GREMLIN Database
META - Homoserine O-succinyltransferase
UniProt: P54167 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 301 (298)
Sequences: 1306 (776)
Seq/√Len: 44.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
244_L265_F4.8951.00
165_F258_V4.7631.00
162_K259_E4.4491.00
244_L248_E4.4211.00
129_E151_Y3.9121.00
68_T100_F3.8291.00
37_K66_H3.3321.00
99_R134_N3.2711.00
198_N201_Q2.9711.00
199_M213_A2.9461.00
219_V222_I2.7761.00
72_P75_H2.7711.00
216_E262_K2.7641.00
189_V220_C2.6781.00
146_Q195_T2.6531.00
240_T274_N2.6101.00
129_E132_K2.5691.00
73_S93_S2.5521.00
103_M131_S2.4521.00
266_A272_P2.4171.00
199_M203_Q2.3251.00
75_H119_S2.2771.00
37_K98_K2.2371.00
248_E265_F2.2311.00
187_Y212_T2.2261.00
158_I198_N2.1741.00
241_N245_Q2.1071.00
39_I103_M2.0901.00
174_S209_N2.0650.99
220_C236_P2.0190.99
140_H152_H1.9900.99
7_T26_S1.9870.99
169_E186_L1.9510.99
194_H258_V1.8970.99
70_L95_I1.8650.99
40_I54_L1.8590.99
141_I146_Q1.8300.99
13_Q17_S1.8190.99
122_E125_K1.8170.99
179_L230_V1.7990.98
112_H159_Q1.7850.98
39_I70_L1.7480.98
12_K16_E1.7250.98
157_K195_T1.7030.98
171_T215_K1.6640.97
55_L67_F1.6640.97
267_K270_N1.6610.97
46_K49_Q1.6590.97
183_F279_H1.5960.97
165_F256_S1.5940.97
39_I95_I1.5930.97
124_L128_M1.5730.96
136_T228_K1.5710.96
116_E150_Y1.5630.96
5_I12_K1.5560.96
115_F146_Q1.5550.96
54_L141_I1.5510.96
165_F194_H1.5490.96
131_S140_H1.5480.96
53_Q239_D1.5430.96
170_H217_A1.5300.96
46_K245_Q1.5270.96
125_K151_Y1.5250.96
96_R126_E1.5200.96
128_M152_H1.5170.96
199_M210_I1.5130.96
170_H191_H1.5130.96
40_I67_F1.4960.95
183_F282_L1.4950.95
188_Y275_R1.4640.95
164_I168_F1.4500.94
136_T295_E1.4370.94
148_G152_H1.4360.94
131_S152_H1.4330.94
194_H255_L1.4270.94
140_H148_G1.4170.94
146_Q157_K1.4170.94
114_A117_E1.4060.93
248_E252_E1.3970.93
138_T148_G1.3940.93
183_F283_L1.3860.93
4_N130_W1.3760.93
153_Y224_S1.3670.92
111_E157_K1.3630.92
28_A31_Q1.3190.91
168_F262_K1.3080.91
160_M164_I1.2780.90
27_R30_H1.2750.89
156_E201_Q1.2690.89
111_E195_T1.2660.89
114_A156_E1.2630.89
251_L260_A1.2550.89
72_P127_I1.2440.88
14_V52_T1.2400.88
156_E198_N1.2370.88
13_Q16_E1.2360.88
65_V288_L1.2320.88
210_I213_A1.2210.87
209_N225_K1.2190.87
141_I236_P1.2110.87
178_R295_E1.1980.86
144_G233_T1.1950.86
236_P283_L1.1920.86
84_H88_F1.1910.86
170_H220_C1.1910.86
31_Q34_R1.1900.86
210_I219_V1.1870.86
216_E263_H1.1840.86
221_L232_L1.1740.85
