GREMLIN Database
YPBR - Uncharacterized protein YpbR
UniProt: P54159 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 1193 (1161)
Sequences: 240 (209)
Seq/√Len: 6.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
651_K758_T6.3691.00
975_Q1030_L5.9041.00
881_K893_R4.8650.98
152_H971_D4.4780.97
815_S1022_E4.4090.97
839_A848_L4.3310.96
152_H974_E4.1940.95
762_T767_E4.0660.94
373_E376_K3.6590.91
827_L831_K3.5680.89
117_D120_Q3.2750.85
818_R1022_E3.2750.85
396_H974_E3.2700.85
745_V788_L3.2440.84
971_D974_E3.2310.84
197_I250_L3.2150.83
971_D975_Q3.1850.83
668_F754_V3.0990.81
716_N720_A3.0970.81
836_I852_T3.0760.81
637_V759_V2.9710.78
145_I333_I2.9660.78
1098_Q1104_G2.9590.78
443_S447_L2.9580.78
205_D875_K2.8130.74
616_A792_Y2.7740.73
77_S81_V2.7600.72
681_L710_H2.7520.72
817_L864_V2.6800.70
757_V808_S2.6550.69
152_H163_A2.6310.69
152_H396_H2.6280.68
974_E1030_L2.5980.68
751_A865_Y2.5700.67
364_F836_I2.5520.66
167_F197_I2.5370.66
118_G613_F2.5200.65
170_V222_L2.5130.65
345_R447_L2.5090.65
737_P740_E2.5070.65
787_E801_Y2.4870.64
720_A783_K2.4310.62
254_L848_L2.4230.62
163_A974_E2.4170.62
91_R101_E2.3870.61
214_Y601_F2.3750.60
916_A1019_Y2.3650.60
344_M388_R2.3390.59
972_T1034_M2.3230.58
607_R643_T2.3060.58
393_A640_S2.2810.57
348_A381_F2.2790.57
152_H1030_L2.2750.57
854_Y992_K2.2710.57
677_E783_K2.2630.56
396_H975_Q2.2540.56
931_H1175_E2.2530.56
643_T800_F2.2440.56
808_S855_V2.2380.55
912_L918_K2.2330.55
25_D280_H2.2310.55
768_K836_I2.2220.55
166_L254_L2.2210.55
206_E209_T2.2200.55
582_Y609_E2.2180.55
778_A833_F2.2040.54
381_F744_Y2.2010.54
971_D1030_L2.1980.54
1029_T1035_S2.1680.53
152_H975_Q2.1590.53
461_A796_A2.1550.52
157_A643_T2.1380.52
629_A1029_T2.1150.51
450_T880_G2.1010.50
865_Y986_F2.1000.50
613_F746_A2.0990.50
364_F848_L2.0920.50
305_V317_K2.0920.50
640_S757_V2.0850.50
96_D99_C2.0780.50
645_T816_F2.0770.50
781_M1139_L2.0760.50
196_F1030_L2.0650.49
584_L916_A2.0500.49
170_V975_Q2.0460.48
152_H155_S2.0430.48
844_D1035_S2.0350.48
763_C772_I2.0340.48
779_S832_M2.0150.47
346_E349_A2.0150.47
71_T104_G2.0070.47
454_A458_R1.9990.47
396_H971_D1.9990.47
65_M808_S1.9970.47
1026_E1033_R1.9960.47
157_A888_Q1.9880.46
801_Y888_Q1.9830.46
191_I912_L1.9820.46
59_L799_F1.9730.46
392_E487_I1.9490.45
80_L870_F1.9460.45
163_A971_D1.9420.45
345_R899_F1.9400.45
815_S818_R1.9390.45
163_A396_H1.9370.45
870_F895_H1.9360.45
60_L71_T1.9180.44
155_S163_A1.8900.43
446_V1016_L1.8900.43
588_L1105_K1.8820.43
386_A389_T1.8800.43
435_V678_I1.8670.42
614_T792_Y1.8660.42
788_L819_K1.8610.42
976_L979_I1.8550.42
346_E447_L1.8530.42
713_L716_N1.8490.41
157_A800_F1.8410.41
345_R833_F1.8350.41
739_S1118_K1.8350.41
