GREMLIN Database
YPKP - Uncharacterized protein YpkP
UniProt: P54174 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 206 (165)
Sequences: 9021 (6203)
Seq/√Len: 482.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
167_E193_S4.3941.00
67_P194_K4.1561.00
63_H191_S4.1491.00
63_H189_E3.8321.00
61_T189_E3.6481.00
61_T187_D3.1161.00
64_Q67_P2.9371.00
59_V187_D2.5661.00
133_T137_E2.5291.00
73_V141_S2.3001.00
162_P197_I2.2121.00
166_V192_F2.1491.00
169_K189_E2.1421.00
134_K138_K2.1411.00
105_F121_S2.1391.00
96_A143_I2.0921.00
71_G162_P2.0281.00
73_V164_V1.9901.00
76_V152_P1.9201.00
105_F115_D1.8931.00
101_N149_S1.8891.00
75_Y141_S1.8441.00
133_T159_Y1.8111.00
133_T158_R1.7861.00
77_H166_V1.7801.00
169_K191_S1.7781.00
97_G140_Q1.7601.00
102_P106_R1.7591.00
75_Y164_V1.7211.00
127_K131_D1.6681.00
136_L161_L1.6461.00
154_E158_R1.6341.00
112_Q116_R1.6041.00
165_M193_S1.5941.00
88_I166_V1.5901.00
100_A104_V1.5871.00
131_D135_Q1.5611.00
103_K122_D1.5361.00
80_L172_D1.4771.00
132_V155_L1.4641.00
197_I200_N1.4611.00
73_V162_P1.4451.00
111_G115_D1.4191.00
131_D134_K1.3941.00
100_A105_F1.3491.00
97_G135_Q1.3331.00
77_H145_S1.3011.00
75_Y92_I1.2601.00
77_H88_I1.2571.00
164_V195_A1.2561.00
62_I192_F1.2521.00
176_N179_F1.2361.00
91_Y192_F1.2291.00
122_D149_S1.1911.00
135_Q140_Q1.1901.00
100_A119_V1.1771.00
101_N104_V1.1651.00
154_E157_A1.1541.00
152_P163_L1.1361.00
80_L151_D1.1251.00
168_T171_T1.1071.00
101_N122_D1.0961.00
108_P111_G1.0881.00
47_A51_G1.0741.00
112_Q115_D1.0681.00
71_G197_I1.0661.00
156_A163_L1.0571.00
107_L110_I1.0571.00
99_I128_V1.0541.00
101_N150_I1.0451.00
74_L152_P1.0341.00
162_P198_P1.0071.00
165_M195_A1.0061.00
134_K137_E1.0061.00
72_P139_G0.9961.00
157_A201_E0.9911.00
35_K39_A0.9871.00
127_K130_E0.9861.00
174_M186_A0.9851.00
91_Y190_L0.9721.00
99_I120_I0.9691.00
130_E133_T0.9531.00
88_I145_S0.9531.00
135_Q142_L0.9491.00
57_G185_P0.9361.00
62_I65_P0.9301.00
197_I201_E0.9241.00
60_V87_L0.9231.00
80_L171_T0.9211.00
160_H198_P0.9131.00
132_V142_L0.9131.00
130_E134_K0.9081.00
104_V114_L0.9081.00
60_V90_G0.9051.00
162_P195_A0.8911.00
98_F143_I0.8891.00
71_G141_S0.8861.00
150_I170_G0.8821.00
92_I192_F0.8781.00
78_P147_D0.8771.00
120_I142_L0.8671.00
77_H143_I0.8651.00
85_L100_A0.8631.00
147_D151_D0.8571.00
152_P156_A0.8461.00
122_D125_S0.8401.00
114_L119_V0.8341.00
49_L53_I0.8331.00
72_P161_L0.8321.00
156_A159_Y0.8301.00
82_L85_L0.8301.00
50_E54_G0.8261.00
51_G55_I0.8191.00
198_P201_E0.8131.00
80_L150_I0.8091.00
156_A198_P0.8061.00
106_R115_D0.8041.00
100_A114_L0.8021.00
99_I144_L0.7951.00
130_E158_R0.7941.00
39_A43_E0.7911.00
72_P141_S0.7861.00
62_I91_Y0.7841.00
50_E53_I0.7771.00
50_E55_I0.7711.00
107_L111_G0.7681.00
133_T155_L0.7681.00
88_I168_T0.7511.00
171_T188_I0.7511.00
120_I128_V0.7441.00