132_K151_Y1.1640.85
200_E204_A1.1570.84
38_I102_G1.1560.84
169_E275_R1.1560.84
48_I84_H1.1550.84
91_T94_N1.1510.84
247_Y251_L1.1420.83
152_H229_Q1.1340.83
251_L258_V1.1310.83
199_M219_V1.1310.83
158_I196_D1.1300.83
248_E251_L1.1190.82
110_I144_G1.1160.82
289_N294_Q1.1140.82
173_L213_A1.1030.81
131_S229_Q1.1000.81
90_T94_N1.0980.81
57_L280_A1.0920.81
49_Q245_Q1.0850.80
266_A270_N1.0830.80
224_S229_Q1.0710.79
158_I201_Q1.0660.79
7_T25_E1.0640.79
214_S217_A1.0560.78
70_L103_M1.0560.78
28_A33_I1.0550.78
105_I128_M1.0490.78
74_T123_E1.0440.77
12_K48_I1.0440.77
177_E223_V1.0420.77
202_L219_V1.0410.77
31_Q64_Q1.0390.77
209_N223_V1.0370.77
8_H87_E1.0350.77
28_A34_R1.0330.77
82_R86_D1.0250.76
90_T98_K1.0160.76
208_L222_I1.0150.75
191_H217_A1.0150.75
224_S228_K1.0110.75
168_F194_H1.0090.75
141_I195_T1.0070.75
189_V217_A1.0040.75
132_K229_Q1.0030.75
111_E146_Q0.9970.74
139_L236_P0.9960.74
37_K300_W0.9900.74
24_D69_F0.9890.74
169_E188_Y0.9890.74
165_F169_E0.9810.73
197_I201_Q0.9720.72
4_N25_E0.9650.72
130_W134_N0.9640.72
110_I157_K0.9590.71
255_L258_V0.9570.71
160_M196_D0.9550.71
141_I157_K0.9500.70
41_L103_M0.9460.70
202_L222_I0.9420.70
179_L221_L0.9300.69
186_L275_R0.9240.68
41_L72_P0.9220.68
256_S259_E0.9180.68
189_V236_P0.9160.68
180_V221_L0.9140.67
41_L70_L0.9130.67
34_R64_Q0.9110.67
278_A282_L0.9100.67
191_H234_G0.8990.66
141_I284_F0.8980.66
112_H194_H0.8960.66
139_L283_L0.8940.66
171_T263_H0.8940.66
13_Q30_H0.8920.66
72_P77_P0.8890.65
128_M151_Y0.8870.65
28_A293_Y0.8850.65
4_N7_T0.8840.65
31_Q293_Y0.8770.64
110_I195_T0.8740.64
33_I64_Q0.8680.63
172_V175_K0.8490.62
164_I217_A0.8480.62
46_K242_T0.8470.62
103_M127_I0.8430.61
68_T90_T0.8400.61
28_A64_Q0.8350.60
7_T24_D0.8250.59
18_E56_R0.8220.59
121_W147_A0.8130.58
75_H78_K0.8120.58
75_H113_L0.7990.57
69_F124_L0.7990.57
134_N144_G0.7980.57
51_E89_Y0.7970.57
212_T220_C0.7970.57
251_L255_L0.7960.57
87_E90_T0.7960.57
128_M148_G0.7960.57
172_V180_V0.7960.57
266_A271_E0.7940.57
34_R293_Y0.7930.56
11_A52_T0.7930.56
46_K52_T0.7870.56
41_L130_W0.7870.56
171_T186_L0.7840.56
21_F290_Y0.7800.55
199_M268_G0.7790.55
164_I194_H0.7770.55
223_V227_E0.7760.55
57_L282_L0.7760.55
223_V230_V0.7740.55
196_D201_Q0.7720.54
6_P282_L0.7700.54
138_T229_Q0.7690.54
165_F251_L0.7660.54
220_C283_L0.7650.54
12_K24_D0.7650.54
253_R258_V0.7640.54
64_Q293_Y0.7630.54
5_I48_I0.7600.53
