GREMLIN Database
GCSPB - Probable glycine dehydrogenase (decarboxylating) subunit 2
UniProt: P54377 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 488 (405)
Sequences: 5282 (2842)
Seq/√Len: 141.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
236_V241_G3.7311.00
234_E238_Q3.4931.00
258_R261_D3.3351.00
370_Y445_I3.2341.00
233_A243_L3.1811.00
173_H221_T3.1591.00
131_D292_K3.1001.00
350_K354_E3.0081.00
366_K441_I2.9021.00
248_A288_P2.8821.00
130_M267_V2.7991.00
207_V235_I2.7571.00
363_M428_P2.7261.00
293_Q296_I2.6961.00
115_E119_D2.6001.00
202_D206_A2.5971.00
365_R368_A2.5321.00
257_A261_D2.5081.00
251_N356_A2.4971.00
151_I266_V2.3601.00
230_T234_E2.3601.00
166_V213_A2.3441.00
230_T257_A2.2411.00
407_F446_Q2.2031.00
92_I339_T2.1971.00
254_L349_L2.1471.00
233_A262_M2.0741.00
133_V290_G2.0241.00
165_K186_E2.0191.00
51_V59_H2.0151.00
148_L215_M2.0111.00
249_N381_H1.9651.00
373_L386_S1.9581.00
165_K208_N1.9521.00
387_G400_I1.9491.00
272_H288_P1.9451.00
81_T431_T1.9441.00
366_K369_P1.9301.00
25_L34_D1.9141.00
363_M437_L1.9101.00
165_K210_E1.9051.00
52_S55_D1.9041.00
371_Y375_F1.8811.00
151_I245_Y1.8301.00
118_Y313_F1.8141.00
363_M441_I1.8101.00
363_M383_F1.8091.00
387_G397_T1.8041.00
57_M87_K1.7771.00
84_Y336_R1.7681.00
231_E234_E1.7561.00
79_S285_G1.7561.00
80_C427_E1.7471.00
201_E204_K1.7271.00
132_E296_I1.7231.00
55_D433_S1.7201.00
128_T269_L1.7181.00
191_K202_D1.7121.00
409_Y443_A1.7031.00
214_L236_V1.7031.00
362_Y434_K1.7011.00
355_N359_N1.7001.00
154_Y295_L1.6981.00
166_V215_M1.6971.00
86_P89_N1.6951.00
207_V211_T1.6811.00
234_E237_H1.6781.00
101_I110_V1.6641.00
116_L335_V1.6431.00
434_K438_D1.6341.00
225_F256_K1.6331.00
411_P440_F1.6271.00
359_N437_L1.5951.00
204_K231_E1.5941.00
91_K339_T1.5871.00
131_D293_Q1.5651.00
412_P425_M1.5581.00
384_V423_C1.5561.00
177_P189_T1.5551.00
68_H73_G1.5521.00
193_N197_L1.5501.00
386_S422_E1.5471.00
164_T186_E1.5451.00
242_K294_D1.5331.00
123_H342_R1.5261.00
216_L229_I1.5221.00
364_M379_C1.5181.00
366_K442_D1.4901.00
122_K125_E1.4841.00
71_D408_G1.4711.00
167_I206_A1.4651.00
258_R262_M1.4571.00
116_L338_Y1.4521.00
204_K235_I1.4521.00
171_S222_L1.4491.00
79_S279_H1.4491.00
230_T262_M1.4441.00
360_A383_F1.4381.00
401_A413_T1.4301.00
331_F335_V1.4181.00
202_D205_R1.4101.00
179_S182_V1.4041.00
415_Y423_C1.4011.00
384_V425_M1.3881.00
367_L444_M1.3751.00
220_N226_E1.3661.00
245_Y264_F1.3611.00
105_Q110_V1.3581.00
366_K445_I1.3541.00
125_E131_D1.3521.00
119_D338_Y1.3501.00
125_E133_V1.3371.00
169_P198_V1.3361.00
144_E215_M1.3331.00
344_M352_V1.3331.00
33_G41_I1.3301.00
