GREMLIN Database
YPEP - Uncharacterized protein YpeP
UniProt: P54164 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 226 (181)
Sequences: 428 (337)
Seq/√Len: 25.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
79_F147_G4.8231.00
126_L145_I4.2091.00
77_V129_A3.7811.00
128_E131_R2.3230.98
117_T129_A2.3190.98
113_F121_A2.3000.98
127_Y177_L2.2920.98
155_Q192_R2.2680.98
96_I164_D2.2490.97
117_T157_D2.2420.97
123_Y151_V2.1660.97
36_E42_Y2.1360.97
138_A143_I2.1290.96
126_L152_V2.0890.96
91_G95_V2.0540.96
123_Y152_V2.0290.95
165_P168_N2.0280.95
32_T37_L1.9380.94
131_R173_K1.8850.93
35_R38_G1.8530.92
127_Y174_I1.8530.92
123_Y155_Q1.8440.92
167_H171_L1.8400.92
79_F123_Y1.8300.92
148_D195_N1.7810.91
130_I181_L1.7150.89
37_L46_L1.7150.89
174_I187_Y1.7060.89
122_E195_N1.6650.88
150_L154_N1.6540.87
152_V171_L1.6390.87
93_G199_D1.6100.86
121_A198_A1.5950.85
75_I138_A1.5570.84
129_A199_D1.5490.83
31_R38_G1.5480.83
73_D173_K1.5150.82
89_L207_S1.4590.80
144_T188_E1.4390.79
26_T29_Q1.4360.78
45_E57_T1.4340.78
89_L107_L1.4250.78
146_K188_E1.4220.78
122_E148_D1.3860.76
52_K66_E1.3720.75
156_L174_I1.3580.74
80_D148_D1.3560.74
37_L40_F1.3550.74
151_V189_T1.3400.73
33_F40_F1.3320.73
92_L198_A1.3210.72
88_E207_S1.2750.70
93_G198_A1.2610.69
172_D176_A1.2560.68
113_F116_K1.2470.68
53_G64_L1.2370.67
153_L189_T1.2250.66
95_V108_R1.2240.66
92_L111_K1.2200.66
82_S203_K1.2200.66
92_L113_F1.2060.65
57_T60_E1.1970.65
25_L29_Q1.1940.64
123_Y147_G1.1870.64
96_I145_I1.1860.64
34_A143_I1.1770.63
139_S182_K1.1720.63
130_I178_L1.1600.62
151_V171_L1.1540.62
123_Y192_R1.1470.61
117_T166_S1.1440.61
75_I143_I1.1430.61
45_E51_E1.1420.61
202_A206_L1.1380.61
87_S116_K1.1150.59
93_G202_A1.1140.59
190_I209_Q1.1080.58
77_V187_Y1.0940.57
33_F44_K1.0940.57
28_Q31_R1.0940.57
30_A36_E1.0780.56
108_R197_E1.0780.56
117_T136_L1.0760.56
24_W29_Q1.0740.56
152_V155_Q1.0720.56
129_A167_H1.0700.56
93_G201_L1.0560.55
80_D195_N1.0540.55
111_K128_E1.0540.55
68_L72_P1.0530.55
33_F145_I1.0520.54
122_E199_D1.0510.54
153_L171_L1.0500.54
97_Y144_T1.0280.53
91_G147_G1.0270.53
154_N178_L1.0240.52
79_F167_H1.0120.52
83_F196_Q1.0050.51
81_G122_E1.0050.51
130_I154_N0.9800.49
86_E190_I0.9780.49
102_G139_S0.9770.49
146_K190_I0.9720.49
44_K59_K0.9720.49
56_W59_K0.9690.48
190_I207_S0.9660.48
126_L147_G0.9650.48
131_R143_I0.9380.46
110_N197_E0.9350.46
147_G167_H0.9340.46
112_S116_K0.9280.45
80_D149_S0.9220.45
81_G90_A0.9210.45
28_Q38_G0.9100.44
95_V205_I0.9090.44
30_A34_A0.9080.44
118_N160_W0.8960.43
66_E69_A0.8940.43
167_H170_W0.8940.43
109_K113_F0.8900.43
201_L204_K0.8850.42
151_V155_Q0.8800.42
110_N201_L0.8800.42
85_K117_T0.8780.42
158_G162_C0.8740.42
77_V157_D0.8720.41
147_G205_I0.8680.41
113_F209_Q0.8620.41
123_Y171_L0.8550.40
31_R35_R0.8530.40
58_L66_E0.8460.40
161_P164_D0.8420.39
121_A171_L0.8390.39
34_A40_F0.8380.39
159_S163_Y0.8370.39
30_A33_F0.8330.39
91_G108_R0.8220.38
174_I196_Q0.8160.38
69_A102_G0.8120.37
52_K55_S0.8070.37
97_Y101_G0.8070.37
33_F42_Y0.8050.37
80_D122_E0.8030.37
