GREMLIN Database
XKDK - Phage-like element PBSX protein XkdK
UniProt: P54331 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 466 (416)
Sequences: 1046 (908)
Seq/√Len: 44.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
375_V450_V4.8941.00
435_I439_E4.8851.00
433_I436_S4.8801.00
433_I439_E4.5801.00
434_T438_N3.7311.00
434_T439_E3.7151.00
407_V444_F3.6601.00
38_A211_F3.4101.00
433_I438_N3.2661.00
238_A266_I3.1211.00
436_S439_E3.0641.00
435_I438_N2.9541.00
237_F254_G2.8631.00
164_T168_D2.8301.00
265_G373_D2.7581.00
40_P89_Y2.6691.00
134_D148_T2.5591.00
165_G168_D2.4831.00
379_L411_I2.4471.00
375_V418_L2.4111.00
289_W308_Y2.4101.00
456_A459_F2.3631.00
400_S422_G2.3481.00
440_D454_D2.3461.00
255_V287_T2.3201.00
241_I254_G2.3001.00
286_A345_V2.2931.00
39_L86_V2.2481.00
374_A414_Y2.2321.00
349_I457_E2.2121.00
292_G296_G2.2101.00
372_L450_V2.2081.00
126_N134_D2.1561.00
240_F252_V2.1531.00
14_R324_V2.1121.00
426_G451_Q2.0800.99
216_E243_R2.0550.99
208_Y237_F2.0550.99
21_F369_V1.9970.99
308_Y311_A1.9940.99
59_D62_K1.9800.99
224_A287_T1.9770.99
419_Q424_I1.9550.99
94_G97_A1.9500.99
268_N351_S1.9280.99
234_K256_T1.9230.99
253_Q366_N1.8770.99
288_A292_G1.8690.99
93_E97_A1.8620.99
52_V64_V1.8570.99
76_L86_V1.8340.99
47_E50_T1.8320.99
253_Q290_V1.8290.99
274_L280_E1.8210.99
164_T167_G1.8160.99
305_F344_S1.7940.98
158_N164_T1.7920.98
151_K154_E1.7860.98
14_R346_E1.7690.98
211_F214_A1.7550.98
257_A284_D1.7540.98
292_G298_T1.7390.98
43_S72_S1.7380.98
161_V164_T1.7300.98
93_E101_I1.7260.98
399_A404_L1.6940.98
45_W115_K1.6930.98
414_Y418_L1.6910.98
415_M424_I1.6870.98
327_L347_K1.6720.97
198_G201_K1.6640.97
113_G117_N1.6600.97
289_W293_A1.6340.97
427_F432_D1.6160.97
428_D431_E1.6120.97
151_K156_T1.6100.97
289_W345_V1.6070.97
149_V152_A1.5980.97
129_D132_S1.5960.97
150_K154_E1.5940.97
14_R320_H1.5940.97
398_P455_A1.5860.96
242_K263_Y1.5760.96
388_K407_V1.5620.96
365_K442_D1.5500.96
38_A89_Y1.5490.96
113_G198_G1.5420.96
53_S85_T1.5180.95
137_T145_D1.5150.95
45_W111_Y1.4990.95
94_G99_A1.4810.95
95_V98_S1.4760.95
405_Q408_K1.4650.94
149_V154_E1.4640.94
289_W292_G1.4590.94
37_V79_A1.4550.94
238_A242_K1.4550.94
113_G116_G1.4510.94
36_T85_T1.4450.94
25_A28_R1.4400.94
424_I450_V1.4330.94
109_A116_G1.4310.94
215_A223_I1.4260.94
144_V147_Q1.4250.94
378_D414_Y1.4160.93
46_G90_R1.4010.93
327_L346_E1.3970.93
23_T362_K1.3910.93
47_E63_K1.3910.93
204_V207_D1.3840.93
137_T144_V1.3650.92
240_F244_L1.3610.92
205_N233_L1.3600.92
161_V165_G1.3600.92
67_S70_D1.3580.92
320_H324_V1.3520.92
447_D462_N1.3390.91
93_E99_A1.3370.91
429_S432_D1.3360.91
319_D322_T1.3350.91
223_I240_F1.3330.91