85_L89_A0.7361.00
120_I132_V0.7271.00
81_R175_Q0.7211.00
43_E46_K0.7191.00
68_I192_F0.7171.00
175_Q179_F0.7171.00
128_V132_V0.7141.00
47_A50_E0.7131.00
137_E159_Y0.7001.00
179_F183_L0.6991.00
69_P73_V0.6951.00
39_A42_Y0.6931.00
42_Y45_P0.6911.00
74_L156_A0.6871.00
173_N186_A0.6861.00
68_I164_V0.6821.00
38_M41_V0.6821.00
114_L121_S0.6801.00
120_I135_Q0.6781.00
81_R171_T0.6771.00
155_L159_Y0.6661.00
89_A98_F0.6651.00
136_L155_L0.6641.00
110_I114_L0.6631.00
98_F145_S0.6621.00
46_K93_E0.6591.00
115_D121_S0.6571.00
160_H199_A0.6541.00
64_Q192_F0.6521.00
51_G54_G0.6501.00
82_L150_I0.6481.00
75_Y166_V0.6481.00
50_E90_G0.6471.00
101_N167_E0.6461.00
85_L98_F0.6441.00
170_G186_A0.6401.00
129_Y132_V0.6401.00
36_K41_V0.6381.00
94_E141_S0.6351.00
67_P192_F0.6311.00
40_L43_E0.6301.00
170_G173_N0.6301.00
135_Q138_K0.6291.00
88_I190_L0.6281.00
77_H168_T0.6271.00
82_L104_V0.6251.00
78_P151_D0.6251.00
164_V193_S0.6221.00
105_F114_L0.6210.99
175_Q178_S0.6200.99
41_V45_P0.6170.99
104_V111_G0.6160.99
59_V185_P0.6140.99
92_I96_A0.6130.99
104_V110_I0.6110.99
106_R109_F0.6080.99
118_D140_Q0.6070.99
53_I90_G0.6040.99
35_K38_M0.6030.99
85_L104_V0.6030.99
69_P164_V0.6020.99
88_I98_F0.6010.99
73_V76_V0.6000.99
84_E168_T0.5980.99
97_G119_V0.5980.99
42_Y46_K0.5970.99
102_P105_F0.5970.99
157_A198_P0.5960.99
36_K39_A0.5960.99
44_Q47_A0.5930.99
75_Y192_F0.5920.99
89_A119_V0.5910.99
37_Q40_L0.5910.99
113_W117_M0.5890.99
160_H197_I0.5860.99
129_Y154_E0.5840.99
81_R150_I0.5840.99
43_E47_A0.5800.99
170_G174_M0.5790.99
71_G94_E0.5780.99
45_P89_A0.5740.99
58_S174_M0.5730.99
62_I190_L0.5720.99
144_L155_L0.5720.99
41_V44_Q0.5700.99
48_F52_C0.5650.99
129_Y158_R0.5620.99
60_V91_Y0.5620.99
46_K50_E0.5590.99
174_M188_I0.5590.99
78_P167_E0.5520.99
53_I60_V0.5520.99
166_V190_L0.5510.99
87_L188_I0.5500.99
102_P123_G0.5460.99
82_L175_Q0.5430.99
173_N176_N0.5390.99
84_E114_L0.5370.99
84_E89_A0.5360.99
108_P112_Q0.5350.99
44_Q48_F0.5330.98
118_D138_K0.5320.98
109_F112_Q0.5310.98
68_I75_Y0.5290.98
153_V163_L0.5280.98
99_I132_V0.5250.98
36_K42_Y0.5250.98
64_Q194_K0.5240.98
167_E191_S0.5230.98
85_L145_S0.5110.98
79_R146_L0.5080.98
58_S188_I0.5040.98
65_P194_K0.5040.98
141_S164_V0.5040.98
58_S87_L0.5030.98
123_G126_E0.5020.98
96_A141_S0.5010.98
179_F182_R0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1iuqA 1 0.9466 100 0.361 Contact Map
3sdbA 6 0.534 20.8 0.937 Contact Map
1k7jA 1 0.432 18.7 0.938 Contact Map
2mr6A 1 0.568 13.3 0.942 Contact Map
1jcuA 1 0.4223 13 0.943 Contact Map
1hruA 2 0.3932 12 0.943 Contact Map
2e11A 2 0.4806 9.7 0.946 Contact Map
3ilvA 2 0.4854 9.4 0.946 Contact Map
3ivzA 2 0.4854 9.2 0.946 Contact Map
2eqaA 1 0.432 7.5 0.948 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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