GREMLIN Database
GCSPA - Probable glycine dehydrogenase (decarboxylating) subunit 1
UniProt: P54376 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 448 (397)
Sequences: 5172 (2739)
Seq/√Len: 137.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
228_P232_Q3.5151.00
251_P254_K3.3791.00
372_A444_G3.2501.00
129_D284_T3.1051.00
165_H216_F3.0061.00
352_K356_R3.0021.00
90_V341_V2.9681.00
375_T389_K2.9401.00
368_E440_I2.8421.00
128_M260_V2.7901.00
149_A290_K2.7361.00
241_A280_F2.7351.00
157_K182_D2.6941.00
365_A427_V2.6251.00
367_Q370_K2.6051.00
285_K288_M2.5681.00
113_Q117_E2.5641.00
230_A235_S2.5241.00
244_L358_N2.4281.00
65_R70_Y2.3481.00
250_T254_K2.3211.00
224_K228_P2.3141.00
158_I208_A2.3081.00
54_T85_V2.2451.00
169_R185_E2.2001.00
227_E237_F2.1561.00
224_K250_T2.1311.00
247_G351_V2.1161.00
202_V229_I2.0591.00
160_V172_L2.0181.00
227_E255_F2.0161.00
159_V186_V1.9951.00
131_A282_A1.9881.00
187_P190_D1.9601.00
164_V169_R1.9551.00
48_K56_E1.9461.00
366_K376_V1.9431.00
157_K203_C1.9311.00
242_N384_N1.9301.00
146_A210_I1.9201.00
71_A435_E1.8941.00
80_D430_L1.8921.00
49_S52_E1.8861.00
296_V310_L1.8541.00
368_E371_K1.8411.00
365_A436_I1.8381.00
365_A386_F1.8271.00
264_A280_F1.8131.00
34_E39_K1.8071.00
157_K205_N1.7911.00
130_I288_M1.7871.00
365_A440_I1.7551.00
52_E432_T1.7301.00
211_V223_L1.7051.00
114_A337_L1.6931.00
225_D228_P1.6841.00
78_V277_H1.6841.00
34_E37_K1.6831.00
79_Y426_A1.6781.00
433_K437_D1.6741.00
83_Q338_A1.6701.00
126_T261_V1.6651.00
209_V230_A1.6641.00
116_F308_F1.6631.00
33_P36_V1.6431.00
364_Y433_K1.6421.00
129_D285_K1.6421.00
196_D199_R1.6411.00
149_A317_Q1.6291.00
158_I210_I1.6281.00
228_P231_H1.6201.00
100_Y108_S1.6181.00
199_R225_D1.6121.00
357_Q361_K1.5971.00
121_M344_T1.5931.00
86_I345_A1.5531.00
116_F298_Q1.5461.00
366_K382_M1.5361.00
220_I249_L1.5341.00
157_K184_V1.5231.00
387_V422_H1.5201.00
156_K180_Y1.5161.00
368_E441_Q1.4971.00
162_K187_P1.4901.00
149_A238_I1.4871.00
361_K436_I1.4781.00
78_V271_S1.4741.00
199_R229_I1.4641.00
114_A340_S1.4641.00
389_K421_C1.4631.00
70_Y405_G1.4591.00
33_P38_Y1.4511.00
120_T123_C1.4491.00
202_V206_T1.4431.00
224_K255_F1.4361.00
172_L183_V1.4331.00
362_A386_F1.4301.00
333_A337_L1.4271.00
163_T217_F1.4271.00
147_M150_S1.4251.00
62_S69_Q1.4221.00
251_P255_F1.4191.00
387_V424_L1.4041.00
238_I257_S1.3931.00
73_F435_E1.3901.00
346_L354_I1.3771.00
27_D31_D1.3661.00
211_V237_F1.3631.00
376_V388_I1.3541.00
91_I338_A1.3481.00
369_A443_L1.3471.00
222_P225_D1.3471.00
215_N221_E1.3441.00
156_K205_N1.3441.00
