431.00
288_L328_A1.4421.00
60_N131_D1.4401.00
343_V352_A1.4351.00
86_A258_A1.4281.00
37_H230_T1.4271.00
137_Q141_I1.4251.00
58_S133_Q1.4211.00
117_I136_N1.4191.00
46_L212_I1.4131.00
122_A126_E1.4081.00
70_M100_I1.4061.00
286_V330_I1.4051.00
55_V112_I1.4011.00
178_S210_K1.3891.00
210_K213_D1.3801.00
180_R203_D1.3721.00
46_L144_L1.3711.00
6_P142_A1.3631.00
252_E283_R1.3631.00
71_T88_C1.3531.00
103_K107_R1.3461.00
128_A134_I1.3281.00
70_M85_T1.3251.00
327_L357_T1.3221.00
69_L127_H1.3131.00
214_A219_G1.3121.00
158_L211_I1.3061.00
43_A221_I1.3031.00
146_V155_L1.2971.00
89_Y246_R1.2971.00
63_L75_S1.2861.00
304_Q334_T1.2851.00
142_A201_S1.2821.00
110_L124_M1.2731.00
43_A219_G1.2721.00
16_G26_L1.2721.00
233_F316_T1.2611.00
86_A255_I1.2581.00
251_I261_H1.2481.00
177_I182_A1.2481.00
57_V110_L1.2461.00
10_L205_M1.2461.00
317_Q322_G1.2461.00
302_V343_V1.2451.00
288_L352_A1.2441.00
35_K221_I1.2401.00
266_D271_S1.2391.00
331_D334_T1.2371.00
19_I28_V1.2321.00
7_L144_L1.2291.00
65_F132_V1.2251.00
248_I329_L1.2151.00
135_D140_Q1.2121.00
102_Q105_E1.2091.00
74_V100_I1.2071.00
330_I341_V1.2001.00
306_G349_L1.1951.00
101_Y172_I1.1891.00
79_P104_G1.1861.00
175_A184_I1.1811.00
291_I351_K1.1781.00
253_A329_L1.1721.00
153_A156_K1.1661.00
251_I281_A1.1651.00
251_I273_L1.1601.00
339_T354_V1.1581.00
121_L134_I1.1521.00
8_F25_E1.1491.00
67_Q75_S1.1401.00
62_S108_Y1.1321.00
271_S275_E1.1251.00
86_A94_T1.1191.00
336_E339_T1.1161.00
265_S270_K1.1151.00
252_E276_Q1.1091.00
233_F314_T1.1091.00
245_T248_I1.1091.00
34_K38_E1.1081.00
309_V341_V1.0971.00
277_K280_G1.0911.00
199_C204_A1.0811.00
118_D122_A1.0761.00
78_T81_R1.0761.00
206_H210_K1.0701.00
180_R206_H1.0691.00
119_K246_R1.0691.00
152_E193_D1.0681.00
65_F124_M1.0661.00
31_S35_K1.0631.00
38_E322_G1.0611.00
345_I350_V1.0591.00
4_R9_D1.0521.00
341_V354_V1.0501.00
304_Q309_V1.0491.00
144_L208_W1.0491.00
79_P105_E1.0411.00
338_G353_K1.0371.00
102_Q108_Y1.0371.00
256_G277_K1.0341.00
116_N119_K1.0321.00
288_L343_V1.0301.00
63_L74_V1.0281.00
57_V124_M1.0271.00
123_W268_F1.0251.00
232_R314_T1.0251.00
337_I356_K1.0251.00
287_G359_F1.0231.00
289_E355_V1.0171.00
44_A220_L1.0161.00
87_M124_M1.0151.00
261_H277_K1.0151.00
157_N219_G1.0131.00
303_F342_D1.0131.00
57_V62_S1.0091.00
290_M352_A1.0051.00
73_D76_A1.0051.00
127_H268_F1.0041.00
146_V154_I1.0001.00
272_V276_Q0.9971.00
303_F306_G0.9911.00
35_K38_E0.9851.00
152_E195_Y0.9851.00
100_I108_Y0.9821.00
8_F18_T0.9801.00
291_I340_V0.9801.00
94_T244_L0.9761.00
150_K219_G0.9751.00
304_Q342_D0.9671.00
68_R268_F0.9651.00
238_P244_L0.9591.00
276_Q281_A0.9471.00
137_Q140_Q0.9461.00
100_I110_L0.9441.00
154_I214_A0.9401.00
136_N139_D0.9391.00
56_E109_L0.9371.00
6_P201_S0.9271.00
32_S35_K0.9261.00
274_S278_E0.9251.00
33_I226_G0.9241.00
334_T339_T0.9151.00
147_Q194_G0.9121.00
308_S311_K0.9101.00
292_E351_K0.9101.00
180_R207_I0.9091.00
210_K214_A0.9041.00
29_Q33_I0.9041.00
72_N260_K0.9021.00
296_P300_Y0.8991.00
199_C203_D0.8971.00
54_E141_I0.8961.00
11_Y27_P0.8930.99
7_L204_A0.8930.99
281_A332_S0.8910.99
72_N85_T0.8860.99
261_H267_F0.8850.99
103_K183_L0.8820.99
