GREMLIN Database
YQER - Oxygen-independent coproporphyrinogen-III oxidase-like protein YqeR
UniProt: P54304 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 379 (369)
Sequences: 6834 (4894)
Seq/√Len: 254.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
38_E77_M3.8741.00
176_N226_K3.1121.00
38_E73_K2.9801.00
172_E222_I2.8101.00
182_D242_K2.8011.00
35_N73_K2.7711.00
148_R184_E2.7231.00
136_K139_D2.7131.00
42_I77_M2.6601.00
42_I81_V2.4811.00
361_T364_G2.3691.00
352_H359_Y2.3671.00
36_A285_I2.3671.00
31_D70_Q2.3281.00
84_P89_S2.2911.00
141_F177_T2.2441.00
102_A149_E2.2331.00
179_L230_H2.1691.00
72_K76_D2.1611.00
3_S252_T2.0911.00
116_L147_A2.0841.00
67_S70_Q2.0731.00
302_T305_E2.0641.00
14_I22_K2.0421.00
125_D137_Q2.0241.00
124_E170_H2.0151.00
145_E149_E2.0121.00
32_E289_A1.9891.00
72_K110_E1.9851.00
172_E226_K1.9751.00
280_P283_H1.9631.00
212_P215_Q1.9481.00
120_V140_V1.9351.00
323_K353_N1.9181.00
177_T180_S1.9091.00
171_L223_V1.9041.00
33_Y264_A1.8911.00
123_F178_A1.8821.00
41_M262_F1.8681.00
31_D73_K1.8491.00
34_L38_E1.8441.00
225_S229_A1.7921.00
173_H177_T1.7671.00
138_K142_T1.7641.00
154_N245_M1.7631.00
125_D138_K1.7541.00
6_I78_I1.7391.00
345_L374_A1.7361.00
179_L226_K1.7211.00
142_T145_E1.7181.00
345_L371_V1.7091.00
4_A53_L1.7041.00
343_K347_E1.6761.00
126_D170_H1.6741.00
105_L147_A1.6661.00
226_K230_H1.6441.00
172_E176_N1.6331.00
169_K172_E1.6221.00
188_V223_V1.6151.00
268_G275_T1.6111.00
168_L222_I1.6031.00
346_A353_N1.5971.00
102_A146_R1.5921.00
8_I66_L1.5811.00
93_V113_V1.5731.00
224_M240_F1.5711.00
168_L218_E1.5561.00
141_F145_E1.5531.00
139_D142_T1.5501.00
36_A289_A1.5481.00
127_L170_H1.5451.00
40_E277_N1.5401.00
157_L178_A1.5231.00
37_L262_F1.5191.00
286_D290_E1.5171.00
109_K152_F1.5141.00
173_H176_N1.5101.00
106_K150_I1.5071.00
68_E107_I1.4991.00
39_Q42_I1.4981.00
222_I225_S1.4971.00
175_I226_K1.4941.00
327_A333_S1.4941.00
137_Q141_F1.4911.00
307_I326_F1.4661.00
162_G216_E1.4651.00
282_K286_D1.4571.00
322_S325_R1.4561.00
34_L74_L1.4491.00
41_M78_I1.4201.00
251_L317_K1.4061.00
106_K110_E1.4051.00
124_E127_L1.4051.00
176_N180_S1.4041.00
123_F177_T1.3951.00
323_K357_A1.3921.00
324_K356_S1.3891.00
343_K346_A1.3871.00
72_K111_A1.3841.00
322_S356_S1.3821.00
228_E362_H1.3741.00
107_I111_A1.3651.00
233_H246_E1.3571.00
148_R182_D1.3561.00
125_D129_E1.3521.00
186_Y227_M1.3461.00
199_F203_M1.3451.00
267_H276_V1.3351.00
318_T365_K1.3321.00
167_T170_H1.3321.00
30_V67_S1.3291.00
344_D374_A1.3291.00
184_E245_M1.3231.00
168_L215_Q1.3221.00
276_V297_D1.3211.00
183_A232_I1.3171.00
120_V123_F1.3011.00
124_E173_H1.2971.00
56_I84_P1.2961.00
278_V287_L1.2951.00
52_D85_S1.2911.00
126_D129_E1.2911.00
360_L368_G1.2791.00
43_N288_I1.2761.00
273_T298_T1.2741.00
102_A106_K1.2701.00
34_L70_Q1.2701.00
255_S319_A1.2671.00
127_L174_S1.2601.00
41_M81_V1.2581.00
39_Q289_A1.2501.00
278_V296_R1.2461.00
227_M232_I1.2461.00
233_H243_A1.2361.00
344_D348_K1.2321.00
