GREMLIN Database
YPNP - Probable multidrug resistance protein YpnP
UniProt: P54181 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 445 (422)
Sequences: 18173 (13632)
Seq/√Len: 663.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
85_D88_G4.6011.00
145_F203_G3.9221.00
134_T192_A3.3691.00
53_A272_G3.1461.00
338_I351_G3.0761.00
116_E133_E3.0691.00
333_F336_Y3.0381.00
78_S297_G2.9681.00
233_A237_K2.8571.00
116_E120_R2.8001.00
161_D164_T2.7821.00
114_L117_L2.7801.00
304_N307_R2.7171.00
182_L187_F2.5761.00
73_T96_F2.5441.00
138_I192_A2.5331.00
175_L204_I2.5291.00
133_E137_Q2.4491.00
229_W233_A2.4021.00
80_Q88_G2.3881.00
39_W184_I2.3461.00
51_A131_L2.2761.00
39_W181_P2.2601.00
47_K127_S2.2241.00
380_A430_Y2.2231.00
13_K17_L2.2001.00
131_L134_T2.1951.00
125_P265_D2.1881.00
172_A205_A2.1811.00
168_F208_Y2.1051.00
148_G206_F2.0971.00
292_V315_G2.0891.00
313_R317_I2.0851.00
353_Q410_K2.0271.00
91_S228_K2.0131.00
345_P349_A2.0011.00
192_A196_Y1.9801.00
130_P134_T1.9661.00
334_G356_K1.9171.00
270_G350_F1.9111.00
138_I195_A1.9101.00
346_D349_A1.8971.00
182_L186_V1.8841.00
45_G48_A1.8791.00
36_D198_T1.8781.00
335_K352_E1.8751.00
189_M196_Y1.8701.00
142_G199_I1.8641.00
184_I194_A1.8471.00
100_L151_F1.8391.00
408_G411_G1.8271.00
299_N307_R1.8251.00
40_I194_A1.8241.00
23_M287_A1.8021.00
266_H346_D1.7981.00
80_Q85_D1.7901.00
120_R129_I1.7881.00
39_W180_A1.7711.00
46_A344_E1.7431.00
163_K167_R1.7381.00
80_Q83_K1.7361.00
115_S133_E1.6971.00
20_M24_L1.6951.00
138_I196_Y1.6931.00
141_I144_L1.6721.00
207_L211_F1.6671.00
334_G352_E1.6631.00
295_M311_I1.6621.00
117_L120_R1.6591.00
228_K231_E1.6591.00
300_I378_A1.6481.00
331_W356_K1.6301.00
19_S291_A1.6211.00
310_T314_L1.6201.00
310_T313_R1.6171.00
364_F421_L1.6111.00
168_F209_G1.6011.00
312_A371_L1.5971.00
127_S265_D1.5791.00
76_I92_Y1.5721.00
145_F206_F1.5711.00
319_V366_G1.5661.00
174_V178_V1.5651.00
309_G313_R1.5441.00
181_P185_S1.5431.00
129_I133_E1.5421.00
327_A331_W1.5311.00
35_I177_T1.5301.00
335_K339_R1.5261.00
300_I308_V1.5181.00
181_P187_F1.5121.00
306_K310_T1.4881.00
299_N304_N1.4831.00
138_I199_I1.4811.00
336_Y339_R1.4751.00
180_A194_A1.4711.00
179_L197_S1.4701.00
115_S137_Q1.4671.00
380_A383_Q1.4521.00
407_L411_G1.4511.00
55_S136_L1.4461.00
116_E130_P1.4441.00
12_L314_L1.4341.00
152_I209_G1.4331.00
108_G144_L1.4331.00
80_Q92_Y1.4261.00
339_R348_V1.4241.00
178_V181_P1.4221.00
429_L432_R1.4201.00
183_F187_F1.4151.00
175_L179_L1.4131.00
178_V182_L1.4111.00
425_C429_L1.4051.00
86_I90_A1.4041.00
40_I52_A1.4021.00
211_F215_K1.4011.00
428_F432_R1.3971.00
312_A374_I1.3951.00
11_V295_M1.3831.00
126_E130_P1.3791.00
120_R126_E1.3781.00
127_S130_P1.3741.00
