GREMLIN Database
YPGR - Uncharacterized protein YpgR
UniProt: P54169 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 377 (310)
Sequences: 399 (329)
Seq/√Len: 18.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
330_I352_L6.7401.00
182_D186_K4.6601.00
265_P297_Q4.2991.00
245_D273_K4.2571.00
307_S335_A4.0191.00
108_V176_L3.7301.00
334_R356_E3.6931.00
275_L301_A3.3001.00
276_E304_K3.0390.99
290_L298_A2.9370.99
133_E137_Q2.8790.99
217_D222_K2.8300.99
254_Q258_Y2.8280.99
118_V173_T2.8240.98
348_V352_L2.8130.98
211_T214_M2.5340.97
137_Q141_K2.3310.95
73_K345_S2.3060.95
272_Y290_L2.2470.94
141_K186_K2.2400.94
272_Y301_A2.2010.93
129_F169_G2.1690.93
129_F173_T2.1370.92
364_S367_K2.0940.91
303_I329_A2.0680.91
116_M149_V2.0530.90
127_E166_D2.0430.90
186_K191_A1.9590.88
299_I328_S1.9500.88
241_Q270_L1.9030.87
210_V214_M1.9030.87
225_A232_P1.8850.86
216_D242_K1.8810.86
62_L65_E1.8630.85
65_E68_A1.8610.85
146_A152_E1.8300.84
275_L290_L1.8070.84
169_G173_T1.8030.84
194_Q198_E1.7770.83
290_L301_A1.7140.80
59_A83_F1.6820.79
287_G302_M1.6700.78
319_M367_K1.6490.77
180_Y184_R1.6250.76
94_N99_E1.6130.76
166_D170_H1.6060.76
182_D196_K1.5960.75
64_V337_E1.5900.75
257_V305_S1.5890.75
302_M305_S1.5830.74
265_P295_D1.5710.74
230_M239_V1.5680.74
241_Q273_K1.5380.72
194_Q201_Q1.5330.72
267_V337_E1.5300.72
259_L267_V1.5240.72
234_E264_T1.5200.71
73_K139_I1.5170.71
136_Q140_L1.5160.71
190_E195_G1.4880.70
67_N70_Y1.4730.69
148_N153_R1.4640.68
122_D125_R1.4620.68
261_M289_C1.4600.68
198_E204_Q1.4460.67
162_F175_E1.4440.67
272_Y298_A1.4370.67
219_D304_K1.4290.66
107_F157_E1.4230.66
132_P177_Q1.4170.66
319_M364_S1.4070.65
172_V175_E1.3890.64
142_L156_K1.3870.64
188_L192_A1.3830.64
187_R190_E1.3830.64
61_F313_V1.3760.63
116_M131_L1.3670.63
153_R163_G1.3600.63
343_E354_R1.3560.62
64_V226_H1.3420.61
188_L193_A1.3310.61
65_E129_F1.3300.61
330_I348_V1.3220.60
195_G201_Q1.3120.60
64_V83_F1.3060.59
112_S152_E1.3060.59
104_V174_E1.3020.59
62_L181_S1.2890.58
105_K309_S1.2880.58
97_D100_S1.2860.58
247_P256_V1.2820.58
256_V289_C1.2670.57
162_F172_V1.2420.55
171_D174_E1.2390.55
148_N155_W1.2370.55
157_E162_F1.2360.55
134_R177_Q1.2350.55
182_D190_E1.2320.55
88_A92_E1.2320.55
186_K190_E1.2160.54
241_Q245_D1.2060.53
206_K209_K1.2060.53
269_P331_E1.1960.52
112_S147_S1.1880.52
118_V129_F1.1870.52
193_A201_Q1.1840.52
154_A158_Q1.1630.50
166_D174_E1.1620.50
62_L70_Y1.1560.50
66_R341_E1.1560.50
146_A149_V1.1500.50
212_L215_L1.1450.49
186_K202_A1.1430.49
193_A198_E1.1380.49
182_D193_A1.1330.49