82_S175_E0.7990.36
168_N172_D0.7990.36
124_A185_P0.7930.36
88_E153_L0.7900.36
129_A145_I0.7890.36
31_R36_E0.7890.36
39_R42_Y0.7880.36
155_Q171_L0.7850.36
30_A35_R0.7790.35
79_F129_A0.7780.35
43_M46_L0.7770.35
143_I196_Q0.7710.35
38_G44_K0.7650.34
119_N152_V0.7620.34
132_E136_L0.7620.34
174_I201_L0.7510.33
134_R180_S0.7480.33
151_V192_R0.7450.33
91_G100_L0.7440.33
77_V89_L0.7390.33
109_K132_E0.7380.32
39_R49_E0.7350.32
135_E180_S0.7350.32
42_Y57_T0.7350.32
130_I172_D0.7300.32
165_P171_L0.7220.31
157_D179_E0.7200.31
46_L166_S0.7200.31
152_V197_E0.7190.31
91_G119_N0.7140.31
158_G168_N0.7050.30
94_I113_F0.7040.30
35_R47_E0.7010.30
77_V101_G0.7010.30
92_L109_K0.6990.30
158_G163_Y0.6980.30
87_S112_S0.6960.30
33_F41_P0.6940.30
51_E56_W0.6910.30
95_V116_K0.6900.29
149_S195_N0.6880.29
34_A37_L0.6850.29
90_A186_T0.6850.29
97_Y181_L0.6840.29
25_L30_A0.6840.29
34_A60_E0.6770.29
155_Q158_G0.6700.28
60_E68_L0.6680.28
117_T167_H0.6670.28
93_G153_L0.6590.28
26_T31_R0.6560.27
23_D26_T0.6550.27
91_G205_I0.6530.27
175_E179_E0.6530.27
78_Y175_E0.6500.27
28_Q32_T0.6470.27
113_F198_A0.6460.27
92_L125_A0.6410.27
145_I185_P0.6380.26
27_A68_L0.6370.26
44_K50_D0.6360.26
54_G65_T0.6350.26
151_V167_H0.6290.26
198_A202_A0.6280.26
24_W28_Q0.6270.26
67_E139_S0.6260.26
48_F61_L0.6240.26
88_E198_A0.6220.26
50_D59_K0.6210.25
110_N124_A0.6200.25
56_W60_E0.6120.25
35_R62_E0.6090.25
34_A39_R0.6060.25
86_E114_R0.6020.24
24_W27_A0.6000.24
156_L189_T0.6000.24
195_N202_A0.5990.24
25_L28_Q0.5990.24
151_V159_S0.5970.24
35_R46_L0.5940.24
47_E57_T0.5930.24
39_R90_A0.5920.24
51_E58_L0.5910.24
126_L171_L0.5900.24
151_V170_W0.5870.24
90_A165_P0.5840.24
123_Y167_H0.5830.23
64_L173_K0.5740.23
125_A130_I0.5730.23
147_G152_V0.5710.23
82_S185_P0.5680.23
33_F163_Y0.5660.23
79_F155_Q0.5630.22
125_A201_L0.5610.22
87_S194_D0.5600.22
91_G123_Y0.5490.22
88_E132_E0.5490.22
79_F152_V0.5460.22
34_A48_F0.5430.21
87_S108_R0.5430.21
63_K67_E0.5400.21
195_N199_D0.5400.21
127_Y203_K0.5360.21
104_R128_E0.5360.21
80_D199_D0.5360.21
79_F151_V0.5310.21
24_W51_E0.5310.21
129_A200_G0.5310.21
111_K166_S0.5310.21
138_A170_W0.5300.21
64_L67_E0.5280.21
112_S156_L0.5270.21
27_A61_L0.5270.21
92_L95_V0.5260.21
95_V194_D0.5250.21
81_G198_A0.5240.21
36_E67_E0.5230.20
43_M50_D0.5140.20
36_E48_F0.5120.20
127_Y186_T0.5100.20
157_D167_H0.5070.20
56_W161_P0.5060.20
94_I121_A0.5060.20
127_Y170_W0.5050.20
82_S140_R0.5030.20
57_T163_Y0.5030.20
163_Y200_G0.5030.20
147_G191_Q0.5020.19
53_G62_E0.5000.19
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3u3gD 1 0.5973 100 0.507 Contact Map
2lsnA 1 0.6062 100 0.512 Contact Map
2e4lA 1 0.6195 100 0.512 Contact Map
3hstB 1 0.6106 100 0.515 Contact Map
1jl1A 1 0.6062 100 0.518 Contact Map
2ehgA 1 0.6283 100 0.523 Contact Map
3h08A 1 0.5664 100 0.523 Contact Map
1rilA 1 0.5796 100 0.524 Contact Map
2qkbA 1 0.5973 100 0.524 Contact Map
4e19A 1 0.5885 100 0.533 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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