124_N136_T1.3310.91
38_A215_A1.3280.91
368_I452_P1.3270.91
109_A113_G1.3260.91
326_R333_L1.3210.91
434_T437_M1.3180.91
327_L349_I1.3160.91
94_G98_S1.2840.89
21_F376_N1.2830.89
415_M450_V1.2790.89
347_K457_E1.2760.89
253_Q267_I1.2760.89
300_N423_G1.2750.89
163_F167_G1.2620.89
31_L374_A1.2600.89
150_K153_E1.2550.88
138_Y143_E1.2540.88
107_A121_I1.2400.88
160_Y164_T1.2270.87
427_F431_E1.2250.87
288_A294_S1.2170.87
451_Q455_A1.1980.86
245_R373_D1.1930.86
116_G119_I1.1930.86
192_G204_V1.1800.85
294_S370_R1.1660.84
350_N369_V1.1640.84
147_Q158_N1.1640.84
135_V145_D1.1520.84
145_D149_V1.1520.84
136_T143_E1.1460.83
210_D213_A1.1420.83
327_L335_T1.1420.83
162_T166_T1.1400.83
412_T416_T1.1330.83
195_L198_G1.1310.82
125_Q129_D1.1250.82
446_I461_F1.1190.82
303_L366_N1.1180.82
97_A100_D1.1120.81
21_F337_D1.1110.81
389_S426_G1.1100.81
363_F372_L1.1060.81
35_G84_K1.1050.81
46_G64_V1.1030.81
244_L252_V1.1020.81
270_T318_L1.1010.81
29_V382_E1.1010.81
126_N129_D1.0990.81
389_S396_D1.0960.80
313_D317_R1.0890.80
111_Y115_K1.0840.80
415_M448_L1.0840.80
223_I254_G1.0820.80
105_V152_A1.0780.79
39_L76_L1.0780.79
139_M142_S1.0670.79
150_K158_N1.0600.78
114_T200_D1.0590.78
76_L88_M1.0580.78
137_T147_Q1.0530.78
20_N462_N1.0530.78
97_A101_I1.0430.77
305_F365_K1.0390.77
41_V72_S1.0350.76
257_A294_S1.0340.76
13_E324_V1.0290.76
438_N445_L1.0260.76
379_L461_F1.0240.76
234_K254_G1.0210.75
136_T146_K1.0210.75
365_K457_E1.0190.75
46_G113_G1.0190.75
49_K89_Y1.0140.75
188_N194_R1.0110.75
79_A288_A1.0110.75
275_L281_V1.0020.74
347_K365_K0.9990.74
347_K442_D0.9970.74
38_A223_I0.9950.74
438_N442_D0.9920.73
211_F215_A0.9880.73
17_I452_P0.9880.73
37_V291_A0.9870.73
124_N127_V0.9850.73
375_V415_M0.9790.72
368_I454_D0.9760.72
442_D455_A0.9760.72
123_I126_N0.9750.72
281_V284_D0.9690.72
49_K91_L0.9610.71
294_S347_K0.9610.71
122_R138_Y0.9610.71
325_E329_K0.9540.70
149_V155_L0.9480.70
326_R331_E0.9450.70
103_E108_T0.9400.69
322_T377_N0.9400.69
265_G269_V0.9390.69
132_S150_K0.9380.69
91_L277_D0.9370.69
231_D235_A0.9340.69
187_L191_A0.9320.69
147_Q150_K0.9310.68
105_V110_V0.9250.68
294_S298_T0.9240.68
417_T421_A0.9220.68
216_E244_L0.9170.67
153_E156_T0.9160.67
282_T285_K0.9150.67
13_E328_G0.9130.67
105_V133_F0.9080.67
25_A193_I0.9060.66
107_A138_Y0.9030.66
81_K310_G0.9010.66
118_D187_L0.8990.66
433_I447_D0.8970.66
211_F218_E0.8970.66
280_E315_L0.8960.65
14_R327_L0.8950.65
398_P418_L0.8920.65
145_D158_N0.8910.65
266_I269_V0.8900.65
29_V378_D0.8850.65
365_K454_D0.8830.64
158_N200_D0.8810.64
14_R323_I0.8810.64
195_L200_D0.8800.64
297_A301_Q0.8800.64
47_E90_R0.8790.64
419_Q426_G0.8780.64
80_K83_A0.8750.64
323_I346_E0.8720.63