118_F147_A1.2281.00
21_N265_G1.2271.00
98_D134_V1.2261.00
142_T146_R1.2151.00
261_G266_A1.2141.00
52_D83_K1.2131.00
255_S317_K1.2091.00
78_I84_P1.1971.00
4_A262_F1.1971.00
126_D165_G1.1941.00
144_F181_L1.1911.00
137_Q177_T1.1891.00
30_V70_Q1.1861.00
323_K335_D1.1741.00
252_T257_E1.1721.00
184_E232_I1.1721.00
221_E366_L1.1711.00
311_M321_V1.1681.00
66_L70_Q1.1671.00
310_E330_Y1.1551.00
354_S359_Y1.1531.00
77_M80_R1.1501.00
348_K363_Q1.1451.00
281_V285_I1.1451.00
154_N184_E1.1401.00
190_S216_E1.1391.00
222_I226_K1.1391.00
131_I163_L1.1371.00
215_Q218_E1.1371.00
202_L207_R1.1361.00
153_E245_M1.1361.00
58_I71_L1.1331.00
155_I184_E1.1331.00
146_R149_E1.1321.00
226_K229_A1.1301.00
34_L66_L1.1271.00
38_E42_I1.1201.00
44_T262_F1.1191.00
64_T108_L1.1151.00
225_S362_H1.1101.00
102_A150_I1.1081.00
104_K108_L1.0961.00
310_E329_K1.0901.00
43_N293_F1.0881.00
95_A100_L1.0881.00
93_V108_L1.0871.00
116_L152_F1.0781.00
58_I74_L1.0781.00
148_R155_I1.0741.00
8_I264_A1.0701.00
333_S336_G1.0681.00
105_L150_I1.0681.00
272_G306_Q1.0641.00
68_E104_K1.0611.00
168_L219_M1.0581.00
64_T95_A1.0571.00
34_L77_M1.0561.00
360_L371_V1.0551.00
310_E314_G1.0421.00
325_R329_K1.0421.00
264_A281_V1.0411.00
76_D80_R1.0411.00
246_E319_A1.0401.00
278_V283_H1.0381.00
168_L172_E1.0361.00
147_A155_I1.0341.00
144_F155_I1.0331.00
51_P258_Q1.0321.00
130_K165_G1.0221.00
322_S357_A1.0191.00
122_T127_L1.0191.00
288_I294_P1.0161.00
42_I80_R1.0151.00
198_V202_L1.0141.00
283_H286_D1.0071.00
64_T93_V1.0061.00
31_D35_N1.0061.00
75_M91_F0.9991.00
339_P343_K0.9951.00
4_A78_I0.9911.00
273_T300_E0.9911.00
103_E107_I0.9901.00
314_G318_T0.9881.00
320_G359_Y0.9821.00
54_K85_S0.9801.00
206_G209_H0.9791.00
231_G243_A0.9761.00
101_S104_K0.9751.00
303_T306_Q0.9751.00
35_N38_E0.9741.00
68_E103_E0.9651.00
178_A186_Y0.9641.00
141_F181_L0.9641.00
144_F148_R0.9631.00
258_Q269_Y0.9571.00
144_F183_A0.9571.00
305_E308_E0.9551.00
348_K374_A0.9531.00
299_H305_E0.9501.00
354_S357_A0.9491.00
70_Q73_K0.9491.00
368_G372_F0.9441.00
314_G321_V0.9441.00
40_E284_Y0.9431.00
224_M234_Q0.9421.00
224_M228_E0.9411.00
107_I110_E0.9341.00
71_L75_M0.9301.00
287_L292_G0.9291.00
324_K328_E0.9091.00
23_Y281_V0.9091.00
64_T99_D0.9061.00
198_V201_N0.9031.00
21_N264_A0.9021.00
165_G209_H0.9001.00
109_K153_E0.9001.00
54_K252_T0.8991.00
123_F174_S0.8991.00
148_R183_A0.8971.00
43_N294_P0.8961.00
159_L174_S0.8921.00
344_D347_E0.8911.00
85_S89_S0.8911.00
36_A39_Q0.8871.00
29_P32_E0.8861.00
352_H361_T0.8821.00
71_L111_A0.8821.00
256_N269_Y0.8811.00
54_K248_K0.8781.00
323_K356_S0.8771.00
16_H199_F0.8761.00
251_L255_S0.8751.00
166_Q219_M0.8721.00
312_F372_F0.8711.00
72_K107_I0.8711.00
58_I93_V0.8691.00
103_E106_K0.8691.00
137_Q140_V0.8661.00
79_N84_P0.8610.99
320_G357_A0.8610.99
71_L93_V0.8600.99
77_M81_V0.8590.99
261_G275_T0.8570.99
75_M78_I0.8560.99
79_N83_K0.8550.99
109_K150_I0.8540.99
214_E218_E0.8520.99
75_M111_A0.8500.99
