META - BACSU - GREMLIN Contacts

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META - Homoserine O-succinyltransferase

UniProt:	P54167	Sequences: MPINIPTHLPAKQVLESEHIFVMDESRAFHQDIRPQKIIILNLMPKKIQTETQLLRLLGNSPLQVHFTFLIPSTHTPKNTAREHLDEFYTTFSNIRHKRFDGMIITGAPIEHLAFEEVSYWEELKEIMEWSKTNVTSTLHICWGAQAGLYYHYGVEKIQMPKKIFGVFEHTVLSKHERLVRGFDELYYVPHSRHTDINMEQLQAVPELNILTASKEAGVCLIVSKDEKQVFLTGHPEYDTNTLLQEYERDLERNLSTVEAPKHYFAKGSNEPVNRWKAHATLLFMNWLNYYVYQETPYEWD	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	301 (298)
Sequences:	1306 (776)
Seq/√Len:	44.9

ECOLI - META
BACSU - META

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
244_L	265_F	4.895	1.00
165_F	258_V	4.763	1.00
162_K	259_E	4.449	1.00
244_L	248_E	4.421	1.00
129_E	151_Y	3.912	1.00
68_T	100_F	3.829	1.00
37_K	66_H	3.332	1.00
99_R	134_N	3.271	1.00
198_N	201_Q	2.971	1.00
199_M	213_A	2.946	1.00
219_V	222_I	2.776	1.00
72_P	75_H	2.771	1.00
216_E	262_K	2.764	1.00
189_V	220_C	2.678	1.00
146_Q	195_T	2.653	1.00
240_T	274_N	2.610	1.00
129_E	132_K	2.569	1.00
73_S	93_S	2.552	1.00
103_M	131_S	2.452	1.00
266_A	272_P	2.417	1.00
199_M	203_Q	2.325	1.00
75_H	119_S	2.277	1.00
37_K	98_K	2.237	1.00
248_E	265_F	2.231	1.00
187_Y	212_T	2.226	1.00
158_I	198_N	2.174	1.00
241_N	245_Q	2.107	1.00
39_I	103_M	2.090	1.00
174_S	209_N	2.065	0.99
220_C	236_P	2.019	0.99
140_H	152_H	1.990	0.99
7_T	26_S	1.987	0.99
169_E	186_L	1.951	0.99
194_H	258_V	1.897	0.99
70_L	95_I	1.865	0.99
40_I	54_L	1.859	0.99
141_I	146_Q	1.830	0.99
13_Q	17_S	1.819	0.99
122_E	125_K	1.817	0.99
179_L	230_V	1.799	0.98
112_H	159_Q	1.785	0.98
39_I	70_L	1.748	0.98
12_K	16_E	1.725	0.98
157_K	195_T	1.703	0.98
171_T	215_K	1.664	0.97
55_L	67_F	1.664	0.97
267_K	270_N	1.661	0.97
46_K	49_Q	1.659	0.97
183_F	279_H	1.596	0.97
165_F	256_S	1.594	0.97
39_I	95_I	1.593	0.97
124_L	128_M	1.573	0.96
136_T	228_K	1.571	0.96
116_E	150_Y	1.563	0.96
5_I	12_K	1.556	0.96
115_F	146_Q	1.555	0.96
54_L	141_I	1.551	0.96
165_F	194_H	1.549	0.96
131_S	140_H	1.548	0.96
53_Q	239_D	1.543	0.96
170_H	217_A	1.530	0.96
46_K	245_Q	1.527	0.96
125_K	151_Y	1.525	0.96
96_R	126_E	1.520	0.96
128_M	152_H	1.517	0.96
199_M	210_I	1.513	0.96
170_H	191_H	1.513	0.96
40_I	67_F	1.496	0.95
183_F	282_L	1.495	0.95
188_Y	275_R	1.464	0.95
164_I	168_F	1.450	0.94
136_T	295_E	1.437	0.94