284_K332_S0.8820.99
5_T8_F0.8780.99
209_K213_D0.8760.99
46_L208_W0.8680.99
66_L108_Y0.8620.99
18_T25_E0.8590.99
37_H231_L0.8590.99
152_E164_S0.8560.99
60_N106_N0.8520.99
89_Y95_V0.8520.99
49_V145_A0.8490.99
212_I222_P0.8490.99
162_D166_L0.8450.99
166_L171_F0.8430.99
249_T252_E0.8430.99
46_L146_V0.8420.99
176_D179_G0.8420.99
24_W117_I0.8400.99
70_M87_M0.8370.99
90_P268_F0.8300.99
53_G117_I0.8280.99
160_D176_D0.8220.99
125_K128_A0.8160.99
39_A223_C0.8150.99
248_I283_R0.8100.99
94_T253_A0.8070.99
66_L74_V0.8050.99
143_L198_Y0.8030.99
142_A199_C0.8020.99
84_Y97_D0.8000.99
156_K161_A0.7990.99
159_T163_V0.7980.99
178_S206_H0.7970.99
14_Y209_K0.7950.99
87_M98_L0.7930.99
161_A173_D0.7930.99
85_T100_I0.7910.99
95_V119_K0.7910.99
178_S182_A0.7900.99
166_L173_D0.7830.99
292_E350_V0.7810.99
261_H274_S0.7790.99
252_E282_K0.7790.99
282_K332_S0.7760.99
335_S339_T0.7750.99
251_I256_G0.7720.99
14_Y208_W0.7720.99
267_F274_S0.7710.98
186_R193_D0.7700.98
121_L136_N0.7680.98
304_Q341_V0.7680.98
159_T177_I0.7680.98
275_E278_E0.7680.98
13_E205_M0.7670.98
214_A220_L0.7660.98
63_L67_Q0.7640.98
68_R266_D0.7640.98
168_P172_I0.7610.98
296_P324_N0.7590.98
184_I197_I0.7580.98
57_V134_I0.7550.98
318_S325_V0.7530.98
12_K25_E0.7520.98
76_A83_Q0.7500.98
184_I195_Y0.7470.98
71_T259_V0.7440.98
302_V341_V0.7430.98
156_K164_S0.7410.98
88_C273_L0.7400.98
245_T311_K0.7400.98
174_E183_L0.7370.98
70_M74_V0.7320.98
65_F128_A0.7310.98
14_Y30_F0.7310.98
58_S106_N0.7270.98
330_I354_V0.7250.98
249_T272_V0.7250.98
197_I211_I0.7240.98
61_D129_A0.7230.98
39_A219_G0.7220.98
182_A197_I0.7210.98
40_V231_L0.7190.98
285_L327_L0.7160.98
55_V124_M0.7140.98
338_G354_V0.7130.98
82_A101_Y0.7110.97
254_G284_K0.7110.97
155_L163_V0.7110.97
67_Q263_K0.7070.97
122_A125_K0.7060.97
215_G219_G0.7050.97
94_T243_E0.7030.97
112_I120_D0.7020.97
107_R174_E0.7010.97
71_T86_A0.7010.97
54_E198_Y0.6990.97
296_P343_V0.6970.97
288_L341_V0.6960.97
55_V134_I0.6950.97
40_V223_C0.6930.97
251_I259_V0.6930.97
140_Q200_R0.6920.97
261_H270_K0.6920.97
169_F237_L0.6920.97
151_A193_D0.6910.97
290_M324_N0.6890.97
212_I220_L0.6890.97
301_E311_K0.6860.97
69_L123_W0.6860.97
37_H320_T0.6840.97
206_H209_K0.6840.97
355_V359_F0.6830.97
103_K109_L0.6810.97
146_V197_I0.6810.97
273_L276_Q0.6810.97
77_L83_Q0.6800.97
283_R331_D0.6790.97
284_K335_S0.6790.97
41_R234_E0.6780.97
180_R200_R0.6780.97
101_Y185_S0.6770.97
95_V246_R0.6760.97
66_L70_M0.6740.97
54_E143_L0.6710.96
146_V220_L0.6700.96
14_Y212_I0.6690.96
10_L212_I0.6620.96
17_K29_Q0.6610.96
123_W126_E0.6600.96
90_P127_H0.6580.96
16_G28_V0.6570.96
172_I183_L0.6570.96
276_Q280_G0.6550.96
10_L208_W0.6550.96
296_P352_A0.6530.96
57_V65_F0.6530.96
317_Q324_N0.6490.96
267_F273_L0.6470.96
141_I200_R0.6460.96
65_F68_R0.6440.95
71_T258_A0.6430.95
243_E285_L0.6400.95
77_L81_R0.6380.95
49_V143_L0.6370.95
161_A175_A0.6350.95
155_L195_Y0.6310.95
47_F223_C0.6290.95
181_K203_D0.6280.95
159_T162_D0.6280.95
153_A157_N0.6270.95
252_E281_A0.6250.95
286_V335_S0.6240.95
230_T316_T0.6230.95
300_Y343_V0.6210.95
186_R195_Y0.6190.94
223_C227_A0.6190.94
66_L110_L0.6180.94
41_R231_L0.6130.94
