GREMLIN Database
AROE - Shikimate dehydrogenase (NADP(+))
UniProt: P54374 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 280 (261)
Sequences: 6338 (4663)
Seq/√Len: 288.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
225_Q233_S4.5671.00
10_N38_K4.0731.00
77_D99_Y3.0661.00
86_V98_G2.9241.00
255_Q261_E2.8181.00
75_H97_V2.8001.00
75_H95_K2.7861.00
104_E252_L2.7681.00
216_V228_L2.6251.00
122_S146_K2.4951.00
252_L255_Q2.4811.00
67_V133_R2.4771.00
91_R96_L2.3501.00
20_I250_A2.1941.00
124_L185_Y2.1741.00
73_L98_G2.1451.00
73_L89_V2.1161.00
225_Q230_K2.0991.00
135_I219_I2.0891.00
227_A231_E2.0791.00
125_M136_F2.0331.00
90_R256_L2.0191.00
80_A86_V1.9971.00
106_F217_C1.9831.00
68_S71_D1.9281.00
111_M142_N1.9061.00
60_N253_S1.8901.00
92_E97_V1.8771.00
229_L239_T1.8641.00
4_L35_H1.8581.00
108_K111_M1.8491.00
133_R163_A1.8381.00
59_I89_V1.8271.00
216_V232_A1.8061.00
10_N41_E1.7971.00
123_F144_P1.7661.00
10_N40_E1.7501.00
154_L158_K1.7451.00
78_E81_K1.7351.00
46_D49_K1.7321.00
70_M76_I1.7281.00
6_G37_F1.7221.00
9_G62_T1.7201.00
106_F135_I1.6911.00
69_I89_V1.6901.00
69_I73_L1.6881.00
158_K162_E1.6671.00
122_S186_D1.6251.00
43_D46_D1.6241.00
99_Y256_L1.6011.00
211_A214_A1.5971.00
25_L32_G1.5961.00
5_Y32_G1.5841.00
8_I59_I1.5571.00
77_D97_V1.5571.00
65_H68_S1.5491.00
108_K248_E1.5441.00
73_L86_V1.5271.00
89_V96_L1.5201.00
76_I81_K1.4961.00
5_Y25_L1.4951.00
128_A151_N1.4941.00
131_A219_I1.4751.00
92_E95_K1.4731.00
146_K171_E1.4681.00
88_T101_T1.4671.00
34_Y60_N1.4571.00
124_L150_C1.4481.00
148_D185_Y1.4381.00
5_Y57_Q1.4281.00
109_S217_C1.4271.00
45_E49_K1.4231.00
83_L103_G1.4091.00
122_S148_D1.4081.00
79_S99_Y1.3651.00
50_G53_A1.3631.00
74_D95_K1.3541.00
51_I56_V1.3511.00
11_P14_H1.3441.00
109_S244_G1.3351.00
153_T156_K1.3271.00
7_V36_A1.3261.00
10_N65_H1.3251.00
63_V193_S1.3131.00
230_K234_Q1.3041.00
79_S141_R1.3031.00
23_A27_D1.2941.00
39_V47_A1.2921.00
4_L33_H1.2821.00
7_V12_I1.2781.00
82_V141_R1.2481.00
40_E43_D1.2481.00
13_G38_K1.2401.00
136_F164_T1.2271.00
214_A237_L1.2191.00
132_A191_T1.2091.00
52_R91_R1.2071.00
233_S239_T1.2021.00
151_N193_S1.1911.00
52_R96_L1.1911.00
90_R99_Y1.1881.00
137_T141_R1.1861.00
6_G59_I1.1821.00
121_L186_D1.1801.00
215_V240_L1.1791.00
123_F139_I1.1701.00
76_I98_G1.1671.00
248_E264_I1.1641.00
103_G138_T1.1611.00
254_F258_T1.1591.00
75_H92_E1.1531.00
112_K248_E1.1471.00
154_L174_S1.1331.00
76_I80_A1.1211.00
144_P147_F1.1151.00
51_I59_I1.1121.00
195_G220_V1.1111.00
139_I189_I1.1051.00
262_P267_M1.0921.00
148_D173_L1.0841.00
30_L258_T1.0831.00
8_I61_V1.0781.00
25_L254_F1.0711.00
106_F189_I1.0611.00
231_E234_Q1.0591.00
27_D266_K1.0551.00
232_A237_L1.0551.00
44_L69_I1.0531.00
19_D23_A1.0391.00
76_I86_V1.0341.00
82_V137_T1.0271.00
22_N33_H1.0251.00
104_E108_K1.0131.00