39_I100_F0.7600.53
180_V211_L0.7600.53
110_I146_Q0.7580.53
28_A32_D0.7520.52
128_M140_H0.7510.52
3_I16_E0.7460.52
236_P281_T0.7450.52
55_L69_F0.7410.51
156_E196_D0.7400.51
48_I52_T0.7400.51
220_C232_L0.7400.51
191_H211_L0.7380.51
111_E141_I0.7370.51
111_E123_E0.7370.51
73_S91_T0.7360.51
40_I55_L0.7350.51
125_K129_E0.7340.51
105_I229_Q0.7330.51
122_E126_E0.7320.51
207_E224_S0.7280.50
60_N290_Y0.7270.50
112_H144_G0.7250.50
159_Q194_H0.7170.49
105_I148_G0.7150.49
228_K299_E0.7130.49
220_C279_H0.7130.49
178_R185_E0.7120.49
78_K210_I0.7110.48
24_D48_I0.7090.48
83_E86_D0.7040.48
138_T152_H0.7040.48
165_F168_F0.7020.48
3_I239_D0.6990.47
115_F195_T0.6950.47
153_Y231_F0.6930.47
254_N258_V0.6920.47
66_H177_E0.6920.47
26_S30_H0.6910.47
21_F27_R0.6880.46
259_E262_K0.6800.45
68_T98_K0.6790.45
115_F280_A0.6780.45
130_W283_L0.6770.45
202_L208_L0.6760.45
178_R298_Y0.6740.45
33_I293_Y0.6740.45
177_E211_L0.6710.45
72_P119_S0.6700.45
148_G151_Y0.6700.45
76_T82_R0.6660.44
57_L281_T0.6630.44
110_I113_L0.6580.43
49_Q52_T0.6560.43
39_I69_F0.6540.43
279_H283_L0.6520.43
174_S284_F0.6500.43
46_K300_W0.6470.42
171_T212_T0.6450.42
75_H123_E0.6450.42
8_H177_E0.6450.42
213_A219_V0.6430.42
45_P192_S0.6370.41
168_F263_H0.6360.41
21_F292_V0.6340.41
8_H13_Q0.6330.41
236_P285_M0.6330.41
156_E205_V0.6320.41
203_Q210_I0.6290.41
293_Y296_T0.6280.41
156_E204_A0.6270.40
77_P85_L0.6270.40
27_R294_Q0.6260.40
149_L233_T0.6260.40
6_P83_E0.6240.40
197_I222_I0.6230.40
203_Q267_K0.6220.40
55_L226_D0.6200.40
115_F157_K0.6190.40
35_P277_K0.6110.39
172_V275_R0.6090.39
209_N221_L0.6080.39
136_T296_T0.6060.38
27_R60_N0.6050.38
112_H280_A0.6030.38
140_H144_G0.6020.38
274_N280_A0.6010.38
224_S227_E0.5990.38
59_G281_T0.5980.38
172_V189_V0.5970.38
8_H12_K0.5970.38
77_P119_S0.5950.37
31_Q35_P0.5950.37
217_A236_P0.5940.37
19_H290_Y0.5940.37
124_L148_G0.5930.37
132_K227_E0.5930.37
200_E251_L0.5910.37
170_H288_L0.5910.37
46_K57_L0.5900.37
37_K68_T0.5880.37
12_K25_E0.5880.37
23_M27_R0.5870.37
110_I152_H0.5870.37
4_N66_H0.5870.37
187_Y220_C0.5860.37
139_L230_V0.5840.36
177_E227_E0.5840.36
219_V233_T0.5840.36
39_I131_S0.5840.36
2_P28_A0.5830.36
19_H60_N0.5820.36
118_V143_W0.5820.36
14_V17_S0.5820.36
204_A210_I0.5800.36
236_P284_F0.5800.36
115_F124_L0.5790.36
203_Q222_I0.5740.36
189_V232_L0.5740.36
111_E115_F0.5740.36
214_S220_C0.5700.35
85_L91_T0.5700.35
105_I140_H0.5700.35
