GREMLIN Database
XKDS - Phage-like element PBSX protein XkdS
UniProt: P54338 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 141 (121)
Sequences: 355 (319)
Seq/√Len: 29.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
107_T125_E4.7581.00
88_E91_R4.2421.00
45_I49_V3.3421.00
109_F122_F3.2251.00
45_I126_T2.9981.00
47_Q100_D2.6100.99
43_E46_R2.3490.99
52_A96_A2.3370.99
51_I67_V2.2210.98
53_L129_G2.0740.97
51_I63_Y2.0670.97
22_S45_I2.0640.97
89_I92_L1.9950.97
51_I55_T1.9190.96
59_A64_S1.7370.93
24_T47_Q1.7190.92
88_E95_E1.6850.92
93_I109_F1.6730.91
48_F100_D1.6560.91
90_P111_I1.6420.91
11_D14_V1.6120.90
59_A72_Q1.6100.90
49_V103_I1.5580.88
27_I51_I1.4960.86
21_T102_R1.4870.86
49_V124_V1.4760.85
27_I47_Q1.4320.83
74_V92_L1.4290.83
82_D113_K1.4250.83
24_T102_R1.3860.81
57_R70_E1.3770.81
26_K43_E1.2910.76
56_E69_N1.2780.76
69_N93_I1.2780.76
24_T100_D1.2720.75
22_S100_D1.2680.75
20_E102_R1.1960.71
45_I103_I1.1790.69
27_I34_I1.1790.69
96_A129_G1.1770.69
86_K111_I1.1760.69
19_I127_D1.1540.68
71_L89_I1.1390.67
62_I99_Y1.1250.66
89_I118_F1.1220.66
112_E119_H1.1140.65
45_I120_V1.0980.64
101_D124_V1.0890.63
27_I32_G1.0580.61
108_D122_F1.0430.60
108_D121_S1.0400.60
104_S127_D1.0050.57
124_V131_L1.0040.57
21_T24_T0.9940.56
27_I100_D0.9900.56
41_G129_G0.9760.55
22_S34_I0.9720.54
22_S102_R0.9690.54
108_D123_V0.9620.54
41_G115_G0.9600.53
12_I15_E0.9350.51
84_Y93_I0.9300.51
40_T102_R0.9270.51
105_A125_E0.9160.50
48_F99_Y0.9020.49
86_K118_F0.9010.49
28_D75_L0.8930.48
40_T47_Q0.8930.48
69_N96_A0.8740.47
14_V112_E0.8710.46
71_L74_V0.8670.46
24_T27_I0.8600.46
56_E72_Q0.8570.45
37_E96_A0.8510.45
45_I53_L0.8460.45
46_R124_V0.8440.44
69_N75_L0.8430.44
73_D134_E0.8380.44
111_I118_F0.8350.44
94_E105_A0.8340.44
93_I98_V0.8340.44
28_D31_N0.8240.43
18_V104_S0.8240.43
48_F101_D0.8220.43
86_K113_K0.8210.43
16_S41_G0.8200.43
51_I91_R0.8140.42
62_I101_D0.8130.42
40_T100_D0.8050.41
20_E127_D0.8010.41
23_Q38_L0.8000.41
49_V113_K0.7980.41
16_S107_T0.7920.40
34_I100_D0.7890.40
58_Y70_E0.7820.40
114_Q117_A0.7800.40
70_E99_Y0.7770.39
93_I120_V0.7750.39
47_Q102_R0.7720.39
42_L46_R0.7670.39
56_E92_L0.7620.38
26_K37_E0.7530.38
76_T92_L0.7520.37
91_R95_E0.7470.37
89_I105_A0.7440.37
17_E110_E0.7410.37
34_I48_F0.7410.37
70_E92_L0.7300.36
53_L83_A0.7300.36
23_Q26_K0.7270.36
86_K116_D0.7150.35
28_D33_R0.7130.35
22_S126_T0.7100.34
60_Y90_P0.7100.34
41_G86_K0.7020.34
103_I113_K0.7010.34
130_T133_I0.7010.34
50_Y54_Q0.6970.34
114_Q119_H0.6950.33
70_E103_I0.6940.33
47_Q96_A0.6940.33
52_A69_N0.6920.33
38_L69_N0.6870.33
61_S99_Y0.6870.33
61_S73_D0.6840.33
76_T85_K0.6820.32
57_R65_H0.6820.32
22_S40_T0.6780.32
34_I83_A0.6730.32
28_D57_R0.6700.32
94_E109_F0.6680.32
57_R68_G0.6680.32
55_T67_V0.6670.31
69_N92_L0.6660.31
123_V132_E0.6640.31
31_N125_E0.6620.31
27_I82_D0.6600.31
42_L49_V0.6520.30
62_I84_Y0.6470.30
24_T40_T0.6460.30
37_E102_R0.6460.30
14_V17_E0.6430.30
81_T131_L0.6420.30
44_A64_S0.6420.30
112_E121_S0.6390.30
24_T101_D0.6360.29
22_S48_F0.6320.29
56_E84_Y0.6280.29
21_T49_V0.6230.29
24_T48_F0.6190.28
15_E18_V0.6080.28
103_I106_V0.6030.27
66_N70_E0.5990.27
124_V130_T0.5960.27
13_E125_E0.5860.26
48_F98_V0.5850.26
87_M118_F0.5790.26
58_Y65_H0.5640.25
52_A99_Y0.5630.25
29_F90_P0.5610.25
74_V84_Y0.5550.24
70_E91_R0.5540.24
108_D119_H0.5510.24
42_L87_M0.5490.24
33_R58_Y0.5490.24
16_S112_E0.5460.24
74_V88_E0.5450.24
73_D92_L0.5430.24
93_I122_F0.5390.24
60_Y118_F0.5370.23
67_V88_E0.5350.23
49_V81_T0.5350.23
85_K119_H0.5330.23
51_I116_D0.5270.23
28_D101_D0.5260.23
90_P94_E0.5240.23
81_T126_T0.5110.22
55_T133_I0.5080.22
21_T100_D0.5050.22
71_L96_A0.5030.22
32_G123_V0.5010.21
115_G121_S0.5000.21
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4hrzA 2 0.8085 99 0.756 Contact Map
2ia7A 1 0.7163 98.8 0.773 Contact Map
2e7gA 1 0.4965 36 0.933 Contact Map
1josA 1 0.4113 16.9 0.943 Contact Map
3w61A 2 0.3972 14.6 0.944 Contact Map
2zztA 2 0.4043 13.8 0.945 Contact Map
2dyjA 1 0.3972 12.1 0.946 Contact Map
3bypA 2 0.4043 11.7 0.947 Contact Map
2kzfA 1 0.4468 11.2 0.947 Contact Map
1v4eA 3 0.6596 7.8 0.951 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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