148_G	152_H	1.436	0.94
131_S	152_H	1.433	0.94
194_H	255_L	1.427	0.94
140_H	148_G	1.417	0.94
146_Q	157_K	1.417	0.94
114_A	117_E	1.406	0.93
248_E	252_E	1.397	0.93
138_T	148_G	1.394	0.93
183_F	283_L	1.386	0.93
4_N	130_W	1.376	0.93
153_Y	224_S	1.367	0.92
111_E	157_K	1.363	0.92
28_A	31_Q	1.319	0.91
168_F	262_K	1.308	0.91
160_M	164_I	1.278	0.90
27_R	30_H	1.275	0.89
156_E	201_Q	1.269	0.89
111_E	195_T	1.266	0.89
114_A	156_E	1.263	0.89
251_L	260_A	1.255	0.89
72_P	127_I	1.244	0.88
14_V	52_T	1.240	0.88
156_E	198_N	1.237	0.88
13_Q	16_E	1.236	0.88
65_V	288_L	1.232	0.88
210_I	213_A	1.221	0.87
209_N	225_K	1.219	0.87
141_I	236_P	1.211	0.87
178_R	295_E	1.198	0.86
144_G	233_T	1.195	0.86
236_P	283_L	1.192	0.86
84_H	88_F	1.191	0.86
170_H	220_C	1.191	0.86
31_Q	34_R	1.190	0.86
210_I	219_V	1.187	0.86
216_E	263_H	1.184	0.86
221_L	232_L	1.174	0.85
132_K	151_Y	1.164	0.85
200_E	204_A	1.157	0.84
38_I	102_G	1.156	0.84
169_E	275_R	1.156	0.84
48_I	84_H	1.155	0.84
91_T	94_N	1.151	0.84
247_Y	251_L	1.142	0.83
152_H	229_Q	1.134	0.83
251_L	258_V	1.131	0.83
199_M	219_V	1.131	0.83
158_I	196_D	1.130	0.83
248_E	251_L	1.119	0.82
110_I	144_G	1.116	0.82
289_N	294_Q	1.114	0.82
173_L	213_A	1.103	0.81
131_S	229_Q	1.100	0.81
90_T	94_N	1.098	0.81
57_L	280_A	1.092	0.81
49_Q	245_Q	1.085	0.80
266_A	270_N	1.083	0.80
224_S	229_Q	1.071	0.79
158_I	201_Q	1.066	0.79
7_T	25_E	1.064	0.79
214_S	217_A	1.056	0.78
70_L	103_M	1.056	0.78
28_A	33_I	1.055	0.78
105_I	128_M	1.049	0.78
74_T	123_E	1.044	0.77
12_K	48_I	1.044	0.77
177_E	223_V	1.042	0.77
202_L	219_V	1.041	0.77
31_Q	64_Q	1.039	0.77
209_N	223_V	1.037	0.77
8_H	87_E	1.035	0.77
28_A	34_R	1.033	0.77
82_R	86_D	1.025	0.76
90_T	98_K	1.016	0.76
208_L	222_I	1.015	0.75
191_H	217_A	1.015	0.75
224_S	228_K	1.011	0.75
168_F	194_H	1.009	0.75
141_I	195_T	1.007	0.75
189_V	217_A	1.004	0.75
132_K	229_Q	1.003	0.75
111_E	146_Q	0.997	0.74
139_L	236_P	0.996	0.74
37_K	300_W	0.990	0.74
24_D	69_F	0.989	0.74
169_E	188_Y	0.989	0.74
165_F	169_E	0.981	0.73
197_I	201_Q	0.972	0.72
4_N	25_E	0.965	0.72
130_W	134_N	0.964	0.72
110_I	157_K	0.959	0.71
255_L	258_V	0.957	0.71
160_M	196_D	0.955	0.71
141_I	157_K	0.950	0.70
41_L	103_M	0.946	0.70
202_L	222_I	0.942	0.70
179_L	221_L	0.930	0.69
186_L	275_R	0.924	0.68
41_L	72_P	0.922	0.68
256_S	259_E	0.918	0.68