143_R179_A1.1230.48
62_L337_E1.1210.48
275_L293_I1.1210.48
172_V192_A1.1200.48
79_V101_F1.1190.48
288_D316_R1.1120.47
266_D337_E1.1040.47
334_R348_V1.1020.47
188_L194_Q1.1020.47
153_R168_I1.0970.46
194_Q202_A1.0880.46
345_S349_K1.0870.46
343_E346_L1.0870.46
186_K198_E1.0860.46
59_A160_V1.0860.46
293_I349_K1.0840.45
220_W252_R1.0830.45
362_K367_K1.0810.45
207_A210_V1.0780.45
217_D226_H1.0770.45
308_D313_V1.0720.45
196_K199_A1.0700.45
117_Q128_R1.0660.44
190_E196_K1.0640.44
197_G204_Q1.0600.44
275_L298_A1.0570.44
127_E142_L1.0530.44
135_F138_A1.0480.43
286_A317_A1.0370.43
65_E169_G1.0310.42
200_K203_V1.0170.41
289_C319_M1.0160.41
191_A195_G1.0160.41
184_R189_T1.0150.41
152_E157_E1.0070.41
75_I136_Q1.0010.40
149_V152_E1.0000.40
292_D316_R1.0000.40
131_L135_F0.9990.40
260_G289_C0.9950.40
242_K247_P0.9930.40
154_A157_E0.9920.40
233_K296_P0.9900.40
197_G200_K0.9890.40
150_V174_E0.9870.40
196_K204_Q0.9830.39
237_I241_Q0.9800.39
148_N163_G0.9790.39
276_E289_C0.9780.39
62_L82_A0.9730.39
288_D291_S0.9720.39
64_V70_Y0.9690.38
75_I152_E0.9680.38
292_D320_F0.9680.38
246_D251_I0.9680.38
335_A338_D0.9630.38
194_Q204_Q0.9620.38
108_V158_Q0.9610.38
237_I267_V0.9590.38
145_E345_S0.9580.38
163_G175_E0.9570.38
77_P124_E0.9550.38
195_G198_E0.9530.38
104_V165_F0.9530.38
64_V73_K0.9490.37
265_P296_P0.9470.37
69_R143_R0.9450.37
59_A73_K0.9350.36
346_L354_R0.9330.36
343_E347_Q0.9310.36
319_M362_K0.9290.36
158_Q173_T0.9260.36
228_E290_L0.9250.36
170_H173_T0.9200.36
308_D354_R0.9180.35
345_S356_E0.9160.35
316_R347_Q0.9150.35
163_G172_V0.9030.35
96_S110_M0.9020.35
74_D304_K0.8990.34
218_E222_K0.8990.34
163_G167_E0.8980.34
228_E256_V0.8870.34
115_P153_R0.8840.34
254_Q323_E0.8840.34
74_D205_R0.8800.33
186_K201_Q0.8790.33
147_S150_V0.8770.33
305_S313_V0.8730.33
189_T196_K0.8720.33
337_E349_K0.8700.33
206_K210_V0.8680.33
107_F310_S0.8630.32
242_K245_D0.8610.32
119_K155_W0.8540.32
99_E233_K0.8510.32
272_Y297_Q0.8460.31
65_E209_K0.8460.31
263_E289_C0.8430.31
330_I337_E0.8390.31
345_S352_L0.8390.31
299_I326_D0.8350.31
183_E353_E0.8330.31
214_M222_K0.8200.30
74_D245_D0.8130.30
149_V157_E0.8110.30
184_R203_V0.8090.30
95_R99_E0.8080.29
153_R162_F0.8050.29
86_E203_V0.8040.29
184_R198_E0.8030.29
208_Y211_T0.8030.29
272_Y300_P0.7930.29
289_C364_S0.7930.29
139_I156_K0.7910.29
181_S189_T0.7910.29
285_T316_R0.7880.28
245_D321_L0.7850.28
260_G291_S0.7830.28
279_A310_S0.7800.28
218_E329_A0.7790.28
196_K203_V0.7770.28
186_K194_Q0.7740.28
181_S186_K0.7730.28
336_A341_E0.7700.28
224_Y290_L0.7690.27
