GREMLIN Database
RNHL - 14.7 kDa ribonuclease H-like protein
UniProt: P54162 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 132 (123)
Sequences: 4057 (2414)
Seq/√Len: 217.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
72_D76_R3.9251.00
66_S108_K3.6991.00
99_K103_P3.3751.00
76_R80_L3.3301.00
52_E55_K2.9851.00
5_I53_G2.9821.00
12_A123_K2.7071.00
32_S117_K2.6921.00
50_L74_V2.5801.00
12_A127_R2.5321.00
69_T75_E2.3801.00
55_K104_L2.1651.00
12_A126_I2.1171.00
48_L52_E1.9481.00
68_R108_K1.9451.00
10_A126_I1.7991.00
66_S106_F1.7261.00
10_A122_A1.6681.00
123_K126_I1.6661.00
34_S124_E1.6261.00
7_V69_T1.6251.00
34_S125_A1.5331.00
22_I33_F1.5251.00
50_L67_F1.5221.00
4_E66_S1.5061.00
123_K127_R1.4761.00
44_E100_A1.4561.00
21_G125_A1.4311.00
120_L124_E1.4221.00
111_P114_Q1.4091.00
23_F118_A1.3981.00
77_A102_F1.3921.00
25_K30_A1.3801.00
117_K120_L1.3581.00
4_E68_R1.3341.00
7_V49_A1.2941.00
4_E25_K1.2801.00
6_Y68_R1.2681.00
18_S40_H1.2441.00
72_D109_W1.2391.00
22_I53_G1.2311.00
19_G126_I1.2001.00
98_L101_A1.1771.00
75_E107_I1.1721.00
20_I37_I1.1641.00
20_I52_E1.1631.00
35_I52_E1.1601.00
10_A123_K1.1601.00
37_I44_E1.1561.00
55_K94_E1.1411.00
75_E79_E1.1101.00
118_A125_A1.1001.00
78_T107_I1.0921.00
72_D75_E1.0891.00
34_S121_L1.0671.00
6_Y25_K1.0501.00
40_H44_E1.0451.00
20_I35_I1.0431.00
95_I98_L1.0191.00
47_F73_I1.0131.00
77_A82_M1.0051.00
37_I45_A0.9911.00
95_I99_K0.9901.00
57_C65_V0.9831.00
78_T82_M0.9711.00
94_E97_R0.9691.00
86_I93_E0.9641.00
121_L125_A0.9611.00
77_A81_E0.9571.00
23_F117_K0.9270.99
96_I99_K0.9080.99
7_V50_L0.9070.99
58_A101_A0.9050.99
5_I67_F0.9050.99
30_A117_K0.9040.99
19_G122_A0.9010.99
26_H63_Q0.8880.99
32_S121_L0.8750.99
79_E107_I0.8730.99
93_E98_L0.8630.99
90_P97_R0.8600.99
5_I65_V0.8430.99
92_V98_L0.8260.99
76_R81_E0.8210.99
33_F56_L0.8130.99
21_G121_L0.8080.99
13_G16_G0.8040.99
21_G118_A0.7910.98
47_F74_V0.7840.98
5_I24_I0.7820.98
113_K116_Q0.7800.98
50_L107_I0.7790.98
64_S106_F0.7660.98
89_Q95_I0.7580.98
89_Q93_E0.7570.98
90_P96_I0.7550.98
18_S45_A0.7550.98
57_C62_Y0.7530.98
36_P125_A0.7510.98
24_I31_E0.7490.98
36_P126_I0.7450.98
98_L102_F0.7380.97
120_L123_K0.7370.97
69_T74_V0.7140.97
51_I104_L0.7100.97
24_I56_L0.7000.96
26_H29_K0.6880.96
72_D82_M0.6810.96
47_F77_A0.6750.96
83_V88_F0.6740.96
44_E48_L0.6660.95
57_C61_G0.6650.95
75_E78_T0.6590.95
19_G23_F0.6520.95
79_E106_F0.6460.94
22_I35_I0.6460.94
96_I103_P0.6430.94
96_I100_A0.6350.94
52_E56_L0.6320.94
43_Q73_I0.6310.94
74_V77_A0.6300.94
23_F32_S0.6270.94
21_G32_S0.6270.94
21_G34_S0.6210.93
37_I48_L0.6170.93
109_W114_Q0.6140.93
119_D123_K0.6140.93
72_D111_P0.6130.93
7_V53_G0.6100.93
13_G126_I0.6090.93
3_T57_C0.6040.92
92_V96_I0.6040.92
34_S123_K0.6020.92
90_P94_E0.5990.92
48_L104_L0.5990.92
73_I77_A0.5990.92
40_H45_A0.5950.92
31_E56_L0.5860.91
41_T73_I0.5830.91
62_Y65_V0.5820.91
90_P93_E0.5780.90
92_V95_I0.5770.90
68_R110_I0.5770.90
18_S44_E0.5730.90
99_K105_F0.5730.90
22_I52_E0.5680.90
7_V67_F0.5670.90
10_A109_W0.5630.89
82_M107_I0.5620.89
67_F105_F0.5620.89
11_S14_N0.5600.89
3_T63_Q0.5550.89
8_D46_E0.5520.88
8_D70_D0.5510.88
61_G64_S0.5510.88
57_C63_Q0.5490.88
46_E70_D0.5480.88
88_F91_F0.5470.88
5_I22_I0.5460.88
3_T24_I0.5430.88
21_G33_F0.5420.87
122_A126_I0.5390.87
13_G123_K0.5370.87
14_N42_N0.5360.87
124_E127_R0.5360.87
83_V92_V0.5350.87
51_I95_I0.5340.87
48_L91_F0.5320.86
121_L124_E0.5240.86
53_G65_V0.5210.85
112_G116_Q0.5200.85
89_Q92_V0.5180.85
51_I55_K0.5170.85
45_A118_A0.5110.84
93_E96_I0.5100.84
122_A125_A0.5090.84
63_Q103_P0.5080.84
51_I98_L0.5070.84
118_A121_L0.5060.84
3_T62_Y0.5050.84
34_S126_I0.5030.83
20_I49_A0.5030.83
58_A62_Y0.5010.83
26_H61_G0.5000.83
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4mh8A 1 0 100 0.302 Contact Map
1jl1A 1 0.9848 100 0.331 Contact Map
3h08A 1 0.9545 100 0.333 Contact Map
2lsnA 1 0.9773 100 0.345 Contact Map
1rilA 1 0.9773 100 0.348 Contact Map
2e4lA 1 0.9848 100 0.35 Contact Map
2qkbA 1 0.9697 100 0.355 Contact Map
3hstB 1 1 100 0.363 Contact Map
3u3gD 1 0.9924 100 0.364 Contact Map
3qioA 1 0.8333 100 0.364 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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