162_K185_E1.3441.00
283_V287_L1.3391.00
210_I240_S1.3361.00
104_Q108_S1.3361.00
238_I261_V1.3331.00
117_E340_S1.3271.00
406_M442_E1.3261.00
412_L439_L1.3241.00
146_A158_I1.3241.00
269_I335_N1.3211.00
115_I133_S1.3131.00
169_R173_K1.3131.00
123_C131_A1.3081.00
368_E437_D1.3001.00
377_M389_K1.2951.00
123_C129_D1.2881.00
111_E333_A1.2841.00
377_M422_H1.2841.00
368_E444_G1.2771.00
109_Q112_L1.2771.00
398_N414_L1.2701.00
157_K206_T1.2691.00
362_A427_V1.2641.00
56_E60_L1.2611.00
187_P192_V1.2591.00
161_S193_T1.2561.00
363_N382_M1.2551.00
118_F336_A1.2451.00
168_S240_S1.2401.00
164_V212_Q1.2271.00
413_G424_L1.2201.00
359_L363_N1.2191.00
80_D428_T1.2021.00
398_N402_L1.2001.00
268_G346_L1.1981.00
143_A259_I1.1941.00
58_T61_A1.1851.00
87_V268_G1.1800.99
33_P39_K1.1780.99
27_D30_A1.1690.99
145_A148_L1.1690.99
427_V431_R1.1680.99
30_A37_K1.1670.99
235_S286_K1.1630.99
152_H155_K1.1560.99
362_A382_M1.1470.99
341_V345_A1.1440.99
80_D431_R1.1420.99
33_P37_K1.1390.99
84_P87_V1.1240.99
82_Y430_L1.1190.99
281_F291_V1.1180.99
159_V201_T1.1140.99
154_K205_N1.1120.99
340_S344_T1.1110.99
213_Y249_L1.1090.99
364_Y437_D1.1080.99
349_N353_D1.1070.99
261_V281_F1.1060.99
230_A237_F1.1050.99
213_Y255_F1.1050.99
120_T124_E1.1010.99
227_E236_M1.1010.99
34_E38_Y1.1010.99
390_L394_V1.0930.99
71_A438_A1.0920.99
127_G251_P1.0850.99
361_K433_K1.0820.99
100_Y111_E1.0810.99
79_Y165_H1.0750.99
243_P264_A1.0730.99
104_Q107_I1.0710.99
79_Y428_T1.0680.99
65_R405_G1.0570.99
404_K441_Q1.0560.99
116_F119_Q1.0540.99
163_T215_N1.0470.99
147_M152_H1.0450.99
374_L388_I1.0430.99
404_K438_A1.0420.99
242_N266_P1.0370.99
151_G290_K1.0290.99
76_A165_H1.0280.99
199_R232_Q1.0260.99
45_K48_K1.0240.99
388_I425_I1.0240.99
142_L210_I1.0240.99
250_T255_F1.0230.99
353_D356_R1.0220.99
58_T62_S1.0210.99
227_E231_H1.0200.99
440_I444_G1.0180.99
122_I282_A1.0160.98
431_R435_E1.0150.98
374_L443_L1.0150.98
144_E148_L1.0140.98
239_V255_F1.0050.98
425_I439_L1.0040.98
129_D283_V1.0040.98
159_V184_V1.0030.98
172_L210_I1.0020.98
114_A341_V0.9910.98
119_Q130_I0.9870.98
164_V210_I0.9830.98
73_F406_M0.9680.98
142_L172_L0.9680.98
211_V227_E0.9670.98
278_C336_A0.9670.98
243_P261_V0.9620.98
223_L255_F0.9620.98
97_Y334_L0.9610.98
117_E121_M0.9600.98
393_P396_A0.9560.98
390_L402_L0.9530.98
395_R414_L0.9530.98
227_E239_V0.9500.98
248_L359_L0.9480.98
392_E396_A0.9470.98
438_A442_E0.9450.98
72_S271_S0.9440.98
353_D357_Q0.9430.98
389_K422_H0.9420.98
86_I341_V0.9410.98
215_N219_R0.9360.97
129_D288_M0.9360.97
117_E344_T0.9350.97
358_N384_N0.9330.97