189_V	236_P	0.916	0.68
180_V	221_L	0.914	0.67
41_L	70_L	0.913	0.67
34_R	64_Q	0.911	0.67
278_A	282_L	0.910	0.67
191_H	234_G	0.899	0.66
141_I	284_F	0.898	0.66
112_H	194_H	0.896	0.66
139_L	283_L	0.894	0.66
171_T	263_H	0.894	0.66
13_Q	30_H	0.892	0.66
72_P	77_P	0.889	0.65
128_M	151_Y	0.887	0.65
28_A	293_Y	0.885	0.65
4_N	7_T	0.884	0.65
31_Q	293_Y	0.877	0.64
110_I	195_T	0.874	0.64
33_I	64_Q	0.868	0.63
172_V	175_K	0.849	0.62
164_I	217_A	0.848	0.62
46_K	242_T	0.847	0.62
103_M	127_I	0.843	0.61
68_T	90_T	0.840	0.61
28_A	64_Q	0.835	0.60
7_T	24_D	0.825	0.59
18_E	56_R	0.822	0.59
121_W	147_A	0.813	0.58
75_H	78_K	0.812	0.58
75_H	113_L	0.799	0.57
69_F	124_L	0.799	0.57
134_N	144_G	0.798	0.57
51_E	89_Y	0.797	0.57
212_T	220_C	0.797	0.57
251_L	255_L	0.796	0.57
87_E	90_T	0.796	0.57
128_M	148_G	0.796	0.57
172_V	180_V	0.796	0.57
266_A	271_E	0.794	0.57
34_R	293_Y	0.793	0.56
11_A	52_T	0.793	0.56
46_K	52_T	0.787	0.56
41_L	130_W	0.787	0.56
171_T	186_L	0.784	0.56
21_F	290_Y	0.780	0.55
199_M	268_G	0.779	0.55
164_I	194_H	0.777	0.55
223_V	227_E	0.776	0.55
57_L	282_L	0.776	0.55
223_V	230_V	0.774	0.55
196_D	201_Q	0.772	0.54
6_P	282_L	0.770	0.54
138_T	229_Q	0.769	0.54
165_F	251_L	0.766	0.54
220_C	283_L	0.765	0.54
12_K	24_D	0.765	0.54
253_R	258_V	0.764	0.54
64_Q	293_Y	0.763	0.54
5_I	48_I	0.760	0.53
39_I	100_F	0.760	0.53
180_V	211_L	0.760	0.53
110_I	146_Q	0.758	0.53
28_A	32_D	0.752	0.52
128_M	140_H	0.751	0.52
3_I	16_E	0.746	0.52
236_P	281_T	0.745	0.52
55_L	69_F	0.741	0.51
156_E	196_D	0.740	0.51
48_I	52_T	0.740	0.51
220_C	232_L	0.740	0.51
191_H	211_L	0.738	0.51
111_E	141_I	0.737	0.51
111_E	123_E	0.737	0.51
73_S	91_T	0.736	0.51
40_I	55_L	0.735	0.51
125_K	129_E	0.734	0.51
105_I	229_Q	0.733	0.51
122_E	126_E	0.732	0.51
207_E	224_S	0.728	0.50
60_N	290_Y	0.727	0.50
112_H	144_G	0.725	0.50
159_Q	194_H	0.717	0.49
105_I	148_G	0.715	0.49
228_K	299_E	0.713	0.49
220_C	279_H	0.713	0.49
178_R	185_E	0.712	0.49
78_K	210_I	0.711	0.48
24_D	48_I	0.709	0.48
83_E	86_D	0.704	0.48
138_T	152_H	0.704	0.48
165_F	168_F	0.702	0.48
3_I	239_D	0.699	0.47
115_F	195_T	0.695	0.47
153_Y	231_F	0.693	0.47
254_N	258_V	0.692	0.47
66_H	177_E	0.692	0.47
26_S	30_H	0.691	0.47
21_F	27_R	0.688	0.46
259_E	262_K	0.680	0.45
68_T	98_K	0.679	0.45
115_F	280_A	0.678	0.45
130_W	283_L	0.677	0.45