72_S436_T1.3281.00
245_Y269_L1.3241.00
402_K406_D1.3231.00
172_A180_A1.3211.00
117_L135_L1.3201.00
148_L166_V1.3171.00
291_V295_L1.3111.00
59_H63_L1.3101.00
215_M247_G1.3081.00
277_G333_I1.3061.00
366_K438_D1.3021.00
180_A187_T1.3011.00
164_T210_E1.2901.00
74_F436_T1.2881.00
360_A428_P1.2801.00
165_K211_T1.2781.00
176_N247_G1.2751.00
156_E161_F1.2751.00
153_A298_Y1.2701.00
170_D189_T1.2691.00
113_A331_F1.2511.00
38_D41_I1.2491.00
357_V361_N1.2461.00
361_N379_C1.2461.00
151_I213_A1.2351.00
216_L243_L1.2311.00
201_E205_R1.2191.00
170_D191_K1.2131.00
111_Q114_L1.2111.00
403_R407_F1.2101.00
428_P432_E1.2051.00
209_E239_A1.2001.00
276_T344_M1.1991.00
81_T429_T1.1961.00
180_A184_G1.1941.00
347_D351_A1.1941.00
172_A217_T1.1931.00
120_L334_N1.1901.00
306_K309_G1.1881.00
441_I445_I1.1831.00
236_V243_L1.1801.00
207_V239_A1.1791.00
88_I339_T1.1771.00
179_S183_A1.1691.00
297_P319_H1.1630.99
38_D43_D1.1580.99
81_T432_E1.1570.99
289_V299_L1.1540.99
74_F409_Y1.1530.99
401_A405_L1.1510.99
68_H408_G1.1470.99
61_T64_S1.1420.99
165_K188_V1.1380.99
398_L413_T1.1360.99
88_I343_S1.1350.99
403_R406_D1.1340.99
218_N256_K1.1320.99
338_Y342_R1.1300.99
171_S220_N1.1270.99
83_K431_T1.1250.99
92_I336_R1.1240.99
360_A379_C1.1140.99
218_N262_M1.1090.99
80_C173_H1.1090.99
250_L272_H1.1070.99
147_G266_V1.1070.99
339_T343_S1.0970.99
89_N276_T1.0930.99
409_Y439_A1.0910.99
48_L51_V1.0880.99
237_H241_G1.0790.99
362_Y438_D1.0770.99
432_E436_T1.0750.99
269_L289_V1.0720.99
359_N434_K1.0720.99
99_A332_G1.0720.99
180_A185_F1.0680.99
122_K126_E1.0670.99
375_F423_C1.0650.99
80_C429_T1.0630.99
233_A237_H1.0560.99
105_Q109_T1.0510.99
129_G258_R1.0500.99
162_K210_E1.0500.99
249_N274_T1.0440.99
257_A262_M1.0410.99
124_L290_G1.0320.99
116_L339_T1.0310.99
144_E176_N1.0260.99
364_M373_L1.0190.99
372_D386_S1.0180.99
101_I113_A1.0170.99
250_L269_L1.0170.99
172_A215_M1.0160.99
151_I242_K1.0150.99
118_Y121_S1.0130.99
61_T65_K1.0080.99
138_A325_K1.0020.98
426_I440_F1.0020.98
368_A373_L0.9980.98
237_H243_L0.9880.98
200_L204_K0.9870.98
227_E230_T0.9870.98
168_V172_A0.9860.98
407_F439_A0.9840.98
181_T184_G0.9810.98
87_K343_S0.9800.98
121_S132_E0.9740.98
153_A156_E0.9720.98
255_S357_V0.9680.98
77_L173_H0.9650.98
286_S334_N0.9640.98
216_L233_A0.9630.98
107_E328_Y0.9540.98
364_M368_A0.9540.98
397_T401_A0.9520.98
356_A381_H0.9510.98
131_D291_V0.9500.98
351_A354_E0.9490.98
246_D262_M0.9420.98
163_R240_G0.9360.98
119_D123_H0.9330.98
65_K72_S0.9260.97
229_I262_M0.9240.97
386_S423_C0.9230.97
375_F386_S0.9220.97
372_D375_F0.9210.97
385_L426_I0.9200.97
131_D296_I0.9180.97
82_M279_H0.9170.97