160_V164_V0.9300.97
29_F32_I0.9290.97
366_K370_K0.9240.97
231_H237_F0.9240.97
191_G378_F0.9210.97
121_M343_M0.9130.97
56_E59_K0.9130.97
81_H271_S0.9040.97
212_Q240_S0.9040.97
132_N281_F0.9030.97
394_V398_N0.9020.97
441_Q444_G0.9010.97
129_D286_K0.9010.97
249_L356_R0.8990.97
147_M179_Q0.8950.97
203_C206_T0.8940.97
268_G335_N0.8920.97
335_N338_A0.8920.97
103_Y329_C0.8910.97
76_A216_F0.8900.97
289_R317_Q0.8900.97
400_R403_A0.8890.96
149_A208_A0.8860.96
70_Y402_L0.8840.96
108_S112_L0.8800.96
278_C339_A0.8790.96
148_L153_T0.8790.96
370_K376_V0.8780.96
241_A264_A0.8780.96
115_I278_C0.8770.96
149_A236_M0.8760.96
94_S97_Y0.8680.96
115_I330_S0.8650.96
209_V226_I0.8650.96
241_A245_A0.8650.96
399_K403_A0.8590.96
80_D271_S0.8580.96
359_L382_M0.8560.96
208_A238_I0.8530.96
32_I37_K0.8500.95
52_E434_E0.8480.95
213_Y245_A0.8470.95
439_L443_L0.8470.95
38_Y42_H0.8460.95
342_A354_I0.8450.95
155_K207_A0.8450.95
204_E233_G0.8430.95
195_L222_P0.8430.95
362_A426_A0.8400.95
398_N423_M0.8400.95
156_K182_D0.8360.95
142_L168_S0.8340.95
243_P247_G0.8330.95
149_A259_I0.8320.95
391_D394_V0.8290.95
404_K442_E0.8280.95
392_E395_R0.8240.95
262_G280_F0.8220.95
437_D440_I0.8200.95
73_F431_R0.8200.95
293_G321_R0.8180.94
128_M253_G0.8170.94
136_Y323_K0.8150.94
146_A172_L0.8150.94
401_L406_M0.8100.94
284_T287_L0.8080.94
219_R380_G0.8080.94
294_R329_C0.8070.94
369_A388_I0.8070.94
213_Y220_I0.8050.94
195_L229_I0.8040.94
159_V206_T0.8030.94
123_C128_M0.8030.94
392_E397_V0.7990.94
142_L281_F0.7990.94
76_A424_L0.7980.94
311_T315_R0.7980.94
247_G354_I0.7970.94
88_D338_A0.7950.94
112_L116_F0.7950.94
295_L324_A0.7950.94
377_M387_V0.7930.93
148_L283_V0.7920.93
264_A278_C0.7910.93
36_V39_K0.7910.93
128_M257_S0.7880.93
298_Q306_R0.7880.93
392_E421_C0.7830.93
369_A374_L0.7810.93
118_F264_A0.7810.93
361_K427_V0.7810.93
349_N356_R0.7800.93
131_A281_F0.7790.93
59_K62_S0.7790.93
238_I255_F0.7760.93
53_L57_L0.7720.93
238_I246_L0.7720.93
124_E251_P0.7710.92
147_M181_I0.7710.92
343_M351_V0.7710.92
437_D441_Q0.7700.92
342_A346_L0.7680.92
103_Y294_R0.7680.92
271_S277_H0.7640.92
38_Y41_E0.7630.92
48_K53_L0.7610.92
125_L343_M0.7600.92
301_D304_G0.7590.92
51_T82_Y0.7590.92
412_L424_L0.7570.92
390_L397_V0.7550.92
72_S80_D0.7520.92
229_I232_Q0.7510.91
382_M386_F0.7500.91
125_L351_V0.7460.91
239_V251_P0.7460.91
83_Q87_V0.7430.91
73_F427_V0.7420.91
230_A234_K0.7410.91
130_I295_L0.7400.91
32_I36_V0.7380.91
162_K186_V0.7320.90
118_F278_C0.7300.90
70_Y73_F0.7300.90
152_H287_L0.7300.90
225_D229_I0.7290.90
354_I358_N0.7270.90
415_T424_L0.7270.90