189_T201_Q0.7550.27
210_V215_L0.7520.27
309_S330_I0.7510.27
269_P308_D0.7500.27
334_R337_E0.7470.26
208_Y226_H0.7430.26
236_D248_K0.7430.26
115_P119_K0.7430.26
181_S194_Q0.7420.26
189_T193_A0.7390.26
168_I295_D0.7370.26
168_I172_V0.7360.26
162_F174_E0.7360.26
99_E112_S0.7350.26
209_K352_L0.7320.26
324_V345_S0.7320.26
144_S156_K0.7290.26
175_E178_A0.7270.25
58_V104_V0.7260.25
217_D324_V0.7250.25
128_R132_P0.7240.25
58_V69_R0.7240.25
262_I267_V0.7220.25
329_A353_E0.7210.25
68_A73_K0.7200.25
313_V341_E0.7200.25
343_E365_V0.7200.25
221_K270_L0.7180.25
189_T192_A0.7170.25
86_E97_D0.7170.25
298_A306_L0.7150.25
214_M345_S0.7150.25
188_L196_K0.7110.25
191_A201_Q0.7100.25
161_R180_Y0.7090.25
156_K352_L0.7080.25
145_E152_E0.7070.24
288_D292_D0.7060.24
162_F178_A0.7060.24
226_H229_Q0.7040.24
145_E181_S0.7030.24
211_T362_K0.7010.24
163_G168_I0.7000.24
114_I117_Q0.6970.24
163_G169_G0.6970.24
256_V274_A0.6950.24
185_L189_T0.6940.24
138_A154_A0.6900.24
245_D338_D0.6870.24
99_E278_K0.6860.24
198_E201_Q0.6850.23
167_E171_D0.6840.23
299_I324_V0.6830.23
304_K307_S0.6830.23
148_N151_F0.6820.23
58_V119_K0.6810.23
288_D315_W0.6800.23
264_T293_I0.6800.23
91_A97_D0.6790.23
221_K237_I0.6770.23
256_V348_V0.6730.23
161_R172_V0.6730.23
241_Q263_E0.6700.23
160_V168_I0.6680.23
291_S344_V0.6630.22
240_L262_I0.6610.22
187_R196_K0.6600.22
159_G163_G0.6590.22
195_G204_Q0.6590.22
189_T194_Q0.6540.22
207_A225_A0.6530.22
168_I178_A0.6520.22
212_L234_E0.6490.22
120_L174_E0.6490.22
208_Y214_M0.6480.22
300_P328_S0.6460.22
357_H362_K0.6460.22
128_R153_R0.6460.22
183_E191_A0.6450.22
154_A189_T0.6440.22
223_R246_D0.6430.22
236_D319_M0.6430.22
205_R266_D0.6400.22
182_D203_V0.6390.21
209_K348_V0.6380.21
228_E254_Q0.6380.21
81_T165_F0.6370.21
350_M354_R0.6360.21
234_E353_E0.6320.21
347_Q361_A0.6310.21
338_D350_M0.6270.21
122_D166_D0.6270.21
145_E154_A0.6260.21
118_V128_R0.6260.21
103_E111_F0.6260.21
68_A156_K0.6250.21
150_V153_R0.6250.21
106_V109_Q0.6250.21
334_R367_K0.6250.21
315_W354_R0.6240.21
61_F341_E0.6220.21
223_R314_R0.6210.21
237_I259_L0.6190.21
129_F139_I0.6180.21
347_Q350_M0.6180.21
291_S347_Q0.6160.21
64_V71_D0.6160.21
332_A342_F0.6160.21
343_E358_G0.6140.20
247_P279_A0.6120.20
291_S358_G0.6110.20
297_Q334_R0.6090.20
260_G288_D0.6090.20
145_E158_Q0.6080.20
176_L186_K0.6060.20
193_A196_K0.6050.20
154_A163_G0.6050.20
207_A211_T0.6020.20
329_A336_A0.5990.20
94_N97_D0.5990.20
329_A332_A0.5980.20
75_I259_L0.5970.20
323_E351_A0.5970.20
161_R175_E0.5950.20
88_A96_S0.5950.20