52_M111_V0.6110.94
72_N83_Q0.6100.94
89_Y93_G0.6100.94
283_R311_K0.6090.94
43_A220_L0.6080.94
51_H225_L0.6050.94
91_D247_D0.6040.94
304_Q339_T0.6030.94
124_M134_I0.6030.94
70_M83_Q0.6010.94
190_T194_G0.6000.93
287_G357_T0.6000.93
240_Y244_L0.5990.93
290_M343_V0.5980.93
109_L141_I0.5970.93
11_Y18_T0.5960.93
29_Q32_S0.5950.93
109_L198_Y0.5950.93
233_F325_V0.5950.93
315_G324_N0.5950.93
46_L220_L0.5910.93
117_I139_D0.5910.93
64_S75_S0.5900.93
36_E224_G0.5890.93
163_V166_L0.5890.93
177_I180_R0.5880.93
230_T318_S0.5880.93
57_V66_L0.5880.93
332_S335_S0.5870.93
95_V123_W0.5850.93
53_G112_I0.5800.92
34_K319_P0.5790.92
236_K357_T0.5790.92
272_V275_E0.5790.92
289_E325_V0.5790.92
330_I335_S0.5790.92
98_L110_L0.5780.92
286_V354_V0.5780.92
85_T98_L0.5780.92
56_E103_K0.5770.92
103_K172_I0.5760.92
259_V267_F0.5760.92
102_Q107_R0.5760.92
50_S142_A0.5750.92
64_S68_R0.5740.92
144_L204_A0.5730.92
243_E248_I0.5720.92
182_A199_C0.5710.92
41_R320_T0.5700.92
73_D260_K0.5700.92
43_A154_I0.5680.91
91_D246_R0.5680.91
16_G19_I0.5680.91
261_H273_L0.5670.91
65_F129_A0.5670.91
61_D132_V0.5660.91
128_A132_V0.5660.91
302_V352_A0.5660.91
147_Q190_T0.5650.91
244_L248_I0.5640.91
297_R300_Y0.5620.91
285_L329_L0.5590.91
11_Y14_Y0.5580.91
7_L11_Y0.5580.91
177_I207_I0.5570.91
344_E348_K0.5550.91
84_Y187_T0.5550.91
251_I277_K0.5550.91
189_Y239_L0.5540.90
66_L124_M0.5530.90
54_E138_S0.5520.90
67_Q265_S0.5520.90
30_F222_P0.5510.90
294_G324_N0.5500.90
193_D235_A0.5500.90
338_G341_V0.5490.90
88_C94_T0.5490.90
240_Y246_R0.5470.90
159_T178_S0.5460.90
274_S277_K0.5460.90
185_S198_Y0.5460.90
337_I357_T0.5410.89
47_F147_Q0.5410.89
87_M120_D0.5390.89
250_P273_L0.5390.89
151_A154_I0.5380.89
112_I121_L0.5360.89
118_D136_N0.5360.89
53_G136_N0.5350.89
250_P259_V0.5350.89
69_L268_F0.5340.89
4_R12_K0.5300.88
318_S323_K0.5290.88
256_G284_K0.5290.88
323_K353_K0.5290.88
44_A146_V0.5290.88
342_D350_V0.5280.88
91_D272_V0.5280.88
51_H114_A0.5270.88
296_P326_G0.5260.88
279_N282_K0.5260.88
172_I185_S0.5250.88
57_V100_I0.5240.88
82_A187_T0.5240.88
31_S221_I0.5230.88
154_I157_N0.5230.88
201_S204_A0.5230.88
117_I138_S0.5200.87
70_M77_L0.5200.87
68_R130_G0.5180.87
64_S67_Q0.5180.87
9_D25_E0.5160.87
69_L87_M0.5160.87
125_K134_I0.5160.87
78_T171_F0.5130.87
46_L211_I0.5130.87
166_L170_A0.5110.87
309_V331_D0.5110.87
61_D128_A0.5100.86
175_A181_K0.5090.86
345_I348_K0.5080.86
127_H130_G0.5080.86
239_L242_Q0.5070.86
158_L210_K0.5070.86
238_P243_E0.5050.86
82_A185_S0.5040.86
101_Y111_V0.5020.86
251_I276_Q0.5020.86
172_I175_A0.5020.86
46_L222_P0.5010.86
151_A195_Y0.5000.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1yx2A 1 0.9945 100 0.086 Contact Map
1v5vA 2 0.9917 100 0.112 Contact Map
1wosA 1 0.9834 100 0.113 Contact Map
2gagA 1 0.9945 100 0.113 Contact Map
1pj5A 3 0.9834 100 0.124 Contact Map
4pabA 1 0.989 100 0.125 Contact Map
3girA 1 0.9696 100 0.125 Contact Map
1wsrA 2 0.9807 100 0.135 Contact Map
3tfiA 2 0.9696 100 0.146 Contact Map
1vloA 1 0.9503 100 0.15 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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