243_A246_E0.8490.99
39_Q43_N0.8460.99
31_D69_E0.8440.99
41_M77_M0.8400.99
92_A247_S0.8400.99
342_L358_V0.8370.99
193_V203_M0.8340.99
114_N154_N0.8320.99
118_F143_S0.8220.99
224_M362_H0.8220.99
179_L227_M0.8190.99
41_M82_L0.8180.99
218_E221_E0.8180.99
182_D232_I0.8180.99
57_F247_S0.8170.99
12_E99_D0.8120.99
283_H287_L0.8090.99
157_L183_A0.8090.99
86_S89_S0.8060.99
353_N358_V0.8010.99
16_H132_G0.7990.99
25_I30_V0.7970.99
67_S104_K0.7920.99
341_V374_A0.7920.99
249_H253_Y0.7880.99
28_Q32_E0.7870.99
159_L178_A0.7850.99
256_N310_E0.7800.99
143_S146_R0.7790.99
3_S55_T0.7780.99
200_Y203_M0.7770.99
215_Q219_M0.7770.99
128_L135_H0.7760.99
303_T307_I0.7720.99
6_I37_L0.7710.99
370_E373_G0.7700.99
161_F188_V0.7700.99
123_F137_Q0.7700.99
95_A118_F0.7690.99
314_G325_R0.7670.99
120_V157_L0.7600.99
159_L171_L0.7590.99
144_F157_L0.7580.99
261_G268_G0.7560.99
369_N372_F0.7510.99
100_L105_L0.7500.99
75_M79_N0.7460.99
34_L73_K0.7450.99
14_I24_F0.7440.99
301_V306_Q0.7440.99
37_L74_L0.7410.98
218_E222_I0.7390.98
36_A288_I0.7370.98
117_S156_S0.7370.98
193_V199_F0.7320.98
53_L89_S0.7290.98
323_K358_V0.7260.98
32_E36_A0.7250.98
69_E72_K0.7240.98
291_K294_P0.7210.98
156_S247_S0.7200.98
363_Q366_L0.7190.98
350_L367_L0.7180.98
45_I81_V0.7170.98
30_V34_L0.7170.98
288_I291_K0.7170.98
91_F113_V0.7160.98
326_F332_R0.7140.98
346_A351_I0.7120.98
285_I289_A0.7110.98
50_Q83_K0.7090.98
32_E285_I0.7090.98
138_K141_F0.7030.98
172_E225_S0.7020.98
325_R328_E0.7020.98
98_D139_D0.7010.98
326_F334_L0.7000.98
350_L364_G0.6990.98
342_L351_I0.6980.98
106_K149_E0.6970.98
217_A366_L0.6950.98
310_E326_F0.6950.98
367_L370_E0.6940.98
56_I89_S0.6940.98
16_H131_I0.6910.98
147_A152_F0.6910.98
161_F171_L0.6890.98
38_E81_V0.6880.98
323_K334_L0.6880.98
338_F341_V0.6860.98
345_L351_I0.6850.97
126_D130_K0.6830.97
195_P200_Y0.6820.97
256_N306_Q0.6810.97
33_Y37_L0.6810.97
171_L175_I0.6800.97
71_L107_I0.6760.97
224_M365_K0.6760.97
64_T104_K0.6760.97
140_V157_L0.6760.97
44_T47_K0.6750.97
163_L174_S0.6730.97
43_N47_K0.6710.97
335_D353_N0.6710.97
12_E134_V0.6710.97
147_A150_I0.6700.97
274_R309_E0.6680.97
199_F208_L0.6620.97
324_K327_A0.6610.97
38_E74_L0.6600.97
84_P91_F0.6590.97
125_D136_K0.6580.97
6_I262_F0.6580.97
127_L166_Q0.6540.97
338_F375_F0.6540.97
44_T260_F0.6530.97
58_I75_M0.6530.97
194_E197_T0.6520.97
58_I113_V0.6520.97
214_E217_A0.6480.97
32_E35_N0.6480.97
54_K89_S0.6470.96
249_H254_W0.6460.96
307_I330_Y0.6410.96
363_Q367_L0.6410.96
308_E312_F0.6400.96
311_M375_F0.6390.96
201_N205_K0.6380.96
76_D79_N0.6350.96
341_V345_L0.6340.96
34_L67_S0.6330.96
304_E308_E0.6330.96
258_Q270_I0.6320.96
343_K353_N0.6320.96
183_A186_Y0.6310.96
71_L108_L0.6300.96
100_L146_R0.6300.96
175_I222_I0.6290.96
169_K173_H0.6290.96
41_M74_L0.6270.96
52_D86_S0.6260.96
327_A331_G0.6260.96
163_L166_Q0.6250.96
146_R150_I0.6250.96
155_I183_A0.6240.96
53_L82_L0.6220.96
69_E107_I0.6200.96
100_L104_K0.6200.96
184_E242_K0.6200.96