119_L129_I1.3731.00
117_L121_L1.3491.00
167_R171_F1.3451.00
87_K91_S1.3441.00
317_I321_S1.3381.00
352_E356_K1.3381.00
88_G91_S1.3281.00
336_Y340_L1.3261.00
357_W414_L1.3211.00
429_L433_Y1.3131.00
192_A195_A1.3111.00
50_G269_S1.3031.00
48_A131_L1.3021.00
81_K298_Q1.3011.00
116_E129_I1.2991.00
349_A353_Q1.2971.00
183_F189_M1.2971.00
28_L170_A1.2961.00
24_L166_L1.2921.00
331_W359_A1.2921.00
79_Q83_K1.2901.00
12_L318_A1.2861.00
402_L406_W1.2831.00
401_A405_A1.2801.00
36_D176_N1.2681.00
168_F212_Y1.2671.00
305_E309_G1.2591.00
81_K89_M1.2531.00
79_Q297_G1.2511.00
179_L200_L1.2471.00
47_K265_D1.2461.00
319_V370_V1.2391.00
111_G140_F1.2371.00
88_G231_E1.2311.00
44_L48_A1.2281.00
277_L337_L1.2241.00
328_V332_V1.2231.00
82_G301_G1.2171.00
382_L386_V1.2121.00
46_A266_H1.2111.00
383_Q430_Y1.2081.00
338_I348_V1.1961.00
112_F137_Q1.1881.00
230_E233_A1.1831.00
395_L422_F1.1681.00
42_N343_S1.1641.00
37_S276_R1.1621.00
176_N198_T1.1581.00
390_I394_V1.1531.00
411_G415_G1.1511.00
47_K131_L1.1461.00
180_A197_S1.1451.00
183_F200_L1.1411.00
108_G112_F1.1371.00
79_Q379_G1.1361.00
407_L414_L1.1331.00
258_S262_S1.1331.00
37_S49_L1.1231.00
52_A191_I1.1161.00
266_H350_F1.1091.00
51_A128_M1.1091.00
95_A232_S1.1091.00
42_N185_S1.1081.00
171_F208_Y1.1081.00
398_P402_L1.0991.00
350_F353_Q1.0961.00
77_L158_A1.0951.00
99_L232_S1.0941.00
119_L132_A1.0881.00
312_A431_Y1.0861.00
93_I155_V1.0851.00
296_A308_V1.0831.00
181_P186_V1.0831.00
90_A225_R1.0811.00
430_Y433_Y1.0811.00
181_P184_I1.0801.00
289_G373_G1.0751.00
222_S225_R1.0681.00
348_V351_G1.0671.00
240_I244_L1.0661.00
387_L427_A1.0641.00
100_L147_F1.0541.00
113_F117_L1.0541.00
183_F186_V1.0521.00
386_V390_I1.0471.00
186_V189_M1.0461.00
394_V398_P1.0451.00
175_L201_S1.0361.00
15_L315_G1.0361.00
274_V354_Y1.0331.00
321_S325_V1.0311.00
91_S231_E1.0271.00
161_D165_P1.0241.00
368_N420_F1.0161.00
267_V409_Q1.0161.00
137_Q141_I1.0131.00
164_T212_Y1.0121.00
94_N226_M1.0111.00
234_L237_K1.0101.00
371_L431_Y1.0061.00
81_K159_L0.9951.00
36_D180_A0.9901.00
92_Y231_E0.9861.00
96_F235_I0.9861.00
16_V20_M0.9841.00
108_G141_I0.9821.00
196_Y199_I0.9821.00
82_G302_I0.9811.00
101_T148_G0.9771.00
160_G298_Q0.9761.00
314_L318_A0.9751.00
170_A174_V0.9661.00
223_I226_M0.9611.00
299_N311_I0.9601.00
270_G347_A0.9571.00
33_Q56_S0.9531.00
106_G110_A0.9531.00
109_A113_F0.9491.00
400_T404_S0.9461.00
349_A352_E0.9421.00
342_I347_A0.9361.00
264_G267_V0.9281.00
277_L330_I0.9251.00
81_K86_I0.9241.00
259_V262_S0.9221.00
115_S136_L0.9201.00
14_Q17_L0.9191.00
375_V430_Y0.9191.00
219_V223_I0.9151.00
134_T137_Q0.9141.00
325_V329_M0.9131.00
79_Q300_I0.9131.00
354_Y409_Q0.9101.00
287_A291_A0.9071.00