396_H1030_L1.8320.41
344_M983_L1.8280.41
824_K833_F1.8280.41
284_L789_A1.8240.41
751_A990_L1.8200.40
196_F971_D1.8190.40
824_K832_M1.7930.40
121_I1036_G1.7870.39
237_V745_V1.7830.39
339_L373_E1.7810.39
344_M384_D1.7810.39
914_S998_G1.7800.39
106_Y1086_F1.7770.39
118_G192_P1.7700.39
385_V457_I1.7680.39
276_L280_H1.7670.39
58_S237_V1.7620.38
852_T871_T1.7600.38
991_L1108_F1.7540.38
581_F912_L1.7420.38
221_M749_T1.7420.38
753_A783_K1.7390.38
779_S783_K1.7380.38
184_L227_I1.7350.38
903_D1097_K1.7280.37
717_F1011_A1.7200.37
336_N615_L1.7150.37
188_K229_R1.7140.37
25_D28_R1.7040.37
758_T801_Y1.7030.37
145_I1094_K1.7010.36
41_D870_F1.6980.36
346_E749_T1.6960.36
614_T820_L1.6960.36
304_L872_V1.6920.36
235_T628_F1.6910.36
696_K1022_E1.6890.36
168_Y183_F1.6850.36
229_R871_T1.6820.36
47_A152_H1.6820.36
521_I870_F1.6740.36
447_L899_F1.6730.36
147_S152_H1.6690.35
1106_A1109_I1.6660.35
854_Y989_D1.6650.35
74_I254_L1.6640.35
254_L335_K1.6630.35
1029_T1033_R1.6550.35
246_Q249_A1.6540.35
115_C338_N1.6440.35
779_S833_F1.6370.34
331_N1131_L1.6340.34
1093_I1096_P1.6270.34
166_L187_I1.6230.34
651_K756_E1.6220.34
165_A257_I1.6220.34
740_E845_K1.6180.34
159_I1030_L1.6160.34
34_A708_E1.6130.34
858_E862_E1.6110.34
152_H196_F1.6090.33
149_D396_H1.6080.33
835_I872_V1.6050.33
83_I108_K1.6030.33
145_I1157_Q1.6020.33
720_A779_S1.6020.33
792_Y833_F1.6000.33
47_A396_H1.5970.33
338_N796_A1.5940.33
643_T782_N1.5920.33
147_S971_D1.5920.33
507_L615_L1.5910.33
790_F830_D1.5870.33
238_T870_F1.5850.33
152_H746_A1.5840.33
633_V651_K1.5760.32
778_A792_Y1.5740.32
716_N783_K1.5730.32
52_Y171_H1.5700.32
184_L815_S1.5690.32
138_A519_W1.5680.32
713_L877_E1.5660.32
187_I1009_S1.5660.32
340_T345_R1.5630.32
615_L1001_N1.5620.32
184_L1022_E1.5600.32
198_V436_K1.5580.32
416_E664_A1.5530.32
147_S746_A1.5490.32
118_G396_H1.5470.31
74_I788_L1.5460.31
165_A839_A1.5450.31
585_S605_V1.5440.31
166_L686_K1.5430.31
117_D153_F1.5430.31
391_A674_L1.5430.31
662_K739_S1.5410.31
831_K991_L1.5360.31
49_T152_H1.5350.31
52_Y156_A1.5300.31
604_R1008_V1.5240.31
728_I744_Y1.5240.31
215_Q1075_K1.5220.31
71_T713_L1.5220.31
783_K824_K1.5160.31
155_S974_E1.5150.31
337_A345_R1.5150.31
854_Y880_G1.5150.31
377_R627_S1.5140.30
59_L237_V1.5110.30
148_T160_L1.5110.30
232_L397_M1.5030.30
371_A375_D1.5020.30
655_P839_A1.4990.30
149_D152_H1.4900.30
171_H203_R1.4880.30
122_E346_E1.4870.30
821_G833_F1.4870.30
203_R623_S1.4810.29
333_I400_T1.4810.29
396_H400_T1.4780.29
156_A620_G1.4740.29
393_A1005_K1.4720.29
206_E321_E1.4680.29
152_H333_I1.4680.29
49_T396_H1.4640.29
589_G602_R1.4590.29
980_A1121_E1.4590.29
364_F1139_L1.4570.29
70_P200_Q1.4560.29
219_E747_E1.4530.29