202_L	208_L	0.676	0.45
178_R	298_Y	0.674	0.45
33_I	293_Y	0.674	0.45
177_E	211_L	0.671	0.45
72_P	119_S	0.670	0.45
148_G	151_Y	0.670	0.45
76_T	82_R	0.666	0.44
57_L	281_T	0.663	0.44
110_I	113_L	0.658	0.43
49_Q	52_T	0.656	0.43
39_I	69_F	0.654	0.43
279_H	283_L	0.652	0.43
174_S	284_F	0.650	0.43
46_K	300_W	0.647	0.42
171_T	212_T	0.645	0.42
75_H	123_E	0.645	0.42
8_H	177_E	0.645	0.42
213_A	219_V	0.643	0.42
45_P	192_S	0.637	0.41
168_F	263_H	0.636	0.41
21_F	292_V	0.634	0.41
8_H	13_Q	0.633	0.41
236_P	285_M	0.633	0.41
156_E	205_V	0.632	0.41
203_Q	210_I	0.629	0.41
293_Y	296_T	0.628	0.41
156_E	204_A	0.627	0.40
77_P	85_L	0.627	0.40
27_R	294_Q	0.626	0.40
149_L	233_T	0.626	0.40
6_P	83_E	0.624	0.40
197_I	222_I	0.623	0.40
203_Q	267_K	0.622	0.40
55_L	226_D	0.620	0.40
115_F	157_K	0.619	0.40
35_P	277_K	0.611	0.39
172_V	275_R	0.609	0.39
209_N	221_L	0.608	0.39
136_T	296_T	0.606	0.38
27_R	60_N	0.605	0.38
112_H	280_A	0.603	0.38
140_H	144_G	0.602	0.38
274_N	280_A	0.601	0.38
224_S	227_E	0.599	0.38
59_G	281_T	0.598	0.38
172_V	189_V	0.597	0.38
8_H	12_K	0.597	0.38
77_P	119_S	0.595	0.37
31_Q	35_P	0.595	0.37
217_A	236_P	0.594	0.37
19_H	290_Y	0.594	0.37
124_L	148_G	0.593	0.37
132_K	227_E	0.593	0.37
200_E	251_L	0.591	0.37
170_H	288_L	0.591	0.37
46_K	57_L	0.590	0.37
37_K	68_T	0.588	0.37
12_K	25_E	0.588	0.37
23_M	27_R	0.587	0.37
110_I	152_H	0.587	0.37
4_N	66_H	0.587	0.37
187_Y	220_C	0.586	0.37
139_L	230_V	0.584	0.36
177_E	227_E	0.584	0.36
219_V	233_T	0.584	0.36
39_I	131_S	0.584	0.36
2_P	28_A	0.583	0.36
19_H	60_N	0.582	0.36
118_V	143_W	0.582	0.36
14_V	17_S	0.582	0.36
204_A	210_I	0.580	0.36
236_P	284_F	0.580	0.36
115_F	124_L	0.579	0.36
203_Q	222_I	0.574	0.36
189_V	232_L	0.574	0.36
111_E	115_F	0.574	0.36
214_S	220_C	0.570	0.35
85_L	91_T	0.570	0.35
105_I	140_H	0.570	0.35
197_I	202_L	0.567	0.35
237_E	249_R	0.566	0.35
112_H	115_F	0.564	0.35
109_P	143_W	0.564	0.35
25_E	239_D	0.564	0.35
184_D	290_Y	0.561	0.34
30_H	119_S	0.561	0.34
19_H	184_D	0.560	0.34
24_D	174_S	0.560	0.34
61_S	285_M	0.559	0.34
102_G	283_L	0.559	0.34
24_D	223_V	0.558	0.34
45_P	51_E	0.556	0.34
21_F	60_N	0.556	0.34
155_V	206_P	0.555	0.34
32_D	293_Y	0.555	0.34
185_E	274_N	0.554	0.34
54_L	283_L	0.553	0.34
146_Q	181_R	0.553	0.34
170_H	214_S	0.552	0.34
56_R	239_D	0.552	0.34
105_I	152_H	0.551	0.34