66_I147_F0.9061.00
259_V263_Y0.9051.00
357_W410_K0.9041.00
152_I206_F0.9041.00
22_I290_T0.9021.00
54_V124_T0.9011.00
335_K349_A0.8961.00
131_L191_I0.8921.00
308_V312_A0.8921.00
331_W335_K0.8901.00
346_D350_F0.8881.00
324_L328_V0.8861.00
180_A198_T0.8861.00
273_A341_F0.8781.00
179_L183_F0.8771.00
325_V328_V0.8741.00
38_L41_G0.8691.00
79_Q234_L0.8681.00
409_Q413_G0.8681.00
208_Y211_F0.8661.00
410_K414_L0.8651.00
403_F407_L0.8641.00
199_I203_G0.8641.00
338_I352_E0.8631.00
316_V367_V0.8611.00
59_V139_Q0.8601.00
399_F418_M0.8571.00
113_F137_Q0.8551.00
102_G106_G0.8501.00
332_V336_Y0.8481.00
419_S423_S0.8461.00
203_G207_L0.8451.00
156_L213_V0.8441.00
308_V378_A0.8421.00
149_Y205_A0.8391.00
171_F175_L0.8391.00
35_I176_N0.8391.00
161_D212_Y0.8381.00
271_F413_G0.8351.00
364_F424_S0.8311.00
307_R310_T0.8311.00
18_F162_S0.8291.00
285_A323_M0.8291.00
152_I213_V0.8281.00
39_W185_S0.8281.00
47_K128_M0.8271.00
348_V352_E0.8261.00
244_L385_L0.8231.00
395_L398_P0.8221.00
267_V350_F0.8211.00
391_S423_S0.8211.00
112_F116_E0.8191.00
35_I173_V0.8191.00
141_I199_I0.8181.00
176_N180_A0.8171.00
130_P133_E0.8151.00
299_N302_I0.8151.00
296_A377_A0.8151.00
73_T77_L0.8131.00
167_R170_A0.8131.00
50_G128_M0.8121.00
270_G351_G0.8121.00
296_A374_I0.8111.00
288_A315_G0.8101.00
257_M261_N0.8091.00
248_V389_L0.8091.00
126_E129_I0.8091.00
314_L317_I0.8051.00
196_Y200_L0.8041.00
15_L314_L0.8041.00
96_F151_F0.8031.00
414_L417_G0.8021.00
310_T317_I0.8011.00
115_S140_F0.7991.00
138_I141_I0.7971.00
161_D216_H0.7931.00
166_L170_A0.7921.00
109_A112_F0.7911.00
28_L173_V0.7911.00
231_E234_L0.7901.00
204_I208_Y0.7881.00
40_I184_I0.7821.00
399_F403_F0.7781.00
87_K225_R0.7781.00
110_A114_L0.7761.00
276_R341_F0.7731.00
90_A222_S0.7731.00
98_V102_G0.7711.00
321_S324_L0.7691.00
211_F214_I0.7691.00
237_K382_L0.7691.00
156_L209_G0.7661.00
46_A347_A0.7651.00
32_F198_T0.7641.00
14_Q298_Q0.7621.00
221_F224_P0.7621.00
14_Q295_M0.7611.00
345_P348_V0.7601.00
261_N268_V0.7581.00
12_L16_V0.7551.00
180_A184_I0.7541.00
188_R192_A0.7541.00
76_I238_L0.7501.00
157_R165_P0.7501.00
263_Y404_S0.7491.00
306_K313_R0.7481.00
75_T79_Q0.7481.00
41_G49_L0.7481.00
273_A351_G0.7451.00
320_I324_L0.7441.00
260_V409_Q0.7431.00
128_M268_V0.7431.00
12_L317_I0.7431.00
134_T191_I0.7431.00
415_G419_S0.7391.00
176_N201_S0.7371.00
78_S158_A0.7361.00
65_F243_G0.7331.00
324_L363_P0.7311.00
234_L379_G0.7311.00
51_A191_I0.7301.00
76_I80_Q0.7281.00
44_L188_R0.7271.00
210_L214_I0.7271.00
259_V401_A0.7261.00
367_V424_S0.7251.00
357_W417_G0.7241.00
421_L425_C0.7241.00
31_S35_I0.7221.00
94_N225_R0.7211.00
83_K301_G0.7201.00
299_N308_V0.7191.00
404_S411_G0.7191.00
315_G370_V0.7171.00
136_L140_F0.7171.00