171_D175_E0.5950.20
213_D216_D0.5950.20
294_G356_E0.5940.20
191_A194_Q0.5940.20
346_L361_A0.5930.20
265_P272_Y0.5930.20
153_R180_Y0.5930.20
93_E190_E0.5930.20
112_S143_R0.5890.19
207_A293_I0.5880.19
208_Y215_L0.5880.19
291_S316_R0.5880.19
220_W313_V0.5850.19
253_R314_R0.5850.19
277_D358_G0.5840.19
328_S360_E0.5830.19
154_A161_R0.5830.19
316_R344_V0.5820.19
194_Q199_A0.5820.19
254_Q290_L0.5810.19
339_D361_A0.5810.19
221_K230_M0.5790.19
309_S340_P0.5750.19
233_K264_T0.5750.19
237_I345_S0.5730.19
117_Q153_R0.5730.19
69_R85_M0.5730.19
312_L346_L0.5720.19
111_F188_L0.5720.19
269_P281_S0.5720.19
260_G316_R0.5680.19
204_Q219_D0.5670.19
122_D337_E0.5660.19
299_I303_I0.5660.19
243_A302_M0.5650.18
291_S315_W0.5640.18
190_E203_V0.5630.18
87_S99_E0.5600.18
161_R164_D0.5600.18
209_K235_E0.5590.18
333_L351_A0.5540.18
228_E236_D0.5530.18
107_F121_T0.5530.18
230_M247_P0.5500.18
292_D315_W0.5500.18
154_A172_V0.5500.18
208_Y345_S0.5490.18
305_S365_V0.5480.18
83_F179_A0.5470.18
139_I151_F0.5460.18
159_G170_H0.5460.18
128_R308_D0.5430.18
136_Q157_E0.5410.18
115_P120_L0.5410.18
190_E201_Q0.5410.18
214_M236_D0.5410.18
92_E98_Q0.5400.18
73_K127_E0.5390.18
269_P330_I0.5380.17
156_K166_D0.5350.17
330_I350_M0.5350.17
158_Q172_V0.5350.17
107_F116_M0.5330.17
264_T295_D0.5310.17
102_G114_I0.5310.17
187_R199_A0.5300.17
209_K349_K0.5290.17
103_E115_P0.5290.17
253_R318_A0.5280.17
139_I142_L0.5280.17
154_A162_F0.5270.17
128_R135_F0.5270.17
313_V361_A0.5250.17
164_D194_Q0.5250.17
319_M344_V0.5250.17
330_I367_K0.5250.17
147_S152_E0.5250.17
118_V183_E0.5200.17
291_S361_A0.5200.17
308_D343_E0.5200.17
181_S190_E0.5190.17
145_E149_V0.5170.17
303_I332_A0.5170.17
288_D302_M0.5160.17
153_R161_R0.5140.17
89_E278_K0.5140.17
312_L316_R0.5140.17
165_F174_E0.5130.17
256_V290_L0.5130.17
222_K337_E0.5100.17
360_E365_V0.5100.17
208_Y217_D0.5090.16
186_K197_G0.5080.16
257_V302_M0.5080.16
257_V324_V0.5070.16
62_L124_E0.5040.16
250_S341_E0.5040.16
124_E136_Q0.5020.16
137_Q144_S0.5000.16
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1pqxA 1 0.2414 99.9 0.812 Contact Map
2k1hA 1 0.2281 99.9 0.812 Contact Map
3ltjA 2 0.4695 99.8 0.819 Contact Map
2ltmA 1 0.2573 99.8 0.825 Contact Map
2ltlA 1 0.2573 99.8 0.825 Contact Map
3ltmA 1 0.4828 99.8 0.826 Contact Map
4lacA 1 0.5172 99.8 0.83 Contact Map
1wa5B 1 0.5517 99.8 0.831 Contact Map
3tpoA 1 0.5013 99.8 0.831 Contact Map
4jw3C 1 0.2573 99.7 0.84 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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