167_V	251_L	0.550	0.33
63_L	298_Y	0.549	0.33
161_P	259_E	0.548	0.33
170_H	189_V	0.548	0.33
153_Y	194_H	0.547	0.33
196_D	233_T	0.546	0.33
35_P	64_Q	0.545	0.33
167_V	245_Q	0.545	0.33
36_Q	208_L	0.541	0.33
202_L	210_I	0.538	0.32
197_I	233_T	0.538	0.32
71_I	85_L	0.538	0.32
103_M	130_W	0.537	0.32
203_Q	213_A	0.536	0.32
139_L	232_L	0.535	0.32
232_L	236_P	0.535	0.32
111_E	160_M	0.535	0.32
177_E	209_N	0.535	0.32
48_I	81_A	0.534	0.32
89_Y	250_D	0.533	0.32
48_I	274_N	0.533	0.32
63_L	288_L	0.532	0.32
162_K	251_L	0.532	0.32
39_I	134_N	0.530	0.32
46_K	53_Q	0.530	0.32
5_I	68_T	0.529	0.32
51_E	218_G	0.528	0.32
102_G	196_D	0.528	0.32
16_E	173_L	0.528	0.32
45_P	89_Y	0.527	0.32
46_K	265_F	0.527	0.32
139_L	300_W	0.526	0.31
221_L	236_P	0.526	0.31
76_T	119_S	0.526	0.31
176_H	180_V	0.526	0.31
169_E	267_K	0.525	0.31
38_I	139_L	0.525	0.31
92_F	130_W	0.525	0.31
20_I	78_K	0.525	0.31
7_T	49_Q	0.524	0.31
79_N	112_H	0.524	0.31
175_K	178_R	0.523	0.31
65_V	245_Q	0.523	0.31
236_P	288_L	0.521	0.31
50_T	286_N	0.521	0.31
85_L	140_H	0.519	0.31
201_Q	204_A	0.518	0.31
72_P	78_K	0.518	0.31
171_T	213_A	0.517	0.31
20_I	59_G	0.516	0.31
159_Q	164_I	0.515	0.31
121_W	150_Y	0.514	0.30
162_K	200_E	0.514	0.30
6_P	274_N	0.513	0.30
64_Q	184_D	0.512	0.30
60_N	285_M	0.510	0.30
277_K	281_T	0.509	0.30
203_Q	298_Y	0.509	0.30
186_L	273_V	0.509	0.30
76_T	269_S	0.507	0.30
55_L	59_G	0.507	0.30
109_P	118_V	0.507	0.30
24_D	29_F	0.505	0.30
47_K	80_T	0.504	0.30
7_T	232_L	0.504	0.30
11_A	48_I	0.504	0.30
56_R	130_W	0.503	0.30
67_F	173_L	0.503	0.30
99_R	198_N	0.503	0.30
220_C	233_T	0.502	0.29
6_P	87_E	0.502	0.29
157_K	160_M	0.501	0.29
122_E	204_A	0.500	0.29

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
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HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2vdjA	2	0.8837	100	0.407	Contact Map
2h2wA	2	0.9502	100	0.42	Contact Map
3m3pA	1	0.7907	100	0.753	Contact Map
1o1yA	2	0.7608	99.8	0.842	Contact Map
3l7nA	1	0.7608	99.8	0.844	Contact Map
1qdlB	2	0.6312	99.7	0.855	Contact Map
2lxnA	1	0.608	99.6	0.86	Contact Map
1wl8A	1	0.608	99.6	0.861	Contact Map
2vpiA	1	0.608	99.6	0.864	Contact Map
2a9vA	1	0.6578	99.6	0.868	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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