403_G456_A0.8720.63
290_V366_N0.8700.63
418_L421_A0.8680.63
367_K398_P0.8670.63
291_A422_G0.8660.63
283_P344_S0.8600.62
205_N230_G0.8580.62
283_P334_F0.8570.62
425_T453_V0.8550.62
152_A155_L0.8530.62
206_S210_D0.8520.62
415_M453_V0.8520.62
273_V278_G0.8510.61
48_A112_G0.8500.61
107_A123_I0.8500.61
288_A293_A0.8470.61
147_Q155_L0.8460.61
258_N351_S0.8450.61
139_M143_E0.8420.61
375_V414_Y0.8410.61
110_V166_T0.8380.60
187_L190_S0.8380.60
161_V166_T0.8380.60
135_V143_E0.8380.60
133_F153_E0.8370.60
269_V332_F0.8340.60
46_G109_A0.8300.60
374_A418_L0.8300.60
58_E62_K0.8270.59
154_E158_N0.8230.59
404_L456_A0.8210.59
95_V100_D0.8200.59
327_L333_L0.8180.58
42_A71_P0.8160.58
188_N191_A0.8150.58
225_L237_F0.8140.58
17_I459_F0.8120.58
32_S378_D0.8100.58
74_L78_E0.8080.57
117_N125_Q0.8060.57
117_N198_G0.8040.57
114_T140_D0.8040.57
221_D373_D0.8040.57
152_A164_T0.8010.57
16_G370_R0.7980.57
17_I456_A0.7970.56
418_L423_G0.7960.56
374_A378_D0.7960.56
147_Q152_A0.7960.56
365_K458_K0.7950.56
163_F287_T0.7950.56
299_F414_Y0.7940.56
154_E165_G0.7940.56
222_V253_Q0.7930.56
95_V99_A0.7930.56
267_I366_N0.7920.56
140_D148_T0.7910.56
115_K139_M0.7890.56
193_I209_T0.7890.56
46_G198_G0.7870.55
114_T117_N0.7870.55
294_S297_A0.7870.55
216_E240_F0.7860.55
266_I351_S0.7860.55
336_F343_V0.7800.55
17_I40_P0.7780.55
83_A86_V0.7780.55
379_L415_M0.7770.54
133_F138_Y0.7730.54
14_R305_F0.7730.54
371_V418_L0.7720.54
104_G331_E0.7710.54
226_P330_G0.7690.54
347_K396_D0.7680.54
262_D353_V0.7660.53
407_V456_A0.7650.53
112_G115_K0.7640.53
302_S348_D0.7630.53
398_P456_A0.7630.53
150_K155_L0.7620.53
99_A117_N0.7600.53
127_V132_S0.7560.52
226_P257_A0.7530.52
93_E100_D0.7510.52
222_V290_V0.7510.52
162_T168_D0.7500.52
137_T165_G0.7490.52
379_L414_Y0.7470.52
267_I332_F0.7470.52
145_D150_K0.7450.51
411_I414_Y0.7440.51
184_A187_L0.7430.51
346_E349_I0.7430.51
117_N199_T0.7410.51
211_F217_T0.7400.51
133_F145_D0.7380.51
214_A277_D0.7360.51
89_Y211_F0.7340.50
113_G195_L0.7340.50
74_L279_T0.7340.50
426_G431_E0.7310.50
106_K142_S0.7310.50
332_F396_D0.7290.50
55_S321_D0.7290.50
332_F366_N0.7270.50
117_N201_K0.7270.50
90_R240_F0.7270.50
426_G455_A0.7250.49
305_F380_T0.7230.49
145_D148_T0.7230.49
433_I437_M0.7220.49
448_L461_F0.7220.49
121_I345_V0.7220.49
121_I137_T0.7210.49
451_Q458_K0.7190.49
263_Y266_I0.7180.49
150_K161_V0.7170.49
429_S446_I0.7120.48
389_S456_A0.7110.48
49_K210_D0.7110.48
51_F87_L0.7100.48
323_I333_L0.7090.48
126_N148_T0.7090.48
212_L237_F0.7080.48
272_G282_T0.7070.48
109_A115_K0.7010.47
98_S153_E0.7010.47
349_I365_K0.7010.47
135_V160_Y0.6990.47
60_L76_L0.6980.47
48_A92_T0.6970.47
292_G297_A0.6960.47