197_I202_L0.5670.35
237_E249_R0.5660.35
112_H115_F0.5640.35
109_P143_W0.5640.35
25_E239_D0.5640.35
184_D290_Y0.5610.34
30_H119_S0.5610.34
19_H184_D0.5600.34
24_D174_S0.5600.34
61_S285_M0.5590.34
102_G283_L0.5590.34
24_D223_V0.5580.34
45_P51_E0.5560.34
21_F60_N0.5560.34
155_V206_P0.5550.34
32_D293_Y0.5550.34
185_E274_N0.5540.34
54_L283_L0.5530.34
146_Q181_R0.5530.34
170_H214_S0.5520.34
56_R239_D0.5520.34
105_I152_H0.5510.34
167_V251_L0.5500.33
63_L298_Y0.5490.33
161_P259_E0.5480.33
170_H189_V0.5480.33
153_Y194_H0.5470.33
196_D233_T0.5460.33
35_P64_Q0.5450.33
167_V245_Q0.5450.33
36_Q208_L0.5410.33
202_L210_I0.5380.32
197_I233_T0.5380.32
71_I85_L0.5380.32
103_M130_W0.5370.32
203_Q213_A0.5360.32
139_L232_L0.5350.32
232_L236_P0.5350.32
111_E160_M0.5350.32
177_E209_N0.5350.32
48_I81_A0.5340.32
89_Y250_D0.5330.32
48_I274_N0.5330.32
63_L288_L0.5320.32
162_K251_L0.5320.32
39_I134_N0.5300.32
46_K53_Q0.5300.32
5_I68_T0.5290.32
51_E218_G0.5280.32
102_G196_D0.5280.32
16_E173_L0.5280.32
45_P89_Y0.5270.32
46_K265_F0.5270.32
139_L300_W0.5260.31
221_L236_P0.5260.31
76_T119_S0.5260.31
176_H180_V0.5260.31
169_E267_K0.5250.31
38_I139_L0.5250.31
92_F130_W0.5250.31
20_I78_K0.5250.31
7_T49_Q0.5240.31
79_N112_H0.5240.31
175_K178_R0.5230.31
65_V245_Q0.5230.31
236_P288_L0.5210.31
50_T286_N0.5210.31
85_L140_H0.5190.31
201_Q204_A0.5180.31
72_P78_K0.5180.31
171_T213_A0.5170.31
20_I59_G0.5160.31
159_Q164_I0.5150.31
121_W150_Y0.5140.30
162_K200_E0.5140.30
6_P274_N0.5130.30
64_Q184_D0.5120.30
60_N285_M0.5100.30
277_K281_T0.5090.30
203_Q298_Y0.5090.30
186_L273_V0.5090.30
76_T269_S0.5070.30
55_L59_G0.5070.30
109_P118_V0.5070.30
24_D29_F0.5050.30
47_K80_T0.5040.30
7_T232_L0.5040.30
11_A48_I0.5040.30
56_R130_W0.5030.30
67_F173_L0.5030.30
99_R198_N0.5030.30
220_C233_T0.5020.29
6_P87_E0.5020.29
157_K160_M0.5010.29
122_E204_A0.5000.29
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2vdjA 2 0.8837 100 0.407 Contact Map
2h2wA 2 0.9502 100 0.42 Contact Map
3m3pA 1 0.7907 100 0.753 Contact Map
1o1yA 2 0.7608 99.8 0.842 Contact Map
3l7nA 1 0.7608 99.8 0.844 Contact Map
1qdlB 2 0.6312 99.7 0.855 Contact Map
2lxnA 1 0.608 99.6 0.86 Contact Map
1wl8A 1 0.608 99.6 0.861 Contact Map
2vpiA 1 0.608 99.6 0.864 Contact Map
2a9vA 1 0.6578 99.6 0.868 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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