176_H627_S1.4510.29
82_V978_H1.4490.29
157_A801_Y1.4400.28
387_K615_L1.4390.28
651_K866_E1.4380.28
184_L975_Q1.4370.28
833_F899_F1.4370.28
854_Y862_E1.4360.28
13_T234_F1.4340.28
668_F724_Y1.4310.28
225_E996_H1.4300.28
681_L787_E1.4290.28
49_T344_M1.4280.28
779_S824_K1.4260.28
639_P748_E1.4250.28
320_T470_K1.4200.28
58_S137_V1.4170.28
871_T933_S1.4170.28
815_S975_Q1.4120.27
77_S819_K1.4110.27
80_L596_K1.4070.27
1014_T1030_L1.4070.27
781_M796_A1.4060.27
152_H166_L1.4040.27
821_G832_M1.4000.27
716_N753_A1.3990.27
779_S822_L1.3950.27
59_L250_L1.3950.27
114_Y272_K1.3950.27
880_G937_K1.3950.27
197_I1006_K1.3940.27
184_L1024_I1.3930.27
28_R197_I1.3880.27
170_V217_Q1.3870.27
86_G330_I1.3850.27
713_L753_A1.3850.27
474_A592_S1.3820.27
674_L1141_R1.3820.27
789_A1012_M1.3800.27
915_E918_K1.3800.27
447_L792_Y1.3760.26
681_L998_G1.3760.26
796_A868_Q1.3750.26
628_F640_S1.3730.26
221_M713_L1.3710.26
187_I983_L1.3710.26
719_L749_T1.3670.26
309_R935_E1.3630.26
330_I466_A1.3620.26
149_D974_E1.3610.26
779_S792_Y1.3600.26
121_I711_V1.3590.26
778_A832_M1.3590.26
157_A782_N1.3580.26
912_L995_F1.3570.26
201_I239_E1.3530.26
225_E713_L1.3520.26
682_T685_P1.3510.26
74_I789_A1.3500.26
106_Y436_K1.3500.26
801_Y887_N1.3500.26
751_A801_Y1.3480.26
940_Q943_C1.3480.26
126_I234_F1.3440.26
333_I970_K1.3440.26
49_T192_P1.3420.26
59_L154_L1.3410.25
119_E1129_E1.3400.25
47_A974_E1.3390.25
49_T975_Q1.3380.25
71_T181_V1.3360.25
147_S396_H1.3290.25
90_V104_G1.3270.25
616_A997_P1.3260.25
792_Y1105_K1.3220.25
654_K978_H1.3220.25
1025_Q1033_R1.3210.25
353_E728_I1.3170.25
933_S936_E1.3160.25
161_H824_K1.3130.25
792_Y997_P1.3120.25
34_A1034_M1.3110.25
121_I712_K1.3110.25
71_T787_E1.3100.25
617_L830_D1.3080.25
397_M580_R1.3070.25
814_R818_R1.3050.25
277_L972_T1.3050.25
166_L971_D1.3010.24
374_R1114_M1.3000.24
800_F889_F1.2990.24
137_V238_T1.2990.24
509_N835_I1.2980.24
215_Q1072_I1.2940.24
796_A1170_H1.2940.24
145_I1135_Y1.2920.24
152_H1139_L1.2900.24
104_G108_K1.2900.24
147_S809_F1.2880.24
752_C772_I1.2860.24
49_T155_S1.2860.24
677_E801_Y1.2850.24
356_E1028_K1.2850.24
877_E975_Q1.2850.24
264_N581_F1.2830.24
177_A354_S1.2800.24
181_V983_L1.2800.24
815_S986_F1.2690.24
181_V679_L1.2680.24
792_Y832_M1.2680.24
185_R971_D1.2660.23
201_I242_H1.2660.23
806_Q819_K1.2640.23
779_S899_F1.2590.23
163_A981_Q1.2580.23
340_T451_K1.2560.23
286_K903_D1.2560.23
148_T152_H1.2550.23
754_V757_V1.2530.23
280_H283_M1.2520.23
1004_W1096_P1.2440.23
942_Q945_M1.2430.23
989_D992_K1.2420.23
907_A1111_A1.2410.23
864_V1105_K1.2400.23
783_K833_F1.2390.23
604_R738_L1.2370.23
232_L987_A1.2350.23
820_L832_M1.2340.23
880_G893_R1.2330.23
249_A1111_A1.2310.23