220_Y234_Q0.6190.95
3_S54_K0.6160.95
199_F202_L0.6140.95
175_I179_L0.6130.95
234_Q365_K0.6120.95
309_E313_L0.6120.95
73_K77_M0.6060.95
127_L163_L0.6060.95
241_A246_E0.6060.95
342_L346_A0.6050.95
36_A284_Y0.6040.95
105_L116_L0.6030.95
170_H174_S0.5990.95
203_M208_L0.5980.95
13_H132_G0.5970.95
370_E374_A0.5960.94
295_Y298_T0.5950.94
100_L118_F0.5940.94
314_G317_K0.5930.94
108_L113_V0.5910.94
311_M326_F0.5900.94
248_K251_L0.5900.94
68_E111_A0.5880.94
13_H24_F0.5850.94
334_L338_F0.5810.94
265_G279_G0.5800.94
21_N281_V0.5790.94
46_A81_V0.5790.94
156_S187_S0.5770.93
335_D339_P0.5760.93
176_N230_H0.5740.93
76_D111_A0.5730.93
145_E148_R0.5730.93
217_A221_E0.5720.93
223_V227_M0.5720.93
78_I81_V0.5690.93
360_L364_G0.5690.93
4_A260_F0.5680.93
247_S251_L0.5670.93
55_T248_K0.5660.93
310_E325_R0.5660.93
55_T89_S0.5630.93
351_I358_V0.5620.93
105_L152_F0.5620.93
123_F140_V0.5610.92
316_R372_F0.5600.92
264_A284_Y0.5590.92
140_V144_F0.5570.92
176_N179_L0.5570.92
326_F330_Y0.5570.92
118_F140_V0.5570.92
58_I91_F0.5530.92
345_L348_K0.5510.92
221_E225_S0.5500.92
78_I262_F0.5490.92
179_L182_D0.5490.92
315_L358_V0.5480.92
161_F223_V0.5470.92
15_C18_C0.5470.92
303_T332_R0.5460.91
237_I249_H0.5450.91
233_H318_T0.5430.91
250_N254_W0.5430.91
100_L143_S0.5420.91
6_I41_M0.5400.91
42_I46_A0.5400.91
234_Q366_L0.5380.91
301_V305_E0.5380.91
13_H134_V0.5380.91
234_Q318_T0.5380.91
185_H235_Y0.5360.91
20_F250_N0.5360.91
122_T174_S0.5350.91
269_Y272_G0.5350.91
29_P281_V0.5350.91
236_E249_H0.5330.90
53_L84_P0.5330.90
153_E184_E0.5320.90
236_E250_N0.5320.90
276_V279_G0.5320.90
147_A151_G0.5310.90
286_D289_A0.5310.90
254_W259_Y0.5300.90
349_G363_Q0.5280.90
30_V65_S0.5270.90
323_K327_A0.5250.90
239_N250_N0.5250.90
57_F92_A0.5230.90
223_V226_K0.5220.90
179_L232_I0.5220.90
38_E80_R0.5210.89
345_L350_L0.5210.89
135_H140_V0.5200.89
124_E174_S0.5200.89
196_K200_Y0.5180.89
43_N291_K0.5180.89
323_K354_S0.5170.89
228_E233_H0.5140.89
247_S254_W0.5140.89
75_M107_I0.5110.89
327_A334_L0.5110.89
346_A358_V0.5100.88
171_L219_M0.5090.88
95_A143_S0.5080.88
53_L78_I0.5080.88
43_N292_G0.5070.88
40_E44_T0.5070.88
141_F180_S0.5070.88
312_F369_N0.5060.88
19_D192_I0.5050.88
8_I34_L0.5040.88
277_N284_Y0.5040.88
166_Q170_H0.5040.88
220_Y224_M0.5040.88
287_L290_E0.5040.88
56_I91_F0.5030.88
109_K114_N0.5030.88
45_I82_L0.5020.88
235_Y250_N0.5020.88
185_H238_S0.5020.88
44_T275_T0.5010.88
185_H249_H0.5000.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1oltA 1 0.9947 100 0.3 Contact Map
1r30A 2 0.7018 100 0.749 Contact Map
4jc0A 1 0.7546 100 0.757 Contact Map
4u0oB 1 0.5884 100 0.757 Contact Map
4wcxA 1 0.8734 99.9 0.766 Contact Map
2qgqA 1 0.6834 99.9 0.767 Contact Map
4r33A 2 0.7678 99.9 0.769 Contact Map
4rtbA 2 0.8391 99.9 0.777 Contact Map
3t7vA 1 0.7388 99.9 0.787 Contact Map
2yx0A 1 0.5963 99.9 0.79 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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