320_R323_K0.7260.90
168_S212_Q0.7240.90
360_L364_Y0.7240.90
192_V380_G0.7240.90
283_V291_V0.7220.90
434_E437_D0.7220.90
163_T219_R0.7210.90
149_A158_I0.7200.90
78_V140_T0.7190.90
269_I338_A0.7160.89
108_S330_S0.7160.89
312_L315_R0.7150.89
150_S207_A0.7140.89
388_I443_L0.7130.89
122_I264_A0.7130.89
365_A439_L0.7110.89
390_L399_K0.7110.89
100_Y104_Q0.7080.89
132_N291_V0.7070.89
71_A406_M0.7070.89
192_V222_P0.7050.89
164_V185_E0.7030.89
365_A369_A0.7030.89
239_V257_S0.7010.88
293_G299_T0.7010.88
158_I207_A0.7000.88
223_L239_V0.6980.88
163_T193_T0.6980.88
73_F439_L0.6970.88
76_A166_P0.6950.88
160_V169_R0.6950.88
414_L423_M0.6950.88
356_R360_L0.6940.88
300_E304_G0.6930.88
124_E348_K0.6930.88
399_K414_L0.6900.88
176_A181_I0.6860.87
432_T435_E0.6840.87
434_E438_A0.6830.87
71_A431_R0.6830.87
157_K180_Y0.6810.87
406_M435_E0.6810.87
30_A34_E0.6800.87
294_R297_G0.6780.87
195_L199_R0.6730.86
119_Q295_L0.6730.86
189_A194_D0.6720.86
264_A267_F0.6700.86
386_F425_I0.6690.86
239_V260_V0.6690.86
208_A234_K0.6690.86
44_I47_A0.6690.86
106_E109_Q0.6680.86
293_G314_A0.6660.86
88_D92_S0.6590.85
146_A176_A0.6580.85
114_A333_A0.6560.85
391_D421_C0.6540.85
361_K364_Y0.6520.85
100_Y106_E0.6520.85
223_L227_E0.6510.84
109_Q116_F0.6510.84
231_H235_S0.6500.84
430_L435_E0.6480.84
35_N39_K0.6480.84
392_E400_R0.6460.84
173_K177_K0.6460.84
191_G221_E0.6440.84
173_K185_E0.6410.84
293_G315_R0.6380.83
371_K444_G0.6380.83
297_G311_T0.6360.83
108_S321_R0.6340.83
341_V344_T0.6330.83
297_G330_S0.6330.83
248_L356_R0.6330.83
37_K40_K0.6310.83
119_Q133_S0.6300.83
378_F387_V0.6270.82
231_H236_M0.6260.82
193_T226_I0.6230.82
135_M281_F0.6210.82
29_F33_P0.6200.82
348_K351_V0.6200.82
263_D280_F0.6170.81
374_L390_L0.6160.81
248_L355_A0.6150.81
128_M282_A0.6150.81
241_A260_V0.6130.81
431_R436_I0.6100.80
143_A208_A0.6080.80
366_K386_F0.6070.80
219_R378_F0.6050.80
196_D200_Q0.6050.80
115_I336_A0.6040.80
293_G323_K0.6020.80
162_K183_V0.6010.79
114_A336_A0.6010.79
153_T207_A0.6010.79
161_S215_N0.6000.79
348_K352_K0.5980.79
247_G355_A0.5980.79
122_I132_N0.5940.79
295_L315_R0.5930.79
290_K317_Q0.5920.78
100_Y297_G0.5920.78
263_D279_G0.5910.78
206_T229_I0.5900.78
244_L342_A0.5900.78
125_L243_P0.5900.78
368_E372_A0.5880.78
310_L315_R0.5860.78
289_R316_E0.5840.78
295_L310_L0.5830.77
306_R310_L0.5810.77
246_L255_F0.5810.77
160_V210_I0.5800.77
87_V91_I0.5800.77
365_A425_I0.5790.77
367_Q371_K0.5740.76
32_I39_K0.5730.76
293_G316_E0.5730.76
259_I290_K0.5730.76
200_Q203_C0.5710.76
127_G253_G0.5710.76
217_F387_V0.5680.76
