GREMLIN Database
HLY3 - Hemolysin-3 homolog
UniProt: P54175 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 213 (198)
Sequences: 3651 (2493)
Seq/√Len: 177.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
55_Y195_S4.1111.00
167_L197_A3.4431.00
167_L193_G2.9061.00
92_F201_C2.8881.00
50_S87_G2.7971.00
17_G192_L2.7811.00
140_W169_S2.6701.00
25_L48_G2.6241.00
18_V52_L2.5681.00
167_L194_G2.5071.00
18_V56_L2.4701.00
136_L169_S2.3941.00
189_S193_G2.3881.00
107_V111_S2.3261.00
38_A42_V2.2891.00
11_A63_S2.2461.00
159_S163_L2.2161.00
155_G159_S2.1641.00
45_T49_V2.1171.00
72_I76_I2.0621.00
100_T104_T2.0331.00
90_T110_W2.0161.00
120_K131_S1.9111.00
136_L172_T1.9071.00
26_V30_I1.8721.00
50_S83_V1.8231.00
160_L197_A1.8161.00
103_F107_V1.8041.00
180_I183_H1.8011.00
104_T108_I1.7751.00
51_M195_S1.7701.00
160_L200_F1.7681.00
7_E10_N1.7501.00
177_W180_I1.7391.00
196_A200_F1.6881.00
57_S76_I1.6821.00
9_A185_A1.6811.00
83_V117_I1.6571.00
103_F106_L1.6491.00
41_I45_T1.6431.00
172_T187_W1.6251.00
15_G59_T1.5151.00
175_Y178_K1.5061.00
86_A110_W1.4951.00
101_L144_I1.4601.00
163_L167_L1.4561.00
147_K151_A1.4211.00
13_T189_S1.4161.00
13_T185_A1.4161.00
101_L104_T1.4111.00
8_I12_I1.4011.00
86_A113_A1.3921.00
56_L60_L1.3731.00
199_F203_L1.3701.00
51_M84_L1.3641.00
61_L74_E1.3421.00
139_G165_G1.3371.00
157_G205_Y1.3331.00
31_F203_L1.3311.00
24_A199_F1.3271.00
104_T107_V1.3191.00
193_G197_A1.3101.00
162_F166_I1.3081.00
93_L105_L1.3071.00
163_L197_A1.3031.00
166_I170_V1.2841.00
112_L138_M1.2831.00
43_S94_L1.2601.00
25_L52_L1.2401.00
39_W98_K1.2151.00
21_S51_M1.1991.00
52_L56_L1.1991.00
40_D95_G1.1971.00
145_A148_P1.1901.00
42_V45_T1.1891.00
98_K102_G1.1871.00
27_F31_F1.1801.00
200_F204_F1.1751.00
161_L201_C1.1661.00
79_S117_I1.1431.00
158_F162_F1.1041.00
79_S121_I1.0861.00
24_A28_L1.0841.00
101_L148_P1.0751.00
105_L145_A1.0701.00
57_S80_A1.0581.00
62_H184_H1.0561.00
173_I177_W1.0561.00
29_I45_T1.0431.00
54_L84_L1.0411.00
37_S40_D1.0391.00
50_S84_L1.0371.00
99_G102_G1.0320.99
47_F51_M1.0290.99
128_I183_H1.0250.99
92_F202_V1.0200.99
156_A159_S1.0080.99
118_V122_F1.0020.99
69_T72_I0.9990.99
64_I69_T0.9860.99
19_L23_P0.9850.99
96_P153_L0.9830.99
10_N13_T0.9830.99
167_L190_F0.9800.99
33_A41_I0.9790.99
109_V138_M0.9760.99
74_E124_V0.9640.99
39_W94_L0.9640.99
88_T164_G0.9570.99
9_A13_T0.9550.99
12_I16_I0.9490.99
78_H175_Y0.9460.99
177_W183_H0.9430.99
178_K183_H0.9390.99
94_L102_G0.9380.99
136_L140_W0.9340.99
129_L133_F0.9190.99
174_F177_W0.9180.99
82_Y116_G0.8910.98
123_F127_F0.8870.98
108_I141_L0.8840.98
179_K182_F0.8830.98
29_I33_A0.8830.98
128_I178_K0.8830.98
46_I90_T0.8810.98
32_A44_F0.8800.98
85_I168_Y0.8800.98
180_I185_A0.8760.98
114_L118_V0.8740.98
43_S95_G0.8720.98
80_A83_V0.8720.98
168_Y195_S0.8700.98
112_L134_V0.8580.98
64_I73_L0.8460.98
132_T187_W0.8450.98
27_F203_L0.8430.98
142_M145_A0.8280.98
168_Y194_G0.8230.97
124_V127_F0.8200.97
132_T172_T0.8190.97
36_G40_D0.8110.97
86_A90_T0.8030.97
47_F55_Y0.8000.97
66_H69_T0.8000.97
93_L97_L0.7910.97
156_A205_Y0.7910.97
42_V46_I0.7910.97
172_T176_I0.7870.97
89_Y109_V0.7820.97
44_F202_V0.7810.97
113_A138_M0.7720.96
187_W198_M0.7700.96
39_W43_S0.7690.96
11_A59_T0.7650.96
88_T168_Y0.7630.96
116_G134_V0.7630.96