743_P747_E1.2290.23
748_E775_T1.2290.23
443_S832_M1.2280.23
616_A832_M1.2240.22
663_T1124_I1.2230.22
83_I1095_S1.2230.22
102_L340_T1.2230.22
844_D903_D1.2200.22
233_Y253_E1.2180.22
192_P810_S1.2180.22
58_S62_C1.2140.22
717_F751_A1.2090.22
161_H650_N1.2080.22
799_F835_I1.2050.22
197_I251_R1.2040.22
710_H713_L1.2030.22
640_S783_K1.2030.22
32_L637_V1.2020.22
779_S819_K1.2010.22
184_L818_R1.2000.22
226_G1153_Q1.2000.22
741_L779_S1.2000.22
370_T439_A1.2000.22
71_T147_S1.1980.22
179_E643_T1.1980.22
381_F449_Y1.1960.22
333_I971_D1.1940.22
443_S783_K1.1940.22
451_K870_F1.1940.22
187_I1177_A1.1940.22
227_I1074_L1.1930.22
217_Q763_C1.1920.22
134_D854_Y1.1900.22
222_L392_E1.1890.22
821_G824_K1.1890.22
833_F997_P1.1890.22
254_L744_Y1.1890.22
1023_Y1039_E1.1890.22
49_T708_E1.1890.22
348_A629_A1.1880.22
321_E1107_T1.1870.22
335_K683_G1.1860.21
163_A833_F1.1860.21
741_L778_A1.1850.21
342_F346_E1.1850.21
614_T821_G1.1830.21
176_H806_Q1.1820.21
985_Y1036_G1.1810.21
312_L317_K1.1810.21
1104_G1108_F1.1800.21
341_P793_I1.1800.21
862_E900_I1.1800.21
716_N779_S1.1750.21
183_F377_R1.1720.21
815_S1030_L1.1710.21
604_R911_Q1.1690.21
71_T166_L1.1680.21
225_E783_K1.1670.21
720_A753_A1.1650.21
247_M1120_T1.1640.21
361_T825_E1.1620.21
198_V233_Y1.1610.21
34_A152_H1.1600.21
269_T410_V1.1600.21
937_K940_Q1.1580.21
508_E674_L1.1570.21
650_N825_E1.1570.21
348_A824_K1.1570.21
72_S173_N1.1530.21
155_S971_D1.1530.21
78_A775_T1.1520.21
210_K1006_K1.1510.21
713_L783_K1.1510.21
400_T974_E1.1490.21
124_V289_T1.1490.21
614_T832_M1.1490.21
152_H400_T1.1460.21
16_L915_E1.1450.21
654_K822_L1.1450.21
222_L770_I1.1440.20
792_Y824_K1.1430.20
868_Q979_I1.1420.20
214_Y451_K1.1410.20
187_I808_S1.1380.20
62_C247_M1.1370.20
1011_A1032_V1.1370.20
245_N485_Q1.1360.20
449_Y793_I1.1360.20
47_A149_D1.1340.20
654_K779_S1.1330.20
793_I987_A1.1310.20
227_I1131_L1.1300.20
770_I996_H1.1260.20
52_Y892_V1.1230.20
206_E244_F1.1230.20
713_L888_Q1.1230.20
354_S377_R1.1220.20
162_Q779_S1.1200.20
354_S848_L1.1190.20
640_S751_A1.1180.20
401_L664_A1.1160.20
779_S997_P1.1150.20
74_I745_V1.1140.20
49_T971_D1.1140.20
59_L1103_K1.1140.20
168_Y640_S1.1130.20
315_A319_M1.1120.20
109_D870_F1.1100.20
792_Y796_A1.1100.20
424_T900_I1.1100.20
107_Q356_E1.1090.20
365_F746_A1.1080.20
150_D825_E1.1080.20
49_T974_E1.1070.20
315_A662_K1.1070.20
372_Q940_Q1.1050.20
81_V832_M1.1050.20
1021_F1025_Q1.1050.20
166_L608_L1.1040.20
629_A830_D1.1030.20
721_Y854_Y1.1000.19
789_A827_L1.1000.19
181_V184_L1.1000.19
782_N865_Y1.0990.19
395_W770_I1.0980.19
1011_A1120_T1.0980.19
125_E608_L1.0940.19
617_L629_A1.0930.19
44_V181_V1.0930.19
49_T892_V1.0930.19
459_K606_K1.0910.19
