GREMLIN Database
SCO1 - SCO1 protein homolog
UniProt: P54178 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 193 (175)
Sequences: 4016 (3168)
Seq/√Len: 239.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
41_D107_K3.0301.00
54_V163_P3.0121.00
96_V152_V2.9501.00
53_E90_R2.8921.00
39_N121_D2.6491.00
135_A143_V2.6371.00
162_G168_L2.5821.00
39_N43_K2.4741.00
126_Y130_E2.4591.00
128_Q132_E2.3551.00
124_T131_I2.3251.00
45_V50_L2.2201.00
83_K86_N2.2011.00
48_E51_K2.1911.00
81_K183_I2.0631.00
102_K105_Q2.0521.00
40_Q107_K2.0111.00
63_N100_N2.0081.00
178_P181_D1.9211.00
107_K111_A1.8841.00
110_A122_F1.8781.00
34_P47_L1.8461.00
125_G131_I1.8081.00
162_G166_K1.7081.00
85_E187_K1.6811.00
88_D163_P1.6511.00
90_R121_D1.6441.00
81_K180_D1.6291.00
14_L18_A1.6281.00
40_Q110_A1.6261.00
57_A94_F1.6001.00
100_N150_D1.5921.00
60_I93_S1.5851.00
33_E138_S1.5711.00
171_Y185_D1.5611.00
39_N45_V1.5611.00
78_L183_I1.5581.00
46_S49_S1.5451.00
61_F151_Q1.5121.00
36_T44_N1.4531.00
97_D100_N1.4341.00
103_P124_T1.4321.00
126_Y129_S1.4231.00
75_M158_F1.4191.00
60_I72_T1.3971.00
83_K87_I1.3941.00
59_F139_F1.3931.00
130_E133_E1.3841.00
50_L121_D1.3831.00
16_L19_C1.3721.00
50_L55_W1.3671.00
38_Q124_T1.3601.00
160_L171_Y1.3431.00
58_D71_M1.3391.00
54_V186_V1.3261.00
18_A22_Q1.3201.00
179_Y183_I1.3131.00
128_Q143_V1.2881.00
132_E137_K1.2641.00
99_E128_Q1.2411.00
99_E145_K1.2361.00
79_Q91_I1.2341.00
17_C20_G1.2291.00
91_I120_W1.2121.00
50_L92_I1.2101.00
56_L158_F1.1711.00
45_V123_L1.1671.00
114_P119_N1.1451.00
141_A159_Y1.1391.00
105_Q108_K1.1241.00
144_K153_I1.1181.00
180_D184_S1.0951.00
169_K185_D1.0941.00
64_C68_C1.0891.00
78_L182_I1.0821.00
71_M158_F1.0811.00
93_S120_W1.0791.00
16_L20_G1.0591.00
37_F125_G1.0581.00
47_L55_W1.0521.00
63_N105_Q1.0491.00
36_T46_S1.0401.00
44_N130_E1.0381.00
10_G13_F1.0261.00
57_A161_V1.0251.00
108_K112_N1.0251.00
19_C22_Q1.0231.00
84_A87_I1.0171.00
157_S170_D1.0091.00
32_V139_F1.0091.00
38_Q44_N1.0061.00
15_F19_C0.9941.00
132_E135_A0.9861.00
94_F134_F0.9831.00
59_F141_A0.9811.00
79_Q119_N0.9671.00
55_W90_R0.9581.00
17_C21_G0.9581.00
98_P124_T0.9491.00
76_T80_K0.9481.00
115_L119_N0.9471.00
184_S188_S0.9461.00
70_P74_H0.9411.00
54_V168_L0.9361.00
181_D184_S0.9321.00
67_I156_S0.9301.00
95_S124_T0.9231.00
185_D188_S0.9181.00
19_C23_Q0.9131.00
133_E138_S0.9111.00
142_I153_I0.9101.00
34_P46_S0.9081.00
45_V49_S0.9041.00
183_I187_K0.8951.00
40_Q106_L0.8931.00
40_Q121_D0.8850.99
72_T109_F0.8840.99
76_T114_P0.8800.99
78_L179_Y0.8770.99
110_A120_W0.8750.99
12_I18_A0.8690.99
9_A13_F0.8630.99
75_M91_I0.8620.99
54_V89_V0.8530.99
11_L15_F0.8520.99
132_E143_V0.8480.99
63_N97_D0.8450.99
26_D29_N0.8430.99
72_T93_S0.8420.99
106_L124_T0.8380.99
71_M173_G0.8340.99
8_T11_L0.8190.99
158_F182_I0.8180.99
58_D93_S0.8170.99
146_P153_I0.8170.99
35_F139_F0.8160.99
55_W92_I0.8120.99
52_G165_G0.8050.99
58_D72_T0.8050.99
