GREMLIN Database
SODM - Superoxide dismutase [Mn]
UniProt: P54375 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 202 (189)
Sequences: 4187 (2356)
Seq/√Len: 171.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
33_N37_T4.0751.00
177_R180_D2.9811.00
102_A106_N2.5761.00
114_K117_E2.5561.00
22_E175_Q2.4541.00
193_E196_R2.4531.00
123_A132_A2.4241.00
137_N142_E2.4221.00
38_N41_K2.3021.00
21_K25_T2.2441.00
193_E197_L2.2311.00
101_L195_A2.2031.00
163_L182_I2.1591.00
18_H187_N2.1121.00
117_E121_A2.0891.00
103_E106_N1.9731.00
89_L185_F1.9311.00
108_V140_K1.9101.00
126_R145_S1.9051.00
120_A183_S1.8871.00
87_T193_E1.8821.00
104_E107_S1.8551.00
12_Y29_T1.8461.00
114_K118_Q1.8131.00
20_D173_N1.8041.00
180_D183_S1.7991.00
104_E198_Y1.7711.00
161_L194_V1.7481.00
19_I85_F1.7461.00
36_V79_H1.7251.00
123_A163_L1.7251.00
123_A182_I1.7041.00
135_V144_T1.6631.00
121_A125_G1.6281.00
195_A199_S1.6191.00
4_E7_E1.6061.00
39_L76_G1.5901.00
118_Q121_A1.5771.00
104_E108_V1.5641.00
41_K44_E1.5631.00
52_K60_D1.5521.00
37_T41_K1.5471.00
115_F119_F1.5311.00
13_D21_K1.5161.00
100_A199_S1.5141.00
6_P83_K1.4931.00
172_L175_Q1.4651.00
163_L185_F1.4281.00
124_A179_P1.4171.00
79_H83_K1.4021.00
53_S56_E1.4011.00
88_L194_V1.3901.00
90_S93_G1.3831.00
32_H86_W1.3681.00
120_A124_A1.3651.00
174_Y184_A1.3511.00
124_A182_I1.3471.00
135_V142_E1.3251.00
24_M85_F1.3041.00
133_W146_T1.3021.00
43_V47_T1.3021.00
45_G50_A1.3001.00
136_V198_Y1.2811.00
120_A182_I1.2801.00
100_A103_E1.2781.00
22_E25_T1.2501.00
11_A14_A1.2331.00
88_L193_E1.2301.00
38_N75_N1.2241.00
87_T197_L1.2031.00
26_I175_Q1.2031.00
12_Y25_T1.1811.00
120_A186_W1.1811.00
96_E113_D1.1801.00
189_V194_V1.1711.00
25_T29_T1.1671.00
47_T50_A1.1541.00
39_L72_V1.1531.00
142_E157_K1.1521.00
186_W189_V1.1501.00
5_L28_H1.1401.00
132_A145_S1.1391.00
122_A132_A1.1301.00
192_D195_A1.1271.00
12_Y28_H1.1181.00
111_S114_K1.1171.00
160_I194_V1.1161.00
165_V178_R1.1151.00
9_P87_T1.1071.00
77_G149_Q1.1001.00
126_R132_A1.0981.00
119_F163_L1.0891.00
170_Y178_R1.0871.00
112_F115_F1.0851.00
80_A151_S1.0831.00
122_A143_I1.0761.00
83_K87_T1.0691.00
3_Y43_V1.0631.00
85_F181_Y1.0631.00
137_N157_K1.0621.00
96_E102_A1.0601.00
80_A84_L1.0520.99
3_Y39_L1.0460.99
190_N193_E1.0390.99
73_R150_D1.0340.99
117_E183_S1.0280.99
100_A195_A1.0090.99
34_T38_N0.9980.99
31_H171_Y0.9980.99
98_T195_A0.9830.99
88_L197_L0.9800.99
185_F189_V0.9750.99
121_A124_A0.9720.99
103_E107_S0.9690.99
105_I115_F0.9660.99
96_E106_N0.9640.99
115_F143_I0.9630.99
113_D116_K0.9520.99
122_A145_S0.9510.99
84_L193_E0.9490.99
180_D184_A0.9450.99
161_L189_V0.9370.99
184_A187_N0.9370.99
119_F185_F0.9340.99
23_T173_N0.9210.99
12_Y21_K0.9010.98
20_D23_T0.9010.98
61_L69_R0.8960.98
89_L188_V0.8920.98
135_V157_K0.8880.98
48_A52_K0.8750.98
136_V139_G0.8720.98
32_H83_K0.8670.98
36_V40_N0.8650.98
104_E136_V0.8630.98
144_T157_K0.8570.98
105_I112_F0.8510.98
78_G149_Q0.8460.98
54_V80_A0.8430.98
99_G103_E0.8400.97
192_D196_R0.8400.97
90_S94_G0.8360.97
22_E173_N0.8220.97
101_L198_Y0.8220.97
34_T37_T0.8170.97
101_L194_V0.8150.97
30_K177_R0.8070.97
52_K56_E0.8060.97
85_F163_L0.7990.97
