GREMLIN Database
BCSA - Putative chalcone synthase
UniProt: P54157 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 365 (292)
Sequences: 20653 (14298)
Seq/√Len: 836.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
335_G338_K3.9021.00
342_R360_S3.4371.00
88_C202_L3.0511.00
165_F204_C2.9221.00
82_R127_E2.8881.00
84_A198_I2.7121.00
85_V167_L2.6261.00
156_E160_A2.4581.00
275_S278_D2.3891.00
155_A159_K2.3471.00
329_K333_Q2.1581.00
81_S124_L2.1101.00
86_R90_S2.0841.00
278_D342_R2.0761.00
152_A234_D2.0751.00
274_L342_R2.0331.00
151_L328_I2.0231.00
226_S332_L1.9641.00
331_H343_G1.9591.00
61_K67_E1.9421.00
204_C222_M1.9271.00
46_G49_H1.9231.00
100_P103_K1.8931.00
84_A200_A1.8781.00
66_F74_I1.8711.00
137_I153_R1.8501.00
312_I326_Y1.8491.00
208_A211_R1.8271.00
38_R42_S1.8181.00
125_M136_R1.8121.00
199_A325_L1.7681.00
151_L203_L1.7651.00
205_G208_A1.7421.00
154_A166_V1.7221.00
195_G319_M1.7141.00
56_P60_Y1.7091.00
158_C205_G1.6671.00
111_S120_I1.6651.00
319_M326_Y1.6581.00
57_I61_K1.6441.00
280_S341_E1.6211.00
121_E138_P1.6191.00
77_T171_A1.6191.00
262_K266_Q1.6191.00
39_L42_S1.5981.00
297_K309_A1.5941.00
38_R43_F1.5881.00
150_G168_V1.5721.00
149_S355_E1.5701.00
281_V331_H1.5671.00
82_R124_L1.5591.00
56_P59_W1.5591.00
338_K341_E1.5491.00
197_G319_M1.5391.00
165_F202_L1.5221.00
157_Y163_E1.5011.00
152_A156_E1.4891.00
266_Q270_D1.4791.00
83_A86_R1.4781.00
156_E162_P1.4751.00
156_E159_K1.4591.00
158_C203_L1.4551.00
68_E315_K1.4551.00
47_Q50_S1.4521.00
38_R41_S1.4421.00
79_K127_E1.4361.00
57_I60_Y1.4261.00
106_A166_V1.4251.00
302_S305_K1.4251.00
37_D42_S1.4021.00
37_D43_F1.3971.00
91_H225_Q1.3951.00
163_E166_V1.3941.00
36_I43_F1.3901.00
81_S200_A1.3901.00
82_R86_R1.3851.00
87_E91_H1.3811.00
85_V200_A1.3691.00
204_C220_K1.3621.00
315_K330_D1.3611.00
124_L169_I1.3591.00
169_I200_A1.3381.00
122_A351_G1.3361.00
301_L306_L1.3241.00
147_G325_L1.3211.00
36_I42_S1.3121.00
274_L278_D1.3071.00
267_I271_K1.3071.00
199_A329_K1.3011.00
296_I303_S1.2881.00
201_A328_I1.2831.00
91_H332_L1.2751.00
337_K340_A1.2731.00
167_L202_L1.2691.00
268_F356_L1.2631.00
232_S360_S1.2631.00
194_F320_S1.2621.00
316_H326_Y1.2521.00
344_L356_L1.2501.00
107_V111_S1.2471.00
154_A168_V1.2401.00
88_C200_A1.2391.00
37_D40_L1.2331.00
36_I39_L1.2301.00
103_K165_F1.2281.00
164_A205_G1.2271.00
39_L43_F1.2181.00
268_F358_L1.2141.00
157_Y162_P1.2111.00
142_L145_A1.2081.00
105_E165_F1.2051.00
99_I165_F1.2011.00
201_A325_L1.1861.00
85_V128_L1.1851.00
105_E109_F1.1801.00
87_E90_S1.1761.00
152_A162_P1.1731.00
301_L305_K1.1611.00
345_I359_F1.1611.00
84_A87_E1.1571.00
85_V88_C1.1561.00
156_E271_K1.1551.00
36_I329_K1.1551.00
139_I153_R1.1491.00
108_F111_S1.1451.00
264_N268_F1.1431.00
206_E210_R1.1321.00
269_L279_I1.1321.00
153_R156_E1.1301.00
86_R127_E1.1281.00
168_V203_L1.1271.00
36_I40_L1.1251.00
42_S45_N1.1211.00
50_S53_F1.1201.00
263_T267_I1.1191.00
269_L274_L1.1191.00
171_A198_I1.1191.00
151_L168_V1.1181.00
49_H52_Q1.1181.00
92_P99_I1.1021.00
235_V268_F1.1011.00
76_E79_K1.0961.00
289_K293_D1.0931.00
88_C167_L1.0931.00
164_A208_A1.0891.00
268_F272_H1.0891.00
91_H333_Q1.0841.00