352_L446_V1.0900.19
245_N365_F1.0900.19
666_V683_G1.0900.19
609_E903_D1.0890.19
633_V770_I1.0880.19
818_R990_L1.0870.19
52_Y203_R1.0840.19
616_A899_F1.0830.19
344_M1119_I1.0820.19
405_A1095_S1.0800.19
218_V1000_Q1.0800.19
713_L801_Y1.0790.19
381_F395_W1.0780.19
166_L944_L1.0780.19
201_I871_T1.0770.19
450_T655_P1.0760.19
648_T933_S1.0760.19
162_Q824_K1.0740.19
679_L970_K1.0740.19
74_I370_T1.0730.19
509_N739_S1.0720.19
783_K832_M1.0700.19
793_I799_F1.0690.19
274_R973_R1.0680.19
796_A1106_A1.0680.19
241_D474_A1.0680.19
397_M505_A1.0680.19
151_A1123_W1.0670.19
156_A176_H1.0670.19
235_T810_S1.0650.19
89_R127_F1.0610.19
713_L899_F1.0610.19
292_P551_Q1.0610.19
351_F432_E1.0600.19
354_S444_E1.0600.19
236_S315_A1.0600.19
907_A1017_H1.0590.19
616_A779_S1.0590.19
778_A899_F1.0580.19
781_M1030_L1.0580.19
894_K1140_R1.0570.19
163_A986_F1.0570.19
121_I127_F1.0560.19
448_Q870_F1.0550.18
167_F195_Y1.0550.18
614_T833_F1.0510.18
340_T899_F1.0500.18
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35_V168_Y0.5140.09
170_V225_E0.5130.09
348_A449_Y0.5130.09
38_K72_S0.5130.09
177_A867_P0.5120.09
306_Q924_F0.5120.09
799_F806_Q0.5120.09
1078_E1123_W0.5120.09
745_V814_R0.5120.09
617_L827_L0.5120.09
775_T790_F0.5120.09
271_Q996_H0.5110.09
604_R643_T0.5110.09
620_G639_P0.5110.09
675_T713_L0.5110.09
755_K788_L0.5110.09
778_A987_A0.5110.09
303_G939_A0.5110.09
237_V343_E0.5100.09
854_Y858_E0.5100.09
617_L821_G0.5090.09
387_K1060_F0.5090.09
140_I975_Q0.5080.09
579_K584_L0.5080.09
418_L509_N0.5080.09
129_R476_V0.5080.09
159_I971_D0.5080.09
96_D364_F0.5070.09
614_T745_V0.5070.09
710_H864_V0.5060.09
779_S1095_S0.5060.09
1152_A1170_H0.5060.09
168_Y830_D0.5050.09
854_Y937_K0.5050.09
764_P1040_R0.5050.09
115_C995_F0.5050.09
975_Q1101_E0.5040.09
38_K649_I0.5040.09
364_F985_Y0.5030.09
102_L1174_I0.5030.09
223_C870_F0.5030.09
676_A845_K0.5030.09
720_A997_P0.5020.09
181_V974_E0.5020.09
432_E487_I0.5020.09
998_G1110_E0.5020.09
459_K496_E0.5020.09
678_I1072_I0.5020.09
247_M490_R0.5010.09
796_A1120_T0.5010.09
225_E623_S0.5010.09
227_I984_S0.5010.09
292_P582_Y0.5010.09
769_G1099_F0.5000.09
500_F678_I0.5000.09
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2j69A 1 0.4803 100 0.907 Contact Map
4aurA 1 0.4174 100 0.934 Contact Map
3j8gX 1 0.3319 99.9 0.939 Contact Map
2akaB 1 0.2288 99.9 0.945 Contact Map
2x2eA 2 0.2523 99.9 0.947 Contact Map
4bejA 2 0.4241 99.9 0.947 Contact Map
3w6pA 2 0.2506 99.9 0.949 Contact Map
3gehA 2 0.2188 99.9 0.949 Contact Map
4uudA 5 0.3705 99.9 0.949 Contact Map
4cidA 2 0.3512 99.9 0.949 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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