400_R404_K0.5680.76
236_M287_L0.5660.75
293_G312_L0.5660.75
249_L352_K0.5650.75
244_L247_G0.5640.75
155_K204_E0.5630.75
220_I359_L0.5630.75
32_I38_Y0.5610.75
56_E105_P0.5610.75
148_L259_I0.5610.75
363_N366_K0.5600.75
106_E297_G0.5600.75
386_F427_V0.5590.74
369_A372_A0.5590.74
109_Q113_Q0.5580.74
145_A293_G0.5580.74
158_I238_I0.5540.74
168_S210_I0.5540.74
427_V430_L0.5540.74
269_I339_A0.5540.74
391_D420_D0.5530.74
312_L316_E0.5530.74
192_V219_R0.5530.74
427_V436_I0.5520.74
211_V226_I0.5520.74
76_A79_Y0.5500.73
135_M279_G0.5500.73
413_G420_D0.5490.73
300_E306_R0.5490.73
308_F312_L0.5480.73
293_G324_A0.5480.73
29_F34_E0.5480.73
269_I272_A0.5480.73
178_G207_A0.5480.73
90_V93_R0.5470.73
55_R82_Y0.5460.73
128_M209_V0.5450.73
103_Y297_G0.5440.72
244_L267_F0.5440.72
103_Y323_K0.5430.72
201_T229_I0.5420.72
128_M238_I0.5420.72
191_G219_R0.5410.72
215_N387_V0.5400.72
246_L250_T0.5390.72
393_P420_D0.5390.72
425_I443_L0.5380.72
246_L252_P0.5380.72
393_P421_C0.5370.71
155_K233_G0.5370.71
364_Y368_E0.5370.71
40_K43_Q0.5360.71
106_E112_L0.5360.71
358_N362_A0.5350.71
217_F378_F0.5350.71
161_S221_E0.5340.71
96_F114_A0.5340.71
106_E299_T0.5340.71
257_S260_V0.5340.71
415_T421_C0.5340.71
267_F358_N0.5310.71
243_P263_D0.5310.71
162_K217_F0.5300.71
29_F39_K0.5280.70
298_Q308_F0.5270.70
135_M328_I0.5270.70
332_Q335_N0.5250.70
106_E321_R0.5250.70
298_Q301_D0.5240.70
76_A426_A0.5230.70
438_A441_Q0.5210.69
119_Q330_S0.5210.69
154_K204_E0.5190.69
397_V443_L0.5180.69
346_L351_V0.5180.69
31_D402_L0.5170.69
364_Y440_I0.5170.69
289_R315_R0.5150.68
261_V337_L0.5150.68
266_P384_N0.5130.68
116_F120_T0.5120.68
139_G168_S0.5110.68
440_I443_L0.5100.68
91_I97_Y0.5100.68
150_S153_T0.5090.67
349_N352_K0.5090.67
217_F415_T0.5090.67
202_V230_A0.5070.67
223_L237_F0.5060.67
374_L402_L0.5060.67
321_R324_A0.5050.67
92_S97_Y0.5050.67
118_F131_A0.5050.67
51_T54_T0.5040.67
255_F260_V0.5040.67
180_Y205_N0.5030.67
293_G310_L0.5030.67
299_T307_G0.5020.66
121_M340_S0.5010.66
146_A208_A0.5000.66
155_K206_T0.5000.66
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4lhdA 2 0.9554 100 0.463 Contact Map
1wyuA 2 0.9732 100 0.582 Contact Map
1wyuB 2 0.942 100 0.677 Contact Map
3mc6A 2 0.8281 100 0.763 Contact Map
3wcnA 2 0.8996 100 0.775 Contact Map
3hl2A 3 0.8527 100 0.803 Contact Map
3bc8A 3 0.8304 100 0.812 Contact Map
2z67A 4 0.8571 100 0.812 Contact Map
4obuE 2 0.8951 100 0.812 Contact Map
2jisA 2 0.9174 100 0.819 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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