45_E72_Y1.0091.00
23_A26_K1.0091.00
231_E235_K1.0051.00
69_I86_V0.9951.00
42_N68_S0.9891.00
12_I38_K0.9871.00
37_F56_V0.9801.00
159_R163_A0.9731.00
251_A264_I0.9691.00
265_E269_S0.9681.00
191_T219_I0.9661.00
70_M73_L0.9581.00
12_I15_S0.9521.00
44_L72_Y0.9481.00
263_N266_K0.9471.00
113_V240_L0.9461.00
203_V231_E0.9461.00
227_A230_K0.9391.00
107_V111_M0.9391.00
39_V65_H0.9381.00
50_G54_L0.9341.00
9_G12_I0.9311.00
116_K215_V0.9271.00
52_R74_D0.9261.00
125_M132_A0.9261.00
247_V251_A0.9171.00
108_K252_L0.9111.00
28_L260_Q0.9061.00
73_L76_I0.9041.00
16_M19_D0.9031.00
136_F147_F0.8971.00
41_E68_S0.8971.00
192_T195_G0.8961.00
52_R55_G0.8951.00
199_N202_D0.8951.00
266_K270_I0.8911.00
45_E68_S0.8881.00
90_R97_V0.8871.00
154_L172_V0.8851.00
244_G248_E0.8821.00
161_T165_P0.8811.00
22_N26_K0.8721.00
107_V138_T0.8661.00
130_G134_A0.8541.00
109_S248_E0.8501.00
47_A54_L0.8471.00
28_L254_F0.8431.00
128_A149_I0.8401.00
24_S28_L0.8381.00
108_K112_K0.8341.00
67_V156_K0.8311.00
188_I214_A0.8301.00
107_V141_R0.8141.00
78_E82_V0.8141.00
91_R94_D0.8111.00
48_V72_Y0.8080.99
61_V65_H0.8020.99
220_V226_T0.7970.99
13_G36_A0.7970.99
85_A100_N0.7940.99
23_A266_K0.7920.99
206_S209_R0.7900.99
20_I246_F0.7890.99
201_D227_A0.7890.99
151_N157_A0.7880.99
122_S184_Q0.7880.99
131_A191_T0.7880.99
116_K187_V0.7860.99
47_A50_G0.7860.99
5_Y258_T0.7860.99
59_I69_I0.7830.99
105_G245_M0.7780.99
174_S177_E0.7780.99
8_I47_A0.7750.99
161_T170_K0.7750.99
139_I144_P0.7670.99
151_N156_K0.7650.99
24_S254_F0.7650.99
150_C173_L0.7630.99
225_Q229_L0.7610.99
21_H250_A0.7590.99
122_S145_K0.7550.99
30_L254_F0.7550.99
207_L231_E0.7500.99
252_L256_L0.7480.99
75_H81_K0.7450.99
215_V238_K0.7450.99
4_L54_L0.7450.99
73_L96_L0.7430.99
121_L145_K0.7420.99
187_V215_V0.7400.99
198_P227_A0.7390.99
117_P121_L0.7350.99
124_L188_I0.7320.99
198_P201_D0.7310.99
24_S267_M0.7280.99
83_L137_T0.7260.99
156_K159_R0.7240.99
63_V196_M0.7190.99
44_L68_S0.7190.99
207_L235_K0.7140.99
109_S113_V0.7120.99
67_V71_D0.7120.99
126_I192_T0.7110.99
155_E159_R0.7110.99
83_L134_A0.7090.99
126_I175_I0.7090.99
112_K244_G0.7090.99
219_I245_M0.7050.99
150_C175_I0.7050.99
159_R162_E0.7020.99
85_A134_A0.6990.99
37_F47_A0.6990.99
132_A136_F0.6990.99
220_V241_D0.6990.99
59_I91_R0.6980.99
16_M222_N0.6970.99
140_V164_T0.6960.99
8_I39_V0.6960.99
203_V227_A0.6950.98
224_I241_D0.6950.98
48_V69_I0.6930.98
210_A216_V0.6900.98
240_L244_G0.6880.98
118_I121_L0.6880.98
225_Q239_T0.6870.98
27_D263_N0.6860.98
216_V229_L0.6820.98
4_L37_F0.6800.98
49_K52_R0.6770.98
48_V52_R0.6710.98
6_G36_A0.6690.98
211_A237_L0.6670.98
14_H63_V0.6590.98
140_V147_F0.6590.98
190_H228_L0.6590.98
21_H88_T0.6560.98
44_L65_H0.6560.98
136_F149_I0.6540.98
125_M149_I0.6520.98
196_M220_V0.6520.98
213_S237_L0.6500.98
103_G141_R0.6440.98