78_L120_I1.0831.00
44_K47_Q1.0751.00
36_I41_S1.0751.00
260_W263_T1.0741.00
80_H198_I1.0731.00
67_E314_Q1.0731.00
301_L304_E1.0671.00
88_C92_P1.0671.00
272_H358_L1.0671.00
280_S342_R1.0661.00
81_S109_F1.0651.00
269_L276_F1.0561.00
107_V110_V1.0541.00
89_L202_L1.0501.00
331_H334_N1.0471.00
80_H173_L1.0321.00
81_S120_I1.0271.00
225_Q332_L1.0261.00
197_G326_Y1.0251.00
149_S353_S1.0181.00
108_F157_Y1.0171.00
264_N356_L1.0161.00
41_S44_K1.0071.00
106_A157_Y1.0071.00
55_K59_W1.0051.00
266_Q276_F1.0031.00
283_L327_V1.0011.00
312_I330_D0.9991.00
55_K58_E0.9991.00
335_G339_E0.9941.00
46_G50_S0.9931.00
119_S253_I0.9931.00
37_D44_K0.9921.00
43_F46_G0.9901.00
36_I44_K0.9891.00
293_D303_S0.9871.00
105_E164_A0.9761.00
99_I202_L0.9761.00
58_E62_E0.9721.00
83_A87_E0.9701.00
122_A136_R0.9681.00
328_I345_I0.9671.00
147_G201_A0.9611.00
38_R44_K0.9601.00
71_Q180_P0.9471.00
85_V169_I0.9441.00
279_I342_R0.9411.00
319_M322_A0.9411.00
223_D226_S0.9391.00
224_A228_L0.9371.00
81_S169_I0.9321.00
91_H223_D0.9301.00
143_G350_P0.9291.00
170_S325_L0.9291.00
281_V341_E0.9251.00
328_I359_F0.9221.00
37_D45_N0.9221.00
52_Q55_K0.9191.00
89_L128_L0.9181.00
63_G86_R0.9141.00
86_R101_Y0.9141.00
49_H53_F0.9141.00
38_R45_N0.9051.00
265_V344_L0.9041.00
131_S263_T0.8991.00
346_G356_L0.8971.00
48_I53_F0.8961.00
211_R220_K0.8951.00
274_L358_L0.8941.00
56_P61_K0.8841.00
335_G340_A0.8801.00
154_A203_L0.8801.00
89_L104_V0.8771.00
86_R128_L0.8761.00
148_A357_L0.8731.00
155_A228_L0.8681.00
37_D41_S0.8611.00
109_F169_I0.8601.00
119_S350_P0.8491.00
145_A353_S0.8481.00
82_R128_L0.8451.00
81_S171_A0.8401.00
279_I344_L0.8391.00
151_L357_L0.8361.00
99_I103_K0.8351.00
43_F48_I0.8331.00
55_K60_Y0.8271.00
89_L167_L0.8171.00
85_V124_L0.8161.00
39_L45_N0.8121.00
279_I358_L0.8071.00
47_Q52_Q0.8051.00
105_E108_F0.8041.00
103_K164_A0.8001.00
50_S54_V0.8001.00
278_D339_E0.7981.00
186_S189_I0.7971.00
237_G354_S0.7961.00
48_I52_Q0.7961.00
72_I173_L0.7951.00
265_V269_L0.7931.00
101_Y104_V0.7921.00
109_F120_I0.7921.00
258_E298_S0.7901.00
344_L358_L0.7901.00
300_G303_S0.7871.00
87_E329_K0.7801.00
303_S306_L0.7791.00
199_A322_A0.7771.00
108_F154_A0.7771.00
239_D242_D0.7761.00
119_S122_A0.7691.00
40_L44_K0.7671.00
55_K61_K0.7601.00
36_I45_N0.7591.00
153_R157_Y0.7541.00
121_E136_R0.7511.00
123_R127_E0.7501.00
172_E320_S0.7491.00
42_S46_G0.7471.00
109_F112_S0.7471.00
173_L176_L0.7461.00
149_S236_M0.7451.00
148_A355_E0.7421.00
167_L200_A0.7401.00
269_L358_L0.7381.00
330_D334_N0.7381.00
43_F47_Q0.7341.00
107_V112_S0.7341.00
44_K48_I0.7331.00
109_F113_T0.7301.00
269_L272_H0.7301.00
192_S320_S0.7151.00
158_C161_Y0.7131.00
45_N49_H0.7131.00
53_F56_P0.7121.00
165_F168_V0.7121.00
41_S47_Q0.7091.00
149_S153_R0.7071.00
59_W62_E0.7051.00
43_F49_H0.7051.00
234_D357_L0.7041.00
48_I54_V0.7041.00
259_K263_T0.7011.00
142_L149_S0.7001.00
267_I270_D0.7001.00
79_K83_A0.6991.00
296_I306_L0.6951.00
47_Q53_F0.6931.00
312_I316_H0.6891.00
170_S322_A0.6851.00
58_E61_K0.6851.00
232_S235_V0.6851.00
92_P98_A0.6851.00
75_E79_K0.6841.00
234_D237_G0.6821.00
41_S45_N0.6811.00
162_P271_K0.6811.00
106_A109_F0.6801.00