360_F363_P0.7161.00
333_F337_L0.7151.00
123_K126_E0.7151.00
19_S287_A0.7151.00
77_L155_V0.7141.00
317_I320_I0.7141.00
334_G355_L0.7081.00
34_F280_I0.7081.00
25_G169_I0.7071.00
28_L31_S0.7001.00
135_Y180_A0.6991.00
236_L240_I0.6991.00
98_V226_M0.6981.00
356_K360_F0.6981.00
262_S405_A0.6961.00
306_K309_G0.6961.00
104_S144_L0.6961.00
260_V412_I0.6941.00
288_A319_V0.6911.00
38_L340_L0.6891.00
247_M251_G0.6891.00
288_A322_C0.6881.00
119_L136_L0.6871.00
260_V271_F0.6871.00
189_M192_A0.6861.00
140_F143_I0.6851.00
156_L164_T0.6851.00
141_I145_F0.6851.00
224_P227_P0.6841.00
296_A312_A0.6811.00
320_I366_G0.6801.00
15_L291_A0.6781.00
383_Q387_L0.6761.00
403_F411_G0.6741.00
239_G243_G0.6721.00
334_G338_I0.6711.00
171_F204_I0.6691.00
51_A132_A0.6691.00
77_L89_M0.6681.00
38_L42_N0.6681.00
331_W334_G0.6671.00
347_A351_G0.6671.00
164_T208_Y0.6671.00
114_L118_L0.6651.00
88_G92_Y0.6641.00
259_V400_T0.6641.00
411_G414_L0.6641.00
323_M366_G0.6611.00
270_G354_Y0.6601.00
40_I44_L0.6561.00
142_G145_F0.6531.00
27_A31_S0.6501.00
329_M333_F0.6501.00
373_G377_A0.6491.00
195_A199_I0.6481.00
137_Q192_A0.6451.00
140_F144_L0.6451.00
35_I39_W0.6441.00
218_L222_S0.6421.00
40_I191_I0.6421.00
240_I243_G0.6401.00
142_G202_Q0.6401.00
238_L381_M0.6391.00
305_E308_V0.6391.00
91_S94_N0.6391.00
193_G197_S0.6391.00
292_V296_A0.6371.00
335_K348_V0.6361.00
128_M131_L0.6351.00
127_S131_L0.6331.00
263_Y267_V0.6331.00
322_C326_I0.6321.00
40_I48_A0.6321.00
112_F141_I0.6321.00
395_L399_F0.6301.00
300_I305_E0.6301.00
47_K50_G0.6301.00
344_E348_V0.6301.00
91_S95_A0.6301.00
68_G243_G0.6301.00
426_A429_L0.6281.00
48_A51_A0.6271.00
101_T105_I0.6271.00
83_K303_G0.6261.00
170_A173_V0.6211.00
284_P322_C0.6201.00
152_I210_L0.6191.00
62_V143_I0.6191.00
87_K90_A0.6191.00
371_L427_A0.6191.00
332_V335_K0.6191.00
183_F194_A0.6171.00
200_L203_G0.6171.00
278_D362_Y0.6131.00
396_R419_S0.6131.00
201_S204_I0.6131.00
75_T238_L0.6101.00
255_A397_Y0.6101.00
14_Q307_R0.6091.00
298_Q302_I0.6081.00
266_H269_S0.6071.00
32_F172_A0.6061.00
129_I132_A0.6061.00
281_I326_I0.6061.00
112_F115_S0.6061.00
259_V404_S0.6061.00
31_S173_V0.6051.00
397_Y401_A0.6021.00
293_N376_R0.6011.00
175_L200_L0.6001.00
403_F406_W0.5991.00
45_G131_L0.5981.00
77_L92_Y0.5971.00
48_A190_G0.5951.00
241_P385_L0.5921.00
256_I412_I0.5911.00
342_I345_P0.5901.00
11_V314_L0.5901.00
282_T365_I0.5901.00
318_A321_S0.5891.00
208_Y212_Y0.5881.00
219_V224_P0.5871.00
94_N98_V0.5861.00
32_F202_Q0.5861.00
230_E234_L0.5851.00
116_E137_Q0.5841.00
267_V270_G0.5811.00
74_L154_T0.5811.00
110_A113_F0.5811.00
69_L243_G0.5811.00
153_S157_R0.5801.00
85_D91_S0.5801.00
145_F199_I0.5791.00
104_S140_F0.5771.00