74_D96_L0.6430.98
107_V142_N0.6390.97
69_I72_Y0.6370.97
146_K169_N0.6340.97
88_T253_S0.6320.97
208_Q235_K0.6320.97
34_Y88_T0.6250.97
83_L100_N0.6250.97
103_G137_T0.6240.97
40_E65_H0.6210.97
23_A270_I0.6200.97
30_L260_Q0.6190.97
103_G107_V0.6180.97
77_D256_L0.6180.97
49_K53_A0.6160.97
266_K269_S0.6130.97
89_V98_G0.6100.97
153_T193_S0.6090.97
78_E141_R0.6090.97
110_L139_I0.6070.96
82_V163_A0.6070.96
23_A267_M0.6060.96
126_I188_I0.6000.96
243_V247_V0.6000.96
252_L261_E0.6000.96
210_A235_K0.5990.96
108_K255_Q0.5990.96
113_V116_K0.5990.96
182_L185_Y0.5970.96
113_V244_G0.5970.96
189_I219_I0.5890.96
188_I216_V0.5890.96
244_G268_R0.5880.96
21_H25_L0.5860.96
112_K268_R0.5850.96
7_V60_N0.5830.96
125_M191_T0.5830.96
124_L182_L0.5820.96
254_F262_P0.5810.95
148_D171_E0.5810.95
263_N267_M0.5810.95
126_I150_C0.5790.95
229_L241_D0.5790.95
132_A151_N0.5790.95
46_D53_A0.5770.95
46_D50_G0.5750.95
255_Q262_P0.5740.95
110_L240_L0.5740.95
190_H220_V0.5730.95
253_S257_W0.5720.95
8_I65_H0.5710.95
22_N35_H0.5680.95
192_T196_M0.5680.95
6_G56_V0.5660.95
109_S240_L0.5640.95
123_F187_V0.5640.95
45_E71_D0.5630.95
105_G109_S0.5580.94
118_I144_P0.5550.94
197_Y222_N0.5540.94
128_A153_T0.5530.94
7_V15_S0.5520.94
137_T164_T0.5510.94
161_T172_V0.5500.94
10_N14_H0.5480.94
33_H36_A0.5470.94
225_Q241_D0.5460.94
79_S103_G0.5460.94
194_V220_V0.5450.94
113_V217_C0.5450.94
120_E145_K0.5430.94
122_S185_Y0.5420.94
210_A231_E0.5410.93
19_D36_A0.5400.93
128_A156_K0.5390.93
203_V207_L0.5390.93
185_Y188_I0.5380.93
119_S143_T0.5380.93
113_V238_K0.5370.93
103_G135_I0.5360.93
12_I62_T0.5350.93
70_M80_A0.5340.93
82_V140_V0.5340.93
224_I243_V0.5340.93
8_I44_L0.5340.93
170_K175_I0.5320.93
155_E158_K0.5310.93
24_S262_P0.5310.93
55_G91_R0.5300.93
125_M139_I0.5290.93
79_S137_T0.5270.93
136_F160_L0.5270.93
138_T142_N0.5270.93
196_M199_N0.5250.92
172_V175_I0.5240.92
123_F189_I0.5220.92
4_L55_G0.5210.92
210_A237_L0.5200.92
148_D181_R0.5200.92
173_L181_R0.5190.92
11_P65_H0.5180.92
63_V220_V0.5170.92
131_A134_A0.5170.92
56_V59_I0.5090.91
57_Q92_E0.5090.91
150_C178_A0.5080.91
70_M86_V0.5070.91
157_A161_T0.5070.91
116_K121_L0.5060.91
135_I189_I0.5050.91
251_A267_M0.5050.91
162_E166_S0.5050.91
39_V50_G0.5020.91
205_L209_R0.5010.91
17_S221_Y0.5000.91
264_I268_R0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1npyA 1 0.9393 100 0.212 Contact Map
4xijA 1 0.925 100 0.222 Contact Map
3t4eA 2 0.975 100 0.226 Contact Map
2o7sA 2 0.9357 100 0.251 Contact Map
3tnlA 2 0.9679 100 0.254 Contact Map
3pwzA 1 0.9607 100 0.265 Contact Map
3phhA 1 0.8964 100 0.269 Contact Map
3jyoA 2 0.9714 100 0.271 Contact Map
3fbtA 2 0.9679 100 0.28 Contact Map
2d5cA 2 0.9393 100 0.294 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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