155_L161_V0.6960.47
327_L365_K0.6960.47
69_D437_M0.6950.47
80_K86_V0.6940.46
18_Y333_L0.6930.46
13_E418_L0.6920.46
256_T415_M0.6920.46
311_A343_V0.6870.46
332_F345_V0.6870.46
286_A366_N0.6870.46
254_G415_M0.6870.46
271_E426_G0.6860.46
140_D144_V0.6840.46
305_F461_F0.6830.45
419_Q427_F0.6830.45
303_L332_F0.6830.45
396_D399_A0.6820.45
115_K119_I0.6780.45
302_S367_K0.6770.45
238_A263_Y0.6760.45
438_N443_G0.6740.45
432_D451_Q0.6720.44
12_K460_Y0.6720.44
190_S194_R0.6720.44
189_A194_R0.6710.44
265_G272_G0.6710.44
83_A432_D0.6710.44
379_L446_I0.6710.44
112_G117_N0.6700.44
41_V326_R0.6690.44
338_A351_S0.6690.44
239_A243_R0.6680.44
74_L277_D0.6660.44
212_L225_L0.6660.44
372_L452_P0.6660.44
18_Y398_P0.6610.43
96_R99_A0.6610.43
323_I335_T0.6600.43
134_D146_K0.6580.43
145_D152_A0.6570.43
162_T165_G0.6560.43
294_S346_E0.6560.43
224_A284_D0.6550.43
184_A198_G0.6540.43
186_T190_S0.6530.43
255_V290_V0.6530.43
143_E146_K0.6520.42
31_L459_F0.6490.42
108_T120_I0.6490.42
237_F344_S0.6480.42
98_S194_R0.6480.42
266_I271_E0.6470.42
226_P457_E0.6460.42
32_S322_T0.6450.42
258_N262_D0.6440.42
371_V453_V0.6440.42
288_A298_T0.6430.42
106_K155_L0.6430.42
323_I327_L0.6430.42
431_E449_A0.6410.41
35_G221_D0.6400.41
305_F410_M0.6360.41
346_E365_K0.6360.41
321_D324_V0.6320.41
182_T204_V0.6310.41
414_Y424_I0.6300.40
367_K371_V0.6280.40
294_S456_A0.6260.40
12_K20_N0.6260.40
217_T441_R0.6260.40
186_T189_A0.6250.40
40_P211_F0.6240.40
304_T341_K0.6240.40
35_G79_A0.6230.40
241_I252_V0.6220.40
98_S108_T0.6220.40
231_D313_D0.6220.40
157_A168_D0.6210.40
382_E410_M0.6200.39
153_E157_A0.6190.39
203_P210_D0.6180.39
200_D203_P0.6180.39
403_G455_A0.6180.39
153_E274_L0.6170.39
271_E455_A0.6170.39
365_K455_A0.6170.39
346_E457_E0.6150.39
155_L158_N0.6150.39
414_Y448_L0.6140.39
160_Y239_A0.6130.39
131_N154_E0.6120.39
371_V452_P0.6100.39
135_V164_T0.6090.38
154_E161_V0.6090.38
297_A306_V0.6090.38
95_V132_S0.6090.38
76_L79_A0.6090.38
51_F80_K0.6080.38
116_G198_G0.6080.38
160_Y166_T0.6080.38
344_S353_V0.6070.38
43_S197_G0.6060.38
136_T139_M0.6050.38
31_L414_Y0.6030.38
257_A346_E0.6010.38
35_G378_D0.6010.38
68_I71_P0.5990.38
388_K459_F0.5980.37
428_D449_A0.5960.37
139_M153_E0.5950.37
115_K118_D0.5940.37
101_I122_R0.5920.37
103_E106_K0.5920.37
21_F347_K0.5920.37
39_L75_L0.5890.37
277_D368_I0.5890.37
375_V448_L0.5880.37
121_I181_D0.5880.37
451_Q457_E0.5860.36
131_N134_D0.5860.36
292_G309_E0.5850.36
352_L369_V0.5830.36
232_Q438_N0.5830.36
335_T346_E0.5760.35
330_G457_E0.5750.35
16_G368_I0.5750.35
94_G100_D0.5750.35
118_D123_I0.5750.35
135_V138_Y0.5740.35
109_A117_N0.5740.35
253_Q369_V0.5730.35
231_D239_A0.5730.35