185_S189_M0.5771.00
374_I378_A0.5771.00
371_L428_F0.5761.00
171_F174_V0.5761.00
134_T138_I0.5761.00
49_L342_I0.5751.00
119_L124_T0.5731.00
316_V320_I0.5731.00
175_L178_V0.5731.00
49_L273_A0.5711.00
219_V222_S0.5701.00
223_I227_P0.5681.00
320_I367_V0.5681.00
197_S201_S0.5671.00
398_P401_A0.5671.00
399_F402_L0.5661.00
119_L133_E0.5651.00
124_T261_N0.5651.00
135_Y194_A0.5651.00
176_N197_S0.5631.00
387_L426_A0.5621.00
220_P223_I0.5581.00
270_G413_G0.5571.00
84_D302_I0.5561.00
232_S236_L0.5561.00
183_F196_Y0.5561.00
144_L203_G0.5561.00
71_N290_T0.5551.00
128_M265_D0.5551.00
69_L103_L0.5541.00
266_H347_A0.5541.00
50_G53_A0.5531.00
344_E347_A0.5531.00
44_L191_I0.5531.00
402_L405_A0.5521.00
128_M132_A0.5511.00
212_Y216_H0.5511.00
375_V380_A0.5511.00
401_A404_S0.5511.00
266_H344_E0.5501.00
388_N391_S0.5481.00
259_V405_A0.5471.00
214_I217_K0.5471.00
285_A366_G0.5471.00
381_M385_L0.5451.00
177_T181_P0.5441.00
221_F226_M0.5441.00
75_T297_G0.5441.00
367_V428_F0.5441.00
371_L424_S0.5431.00
279_S282_T0.5411.00
33_Q139_Q0.5411.00
22_I287_A0.5391.00
101_T104_S0.5391.00
157_R162_S0.5391.00
353_Q356_K0.5391.00
149_Y153_S0.5391.00
86_I218_L0.5381.00
54_V132_A0.5381.00
359_A363_P0.5371.00
189_M193_G0.5371.00
44_L184_I0.5361.00
400_T412_I0.5361.00
424_S428_F0.5351.00
149_Y206_F0.5331.00
87_K224_P0.5331.00
56_S60_L0.5331.00
89_M93_I0.5301.00
168_F205_A0.5301.00
11_V310_T0.5291.00
16_V318_A0.5260.99
391_S426_A0.5260.99
368_N423_S0.5250.99
320_I363_P0.5250.99
190_G193_G0.5240.99
396_R400_T0.5210.99
401_A406_W0.5200.99
256_I400_T0.5180.99
252_G392_F0.5180.99
35_I38_L0.5170.99
313_R316_V0.5160.99
95_A231_E0.5160.99
273_A347_A0.5160.99
425_C428_F0.5160.99
292_V370_V0.5150.99
414_L418_M0.5150.99
400_T403_F0.5140.99
54_V268_V0.5140.99
248_V385_L0.5130.99
105_I108_G0.5110.99
80_Q231_E0.5110.99
312_A316_V0.5100.99
15_L318_A0.5100.99
274_V355_L0.5080.99
339_R343_S0.5070.99
293_N373_G0.5070.99
316_V371_L0.5070.99
112_F140_F0.5070.99
124_T129_I0.5060.99
19_S23_M0.5060.99
422_F426_A0.5050.99
342_I348_V0.5030.99
390_I426_A0.5020.99
154_T157_R0.5020.99
313_R431_Y0.5010.99
395_L419_S0.5010.99
327_A363_P0.5000.99
408_G415_G0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3mktA 1 0.9933 100 0.285 Contact Map
4humA 1 0.9978 100 0.294 Contact Map
4lz6A 1 0.991 100 0.3 Contact Map
3w4tA 1 0.9798 100 0.365 Contact Map
4xnjA 1 0.8787 78.7 0.941 Contact Map
3wdoA 1 0.8674 76.1 0.942 Contact Map
2cfqA 1 0.8742 55.4 0.95 Contact Map
1pw4A 1 0.8809 54.1 0.95 Contact Map
3o7qA 1 0.8404 43.1 0.953 Contact Map
4tphA 2 0.8292 33.7 0.956 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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