123_H341_I0.9150.97
396_R399_D0.9120.97
233_A246_D0.9100.97
59_H62_A0.9070.97
351_A355_N0.9060.97
220_N224_L0.9040.97
182_V185_F0.9030.97
407_F443_A0.9010.97
150_M321_I0.8960.97
248_A272_H0.8960.97
213_A245_Y0.8960.97
414_I425_M0.8960.97
217_T247_G0.8950.97
208_N211_T0.8950.97
68_H71_D0.8930.97
286_S337_A0.8900.97
155_H163_R0.8880.97
182_V187_T0.8860.97
134_T289_V0.8810.97
204_K238_Q0.8790.97
439_A443_A0.8760.96
167_I211_T0.8750.96
401_A424_I0.8720.96
357_V379_C0.8710.96
117_L286_S0.8650.96
301_K316_D0.8640.96
134_T146_T0.8590.96
131_D294_D0.8580.96
74_F432_E0.8580.96
301_K320_A0.8560.96
442_D445_I0.8540.96
180_A183_A0.8540.96
36_L41_I0.8520.96
314_D317_R0.8520.96
119_D342_R0.8520.96
347_D354_E0.8510.96
42_R45_D0.8490.96
397_T414_I0.8490.96
71_D405_L0.8470.96
218_N252_A0.8470.96
150_M291_V0.8470.96
248_A252_A0.8460.96
371_Y400_I0.8410.96
214_L232_M0.8400.96
256_K354_E0.8390.95
208_N239_A0.8380.95
72_S439_A0.8380.95
333_I336_R0.8370.95
125_E130_M0.8330.95
388_K397_T0.8330.95
167_I190_V0.8270.95
367_L385_L0.8270.95
199_D202_D0.8250.95
81_T279_H0.8250.95
26_D31_E0.8230.95
151_I166_V0.8230.95
340_Y352_V0.8220.95
150_M289_V0.8220.95
132_E303_V0.8210.95
77_L221_T0.8210.95
55_D435_E0.8190.95
409_Y440_F0.8180.95
404_L411_P0.8080.94
270_N288_P0.8080.94
150_M154_Y0.8070.94
409_Y436_T0.8070.94
399_D402_K0.8060.94
117_L328_Y0.8050.94
398_L402_K0.8040.94
360_A427_E0.8040.94
197_L377_R0.8010.94
440_F444_M0.8000.94
104_L327_Y0.8000.94
218_N225_F0.7990.94
292_K295_L0.7980.94
272_H286_S0.7950.94
163_R212_A0.7940.94
235_I239_A0.7920.94
54_L83_K0.7920.94
250_L254_L0.7920.94
73_G279_H0.7900.94
130_M260_G0.7880.94
303_V323_R0.7870.94
120_L272_H0.7870.94
341_I349_L0.7850.94
389_R422_E0.7840.94
359_N428_P0.7840.94
77_L425_M0.7830.94
184_G187_T0.7830.94
155_H212_A0.7830.94
133_V289_V0.7820.93
130_M264_F0.7810.93
22_L25_L0.7790.93
42_R46_A0.7760.93
127_I341_I0.7750.93
152_R212_A0.7730.93
279_H285_G0.7670.93
152_R164_T0.7650.93
385_L444_M0.7650.93
245_Y262_M0.7650.93
226_E229_I0.7610.93
322_G325_K0.7600.92
276_T333_I0.7590.92
127_I349_L0.7580.92
56_I60_Y0.7560.92
44_E47_A0.7550.92
396_R422_E0.7540.92
224_L377_R0.7540.92
104_L302_P0.7450.92
231_E235_I0.7450.92
110_V114_L0.7440.92
403_R447_I0.7430.92
227_E231_E0.7430.92
235_I238_Q0.7420.92
74_F428_P0.7420.92
186_E191_K0.7390.91
124_L272_H0.7380.91
404_L409_Y0.7380.91
352_V356_A0.7370.91
340_Y344_M0.7350.91
51_V56_I0.7340.91
363_M367_L0.7340.91
301_K319_H0.7330.91
254_L352_V0.7300.91
407_F442_D0.7300.91
110_V328_Y0.7290.91
373_L385_L0.7290.91
204_K208_N0.7270.91
371_Y444_M0.7270.91