112_F116_K0.7980.97
74_N127_F0.7930.96
126_R147_P0.7910.96
90_S192_D0.7900.96
118_Q122_A0.7860.96
80_A153_L0.7850.96
6_P32_H0.7840.96
49_L52_K0.7840.96
101_L105_I0.7750.96
137_N140_K0.7740.96
22_E26_I0.7650.96
29_T33_N0.7520.95
13_D16_E0.7490.95
10_Y89_L0.7420.95
44_E50_A0.7340.95
79_H86_W0.7320.94
92_N95_G0.7300.94
108_V141_L0.7280.94
70_T73_R0.7260.94
96_E116_K0.7250.94
132_A163_L0.7240.94
3_Y57_L0.7230.94
90_S190_N0.7180.94
5_L32_H0.7110.94
136_V158_T0.7110.94
107_S140_K0.7040.93
12_Y24_M0.7040.93
113_D117_E0.7010.93
34_T124_A0.6970.93
82_H164_D0.6970.93
16_E21_K0.6960.93
39_L54_V0.6910.93
136_V160_I0.6860.92
116_K120_A0.6840.92
32_H79_H0.6800.92
58_V61_L0.6790.92
84_L197_L0.6740.92
151_S154_S0.6710.92
97_P102_A0.6690.91
133_W162_G0.6660.91
129_S148_N0.6660.91
116_K183_S0.6660.91
41_K45_G0.6630.91
18_H184_A0.6580.91
30_K176_N0.6580.91
81_N133_W0.6560.91
102_A112_F0.6550.91
19_I181_Y0.6530.90
109_F118_Q0.6530.90
30_K33_N0.6520.90
45_G48_A0.6410.90
106_N111_S0.6380.89
7_E11_A0.6370.89
56_E60_D0.6370.89
27_H82_H0.6360.89
33_N36_V0.6340.89
174_Y180_D0.6330.89
38_N71_A0.6270.89
36_V83_K0.6260.88
130_G165_V0.6210.88
116_K186_W0.6200.88
116_K187_N0.6200.88
24_M181_Y0.6160.88
99_G102_A0.6110.87
77_G81_N0.6090.87
191_W194_V0.6030.87
5_L33_N0.6030.87
61_L154_S0.6010.86
162_G181_Y0.5960.86
35_Y78_G0.5950.86
73_R149_Q0.5940.86
19_I89_L0.5930.86
19_I24_M0.5920.86
144_T154_S0.5850.85
98_T192_D0.5800.84
55_E80_A0.5800.84
149_Q162_G0.5790.84
55_E59_A0.5780.84
49_L69_R0.5770.84
90_S95_G0.5760.84
108_V142_E0.5750.84
18_H185_F0.5740.84
27_H164_D0.5740.84
164_D168_H0.5670.83
125_G145_S0.5660.83
122_A126_R0.5660.83
118_Q143_I0.5640.83
109_F141_L0.5620.83
179_P183_S0.5620.83
73_R78_G0.5620.83
82_H168_H0.5580.82
98_T102_A0.5570.82
126_R143_I0.5560.82
18_H188_V0.5550.82
132_A165_V0.5540.82
39_L43_V0.5540.82
99_G112_F0.5540.82
134_L141_L0.5510.81
9_P190_N0.5510.81
43_V57_L0.5480.81
26_I172_L0.5460.81
5_L36_V0.5400.80
79_H85_F0.5400.80
42_A72_V0.5360.79
69_R155_E0.5340.79
153_L159_P0.5310.79
7_E29_T0.5300.79
27_H168_H0.5290.79
144_T155_E0.5290.79
61_L73_R0.5240.78
3_Y80_A0.5240.78
54_V61_L0.5230.78
31_H176_N0.5230.78
85_F162_G0.5210.78
81_N149_Q0.5200.77
57_L61_L0.5200.77
171_Y176_N0.5160.77
196_R199_S0.5150.77
150_D155_E0.5110.76
47_T51_N0.5110.76
88_L160_I0.5100.76
112_F186_W0.5090.76
26_I177_R0.5090.76
26_I30_K0.5080.76
119_F143_I0.5060.76
123_A165_V0.5060.76
20_D26_I0.5060.76
182_I186_W0.5050.75
98_T101_L0.5040.75
60_D69_R0.5020.75
18_H173_N0.5020.75
3_Y40_N0.5010.75
95_G98_T0.5000.75
22_E172_L0.5000.75
26_I29_T0.5000.75
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2rcvA 2 0.9901 100 -0.021 Contact Map
1gv3A 2 0.995 100 -0.018 Contact Map
1mngA 3 0.9703 100 -0.013 Contact Map
3kkyA 2 0.9802 100 -0.011 Contact Map
3tjtA 2 0.9901 100 -0.01 Contact Map
1xreA 2 0.995 100 -0.007 Contact Map
2cw2A 2 0.9604 100 -0 Contact Map
5a9gA 2 0.9752 100 0.006 Contact Map
3tqjA 2 0.9455 100 0.008 Contact Map
2awpA 2 0.9604 100 0.008 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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