400_S425_T0.5720.35
19_F450_V0.5720.35
181_D186_T0.5710.35
198_G204_V0.5710.35
409_T416_T0.5700.35
434_T447_D0.5700.35
135_V155_L0.5690.35
342_S347_K0.5690.35
272_G283_P0.5680.35
410_M413_Q0.5680.35
269_V272_G0.5670.35
110_V115_K0.5660.35
21_F301_Q0.5660.35
105_V186_T0.5660.35
453_V459_F0.5650.35
334_F343_V0.5640.34
335_T365_K0.5640.34
62_K123_I0.5630.34
140_D149_V0.5610.34
185_E191_A0.5600.34
114_T196_S0.5600.34
202_A209_T0.5590.34
123_I207_D0.5570.34
454_D457_E0.5570.34
54_I112_G0.5570.34
181_D197_G0.5570.34
403_G442_D0.5560.34
38_A440_D0.5530.33
183_A186_T0.5510.33
415_M419_Q0.5510.33
254_G372_L0.5510.33
53_S87_L0.5510.33
301_Q306_V0.5500.33
342_S346_E0.5490.33
280_E283_P0.5490.33
319_D364_A0.5480.33
205_N209_T0.5480.33
365_K396_D0.5470.33
349_I379_L0.5460.33
267_I302_S0.5460.33
262_D289_W0.5450.33
137_T140_D0.5440.33
62_K182_T0.5430.33
346_E350_N0.5410.32
145_D154_E0.5400.32
40_P268_N0.5400.32
35_G302_S0.5400.32
215_A218_E0.5390.32
233_L236_T0.5370.32
257_A347_K0.5360.32
15_A396_D0.5360.32
292_G306_V0.5360.32
140_D143_E0.5350.32
301_Q369_V0.5350.32
49_K207_D0.5330.32
166_T189_A0.5330.32
138_Y192_G0.5320.32
332_F369_V0.5320.32
34_R221_D0.5320.32
223_I237_F0.5310.32
134_D140_D0.5280.31
114_T131_N0.5270.31
78_E281_V0.5260.31
103_E186_T0.5250.31
117_N195_L0.5240.31
102_A185_E0.5240.31
26_Q402_D0.5240.31
93_E96_R0.5240.31
327_L455_A0.5230.31
95_V232_Q0.5220.31
378_D403_G0.5220.31
98_S101_I0.5200.31
40_P253_Q0.5190.31
411_I446_I0.5190.31
234_K260_A0.5190.31
220_F240_F0.5190.31
121_I163_F0.5180.31
206_S229_E0.5180.31
365_K451_Q0.5170.30
300_N424_I0.5160.30
54_I64_V0.5160.30
332_F397_I0.5160.30
100_D188_N0.5160.30
116_G195_L0.5150.30
127_V155_L0.5150.30
127_V134_D0.5140.30
226_P327_L0.5140.30
204_V209_T0.5130.30
91_L143_E0.5110.30
281_V315_L0.5100.30
133_F139_M0.5100.30
62_K375_V0.5090.30
302_S332_F0.5080.30
208_Y216_E0.5080.30
397_I400_S0.5080.30
271_E369_V0.5070.30
110_V181_D0.5070.30
34_R374_A0.5060.30
107_A153_E0.5060.30
41_V331_E0.5060.30
25_A216_E0.5040.29
352_L360_N0.5030.29
119_I183_A0.5030.29
347_K379_L0.5010.29
267_I290_V0.5010.29
274_L313_D0.5000.29
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3j2mU 1 0.8433 100 0.294 Contact Map
3hxlA 1 0.8863 100 0.33 Contact Map
3lmlA 1 0.9185 100 0.332 Contact Map
3j9qA 8 0.7189 100 0.436 Contact Map
3foaA 1 0.5687 100 0.579 Contact Map
3fo8D 4 0.3691 53.5 0.965 Contact Map
1ywmA 1 0.0966 16.2 0.973 Contact Map
4ycsA 1 0.2597 12.8 0.975 Contact Map
3qdsA 4 0.2339 7.6 0.977 Contact Map
4hrzA 2 0.2403 7.5 0.977 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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