232_S237_G0.6791.00
105_E163_E0.6791.00
137_I142_L0.6751.00
225_Q228_L0.6741.00
42_S70_N0.6731.00
42_S47_Q0.6731.00
45_N48_I0.6711.00
332_L337_K0.6711.00
37_D46_G0.6691.00
238_W242_D0.6691.00
206_E209_D0.6681.00
40_L43_F0.6651.00
201_A329_K0.6641.00
104_V165_F0.6641.00
92_P202_L0.6631.00
291_V295_Y0.6631.00
107_V113_T0.6611.00
39_L44_K0.6581.00
117_T140_W0.6541.00
78_L114_G0.6421.00
258_E262_K0.6411.00
110_V150_G0.6401.00
38_R46_G0.6391.00
89_L101_Y0.6381.00
39_L48_I0.6381.00
108_F114_G0.6351.00
259_K262_K0.6351.00
289_K314_Q0.6351.00
77_T173_L0.6331.00
69_K72_I0.6311.00
238_W241_T0.6311.00
108_F112_S0.6311.00
263_T266_Q0.6291.00
38_R316_H0.6291.00
265_V346_G0.6271.00
108_F113_T0.6271.00
75_E83_A0.6271.00
265_V299_L0.6231.00
44_K49_H0.6221.00
274_L279_I0.6221.00
240_F244_G0.6171.00
76_E80_H0.6161.00
307_S327_V0.6121.00
52_Q56_P0.6111.00
40_L75_E0.6101.00
53_F191_T0.6091.00
78_L123_R0.6071.00
106_A135_K0.6071.00
172_E194_F0.6031.00
44_K68_E0.6021.00
89_L130_F0.6001.00
126_N222_M0.6001.00
57_I62_E0.5991.00
239_D243_Q0.5991.00
38_R48_I0.5991.00
36_I46_G0.5971.00
81_S85_V0.5971.00
294_A297_K0.5941.00
293_D296_I0.5921.00
292_I306_L0.5921.00
151_L325_L0.5921.00
206_E227_V0.5911.00
112_S117_T0.5911.00
38_R47_Q0.5911.00
221_I227_V0.5881.00
56_P62_E0.5871.00
37_D80_H0.5831.00
132_P135_K0.5831.00
49_H54_V0.5791.00
243_Q255_T0.5781.00
336_H340_A0.5731.00
172_E321_S0.5731.00
101_Y130_F0.5661.00
343_G359_F0.5661.00
41_S46_G0.5661.00
111_S138_P0.5651.00
289_K292_I0.5591.00
269_L344_L0.5581.00
116_S140_W0.5561.00
311_S314_Q0.5541.00
147_G170_S0.5531.00
207_K210_R0.5521.00
221_I224_A0.5521.00
41_S73_Y0.5521.00
302_S306_L0.5501.00
78_L82_R0.5501.00
144_C285_H0.5481.00
289_K311_S0.5481.00
220_K223_D0.5461.00
107_V115_L0.5461.00
54_V58_E0.5431.00
174_C194_F0.5431.00
107_V157_Y0.5431.00
118_P143_G0.5411.00
255_T291_V0.5411.00
208_A220_K0.5381.00
135_K163_E0.5381.00
80_H171_A0.5371.00
220_K227_V0.5361.00
236_M355_E0.5351.00
46_G53_F0.5311.00
99_I204_C0.5301.00
224_A227_V0.5251.00
180_P187_N0.5251.00
221_I226_S0.5241.00
77_T120_I0.5241.00
233_E237_G0.5211.00
40_L45_N0.5191.00
325_L328_I0.5171.00
342_R358_L0.5171.00
312_I327_V0.5171.00
301_L307_S0.5161.00
200_A325_L0.5151.00
43_F71_Q0.5151.00
189_I192_S0.5141.00
280_S305_K0.5131.00
175_S196_D0.5111.00
116_S119_S0.5111.00
331_H337_K0.5111.00
159_K271_K0.5111.00
108_F137_I0.5101.00
235_V264_N0.5101.00
294_A298_S0.5091.00
329_K332_L0.5081.00
42_S68_E0.5071.00
102_E131_S0.5071.00
282_F344_L0.5061.00
54_V60_Y0.5021.00
36_I47_Q0.5021.00
284_A311_S0.5021.00
277_H303_S0.5021.00
104_V130_F0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4jaqD 2 0.9534 100 0.227 Contact Map
1u0mA 2 0.9507 100 0.233 Contact Map
3v7iA 2 0.9397 100 0.237 Contact Map
1ee0A 2 0.9726 100 0.262 Contact Map
3wd8A 2 0.9699 100 0.262 Contact Map
1xesA 2 0.9726 100 0.263 Contact Map
2d3mA 2 0.9671 100 0.265 Contact Map
3oitA 2 0.9507 100 0.266 Contact Map
2p0uA 2 0.9699 100 0.267 Contact Map
3ov2A 3 0.9726 100 0.267 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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