123_F126_R0.7620.96
67_K71_D0.7610.96
100_T103_F0.7580.96
10_N184_H0.7570.96
133_F137_V0.7570.96
93_L102_G0.7540.96
71_D125_K0.7510.96
84_L88_T0.7500.96
53_L57_S0.7490.96
64_I67_K0.7470.96
150_Y155_G0.7460.95
105_L148_P0.7410.95
160_L201_C0.7390.95
10_N62_H0.7390.95
72_I75_I0.7370.95
111_S115_G0.7340.95
13_T192_L0.7300.95
60_L73_L0.7290.95
143_I146_V0.7260.95
200_F203_L0.7230.95
25_L45_T0.7230.95
38_A41_I0.7180.94
150_Y158_F0.7170.94
190_F193_G0.7160.94
12_I15_G0.7140.94
88_T198_M0.7120.94
140_W165_G0.7120.94
53_L80_A0.7070.94
85_I89_Y0.7000.94
105_L141_L0.6990.94
195_S198_M0.6970.94
169_S173_I0.6950.93
101_L145_A0.6900.93
18_V22_I0.6850.93
8_I15_G0.6840.93
186_I190_F0.6820.93
11_A15_G0.6790.93
22_I26_V0.6700.92
191_V194_G0.6660.92
33_A38_A0.6650.92
7_E184_H0.6650.92
84_L195_S0.6620.92
90_T106_L0.6610.92
72_I121_I0.6600.92
122_F125_K0.6560.91
181_P185_A0.6540.91
23_P27_F0.6510.91
30_I33_A0.6450.91
147_K150_Y0.6370.90
180_I186_I0.6350.90
20_L196_A0.6310.90
47_F168_Y0.6300.90
184_H188_H0.6270.89
93_L142_M0.6250.89
96_P152_S0.6230.89
112_L141_L0.6220.89
182_F185_A0.6210.89
37_S98_K0.6170.89
99_G104_T0.6170.89
131_S135_Y0.6160.89
168_Y171_G0.6090.88
150_Y162_F0.6080.88
94_L106_L0.6080.88
68_K72_I0.6080.88
13_T184_H0.6060.88
143_I150_Y0.6050.88
23_P26_V0.6010.87
40_D43_S0.6000.87
109_V141_L0.5990.87
50_S132_T0.5980.87
132_T176_I0.5980.87
29_I41_I0.5960.87
119_F130_L0.5950.87
174_F182_F0.5910.86
174_F187_W0.5910.86
170_V190_F0.5900.86
142_M146_V0.5890.86
18_V59_T0.5880.86
71_D75_I0.5880.86
38_A49_V0.5870.86
27_F199_F0.5860.86
79_S83_V0.5850.86
74_E78_H0.5840.86
22_I52_L0.5820.86
128_I132_T0.5810.85
128_I176_I0.5810.85
58_S62_H0.5800.85
157_G201_C0.5780.85
183_H186_I0.5760.85
91_P202_V0.5730.85
179_K183_H0.5730.85
10_N183_H0.5720.85
47_F195_S0.5720.85
120_K182_F0.5710.85
93_L109_V0.5700.84
170_V173_I0.5690.84
136_L139_G0.5690.84
165_G169_S0.5680.84
59_T63_S0.5650.84
7_E13_T0.5640.84
122_F145_A0.5590.83
60_L63_S0.5570.83
163_L166_I0.5560.83
142_M149_L0.5550.83
12_I88_T0.5550.83
51_M168_Y0.5530.83
74_E128_I0.5500.82
153_L158_F0.5500.82
15_G63_S0.5500.82
109_V113_A0.5490.82
94_L98_K0.5460.82
13_T62_H0.5450.82
192_L196_A0.5440.82
159_S162_F0.5400.81
40_D44_F0.5400.81
154_S157_G0.5380.81
80_A125_K0.5320.80
65_T70_K0.5310.80
75_I79_S0.5290.80
18_V192_L0.5280.80
132_T136_L0.5250.79
47_F202_V0.5230.79
47_F84_L0.5230.79
42_V114_L0.5220.79
60_L64_I0.5210.79
75_I121_I0.5210.79
170_V179_K0.5160.78
17_G20_L0.5160.78
68_K170_V0.5130.78
29_I48_G0.5120.78
77_D188_H0.5110.77
55_Y135_Y0.5100.77
15_G18_V0.5090.77
92_F161_L0.5090.77
99_G103_F0.5080.77
106_L138_M0.5050.77
44_F48_G0.5050.77
86_A89_Y0.5050.77
45_T48_G0.5030.76
148_P151_A0.5010.76
51_M55_Y0.5000.76
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3wxwA 1 0.9812 100 0.172 Contact Map
4fbzA 3 0.3005 8.2 0.955 Contact Map
4qi1A 3 0.2911 4.2 0.961 Contact Map
3qapA 1 0.2817 3.7 0.962 Contact Map
1jr8A 2 0.1455 2.6 0.965 Contact Map
3am6A 3 0.2911 2.1 0.967 Contact Map
3ddlA 2 0.3099 1.8 0.968 Contact Map
1xioA 2 0.2629 1.7 0.968 Contact Map
4hyjA 2 0.3005 1.6 0.969 Contact Map
4l35A 3 0.2958 1.6 0.969 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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