246_D264_F0.7240.91
396_R400_I0.7230.90
170_D192_S0.7220.90
172_A177_P0.7220.90
415_Y422_E0.7220.90
363_M440_F0.7210.90
74_F440_F0.7210.90
438_D442_D0.7180.90
379_C383_F0.7160.90
372_D385_L0.7160.90
246_D258_R0.7140.90
62_A65_K0.7130.90
179_S185_F0.7130.90
64_S71_D0.7120.90
190_V206_A0.7120.90
435_E438_D0.7120.90
166_V212_A0.7100.90
121_S303_V0.7090.90
146_T324_V0.7090.90
358_L362_Y0.7070.90
242_K295_L0.7070.90
126_E258_R0.7070.90
176_N217_T0.7060.89
302_P327_Y0.7060.89
120_L286_S0.7040.89
134_T299_L0.7020.89
438_D441_I0.7010.89
95_I98_F0.7010.89
79_S142_H0.7010.89
410_H413_T0.7010.89
229_I246_D0.6980.89
126_E346_P0.6970.89
431_T436_T0.6960.89
111_Q118_Y0.6940.89
107_E114_L0.6940.89
291_V299_L0.6930.89
237_H242_K0.6930.89
277_G336_R0.6910.88
433_S436_T0.6880.88
101_I105_Q0.6880.88
272_H275_F0.6880.88
154_Y298_Y0.6870.88
435_E439_A0.6850.88
405_L411_P0.6820.88
307_K310_R0.6790.88
245_Y253_V0.6770.87
182_V186_E0.6740.87
91_K94_R0.6730.87
171_S224_L0.6720.87
114_L118_Y0.6700.87
200_L203_L0.6690.87
96_P99_A0.6680.87
83_K86_P0.6670.87
400_I444_M0.6660.87
182_V191_K0.6650.86
197_L200_L0.6640.86
148_L179_S0.6580.86
301_K306_K0.6580.86
197_L224_L0.6570.86
33_G38_D0.6570.86
301_K317_R0.6560.86
185_F213_A0.6550.86
370_Y441_I0.6550.86
107_E121_S0.6520.85
298_Y319_H0.6520.85
93_A336_R0.6480.85
121_S135_L0.6470.85
398_L414_I0.6470.85
207_V236_V0.6460.85
383_F426_I0.6450.85
302_P323_R0.6450.85
130_M290_G0.6440.85
151_I155_H0.6430.85
354_E358_L0.6430.85
271_L288_P0.6430.85
246_D267_V0.6410.84
171_S198_V0.6380.84
301_K318_P0.6360.84
229_I233_A0.6360.84
374_P386_S0.6360.84
388_K422_E0.6350.84
73_G81_T0.6350.84
432_E437_L0.6340.84
213_A241_G0.6340.84
359_N362_Y0.6320.84
371_Y374_P0.6310.83
154_Y292_K0.6310.83
193_N199_D0.6310.83
255_S353_T0.6280.83
167_I201_E0.6280.83
363_M426_I0.6240.83
255_S354_E0.6240.83
84_Y89_N0.6230.83
389_R399_D0.6230.83
346_P349_L0.6220.83
137_P289_V0.6210.82
185_F189_T0.6150.82
305_V311_F0.6130.82
168_V215_M0.6120.82
186_E189_T0.6110.81
369_P445_I0.6110.81
36_L39_T0.6100.81
152_R156_E0.6080.81
301_K315_Y0.6080.81
89_N336_R0.6070.81
195_K227_E0.6060.81
90_E94_R0.6050.81
397_T415_Y0.6040.81
124_L134_T0.6030.81
58_R83_K0.6020.81
428_P437_L0.6020.81
346_P350_K0.6010.80
221_T412_P0.6000.80
414_I422_E0.5980.80
153_A321_I0.5980.80
121_S328_Y0.5970.80
411_P425_M0.5960.80
154_Y242_K0.5930.80
366_K370_Y0.5930.80
144_E247_G0.5910.79
154_Y291_V0.5900.79
403_R446_Q0.5900.79
92_I116_L0.5900.79
77_L412_P0.5880.79
25_L31_E0.5880.79
254_L353_T0.5860.79
150_M266_V0.5860.79
116_L331_F0.5850.79
251_N254_L0.5850.79
271_L287_G0.5840.79