8_T12_I0.8020.99
60_I122_F0.8010.99
51_K55_W0.8000.99
54_V189_A0.7960.99
73_A113_Y0.7930.99
36_T130_E0.7850.99
139_F159_Y0.7790.99
79_Q114_P0.7780.99
74_H178_P0.7750.99
32_V134_F0.7590.98
133_E137_K0.7520.98
18_A21_G0.7470.98
56_L160_L0.7450.98
71_M74_H0.7430.98
171_Y182_I0.7390.98
77_D81_K0.7370.98
96_V135_A0.7350.98
12_I19_C0.7340.98
93_S122_F0.7330.98
129_S132_E0.7290.98
55_W161_V0.7280.98
60_I120_W0.7270.98
168_L189_A0.7250.98
95_S98_P0.7240.98
9_A12_I0.7070.97
131_I135_A0.7070.97
12_I16_L0.7050.97
128_Q131_I0.7040.97
21_G24_I0.7020.97
20_G23_Q0.7000.97
56_L171_Y0.6920.97
185_D189_A0.6900.97
74_H174_V0.6900.97
171_Y175_E0.6850.97
12_I15_F0.6840.97
56_L75_M0.6810.97
35_F47_L0.6790.97
45_V121_D0.6790.97
12_I24_I0.6780.97
56_L186_V0.6760.97
61_F69_P0.6750.97
77_D179_Y0.6640.96
72_T122_F0.6610.96
68_C154_H0.6570.96
54_V162_G0.6560.96
143_V157_S0.6560.96
59_F94_F0.6560.96
167_V170_D0.6540.96
58_D156_S0.6520.96
38_Q43_K0.6470.96
39_N107_K0.6470.96
115_L122_F0.6420.96
8_T15_F0.6410.96
40_Q103_P0.6380.95
79_Q120_W0.6360.95
37_F94_F0.6340.95
158_F173_G0.6330.95
161_V167_V0.6320.95
87_I119_N0.6260.95
35_F46_S0.6250.95
10_G14_L0.6240.95
91_I114_P0.6220.95
74_H173_G0.6210.95
15_F20_G0.6200.95
32_V161_V0.6200.95
72_T113_Y0.6180.95
131_I134_F0.6180.95
14_L20_G0.6160.94
47_L51_K0.6140.94
175_E185_D0.6110.94
10_G18_A0.6090.94
13_F16_L0.6060.94
61_F154_H0.6050.94
82_L187_K0.6050.94
9_A20_G0.6040.94
14_L17_C0.5960.93
175_E182_I0.5890.93
83_K119_N0.5890.93
15_F18_A0.5880.93
76_T113_Y0.5870.93
65_E109_F0.5840.93
13_F17_C0.5800.93
114_P120_W0.5780.92
140_K167_V0.5730.92
9_A14_L0.5710.92
34_P48_E0.5700.92
79_Q86_N0.5690.92
134_F138_S0.5670.92
159_Y170_D0.5670.92
81_K179_Y0.5650.92
140_K159_Y0.5640.91
47_L165_G0.5630.91
161_V165_G0.5570.91
62_T109_F0.5570.91
96_V143_V0.5530.91
57_A92_I0.5500.90
186_V189_A0.5480.90
56_L91_I0.5450.90
159_Y167_V0.5450.90
146_P151_Q0.5440.90
8_T16_L0.5430.90
82_L186_V0.5420.90
19_C24_I0.5400.90
31_E166_K0.5360.89
37_F131_I0.5330.89
109_F113_Y0.5310.89
32_V138_S0.5290.89
85_E88_D0.5250.88
134_F139_F0.5250.88
70_P73_A0.5240.88
14_L23_Q0.5190.88
65_E151_Q0.5180.88
64_C154_H0.5140.87
94_F139_F0.5130.87
100_N105_Q0.5130.87
135_A141_A0.5120.87
69_P154_H0.5120.87
30_Y140_K0.5090.87
115_L120_W0.5090.87
73_A77_D0.5080.87
156_S173_G0.5030.86
71_M156_S0.5020.86
96_V156_S0.5000.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1xzoA 3 0.8912 100 0.415 Contact Map
2ggtA 1 0.8135 100 0.417 Contact Map
2k6vA 1 0.8601 100 0.459 Contact Map
4hdeA 1 0.8653 100 0.468 Contact Map
4bpyA 1 0.8083 100 0.485 Contact Map
4txoD 1 0.8083 100 0.491 Contact Map
2b7kA 1 0.8342 100 0.493 Contact Map
2rliA 1 0.8238 100 0.498 Contact Map
3me7A 1 0.8342 100 0.499 Contact Map
2hyxA 2 0.8756 99.9 0.526 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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