104_L328_Y0.5780.78
152_R185_F0.5770.78
200_L235_I0.5770.78
248_A267_V0.5770.78
92_I335_V0.5760.78
70_V73_G0.5740.77
339_T342_R0.5720.77
165_K193_N0.5710.77
315_Y320_A0.5710.77
251_N340_Y0.5700.77
88_I92_I0.5680.77
370_Y446_Q0.5680.77
253_V259_P0.5680.77
137_P287_G0.5660.76
253_V262_M0.5650.76
211_T235_I0.5630.76
297_P318_P0.5610.76
189_T192_S0.5610.76
198_V203_L0.5600.76
442_D446_Q0.5580.75
330_N333_I0.5580.75
303_V317_R0.5580.75
21_S26_D0.5580.75
320_A323_R0.5560.75
383_F428_P0.5550.75
107_E111_Q0.5550.75
266_V298_Y0.5530.75
77_L427_E0.5530.75
277_G337_A0.5530.75
426_I444_M0.5460.74
114_L304_L0.5460.74
114_L328_Y0.5450.74
31_E35_L0.5450.74
166_V245_Y0.5450.74
397_T400_I0.5440.73
37_S40_Y0.5440.73
179_S184_G0.5430.73
275_F356_A0.5420.73
356_A360_A0.5420.73
117_L334_N0.5420.73
306_K311_F0.5420.73
155_H242_K0.5410.73
413_T422_E0.5410.73
41_I44_E0.5410.73
116_L334_N0.5400.73
243_L264_F0.5400.73
29_E41_I0.5400.73
365_R369_P0.5390.73
155_H240_G0.5380.73
225_F357_V0.5380.73
77_L174_G0.5370.73
222_L384_V0.5370.73
149_M153_A0.5370.73
428_P431_T0.5360.72
364_M374_P0.5360.72
127_I250_L0.5360.72
301_K323_R0.5360.72
132_E299_L0.5310.72
73_G76_P0.5310.72
364_M383_F0.5290.71
344_M349_L0.5270.71
77_L80_C0.5260.71
167_I188_V0.5250.71
148_L187_T0.5240.71
179_S187_T0.5240.71
176_N215_M0.5230.71
361_N365_R0.5230.71
123_H338_Y0.5230.71
251_N275_F0.5220.70
397_T424_I0.5220.70
224_L376_D0.5210.70
33_G36_L0.5200.70
368_A377_R0.5200.70
167_I236_V0.5180.70
31_E34_D0.5160.70
21_S25_L0.5160.70
172_A221_T0.5150.69
216_L232_M0.5150.69
107_E110_V0.5150.69
306_K319_H0.5150.69
121_S321_I0.5140.69
361_N364_M0.5130.69
264_F267_V0.5130.69
387_G396_R0.5120.69
123_H275_F0.5120.69
347_D350_K0.5120.69
106_D376_D0.5120.69
118_Y122_K0.5110.69
220_N384_V0.5100.69
188_V206_A0.5100.69
169_P202_D0.5100.69
258_R267_V0.5090.69
105_Q111_Q0.5090.69
266_V289_V0.5070.68
400_I440_F0.5070.68
121_S319_H0.5050.68
147_G245_Y0.5040.68
256_K350_K0.5040.68
401_A411_P0.5030.68
277_G280_G0.5030.68
274_T381_H0.5020.67
32_L35_L0.5010.67
107_E319_H0.5000.67
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4lhdA 2 0.9344 100 0.535 Contact Map
1wyuB 2 0.9631 100 0.622 Contact Map
1wyuA 2 0.8545 100 0.639 Contact Map
3mc6A 2 0.8238 100 0.759 Contact Map
3wcnA 2 0.8238 100 0.785 Contact Map
3hl2A 3 0.7971 100 0.799 Contact Map
2z67A 4 0.7889 100 0.804 Contact Map
3bc8A 3 0.7828 100 0.806 Contact Map
4obuE 2 0.8607 100 0.822 Contact Map
2jisA 2 0.8566 100 0.828 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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